Conserved Role for Biofilm Matrix Polysaccharides in Candida auris Drug Resistance
Open accessAbstract
Candida auris is an emerging fungal threat linked to poor patient outcomes. The factors responsible for this apparent increase in pathogenicity remain largely unknown. Biofilm formation has been suggested as an important factor for persistence of this organism in patients and the environment. Our findings reveal one mechanism utilized by C. auris to evade the effect of triazole antifungal therapy during biofilm growth. The conservation of the protective biofilm matrix among Candida spp. suggests that is a promising pan-fungal Candida biofilm drug target.
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In the biofilm community, a unique extracellular mannan-glucan complex prevents antifungal drugs from reaching intracellular drug targets.
“In the biofilm community, a unique extracellular mannan-glucan complex has been shown to prevent antifungal drugs from reaching intracellular drug targets (17–20).”
From Dual function of <i>Candida auris</i> mannosyltransferase, MNT5, in biofilm community protection from antifungal therapy and the host (2025) · cites this paper as [18]
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Bacterial biofilms: from the Natural environment to infectious diseases
Hall‐Stoodley, L., Costerton, J. W., & Stoodley, P. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro821 · Cited by 7,133 · see citing works
Lockhart, S. R., Etienne, K. A., Vallabhaneni, S., Farooqi, J., Chowdhary, A., Govender, N. P., Colombo, A. L., Calvo, B., Cuomo, C. A., Desjardins, C. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw691 · Cited by 1,662 · see citing works
Chandra, J., Kuhn, D. M., Mukherjee, P. K., Hoyer, L. L., McCormick, T., & Ghannoum, M. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5385-5394.2001 · Cited by 1,578 · see citing works
Pierce, C. G., Uppuluri, P., Tristan, A. R., Wormley, F. L., Mowat, E., Ramage, G., & Lopez-Ribot, J. L. (2008) · Nature Protocols · doi:10.1038/nprot.2008.141 · Cited by 1,041 · see citing works
Andes, D. R., Safdar, N., Baddley, J. W., Playford, G., Reboli, A. C., Rex, J. H., Sobel, J. D., Pappas, P. G., Kullberg, B. J., & for the Mycoses Study Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis021 · Cited by 793 · see citing works
Self-citationRamage, G. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf049 · Cited by 468 · see citing works
Mechanisms of <i>Candida</i> Biofilm Drug Resistance
Taff, H. T., Mitchell, K. F., Edward, J. A., & Andes, D. R. (2013) · Future Microbiology · doi:10.2217/fmb.13.101 · Cited by 422 · see citing works
Self-citationBiofilm-Forming Capability of Highly Virulent, Multidrug-Resistant <i>Candida auris</i>
Sherry, L., Ramage, G., Kean, R., Borman, A., Johnson, E. M., Richardson, M. D., & Rautemaa-Richardson, R. (2017) · Emerging Infectious Diseases · doi:10.3201/eid2302.161320 · Cited by 420 · see citing works
Larkin, E., Hager, C., Chandra, J., Mukherjee, P. K., Retuerto, M., Salem, I., Long, L., Isham, N., Kovanda, L., Borroto-Esoda, K., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02396-16 · Cited by 395 · see citing works
Andes, D., Nett, J., Oschel, P., Albrecht, R., Marchillo, K., & Pitula, A. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.6023-6031.2004 · Cited by 389 · see citing works
Self-citationNovel Entries in a Fungal Biofilm Matrix Encyclopedia
Zarnowski, R., Westler, W. M., Lacmbouh, G. A., Marita, J. M., Bothe, J. R., Bernhardt, J., Lounes-Hadj Sahraoui, A., Fontaine, J., Sanchez, H., Hatfield, R. D., et al. (2014) · mBio · doi:10.1128/mbio.01333-14 · Cited by 315 · see citing works
Self-citationA Candida Biofilm-Induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance
Taff, H. T., Nett, J. E., Zarnowski, R., Ross, K. M., Sanchez, H., Cain, M. T., Hamaker, J., Mitchell, A. P., & Andes, D. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002848 · Cited by 291 · see citing works
Self-citationKean, R., Delaney, C., Sherry, L., Borman, A., Johnson, E. M., Richardson, M. D., Rautemaa-Richardson, R., Williams, C., & Ramage, G. (2018) · mSphere · doi:10.1128/msphere.00334-18 · Cited by 220 · see citing works
Community participation in biofilm matrix assembly and function
Mitchell, K. F., Zarnowski, R., Sanchez, H., Edward, J. A., Reinicke, E. L., Nett, J. E., Mitchell, A. P., & Andes, D. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421437112 · Cited by 183 · see citing works
Self-citationEmerging fungal pathogen Candida auris evades neutrophil attack
Johnson, C. J., Davis, J. M., Huttenlocher, A., Kernien, J. F., & Nett, J. E. (2018) · mBio · doi:10.1128/mbio.01403-18 · Cited by 157 · see citing works
Self-citationOh, B. J., Shin, J. H., Kim, M., Sung, H., Lee, K., Joo, M. Y., Shin, M., Suh, S., & Ryang, D. W. (2010) · Medical Mycology · doi:10.3109/13693786.2010.493563 · Cited by 143 · see citing works
Emergence ofCandida auris: An International Call to Arms
Clancy, C. J., & Nguyen, M. H. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw696 · Cited by 133 · see citing works
Surface disinfection challenges for Candida auris: an in-vitro study
Kean, R., Sherry, L., Townsend, E. R., McKloud, E., Short, B., Akinbobola, A., Mackay, W. G., Williams, C., Jones, B., & Ramage, G. (2017) · Journal of Hospital Infection · doi:10.1016/j.jhin.2017.11.015 · Cited by 125 · see citing works
Candida auris: a global fungal public health threat
Meis, J. F. G. M., & Chowdhary, A. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30609-1 · Cited by 103 · see citing works
Pierce, C. G., Uppuluri, P., Tummala, S., & Lopez-Ribot, J. L. (2010) · Journal of Visualized Experiments · doi:10.3791/2287 · Cited by 103 · see citing works
The Candida auris Alert: Facts and Perspectives
Lamoth, F., & Kontoyiannis, D. P. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix597 · Cited by 95 · see citing works
Dominguez, E., Zarnowski, R., Sanchez, H., Covelli, A. S., Westler, W. M., Azadi, P., Nett, J., Mitchell, A. P., & Andes, D. R. (2018) · mBio · doi:10.1128/mbio.00451-18 · Cited by 77 · see citing works
Self-citationHost Contributions to Construction of Three Device-Associated Candida albicans Biofilms
Nett, J. E., Żarnowski, R., Cabezas‐Olcoz, J., Brooks, E. G., Bernhardt, J., Marchillo, K., Mosher, D. F., & Andes, D. R. (2015) · Infection and Immunity · doi:10.1128/iai.00931-15 · Cited by 68 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ahmad, S., & Alfouzan, W. (2021) · Microorganisms · doi:10.3390/microorganisms9040807 · Cited by 269 · see citing works
Antifungal drug-resistance mechanisms in Candida biofilms
Kaur, J., & Nobile, C. J. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102237 · Cited by 279 · see citing works
Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris
Chaabane, F., Graf, A., Jequier, L., & Coste, A. T. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02788 · Cited by 223 · see citing works
Biofilm formation in medically important Candida species
Malinovská, Z., Čonková, E., & Váczi, P. (2023) · Journal of Fungi · doi:10.3390/jof9100955 · Cited by 167 · see citing works
Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin
Horton, M. V., Johnson, C. J., Kernien, J. F., Patel, T. D., Lam, B. C., Cheong, J. Z. A., Meudt, J. J., Shanmuganayagam, D., Kalan, L. R., & Nett, J. E. (2020) · mSphere · doi:10.1128/msphere.00910-19 · Cited by 159 · see citing works
Self-citationContributions of the Biofilm Matrix to Candida Pathogenesis
Nett, J. E., & Andes, D. R. (2020) · Journal of Fungi · doi:10.3390/jof6010021 · Cited by 158 · see citing works
Self-citationCombined Antifungal Resistance and Biofilm Tolerance: the Global Threat of Candida auris
Kean, R., & Ramage, G. (2019) · mSphere · doi:10.1128/msphere.00458-19 · Cited by 155 · see citing works
Chakrabarti, A., & Sood, P. (2021) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001318 · Cited by 132 · see citing works
Candida auris Infection and Biofilm Formation: Going Beyond the Surface
Horton, M. V., & Nett, J. E. (2020) · Current Clinical Microbiology Reports · doi:10.1007/s40588-020-00143-7 · Cited by 132 · see citing works
Self-citationWays to control harmful biofilms: prevention, inhibition, and eradication
Yin, W., Xu, S., Wang, Y., Zhang, Y., Chou, S., Galperin, M. Y., & He, J. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1842325 · Cited by 120 · see citing works
Lara, H. H., Ixtepan-Turrent, L., Jose Yacaman, M., & Lopez-Ribot, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b20708 · Cited by 116 · see citing works
de Jong, A. W., & Hagen, F. (2019) · Mycopathologia · doi:10.1007/s11046-019-00351-w · Cited by 98 · see citing works
Biofilm formation by <i>Candida auris</i> isolated from colonising sites and candidemia cases
Singh, R., Kaur, M., Chakrabarti, A., Shankarnarayan, S. A., & Rudramurthy, S. M. (2019) · Mycoses · doi:10.1111/myc.12947 · Cited by 86 · see citing works
Candida auris: A Decade of Understanding of an Enigmatic Pathogenic Yeast
Kean, R., Brown, J. L., Gülmez, D., Ware, A., & Ramage, G. (2020) · Journal of Fungi · doi:10.3390/jof6010030 · Cited by 86 · see citing works
What do we know about the biology of the emerging fungal pathogen of humans Candida auris?
Ruiz, G. B., & Lorenz, A. (2020) · Microbiological Research · doi:10.1016/j.micres.2020.126621 · Cited by 83 · see citing works
Antibiofilm Activities of Biogenic Silver Nanoparticles Against Candida albicans
Ahamad, I., Bano, F., Anwer, R., Srivastava, P., Kumar, R., & Fatma, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.741493 · Cited by 86 · see citing works
Candida auris: A Quick Review on Identification, Current Treatments, and Challenges
Černáková, L., Roudbary, M., Brás, S., Tafaj, S., & Rodrigues, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094470 · Cited by 83 · see citing works
What Do We Know about Candida auris? State of the Art, Knowledge Gaps, and Future Directions
García-Bustos, V., Cabañero-Navalón, M. D., Ruiz‐Saurí, A., Gaitán, A. C. R., Salavert, M., Tormo‐Más, M. Á., & Pemán, J. (2021) · Microorganisms · doi:10.3390/microorganisms9102177 · Cited by 82 · see citing works
Fungal biofilms in human health and disease
Ramage, G., Kean, R., Rautemaa-Richardson, R., Williams, C., & Lopez-Ribot, J. L. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01147-0 · Cited by 72 · see citing works
How Biofilm Growth Affects Candida-Host Interactions
Eix, E. F., & Nett, J. E. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01437 · Cited by 69 · see citing works
Self-citationUpdate on the Pathogenesis, Virulence, and Treatment of Candida auris
Watkins, R. R., Gowen, R., Lionakis, M., & Ghannoum, M. (2022) · Pathogens and Immunity · doi:10.20411/pai.v7i2.535 · Cited by 68 · see citing works
Mechanisms of pathogenicity for the emerging fungus Candida auris
Horton, M. V., Holt, A. M., & Nett, J. E. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1011843 · Cited by 67 · see citing works
Self-citationMultidrug-resistant Candida auris : an epidemiological review
Chakrabarti, A., & Singh, S. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1750368 · Cited by 66 · see citing works
The many faces of Candida auris: Phenotypic and strain variation in an emerging pathogen
Santana, D. J., Zhao, G., & O’Meara, T. R. (2024) · PLOS Pathogens · doi:10.1371/journal.ppat.1012011 · Cited by 62 · see citing works
Rao, H., Choo, S., Mahalingam, S. R. R., Adisuri, D. S., Madhavan, P., Akim, A. M., & Chong, P. P. (2021) · Molecules · doi:10.3390/molecules26071870 · Cited by 64 · see citing works
A common vesicle proteome drives fungal biofilm development
Zarnowski, R., Sanchez, H., Jaromin, A., Zarnowska, U. J., Nett, J. E., Mitchell, A. P., & Andes, D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211424119 · Cited by 63 · see citing works
Self-citationVazquez-Munoz, R., Lopez, F. D., & Lopez-Ribot, J. L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01673 · Cited by 59 · see citing works
Vila, T., Montelongo-Jauregui, D., Ahmed, H., Puthran, T., Sultan, A. S., & Jabra-Rizk, M. A. (2020) · mSphere · doi:10.1128/msphere.00760-20 · Cited by 58 · see citing works
Clade II Candida auris possess genomic structural variations related to an ancestral strain
Sekizuka, T., Iguchi, S., Umeyama, T., Inamine, Y., Makimura, K., Kuroda, M., Miyazaki, Y., & Kikuchi, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223433 · Cited by 60 · see citing works
Krzyżek, P., Migdał, P., Grande, R., & Gościniak, G. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.868905 · Cited by 55 · see citing works
de Alteriis, E., Maione, A., Falanga, A., Bellavita, R., Galdiero, S., Albarano, L., Salvatore, M. M., Galdiero, E., & Guida, M. (2021) · Antibiotics · doi:10.3390/antibiotics11010026 · Cited by 54 · see citing works
Ali, S. A., JALAL, M. S., Ahmad, H., Sharma, D., Ahmad, A., Umar, K., & Khan, H. M. (2022) · Materials · doi:10.3390/ma15196978 · Cited by 53 · see citing works
Azole resistance in Candida auris: mechanisms and combinatorial therapy
Jangir, P., Kalra, S., Tanwar, S., & Bari, V. K. (2023) · Apmis · doi:10.1111/apm.13336 · Cited by 53 · see citing works
Candida auris: A Continuing Threat
Bhargava, A., Klamer, K., Sharma, M., Ortiz, D. A., & Saravolatz, L. I. I. (2025) · Microorganisms · doi:10.3390/microorganisms13030652 · Cited by 58 · see citing works
Candida auris: A Mini Review on Epidemiology in Healthcare Facilities in Asia
Thatchanamoorthy, N., Rukumani, D. V., Samudi, C., & Tay, S. T. (2022) · Journal of Fungi · doi:10.3390/jof8111126 · Cited by 48 · see citing works
Wang, T. W., Sofras, D., Montelongo-Jauregui, D., Paiva, T. O., Carolus, H., Dufrêne, Y. F., Alfaifi, A. A., McCracken, C., Bruno, V. M., Van Dijck, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53588-5 · Cited by 47 · see citing works
Smith, D. F. Q., & Casadevall, A. (2021) · Pathogens and Disease · doi:10.1093/femspd/ftab013 · Cited by 47 · see citing works
Role of the extracellular matrix in Candida biofilm antifungal resistance
Massey, J., Żarnowski, R., & Andes, D. R. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad059 · Cited by 47 · see citing works
Self-citationCandida–Bacterial Biofilms and Host–Microbe Interactions in Oral Diseases
Negrini, T. D. C., Koo, H., & Arthur, R. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-28524-1_10 · Cited by 44 · see citing works
Antifungal and anti‐biofilm effects of 6‐shogaol againstCandida auris
Kim, H.-J., & Eom, Y. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14870 · Cited by 45 · see citing works
Vázquez-Muñoz, R., Lopez, F. D., & Lopez-Ribot, J. L. (2020) · Antibiotics · doi:10.3390/antibiotics9080461 · Cited by 43 · see citing works
Eldesouky, H. E., Lanman, N. A., Hazbun, T. R., & Seleem, M. N. (2020) · Virulence · doi:10.1080/21505594.2020.1838741 · Cited by 37 · see citing works
Le, P. H., Linklater, D. P., Aburto‐Medina, A., MacLaughlin, S. A., Crawford, R. J., & Ivanova, E. P. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.02.006 · Cited by 39 · see citing works
Liu, X., Guo, C., Zhuang, K., Chen, W., Zhang, M., Dai, Y., Tan, L., & Ran, Y. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010534 · Cited by 36 · see citing works
Candida auris: Epidemiology Update and a Review of Strategies to Prevent Spread
Hayes, J. F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226675 · Cited by 35 · see citing works
Photodynamic Therapy Is Effective Against Candida auris Biofilms
Bapat, P. S., & Nobile, C. J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.713092 · Cited by 36 · see citing works
Candida auris:a fungus with identity crisis
Vila, T. V. M., Sultan, A. S., Montelongo‐Jauregui, D., & Jabra‐Rizk, M. A. (2020) · Pathogens and Disease · doi:10.1093/femspd/ftaa034 · Cited by 37 · see citing works
Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects
Fayed, B. E. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01749-w · Cited by 30 · see citing works
Marena, G. D., Ramos, M. A. D. S., Carvalho, G. C., de Lima, L. C., do Nascimento, A. L. C. S., Sábio, R. M., Rodero, C. F., Spósito, L., Bauab, T. M., & Chorilli, M. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103566 · Cited by 30 · see citing works
Transcriptional and translational landscape of <i>Candida auris</i> in response to caspofungin
Zamith-Miranda, D., Amatuzzi, R. F., Munhoz da Rocha, I. F., Martins, S. T., Lucena, A. C. R., Vieira, A. Z., Trentin, G., Almeida, F., Rodrigues, M. L., Nakayasu, E. S., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.09.007 · Cited by 29 · see citing works
Shizari, L. N., Dounighi, N. M., Bayat, M., & Mosavari, N. (2021) · PubMed Central · doi:10.22092/ari.2020.342702.1477 · Cited by 29 · see citing works
A decade after the emergence of Candida auris: what do we know?
ElBaradei, A. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-03886-9 · Cited by 30 · see citing works
Liu, J., Li, Q., Wang, C., Shao, J., Wang, T., Wu, D., Ma, K., Yan, G., & Yin, D. (2020) · Biofouling · doi:10.1080/08927014.2020.1759559 · Cited by 27 · see citing works
Uniqueness of Candida auris cell wall in morphogenesis, virulence, resistance, and immune evasion
Dakalbab, S., Hamdy, R., Holigová, P., Abuzaid, E. J., Abu-Qiyas, A., Lashine, Y., Mohammad, M. G., & Soliman, S. S. M. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127797 · Cited by 27 · see citing works
Zatorska, B., Moser, D., Diab‐Elschahawi, M., Ebner, J., Lusignani, L. S., & Presterl, E. (2021) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2021.101178 · Cited by 27 · see citing works
Willaert, R., Kayacan, Y., & Devreese, B. (2021) · Pathogens · doi:10.3390/pathogens10111397 · Cited by 26 · see citing works
Jaromin, A., Żarnowski, R., Markowski, A., Zagórska, A., Johnson, C. J., Etezadi, H., Kihara, S., Mota‐Santiago, P., Nett, J. E., Boyd, B. J., et al. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00955-23 · Cited by 27 · see citing works
Self-citationSkin and hard surface disinfection against Candida auris – What we know today
Omardien, S., & Teska, P. J. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1312929 · Cited by 29 · see citing works
Small molecules for combating multidrug-resistant superbug Candida auris infections
Tu, J., Liu, N., Huang, Y., Yang, W., & Sheng, C. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.08.001 · Cited by 26 · see citing works
West, P. T., Peters, S. L., Olm, M. R., Yu, F. B., Gause, H., Lou, Y. C., Firek, B., Baker, R. W., Johnson, A. D., Morowitz, M. J., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01085-y · Cited by 25 · see citing works
Prospects for anti-Candida therapy through targeting the cell wall: A mini-review
Ahmadipour, S., Field, R. A., & Miller, G. J. (2021) · The Cell Surface · doi:10.1016/j.tcsw.2021.100063 · Cited by 24 · see citing works
Satała, D., Juszczak, M., Wronowska, E., Surowiec, M., Kulig, K., Kozik, A., Rąpała‐Kozik, M., & Karkowska‐Kuleta, J. (2022) · Cellular Microbiology · doi:10.1155/2022/2599136 · Cited by 26 · see citing works
Ramos, L. S., Barbosa, P. F., Lorentino, C. M. A., Lima, J. C., Braga, A. L., Lima, R., Giovanini, L., Casemiro, A. L., Siqueira, N. L. M., da Costa, S. C., et al. (2025) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2025.100354 · Cited by 24 · see citing works
Demin, K. A., Refeld, A. G., Bogdanova, A. A., Prazdnova, E. V., Popov, I. V., Kutsevalova, O. Y., Ermakov, A. M., Bren, A. B., Rudoy, D. V., Chistyakov, V. A., et al. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09776-6 · Cited by 24 · see citing works
Ware, A., Johnston, W., Delaney, C., Butcher, M. C., Ramage, G., Price, L., Butcher, J. P., & Kean, R. (2025) · Apmis · doi:10.1111/apm.70022 · Cited by 22 · see citing works
Research progress on the drug resistance mechanisms of Candida tropicalis and future solutions
Xiong, H., Zhao, R., Han, S., Liu, Z., Zhang, X., Jia, Z., Cui, J., Zhang, Y., & Wang, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1594226 · Cited by 22 · see citing works
Activities of nine antifungal agents against Candida auris biofilms
Chatzimoschou, A., Giampani, A., Meis, J. F. G. M., & Roilides, E. (2020) · Mycoses · doi:10.1111/myc.13223 · Cited by 21 · see citing works
Essential Oils against Candida auris—A Promising Approach for Antifungal Activity
Kowalczyk, A. (2024) · Antibiotics · doi:10.3390/antibiotics13060568 · Cited by 21 · see citing works
Drug repurposing against Candida auris: A systematic review
Izadi, A., Gharehbolagh, S. A., Sadeghi, F., Talebi, M., Darmiani, K., Zarrinnia, A., Zarei, F., Peymaeei, F., Khojasteh, S., Borman, A. M., et al. (2022) · Mycoses · doi:10.1111/myc.13477 · Cited by 20 · see citing works
Modeling Candida auris skin colonization: Mice, swine, and humans
Eix, E. F., & Nett, J. E. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010730 · Cited by 19 · see citing works
Self-citationDyeing fungi: amphotericin B based fluorescent probes for multiplexed imaging
Baibek, A., Üçüncü, M., Short, B., Ramage, G., Lilienkampf, A., & Bradley, M. (2021) · Chemical Communications · doi:10.1039/d0cc08177a · Cited by 18 · see citing works
Candida auris biofilm: a review on model to mechanism conservation
Khari, A., Biswas, B., Gangwar, G., Thakur, A., & Puria, R. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2179036 · Cited by 18 · see citing works
Ceballos-Garzón, A., Lebrat, J., Holzapfel, M., Josa, D. F., Welsch, J., & Mercer, D. K. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00137-25 · Cited by 18 · see citing works
Candida auris: A focused review for emergency clinicians
Long, B., Lacy, A. J., Koyfman, A., & Liang, S. Y. (2024) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2024.07.062 · Cited by 16 · see citing works
de Mello, T. P., Oliveira, S. S. C., Branquinha, M. H., & dos Santos, A. L. S. (2022) · Medical Mycology · doi:10.1093/mmy/myac036 · Cited by 16 · see citing works
The Gordian Knot of C. auris: If You Cannot Cut It, Prevent It
Rapti, V., Iliopoulou, K., & Poulakou, G. (2023) · Pathogens · doi:10.3390/pathogens12121444 · Cited by 16 · see citing works
Investigating Dual-Species Candida auris and Staphylococcal Biofilm Antiseptic Challenge
Gülmez, D., Brown, J. L., Butcher, M. C., Delaney, C., Kean, R., Ramage, G., & Short, B. (2022) · Antibiotics · doi:10.3390/antibiotics11070931 · Cited by 15 · see citing works
Candida auris, a singular emergent pathogenic yeast: its resistance and new therapeutic alternatives
Fernandes, L., Ribeiro, R., Henriques, M., & Rodrigues, M. E. (2022) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-022-04497-2 · Cited by 14 · see citing works
Biofilms formed byScedosporiumandLomentosporaspecies: focus on the extracellular matrix
de Mello, T. P., Branquinha, M. H., & dos Santos, A. L. S. (2020) · Biofouling · doi:10.1080/08927014.2020.1759558 · Cited by 14 · see citing works
Candida auris Resistance Mechanisms to Amphotericin B Alternative Treatments Development
Fenton, A., & John, G. K. (2024) · Current Clinical Microbiology Reports · doi:10.1007/s40588-024-00233-w · Cited by 12 · see citing works
Octenidine effectively reduces Candida auris colonisation on human skin
Cerbu, D., Seiser, S., Phan-Canh, T., Moser, D., Freystätter, C., Matiasek, J., Kuchler, K., & Elbe‐Bürger, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-11914-x · Cited by 11 · see citing works
Mishra, S. K., Yasir, M., Kuppusamy, R., Wong, E. H. H., Hui, A., Sørensen, K., Lin, J. S., Jenssen, H., Barron, A. E., & Willcox, M. D. P. (2025) · Journal of Applied Microbiology · doi:10.1093/jambio/lxaf031 · Cited by 11 · see citing works
Żarnowski, R., Sánchez, H., Andreu, C., Andes, D. R., & del Olmo, M. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11132-1 · Cited by 11 · see citing works
Self-citationSquitieri, D., Rizzo, S., Torelli, R., Mariotti, M., Sanguinetti, M., Cacaci, M., & Bugli, F. (2025) · Pharmaceuticals · doi:10.3390/ph19010008 · Cited by 11 · see citing works
Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review
Atkinson, I. (2022) · Bioengineering · doi:10.3390/bioengineering9100489 · Cited by 10 · see citing works
Rosario-Colon, J., EBERLE, K. E., & Xin, H. (2025) · iScience · doi:10.1016/j.isci.2025.112459 · Cited by 12 · see citing works
Enablers of Candida auris persistence on medical devices and their mode of eradication.
Nwachukwu, K. C., Nwarunma, E., Uchenna, C. D., & Ugbogu, O. C. (2023) · PubMed Central · doi:10.18502/cmm.2023.150673 · Cited by 10 · see citing works
Ahamad, I., & Fatma, T. (2025) · BioMetals · doi:10.1007/s10534-025-00680-y · Cited by 9 · see citing works
Balkrishna, A., Kharayat, B., Rastogi, S., Kabdwal, M., Haldar, S., & Varshney, A. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad087 · Cited by 10 · see citing works
Infection caused by Candida auris: state of the art
Marena, G. D., Carvalho, G. C., Monazzi, L., Maschio-Lima, T., Almeida, M. D., Silva, J. D., Fortunato, G., Araújo, V., Venancio, D. C. V., Chang, M., et al. (2022) · Mycosphere · doi:10.5943/mycosphere/13/1/10 · Cited by 6 · see citing works
A Fungus for Our Time: Candida auris Emerges into the Anthropocene
Stephenson, J. C., Garza, D. R., & Bouklas, T. (2023) · Current Tropical Medicine Reports · doi:10.1007/s40475-023-00293-w · Cited by 6 · see citing works
Production and Isolation of the Candida Species Biofilm Extracellular Matrix
Heredia, M. Y., & Andes, D. R. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2549-1_19 · Cited by 6 · see citing works
Self-citationArtemisia annua and artemisinins are ineffective against human Babesia microti and six Candida sp
Elfawal, M. A., Gray, O., Dickson-Burke, C., Weathers, P. J., & Rich, S. M. (2021) · Longhua Chinese Medicine · doi:10.21037/lcm-21-2 · Cited by 6 · see citing works
Zarnowski, R., Horton, M. V., Johnson, C. J., Vang, P. C., Uram, J., Fernando, L. D. P., Vlach, J., Heiss, C., Azadi, P., Nett, J. E., et al. (2025) · mBio · doi:10.1128/mbio.00346-25 · Cited by 5 · see citing works
“Previous studies have demonstrated the importance of the extracellular matrix in protection of the Candida biofilm community from antifungal drugs, including for C. auris (17, 18, 22).”
Self-citationGawad, M. M. A. E., & Shady, R. M. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10405-4 · Cited by 5 · see citing works
Li, K., Liu, Z., Liu, X., Wang, L., Zhao, J., Zhang, X., Kong, Y., & Chen, M. (2021) · Nanotechnology · doi:10.1088/1361-6528/abf68e · Cited by 5 · see citing works
Bera, J. H., Leyon Selvin Raj., A., Gang, S. D., & Patel, D. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95715-1.00010-8 · Cited by 3 · see citing works
Luo, Z., Ning, Y., Dai, R., Ainiwaer, A., Li, Y., Zhang, R., Xiao, M., Wang, X., Yang, Y., Huang, Y., et al. (2025) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2025.151689 · Cited by 2 · see citing works
Dimopoulou, G., Papadoulakis, M., Premetis, I., Papachristou, K., & Magira, E. E. (2026) · Journal of Fungi · doi:10.3390/jof12090629 · Cited by 2 · see citing works
Impact of biofilms on healthcare settings and management strategies
Bayatlı, N., Malkawi, A. S., Malkawi, A., Khaled, K., Alrabadi, N., Ovenseri, A. C., Alhajj, L., Sarayrih, L. A., & Elnefaily, S. E. (2025) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000425 · Cited by 2 · see citing works
- Authors
- Dominguez, E. G., Zarnowski, R., Choy, H. L., Zhao, M., Sanchez, H., Nett, J. E., & Andes, D. R.
- Affiliations
- University of Wisconsin–Madison (US)
- Department of Medicine, Section of Infectious Disease, University of Wisconsin—Madison, Madison, Wisconsin, USA
- Corresponding author
- Andes, D. R.
- Venue
- mSphere
- Publisher
- American Society for Microbiology
- Published
- 2019-02-27
- Volume
- 4
- Issue
- 1
- ISSN
- 2379-5042 (ISSN-L)
- PMC
- PMC6315084
- OpenAlex
- W2908106770
- Cited by
- 132
- References
- 23
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 12 · 2023: 11 · 2022: 20 · 2021: 31 · 2020: 19 · 2019: 6
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSphere (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI073289)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida auris, biofilm matrix polysaccharides, antifungal resistance, triazole antifungal therapy, biofilm formation, fungal pathogenicity, Candida
- MeSH terms
- Extracellular Polymeric Substance Matrix, Antifungal Agents, Candida, Drug Tolerance, Humans, Microbial Sensitivity Tests, Biofilms, Drug Resistance, Fungal
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