Cited by 121Stress Responses and CortisolAdipokines, Inflammation, and Metabolic DiseasesTryptophan and brain disorders

Systematic review of the evidence of a relationship between chronic psychosocial stress and C-reactive protein

Johnson, Timothy V., Abbasi, Ammara, Master, Viraj A.·2013·Molecular Diagnosis & Therapy

Abstract

Introduction C-reactive protein (CRP) is an acute-phase reactant with an increasing number of clinical functions. Studies in recent years have identified several social, economic, demographic, and psychological factors that contribute to baseline inflammation. Psychosocial stress represents a significant contributor to baseline inflammation. Given the importance of understanding background drivers of CRP levels, we conducted this review to assess the impact of chronic psychosocial stress on CRP levels.Methods Medline was searched through February 2013 for human studies examining CRP levels with respect to chronic psychosocial stress.Results The initial search identified 587 articles from which 129 potentially appropriate articles were reviewed. Of these 129 articles, 41 articles were included in the review. These studies were published between 2003 and 2013. Of these studies, 6 analyzed employment stress, 2 analyzed unemployment stress, 6 analyzed burnout and vital exhaustion, 6 analyzed caregiver stress, 3 analyzed interpersonal stress, 17 analyzed socioeconomic position, and 2 analyzed discrimination.Conclusion We conclude that psychosocial stress significantly impacts CRP and should be considered when interpreting the meaning of CRP elevations.

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Crossref · 10.1007/s40291-013-0026-7

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  • Chronic psychological stress, such as experienced by LSEs relative to HSEs when using social media, can lead to elevated levels of systemic inflammation over time.

    “The reason to focus on inflammation is that chronic psychological stress, such as experienced by LSEs relative to HSEs when using social media, can lead to elevated levels of systemic inflammation over time (Johnson et al., 2013; Nersesian et al., 2018; Walker et al., 2019).”

    From Social media use and systemic inflammation: The moderating role of self-esteem (2021) · cites this paper as Johnson et al., 2013

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Authors
Johnson, T. V., Abbasi, A., & Master, V. A.
Affiliations
  • Thomas Jefferson University (US)
  • Beth Israel Deaconess Medical Center (US)
Corresponding author
Johnson, Timothy V.
Venue
Molecular Diagnosis & Therapy
Published
2013-04-25
Volume
17
Issue
3
Pages
147-164
ISSN
  • 1177-1062 (ISSN-L)
  • 1179-2000
OpenAlex
W1966668500
Cited by
121
References
120
Citations by year
2026: 7 · 2025: 18 · 2024: 20 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 1
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Diagnosis & Therapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
chronic psychosocial stress, C-reactive protein, acute phase proteins, occupational stress, burnout, vital exhaustion, caregiver stress, interpersonal stress, socioeconomic position, discrimination
MeSH terms
Adult, Age Factors, Analysis of Variance, C-Reactive Protein, Conflict, Psychological, Female, Humans, Inflammation, Male, Middle Aged, Sex Factors, Social Environment, Socioeconomic Factors, Stress, Psychological

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