Cited by 133Antifungal resistance and susceptibilityFungal and yeast genetics researchBacterial biofilms and quorum sensing

Conserved Role for Biofilm Matrix Polysaccharides in Candida auris Drug Resistance

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Dominguez, E. G., Zarnowski, R., Choy, H. L., Zhao, M., Sanchez, H., Nett, Jeniel E., Andes, D. R.·2019·mSphere

Abstract

Candida auris is an emerging fungal threat linked to poor patient outcomes. The factors responsible for this apparent increase in pathogenicity remain largely unknown. Biofilm formation has been suggested as an important factor for persistence of this organism in patients and the environment. Our findings reveal one mechanism utilized by C. auris to evade the effect of triazole antifungal therapy during biofilm growth. The conservation of the protective biofilm matrix among Candida spp. suggests that is a promising pan-fungal Candida biofilm drug target.

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Authors
Dominguez, E. G., Zarnowski, R., Choy, H. L., Zhao, M., Sanchez, H., Nett, J. E., & Andes, D. R.
Affiliations
  • University of Wisconsin–Madison (US)
  • Department of Medicine, Section of Infectious Disease, University of Wisconsin—Madison, Madison, Wisconsin, USA
Corresponding author
Andes, D. R.
Venue
mSphere
Published
2019-02-27
Volume
4
Issue
1
ISSN
2379-5042 (ISSN-L)
OpenAlex
W2908106770
Cited by
132
References
23
Citations by year
2026: 12 · 2025: 21 · 2024: 12 · 2023: 11 · 2022: 20 · 2021: 31 · 2020: 19 · 2019: 6
FWCI
14.57
Type
journal article
Language
en
Open access
Locations
  • mSphere (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI073289)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
Candida auris, biofilm matrix polysaccharides, antifungal resistance, triazole antifungal therapy, biofilm formation, fungal pathogenicity, Candida
MeSH terms
Extracellular Polymeric Substance Matrix, Antifungal Agents, Candida, Drug Tolerance, Humans, Microbial Sensitivity Tests, Biofilms, Drug Resistance, Fungal

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