Candida auris Infection and Biofilm Formation: Going Beyond the Surface
Open accessAbstract
Purpose of Review: Emergent fungal pathogen C. auris is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy. Recent Findings: Current investigations show that C. auris produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when C. auris is growing on skin or in conditions expected in the hospital environment and on implanted medical devices. Summary: Here, we will highlight the topic of biofilm formation by C. auris. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Biofilm formation enhances Candida auris adhesive capacity and colonization efficiency.
“with biofilm formation enhancing its adhesive capacity and colonization efficiency9–11”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
The section ‘Does C. auris form biofilms in healthcare settings?’ describes biofilms as adherent communities and says growth as a biofilm on skin likely contributes to C. auris colonization. It does not establish that forming a biofilm increases the organism’s adhesive capacity relative to non-biofilm growth. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe cell wall adhesin Als4 plays a central role in biofilm formation in C. auris and is required for adhesion to both biotic and abiotic surfaces.
“The cell wall adhesin Als4 plays a central role in biofilm formation in C. auris and is required for adhesion to both biotic and abiotic surfaces11,14,17,50,52.”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
The sections on biofilms in healthcare settings describe C. auris growing as adherent biofilms on skin and catheter surfaces. They do not identify Als4 or establish that it is central to biofilm formation or required for adhesion to either surface type (searched: Als4 and adhesin-mediated adhesion). (LLM, conf=0.84)
Experimental — accuracy not yet measuredBiofilms are often associated with increased persistence on environmental surfaces and colonization on host skin.
“Since biofilms are often associated with increased persistence on the environmental surfaces and colonization on host skin4,5,11,49, this mutation could contribute to the prevalence and rapid transmission of C. auris.”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
The WOR2 mutation could contribute to the prevalence and rapid transmission of C. auris.
“Since biofilms are often associated with increased persistence on the environmental surfaces and colonization on host skin4,5,11,49, this mutation could contribute to the prevalence and rapid transmission of C. auris.”
From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lockhart, S. R., Etienne, K. A., Vallabhaneni, S., Farooqi, J., Chowdhary, A., Govender, N. P., Colombo, A. L., Calvo, B., Cuomo, C. A., Desjardins, C. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw691 · Cited by 1,662 · see citing works
Satoh, K., Makimura, K., Hasumi, Y., Nishiyama, Y., Uchida, K., & Yamaguchi, H. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2008.00083.x · Cited by 1,381 · see citing works
Biofilm Formation: A Clinically Relevant Microbiological Process
Donlan, R. M. (2001) · Clinical Infectious Diseases · doi:10.1086/322972 · Cited by 1,343 · see citing works
<i>Candida</i> Infections of Medical Devices
Kojic, E. M., & Darouiche, R. O. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.255-267.2004 · Cited by 1,055 · see citing works
Pfaller, M. A., Diekema, D. J., Turnidge, J. D., Castanheira, M., & Jones, R. N. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy358 · Cited by 825 · see citing works
First hospital outbreak of the globally emerging Candida auris in a European hospital
Schelenz, S., Hagen, F., Rhodes, J. L., Abdolrasouli, A., Chowdhary, A., Hall, A., Ryan, L., Shackleton, J., Trimlett, R., Meis, J. F., et al. (2016) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-016-0132-5 · Cited by 768 · see citing works
Chowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750 · see citing works
Antifungal Resistance of Candidal Biofilms Formed on Denture Acrylic in vitro
Chandra, J., Mukherjee, P. K., Leidich, S. D., Faddoul, F., Hoyer, L. L., Douglas, L., & Ghannoum, M. A. (2001) · Journal of Dental Research · doi:10.1177/00220345010800031101 · Cited by 588 · see citing works
Chowdhary, A., Prakash, A., Sharma, C., Kordalewska, M., Kumar, A., Sarma, S., Tarai, B., Singh, A., Upadhyaya, G., Upadhyay, S., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx480 · Cited by 577 · see citing works
<i>Candida</i> biofilms on implanted biomaterials: a clinically significant problem
Ramage, G., MartÃnez, J. P., & López-Ribot, J. L. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00117.x · Cited by 575 · see citing works
A <i>Candida auris</i> Outbreak and Its Control in an Intensive Care Setting
Eyre, D. W., Sheppard, A. E., Madder, H., Moir, I., Moroney, R., Quan, T. P., Griffiths, D., George, S., Butcher, L., Morgan, M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1714373 · Cited by 517 · see citing works
Mukherjee, P. K., Chandra, J., Kuhn, D. M., & Ghannoum, M. A. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4333-4340.2003 · Cited by 511 · see citing works
Welsh, R. M., Bentz, M. L., Shams, A., Houston, H., Lyons, A., Rose, L. J., & Litvintseva, A. P. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.00921-17 · Cited by 499 · see citing works
Comparison of Biofilms Formed byCandidaalbicansandCandidaparapsilosison Bioprosthetic Surfaces
Kuhn, D. M., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.878-888.2002 · Cited by 485 · see citing works
Ramage, G. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf049 · Cited by 468 · see citing works
Calvo, B., Melo, A. S. D. A., Mena, A. J. P., Hernandez, M., Francisco, E. C., Hagen, F., Meis, J. F. G. M., & Colombo, A. L. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.07.008 · Cited by 448 · see citing works
Biofilm-Forming Capability of Highly Virulent, Multidrug-Resistant <i>Candida auris</i>
Sherry, L., Ramage, G., Kean, R., Borman, A., Johnson, E. M., Richardson, M. D., & Rautemaa-Richardson, R. (2017) · Emerging Infectious Diseases · doi:10.3201/eid2302.161320 · Cited by 420 · see citing works
Resistance of Candida albicans biofilms to antifungal agents in vitro
Hawser, S., & Douglas, L. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.9.2128 · Cited by 407 · see citing works
Larkin, E., Hager, C., Chandra, J., Mukherjee, P. K., Retuerto, M., Salem, I., Long, L., Isham, N., Kovanda, L., Borroto-Esoda, K., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02396-16 · Cited by 395 · see citing works
Baillie, G. S. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.3.397 · Cited by 389 · see citing works
Characteristics of biofilm formation by Candida albicans.
Ramage, G., VandeWalle, K., Wickes, B. L., & Lopez-Ribot, J. L. (2001) · PubMed · Cited by 370 · see citing works
Candida auris candidaemia in Indian ICUs: analysis of risk factors
Rudramurthy, S. M., Chakrabarti, A., Paul, R. A., Sood, P., Kaur, H., Capoor, M. R., Kindo, A. J., Marak, R. S. K., Arora, A., Sardana, R., et al. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx034 · Cited by 357 · see citing works
<i>Candida auris</i> in Healthcare Facilities, New York, USA, 2013–2017
Adams, E., Quinn, M., Tsay, S., Poirot, E., Chaturvedi, S., Southwick, K., Greenko, J., Fernandez, R., Kallen, A., Vallabhaneni, S., et al. (2018) · Emerging Infectious Diseases · doi:10.3201/eid2410.180649 · Cited by 284 · see citing works
Candida auris Isolates Resistant to Three Classes of Antifungal Medications — New York, 2019
Ostrowsky, B. E., Greenko, J. A., Adams, E. H., Quinn, M., O’Brien, B., Chaturvedi, V. P., Berkow, E. L., Vallabhaneni, S., Forsberg, K., Chaturvedi, S., et al. (2020) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6901a2 · Cited by 247 · see citing works
Biswal, M., Rudramurthy, S. M., Jain, N., Shankarnarayan, S. A., Sharma, D., Jain, K., Yaddanapudi, L. N., & Chakrabarti, A. (2017) · Journal of Hospital Infection · doi:10.1016/j.jhin.2017.09.009 · Cited by 224 · see citing works
Escandón, P., Chow, N. A., Caceres, D. H., Gade, L., Berkow, E. L., Armstrong, P., Rivera, S., Misas, E., Duarte, C., Moulton-Meissner, H., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciy411 · Cited by 222 · see citing works
Kean, R., Delaney, C., Sherry, L., Borman, A., Johnson, E. M., Richardson, M. D., Rautemaa-Richardson, R., Williams, C., & Ramage, G. (2018) · mSphere · doi:10.1128/msphere.00334-18 · Cited by 220 · see citing works
Effectiveness of Disinfectants Against Candida auris and Other Candida Species
Cadnum, J. L., Shaikh, A., Piedrahita, C. T., Thriveen Sankar, C., Jencson, A. L., Larkin, E. L., Ghannoum, M. A., & Donskey, C. J. (2017) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2017.162 · Cited by 209 · see citing works
Nett, J. E., Crawford, K., Marchillo, K., & Andes, D. R. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00227-10 · Cited by 207 · see citing works
Self-citationCommunity participation in biofilm matrix assembly and function
Mitchell, K. F., Zarnowski, R., Sanchez, H., Edward, J. A., Reinicke, E. L., Nett, J. E., Mitchell, A. P., & Andes, D. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421437112 · Cited by 183 · see citing works
Self-citationVediyappan, G., Rossignol, T., & d'Enfert, C. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01638-09 · Cited by 183 · see citing works
Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin
Horton, M. V., Johnson, C. J., Kernien, J. F., Patel, T. D., Lam, B. C., Cheong, J. Z. A., Meudt, J. J., Shanmuganayagam, D., Kalan, L. R., & Nett, J. E. (2020) · mSphere · doi:10.1128/msphere.00910-19 · Cited by 159 · cited 1× · see citing works
“The degree of this biofilmassociated drug resistance varies by species and antifungal, with biofilms withstanding up to 1000×-fold higher concentrations of antifungals compared to planktonic cells. Consequently, one would speculate that biofilm formation is likely to be associated with increased antifungal tolerance f…”
Self-citationCandida biofilm: a well-designed protected environment
Mukherjee, P. K., Zhou, G., Munyon, R., & Ghannoum, M. A. (2005) · Medical Mycology · doi:10.1080/13693780500107554 · Cited by 149 · see citing works
Epidemiologic Shift in Candidemia Driven by <i>Candida auris</i>, South Africa, 2016–20171
van Schalkwyk, E., Mpembe, R. S., Thomas, J., Shuping, L., Ismail, H., Lowman, W., Karstaedt, A. S., Chibabhai, V., Wadula, J., Avenant, T., et al. (2019) · Emerging Infectious Diseases · doi:10.3201/eid2509.190040 · Cited by 137 · see citing works
Emergence ofCandida auris: An International Call to Arms
Clancy, C. J., & Nguyen, M. H. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw696 · Cited by 133 · see citing works
Conserved Role for Biofilm Matrix Polysaccharides in <i>Candida auris</i> Drug Resistance
Dominguez, E. G., Zarnowski, R., Choy, H. L., Zhao, M., Sanchez, H., Nett, J. E., & Andes, D. R. (2019) · mSphere · doi:10.1128/mspheredirect.00680-18 · Cited by 132 · see citing works
Self-citationRole of matrix β-1,3 glucan in antifungal resistance of non-albicans Candida biofilms
Mitchell, K. F., Taff, H. T., Cuevas, M. A., Reinicke, E. L., Sanchez, H., & Andes, D. R. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02378-12 · Cited by 104 · see citing works
Shastri, P. S., Shankarnarayan, S. A., Oberoi, J., Rudramurthy, S. M., Wattal, C., & Chakrabarti, A. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.01.004 · Cited by 103 · see citing works
Candida auris for the Clinical Microbiology Laboratory: Not Your Grandfather's Candida Species
Lockhart, S. R., Berkow, E. L., Chow, N. A., & Welsh, R. M. (2017) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2017.06.003 · Cited by 92 · see citing works
Sayeed, M. A., Farooqi, J. Q., Jabeen, K., Awan, S., & Mahmood, S. F. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-3999-y · Cited by 78 · see citing works
Candida auris: a comparison between planktonic and biofilm susceptibility to antifungal drugs
Romera, D., Aguilera-Correa, J. J., Gadea, I., Viñuela-Sandoval, L., García‐Rodríguez, J., & Esteban, J. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001036 · Cited by 68 · see citing works
Sayeed, M. A., Farooqi, J. Q., Jabeen, K., & Mahmood, S. F. (2019) · Medical Mycology · doi:10.1093/mmy/myz112 · Cited by 62 · see citing works
García-Bustos, V., Salavert, M., Gaitán, A. C. R., Cabañero-Navalón, M. D., Sigona-Giangreco, I. A., & Pemán, J. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.02.001 · Cited by 62 · see citing works
Park, J. Y., Bradley, N. E., Brooks, S., Burney, S., & Wassner, C. (2019) · Emerging infectious diseases · doi:10.3201/eid2503.180927 · Cited by 49 · see citing works
Farnesol increases the activity of echinocandins against Candida auris biofilms
Nagy, F., Tóth, Z., Daróczi, L., Székely, A., Borman, A. M., Majoros, L., & Kovács, R. (2019) · Medical Mycology · doi:10.1093/mmy/myz057 · Cited by 41 · see citing works
Khatamzas, E., Madder, H., & Jeffery, K. J. (2019) · Journal of Infection · doi:10.1016/j.jinf.2019.02.004 · Cited by 31 · see citing works
Successful treatment of a Candida auris intra-articular infection
Roberts, S. C., Zembower, T., Bolon, M. K., Kadakia, A. R., Gilley, J. H., Ko, J. H., Clark, J., Ward-Fore, S., & Taiwo, B. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2019.1625287 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [21]Schelenz S, Hagen F, Rhodes JL, Abdolrasouli A, Chowdhary A, Hall A First hospital outbreak of the globally emerging Candida auris in a European hospital. Antimicrobial Resistance and Infection Control. 2016; 5(35). doi: 10.1186/s13756-016-0132-5. PMC5069812 27777756 · DOI · Paper page
- [32]Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infection and immunity. 2003; 71(8): 4333– 40. 12874310 PMC165995
Cited by
Sorted by citations
Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species
Czajka, K. M., Venkataraman, K., Brabant-Kirwan, D., Santi, S. A., Verschoor, C. P., Appanna, V. D., Singh, R. I., Saunders, D., & Tharmalingam, S. (2023) · Cells · doi:10.3390/cells12222655 · Cited by 196 · see citing works
Diagnosis and Treatment of Invasive Candidiasis
Barantsevich, N. E., & Петровна, Б. Е. (2022) · Antibiotics · doi:10.3390/antibiotics11060718 · Cited by 193 · see citing works
Barber, C. A., Crank, K. C., Papp, K., Innes, G. K., Schmitz, B. W., Chavez, J., Rossi, A., & Gerrity, D. W. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c07763 · Cited by 88 · see citing works
Candida auris: A Quick Review on Identification, Current Treatments, and Challenges
Černáková, L., Roudbary, M., Brás, S., Tafaj, S., & Rodrigues, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094470 · Cited by 83 · see citing works
de Melo, C. C., de Sousa, B. R., da Costa, G. L., Oliveira, M. M. E., & de Lima-Neto, R. G. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1033707 · Cited by 60 · see citing works
Antifungal drug resistance in Candida: a special emphasis on amphotericin B
Ahmady, L., Gothwal, M., Mukkoli, M. M., & Bari, V. K. (2024) · Apmis · doi:10.1111/apm.13389 · Cited by 58 · see citing works
Azole resistance in Candida auris: mechanisms and combinatorial therapy
Jangir, P., Kalra, S., Tanwar, S., & Bari, V. K. (2023) · Apmis · doi:10.1111/apm.13336 · Cited by 53 · see citing works
Biofilm: The invisible culprit in catheter-induced candidemia
Wijaya, M., Halleyantoro, R., & Kalumpiu, J. F. (2023) · AIMS Microbiology · doi:10.3934/microbiol.2023025 · Cited by 52 · see citing works
Candida auris: A Mini Review on Epidemiology in Healthcare Facilities in Asia
Thatchanamoorthy, N., Rukumani, D. V., Samudi, C., & Tay, S. T. (2022) · Journal of Fungi · doi:10.3390/jof8111126 · Cited by 48 · see citing works
Baldim, I., Paziani, M. H., Barião, P. H. G., Kress, M. R. V. Z., & OLIVEIRA, W. P. D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010180 · Cited by 44 · see citing works
AlJindan, R. Y., & AlEraky, D. M. (2022) · Journal of Fungi · doi:10.3390/jof8070744 · Cited by 43 · see citing works
Photodynamic Therapy Is Effective Against Candida auris Biofilms
Bapat, P. S., & Nobile, C. J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.713092 · Cited by 36 · see citing works
Kovács, R., Nagy, F., Tóth, Z., Forgács, L., Tóth, L., Váradi, G., Tóth, G. K., Vadászi, K., Borman, A. M., Majoros, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020771 · Cited by 33 · see citing works
Singh, S., Barbarino, A., Youssef, E. G., Coleman, D., Gebremariam, T., & Ibrahim, A. (2023) · Journal of Fungi · doi:10.3390/jof9010103 · Cited by 35 · see citing works
Mariita, R. M., Davis, J., Lottridge, M. M., & Randive, R. V. (2022) · MicrobiologyOpen · doi:10.1002/mbo3.1261 · Cited by 29 · see citing works
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity
Ma, X., Tan, X., Yu, B., Sun, W., Wang, H., Hu, H., Du, Y., He, R., Gao, R., Peng, Q., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00835-0 · Cited by 30 · see citing works
Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects
Fayed, B. E. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01749-w · Cited by 30 · see citing works
Nagy, F., Tóth, Z., Nyikos, F., Forgács, L., Jakab, Á., Borman, A. M., Majoros, L., & Kovács, R. (2021) · Medical Mycology · doi:10.1093/mmy/myab032 · Cited by 30 · see citing works
Marena, G. D., Ramos, M. A. D. S., Carvalho, G. C., de Lima, L. C., do Nascimento, A. L. C. S., Sábio, R. M., Rodero, C. F., Spósito, L., Bauab, T. M., & Chorilli, M. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103566 · Cited by 30 · see citing works
Transcriptional and translational landscape of <i>Candida auris</i> in response to caspofungin
Zamith-Miranda, D., Amatuzzi, R. F., Munhoz da Rocha, I. F., Martins, S. T., Lucena, A. C. R., Vieira, A. Z., Trentin, G., Almeida, F., Rodrigues, M. L., Nakayasu, E. S., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.09.007 · Cited by 29 · see citing works
Asghar, S., Khan, I. U., Salman, S., Khalid, S. H., Ashfaq, R., & Vandamme, T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114019 · Cited by 27 · see citing works
Candida auris: the new fungal threat.
Pallotta, F., Viale, P., & Barchiesi, F. (2023) · PubMed Central · doi:10.53854/liim-3103-6 · Cited by 27 · see citing works
Melanization of Candida auris Is Associated with Alteration of Extracellular pH
Smith, D. F. Q., Mudrak, N. J., Zamith‐Miranda, D., Honorato, L., Nimrichter, L., Chrissian, C., Smith, B., Gerfen, G. J., Stark, R. E., Nosanchuk, J. D., et al. (2022) · Journal of Fungi · doi:10.3390/jof8101068 · Cited by 26 · see citing works
Barião, P. H. G., Tonani, L., Brancini, G. T. P., Nascimento, É., Braga, G. Ú. L., Wainwright, M. S., & Kress, M. R. V. Z. (2022) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-022-00258-4 · Cited by 26 · see citing works
Multicenter Candida auris outbreak caused by azole‐susceptible clade IV in Pernambuco, Brazil
Spruijtenburg, B., de Almeida, J. N., Ribeiro, F. D. C., Kemmerich, K. K., Baêta, K. F., Meijer, E. F. J., de Groot, T., Meis, J. F. G. M., Colombo, A. L., & Brazilian Candida auris collaborative network (2024) · Mycoses · doi:10.1111/myc.13752 · Cited by 24 · see citing works
Unveiling the menace: a thorough review of potential pandemic fungal disease
Jafarlou, M. (2024) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2024.1338726 · Cited by 24 · see citing works
Elgammal, Y., Salama, E. A., & Seleem, M. N. (2024) · Scientific Reports · doi:10.1038/s41598-024-52012-8 · Cited by 22 · see citing works
Ramos, L. S., Barbosa, P. F., Lorentino, C. M. A., Lima, J. C., Braga, A. L., Lima, R., Giovanini, L., Casemiro, A. L., Siqueira, N. L. M., da Costa, S. C., et al. (2025) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2025.100354 · Cited by 24 · see citing works
Lee, E. H., Choi, M. H., Lee, K. H., Kim, D., Jeong, S. H., Song, Y. G., & Han, S. H. (2023) · Journal of Hospital Infection · doi:10.1016/j.jhin.2023.10.017 · Cited by 20 · see citing works
Ware, A., Johnston, W., Delaney, C., Butcher, M. C., Ramage, G., Price, L., Butcher, J. P., & Kean, R. (2025) · Apmis · doi:10.1111/apm.70022 · Cited by 22 · see citing works
Candida auris and COVID-19: A health threatening combination
Khojasteh, S., Jafarzdeh, J., Hosseini, S. A., Haghani, I., Turki, H., Gharehbolagh, S. A., Abastabar, M., & Mahmoudi, S. (2022) · Current Medical Mycology · doi:10.18502/cmm.8.3.11211 · Cited by 22 · see citing works
Bravo-Chaucanés, C. P., Vargas‐Casanova, Y., Chitiva, L. C., Ceballos-Garzón, A., Costa, G. M., & Parra‐Giraldo, C. M. (2022) · Journal of Fungi · doi:10.3390/jof8080784 · Cited by 21 · see citing works
Candida auris biofilm: a review on model to mechanism conservation
Khari, A., Biswas, B., Gangwar, G., Thakur, A., & Puria, R. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2179036 · Cited by 18 · see citing works
Akinbobola, A., Kean, R., & Quilliam, R. S. (2023) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2023.115841 · Cited by 18 · see citing works
Biofilm formation on cat claws by Sporothrix species: An ex vivo model
Brilhante, R. S. N., Fernandes, M. R., Pereira, V. S., Costa, A. D. C., de Oliveira, J. S., de Aguiar, L., Rodrigues, A. M., Camargo, Z. P. D., Pereira‐Neto, W. D. A., Sidrim, J. J. C., et al. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104670 · Cited by 18 · see citing works
Ceballos-Garzón, A., Lebrat, J., Holzapfel, M., Josa, D. F., Welsch, J., & Mercer, D. K. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00137-25 · Cited by 18 · see citing works
Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?
Kovács, R., & Majoros, L. (2022) · Letters in Applied Microbiology · doi:10.1111/lam.13653 · Cited by 17 · see citing works
Comparing the effect of Thymus spp. essential oils on Candida auris
Ribeiro, R., Fernandes, L., Costa, R. S., Cavaleiro, C., Salgueiro, L., Henriques, M., & Rodrigues, M. E. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.114667 · Cited by 18 · see citing works
Peptide‐Decorated Liposomes Enhance Fungal Targeting and Antifungal Drug Delivery
LaMastro, V., Walker, D., Liu, J., Meng‐Saccoccio, T., & Shukla, A. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202508570 · Cited by 17 · see citing works
Candida auris cells form giant lipid droplets to survive in harsh environments
Zheng, Q., Li, C., Hu, T., Bing, J., Nobile, C. J., Chu, H., & Huang, G. (2025) · Communications Biology · doi:10.1038/s42003-025-08204-7 · Cited by 17 · see citing works
Hong, H., Ximing, Y., Jinghan, M., Al-Danakh, A. Y., Shujuan, P., Ying, L., Yang, Y., Yuehong, L., & Xingwei, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1211626 · Cited by 16 · see citing works
The Gordian Knot of C. auris: If You Cannot Cut It, Prevent It
Rapti, V., Iliopoulou, K., & Poulakou, G. (2023) · Pathogens · doi:10.3390/pathogens12121444 · Cited by 16 · see citing works
Balla, N., Kovács, F., Balázs, B., Borman, A. M., Bozó, A., Jakab, Á., Tóth, Z., Kobaissi, O., Majoros, L., & Kovács, R. (2022) · Antibiotics · doi:10.3390/antibiotics11111601 · Cited by 15 · see citing works
Occidiofungin: Actin Binding as a Novel Mechanism of Action in an Antifungal Agent
Hansanant, N., & Smith, L. (2022) · Antibiotics · doi:10.3390/antibiotics11091143 · Cited by 14 · see citing works
Efflux systems as a target for anti-biofilm nanoparticles: perspectives on emerging applications
Musioł, R. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2263910 · Cited by 14 · see citing works
Key Factors to Consider for Candida auris Screening in Healthcare Settings: A Systematic Review
Danielsen, A. S., Ødeskaug, L. E., Raastad, R., Kjerulf, A., Andersen, A., Tornes, R. A., Himmels, J. P. W., Dahle, U. R., Sare, M., Kristensen, B., et al. (2025) · Mycoses · doi:10.1111/myc.70043 · Cited by 13 · see citing works
Zeng, H., Stadler, M., Abraham, W., Müsken, M., & Schrey, H. (2023) · Journal of Fungi · doi:10.3390/jof9070726 · Cited by 13 · see citing works
Candida auris, a singular emergent pathogenic yeast: its resistance and new therapeutic alternatives
Fernandes, L., Ribeiro, R., Henriques, M., & Rodrigues, M. E. (2022) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-022-04497-2 · Cited by 14 · see citing works
Candida auris Resistance Mechanisms to Amphotericin B Alternative Treatments Development
Fenton, A., & John, G. K. (2024) · Current Clinical Microbiology Reports · doi:10.1007/s40588-024-00233-w · Cited by 12 · see citing works
Beattie, S. R., Esan, T. E., Żarnowski, R., Eix, E. F., Nett, J. E., Andes, D. R., Hagen, T. J., & Krysan, D. J. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00081-23 · Cited by 11 · see citing works
Self-citationOyardı, Ö., Demir, E. S., Alkan, B., Kömeç, S., Genç, G. E., Aygün, G., Teke, L., Turan, D., Erturan, Z., Savage, P. B., et al. (2023) · Journal of Fungi · doi:10.3390/jof9101026 · Cited by 11 · see citing works
Janeczko, M., & Skrzypek, T. (2025) · Pathogens · doi:10.3390/pathogens14010040 · Cited by 11 · see citing works
Mycological Investigation of Bottled Water Dispensers in Healthcare Facilities
Tischner, Z., Sebők, R., Kredics, L., Allaga, H., Vargha, M., Sebestyén, Á., Dobolyi, C., Kriszt, B., & Magyar, D. (2021) · Pathogens · doi:10.3390/pathogens10070871 · Cited by 11 · see citing works
Squitieri, D., Rizzo, S., Torelli, R., Mariotti, M., Sanguinetti, M., Cacaci, M., & Bugli, F. (2025) · Pharmaceuticals · doi:10.3390/ph19010008 · Cited by 11 · see citing works
Self-Sanitizing Polycaprolactone Electrospun Nanofiber Membrane with Ag Nanoparticles
Permyakova, E. S., Manakhov, A. M., Kiryukhantsev–Korneev, P. V., Сергеевич, К. А., Makarets, Y. А., Kotyakova, K. Y., Filippovich, S. Y., Ignatov, S. G., Solovieva, A. O., & Shtansky, D. V. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14070336 · Cited by 10 · see citing works
Kerai, A., Doshi, S., Laleker, A., & Majumdar, A. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae286 · Cited by 10 · see citing works
Insights into Candida auris dispersal cells and their impact on antifungal resistance
Fayed, B. E. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04055-8 · Cited by 10 · see citing works
Biswas, B., Rana, A., Gupta, N., Gupta, I., Puria, R., & Thakur, A. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00892-23 · Cited by 10 · see citing works
Enablers of Candida auris persistence on medical devices and their mode of eradication.
Nwachukwu, K. C., Nwarunma, E., Uchenna, C. D., & Ugbogu, O. C. (2023) · PubMed Central · doi:10.18502/cmm.2023.150673 · Cited by 10 · see citing works
Technology landscape and a short patentometric review for antibiofilm technologies
Speziali, M. G., Lívio, D. F., Tarabal, V. S., & Granjeiro, P. A. (2022) · World Patent Information · doi:10.1016/j.wpi.2022.102158 · Cited by 9 · see citing works
Balkrishna, A., Kharayat, B., Rastogi, S., Kabdwal, M., Haldar, S., & Varshney, A. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad087 · Cited by 10 · see citing works
Gupta, N., Haughton, S., Kemper, S., Koehler, M., Antoon, R., Edwards, C. G., & Bardin-Spencer, A. J. (2024) · American Journal of Infection Control · doi:10.1016/j.ajic.2024.06.015 · Cited by 9 · see citing works
Fayed, B. E., Shakartalla, S. B., Sabbah, H., Dalle, H., Tannira, M., Senok, A. C., & Soliman, S. S. M. (2024) · Mycopathologia · doi:10.1007/s11046-024-00868-9 · Cited by 8 · see citing works
Garvey, M., Kremer, T. A., & Rowan, N. J. (2025) · Journal of Applied Microbiology · doi:10.1093/jambio/lxaf005 · Cited by 9 · see citing works
New Insights in Phenothiazinium-Mediated Photodynamic Inactivation of Candida Auris
da Silva, A. R., Cabral, F. V., Silva, C. R., da Silva, D. D. F. T., de Freitas, A. Z., Fontes, A., & Ribeiro, M. S. (2023) · Journal of Fungi · doi:10.3390/jof9070717 · Cited by 8 · see citing works
Kumar, A., Francis, A., Hans, S., & Thakur, A. (2024) · Springer eBooks · doi:10.1007/978-981-97-4909-6_8 · Cited by 6 · see citing works
Cox, C. A., Manavathu, E. K., Wakade, S., Myntti, M. F., & Vázquez, J. A. (2023) · Mycoses · doi:10.1111/myc.13684 · Cited by 6 · see citing works
The emerging pathogen Candida auris: host interactions and disease drivers
Sanya, D. R. A., Arevalo, A. V., Onésime, D., & Nobile, C. J. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-026-01230-5 · Cited by 5 · see citing works
Valente, M. R., Alcântara, L. M., Cintra, D. S., Mendoza, S. R., Medeiros, E. G., Gomes, K. X., Honorato, L., Almeida, M. D. A., Vieira, C. B., Nosanchuk, J. D., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01746-24 · Cited by 5 · see citing works
HIV protease inhibitors restore amphotericin B activity against Candida
Elgammal, Y., Salama, E. A., & Seleem, M. N. (2025) · PLoS ONE · doi:10.1371/journal.pone.0324080 · Cited by 5 · see citing works
Marena, G. D., López, A., Carvalho, G. C., Marín, M. P., Ruiz, M. D. P., Pérez-Royo, J. M., Tormo‐Más, M. Á., Bernabé, P., Valentı́n, E., Bauab, T. M., et al. (2024) · Pathogens · doi:10.3390/pathogens13070549 · Cited by 5 · see citing works
Efficacy Of C-10 Massoialactone against-Multispecies Microbial Biofilm
(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac123.34723487 · Cited by 6 · see citing works
Emergence, Transmission, and Containment of Candida auris in the Perioperative Setting
Curless, M. S., Hodges, C. A., & Rock, C. (2025) · AORN Journal · doi:10.1002/aorn.14283 · Cited by 4 · see citing works
Wimmer, A., Jernej, L., Liu, J., Fefer, M., & Plaetzer, K. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00768-x · Cited by 4 · see citing works
Current and emerging therapies for fungal biofilms and systemic infections
Elgammal, Y., Martinez, R. I. G., Requejo, A., & Martinez, L. R. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2570185 · Cited by 4 · see citing works
Fathima, K., Khan, N., Faraz, A., Kazmi, S. Y., & al Motery, A. S. (2022) · Journal of Ayub Medical College Abbottabad · doi:10.55519/jamc-03-s1-9274 · Cited by 4 · see citing works
CANDIDA AURIS: THE UNWELCOME SUPERFUNGUS
Nedea, M. I. (2023) · FARMACIA · doi:10.31925/farmacia.2023.2.1 · Cited by 4 · see citing works
Potent anti-biofilm properties of plumbagin against fluconazole-resistant Candida auris
Jin, H.-W., & Eom, Y. (2024) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2024.06.005 · Cited by 4 · see citing works
Ramli, A. H., Jayathilaka, E. H. T. T., Dias, M. K. H. M., Malek, E. A., Jain, N., An, J., Churchill, D. G., Rukayadi, Y., Swain, P., Kim, C., et al. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106797 · Cited by 4 · see citing works
Gierke, A.-M., & Heßling, M. (2024) · Pathogens and Immunity · doi:10.20411/pai.v9i2.723 · Cited by 4 · see citing works
Rodrigues, M. I. D. S., da Cruz, G. H. R., Lucini, F., de Almeida, A. M., Pereira, F. F., Ramalho, R. T., Simionatto, S., & Rossato, L. L. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107115 · Cited by 4 · see citing works
β-Glucan chitosan particle provides cross-protection against multi-drug-resistant Candida auris
Singh, S., Barbarino, A., Youssef, E. G., Gupta, K. D., Nabeela, S., Gebremariam, T., Alkhazraji, S., Uppuluri, P., Ostroff, G., & Ibrahim, A. (2026) · npj Vaccines · doi:10.1038/s41541-026-01485-x · Cited by 2 · see citing works
Stergiou, K. I., Skourtsidis, K., Kiosis, G., Ioannou, D., Tseriotis, V., Fouskas, V., Karachrysafi, S., Iosifidis, Ε., Roilides, E., Papamitsou, T., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14010228 · Cited by 3 · see citing works
Kovács, F., Harmath, A., Balázsi, D., Forgács, L., Ragyák, Á. Z., Balla, N., Tóth, Z., Bozó, A., Borman, A. M., Majoros, L., et al. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.02686-25 · Cited by 3 · see citing works
Reedy, J. M., Fernando, T., Awuor, S. O., Omwenga, E. O., Koutchma, T., & Mariita, R. M. (2024) · Hygiene · doi:10.3390/hygiene4030030 · Cited by 4 · see citing works
Kumaran, S. U., & Rajagopal, L. (2022) · Mathematical Methods in the Applied Sciences · doi:10.1002/mma.8212 · Cited by 3 · see citing works
Iron chelators enhance the potency of Echinocandins against Candida aurisPreprint
Sharma, P., & Pasrija, R. (2025) · Research Square · doi:10.21203/rs.3.rs-7042978/v1 · Cited by 3 · see citing works
Bae, J.-H., & Eom, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1631780 · Cited by 2 · see citing works
Erganiş, S., Seyer, A., Mustapha, M. T., Yuvalı, M., Martli, F., Algın, S., Uzuntaş, S. T., Yavuz, B., Dogan, A., Kılıç, E., et al. (2025) · MicrobiologyOpen · doi:10.1002/mbo3.70093 · Cited by 2 · see citing works
Zainal, M., Sarmin, N. ‘. M., Ibrahim, M. J., Cirillo, N., Dashper, S. G., & Arzmi, M. H. (2025) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2025.106478 · Cited by 2 · see citing works
Investigating strategies for control of Candidozyma auris biofilms on surfaces
Brown, L., Fraser, E., Martinez-Garcia, G., & Clarke, J. (2026) · Journal of Hospital Infection · doi:10.1016/j.jhin.2026.01.025 · Cited by 2 · see citing works
Mies, K., Hermes, G., Beckers, J., Mörgelin, M., Simon, M., Ruegamer, T., Jantsch, J., Klatt, A. R., Streichert, T., & Elezagic, D. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1756518 · Cited by 2 · see citing works
Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden
Baral, B. (2026) · ChemFoodChem · doi:10.1002/cfch.70026 · Cited by 2 · see citing works
Shi, L., Liu, Y., & Li, T. (2022) · Materials Research Express · doi:10.1088/2053-1591/ac6fbe · Cited by 2 · see citing works
Molecular Insights Into the Interplay Between Host Platelets and Fungal Pathogens
Kumari, N., Maharaj, S., Chattopadhyay, R., Singh, S. K., & Bari, V. K. (2024) · Current Clinical Microbiology Reports · doi:10.1007/s40588-024-00237-6 · Cited by 2 · see citing works
Pinna, A., Donadu, M. G., Dore, S., Serra, R., Sacchi, M., Boscia, G., Bozó, A., & Kovács, R. (2025) · Vision · doi:10.3390/vision9010012 · Cited by 2 · see citing works
Electroactive nanostructured antibacterial materials
Saraeva, I. N., Zayarny, D. A., Ромеовна, Т. Э., Nastulyavichus, A., Khaertdinova, L. F., Kudryashov, S. I., Zhizhimova, Y. S., Ионин, А. А., & Gonchukov, S. A. (2022) · Laser Physics Letters · doi:10.1088/1612-202x/ac772d · Cited by 2 · see citing works
Candida auris: Multidrug resistance and new treatment strategies
Bensusan, E. C., Soares, J. A., Giorgetti, L., & de Macêdo-Sales, P. A. (2022) · Revista Brasileira de Ciências Biomédicas · doi:10.46675/rbcbm.v3i1.68 · Cited by 2 · see citing works
Cavalcanti, B. C., Magalhães, I. L., Rodrigues, D. S., Cabral, V. P. D. F., Barbosa, A. D., Sá, L. G. D. A. V., da Silva, L. J., Neto, J. B. D. A., da Silva, C. R., de Moraes, M. O., et al. (2024) · Future Microbiology · doi:10.1080/17460913.2024.2380601 · Cited by 1 · see citing works
Antifungal activity of cephalosporins as an alternative for the combat of Candida auris
Rodrigues, M. I. D. S., Lucini, F., da Silva, G. A., Sturaro, M. C., Silva, O. N., de Aquino, T. M., Careaga, L. L. P., Carvalho, A. P., Pereira, F. F., Simionatto, S., et al. (2025) · Brazilian Journal of Microbiology · doi:10.1007/s42770-025-01786-8 · Cited by 1 · see citing works
- Authors
- Horton, M. V., & Nett, J. E.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Nett, Jeniel E.
- ORCID
- Nett, Jeniel E.
- Venue
- Current Clinical Microbiology Reports
- Published
- 2020-07-17
- Volume
- 7
- Issue
- 3
- Pages
- 51-56
- ISSN
- 2196-5471 (ISSN-L)
- PMC
- PMC7654955
- OpenAlex
- W3042454077
- Cited by
- 132
- References
- 47
- Citations by year
- 2026: 30 · 2025: 23 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 8 · 2020: 1
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Clinical Microbiology Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Doris Duke Charitable Foundation (2017074)
- National Institute of Allergy and Infectious Diseases (R21AI159583, R01AI145939)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- Candida auris, biofilm formation, antifungal resistance, nosocomial transmission, invasive candidiasis, skin colonization, biomedical implants, desiccation tolerance, emerging fungal pathogens
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
