Oxytocin potently enhances novelty-induced grooming behavior in the rat
Abstract
Intracerebroventricular (i.c.v.) injection of oxytocin was followed by an enhancement of novelty-induced grooming in male and female rats. This effect was dose-dependent, in a dose range of 0.1-10 micrograms. Grooming activity of rats injected i.c.v. with 10 micrograms of oxytocin was 9-fold higher than that of saline-injected controls. The analysis of behavioral element composition revealed an increased occurrence of genital grooming in oxytocin-injected rats. A time-course study revealed a sustained increase in grooming activity of oxytocin-treated rats during 45 min of behavioral testing. Intraperitoneal (i.p.) injection of the dopamine antagonist, haloperidol, totally suppressed oxytocin-enhanced grooming. Furthermore, i.p. injection of the opiate receptor antagonist, naloxone, was followed by an attenuation but not a suppression of grooming enhanced by i.c.v. administration of oxytocin. In addition, a small but significant increase in grooming activity was observed after subcutaneous injection of oxytocin. These results suggest that oxytocin-enhanced grooming behavior involves central mechanisms, e.g. dopamine and opioid transmission in the brain.
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In rats, OXT-enhanced grooming is attenuated by the opiate antagonist naloxone.
“in rats OXT-enhanced grooming is attenuated by the opiate antagonist naloxone”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Drago et al, 1986
An interplay between OXT and endorphins may have contributed to the observed pattern of effects.
“suggesting that an interplay between OXT and endorphins may have contributed to the observed pattern of effects.”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Drago et al, 1986
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Roeling, T. A. P., Veening, J. G., Peters, J. P. W., Vermelis, M. E. J., & Nieuwenhuys, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90574-y · Cited by 79 · see citing works
Neurohypophyseal hormones and excessive grooming behaviour
Greidanus, T. B. V. W., Kroodsma, J.-M., Pot, M., Stevens, M., & Maigret, C. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90334-3 · Cited by 69 · see citing works
Effects of hormonal, sexual, and social history on mating and pair bonding in prairie voles
Carter, C. S., Witt, D. M., Thompson, E. G., & Carlstead, K. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90049-2 · Cited by 64 · see citing works
Oxytocin-induced inhibition of feeding and drinking: No sexual dimorphism in rats
Benelli, A., Bertolini, A., & Arletti, R. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90040-p · Cited by 61 · see citing works
Seltzer, L. J., & Ziegler, T. E. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.12.012 · Cited by 58 · see citing works
“OT also functions to regulate the stress response (Kalin et al., 1985; Heinrichs et al., 2003;Amicoetal.,2004a),sexualbehaviors(Arletti etal.,1992; Kruger et al., 2003; Argiolas and Melis, 2004), aggressive behaviors (Winslow and Insel, 1991a; Harmon et al., 2002) and grooming, particularly allogrooming ( Drago et al.…”
BackgroundOxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice
Tan, O., Musullulu, H., Raymond, J. S., Wilson, B. B., Langguth, M., & Bowen, M. T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.016 · Cited by 56 · see citing works
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“Although Drago et al. (1986) did an i.c.v. OT dose– response curve, we did not do so with CeA microinjections, but used the optimal dose utilized by these authors, which was clearly effective in the current induction of hypergrooming and as said above, this hypergrooming was also blocked…”
MethodGrund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenländer, L., Neumann, I. D., & Grinevich, V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.019 · Cited by 53 · see citing works
Vasopressin interactions with oxytocin in the control of female sexual behavior
Pedersen, C. A., & Boccia, M. L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.002 · Cited by 68 · see citing works
Self-citationDrago, F., Contarino, A., & Busă, L. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00877-2 · Cited by 52 · see citing works
Self-citationMantella, R. C., Vollmer, R. R., Rinaman, L., Li, X., & Amico, J. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00387.2004 · Cited by 71 · see citing works
“CENTRALLY RELEASED OXYTOCIN (OT) is involved in processes that include maternal (50) and affiliative behavior (13, 71), lordosis (6), ingestion of food (64) and sodium chloridecontaining solutions (1, 3, 52, 60, 63), social memory (22, 23), and grooming (18).”
Drago, F., Caldwell, J. D., Pedersen, C. A., Continella, G., Scapagnini, U., & Prange, A. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90168-1 · Cited by 45 · see citing works
Self-citationCentrally administered oxytocin elicits exaggerated grooming in oxytocin null mice
Amico, J. A., Vollmer, R. R., Karam, J. R., Lee, P. R., Li, X., Koenig, J. I., & McCarthy, M. M. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.04.006 · Cited by 46 · see citing works
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Seven computations of the social brain
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“Oxytocin is believed to be the core biological chemical that facilitates mother–infant attachment (Drago et al., 1986; Preston, 2013).”
Neonatal stress transiently alters the development of hippocampal oxytocin receptors
Noonan, L. R., Caldwell, J. D., Li, L., Walker, C. H., Pedersen, C. A., & Mason, G. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90094-9 · Cited by 42 · see citing works
Self-citationTransport of estrogen-induced oxytocin receptors in the ventromedial hypothalamus
Coirini, H., Schumacher, M., Flanagan, L., & McEwen, B. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03317.1991 · Cited by 40 · see citing works
“Thus, OT is involved in the regulation of many other central mechanisms (Fahrbach et al., 198 5; Drago et al., 1986; Argiolas et al., 1988; Arletti et al., 1989).”
BackgroundVasopressin modulates male squirrel monkeys' behavior during social separation
Winslow, J., & Insel, T. R. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90671-c · Cited by 37 · see citing works
The “low-dose” concept and the paradoxical effects of prolactin on grooming and sexual behavior
Drago, F., & Lissandrello, C. O. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00678-6 · Cited by 37 · see citing works
Self-citation1-Oleoyl Lysophosphatidic Acid: A New Mediator of Emotional Behavior in Rats
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A comparison of grooming behavior potencies of neurohypophyseal nonapeptides
Caldwell, J. D., Drago, F., Prange, A. J., & Pedersen, C. A. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90009-1 · Cited by 35 · see citing works
Self-citationNew directions in the treatment of autism spectrum disorders from animal model research
Chadman, K. K., Guariglia, S. R., & Yoo, J. H. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.678828 · Cited by 32 · see citing works
“In other animal models, reduced oxytocin has also been shown to increase the frequency of grooming [97,98] and wing flapping [99].”
BackgroundEffects of nonapeptide antagonists on oxytocin- and arginine-vasopressin-induced analgesia in mice
Caldwell, J. D., Mason, G., Stanley, D. A., Jerdack, G. R., Hruby, V. J., Hill, P. S., Prange, A. J., & Pedersen, C. A. (1987) · Regulatory Peptides · doi:10.1016/0167-0115(87)90011-5 · Cited by 33 · see citing works
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Initiation of self-grooming in resting rats by local PVH infusion of oxytocin but not α-MSH
van Erp, A. M. M., Kruk, M. R., Semple, D. M., & Verbeet, D. W. P. (1993) · Brain Research · doi:10.1016/0006-8993(93)91494-d · Cited by 31 · see citing works
Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat
Kaltwasser, M.-T., & Crawley, J. N. (1987) · Brain Research · doi:10.1016/0006-8993(87)90418-5 · Cited by 31 · see citing works
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“…be altered by both cocaine and by manipulation of each of the aforementioned neurotransmitter systems (Rosenberg et al., 1977; Honda et al., 1985; Drago et al., 1986; Giordano et al., 1990; Kovacs et al., 1990; Cunningham et al., 1992; Kendrick et al., 1992; Sarnyai et al., 1992; Hansen, 1994;…”
BackgroundOvarian Steroid Modulation of Oxytocin Receptor Binding in the Ventromedial Hypothalamus
Schumacher, M., Coirini, H., Flanagan‐Cato, L. M., Frankfurt, M., Pfaff, D. W., & McEwen, B. S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34368.x · Cited by 30 · see citing works
Affiliation, Social Support, and Biobehavioral Responses to Stress
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Oxytocin: Neurobiologic considerations and their implications for affective illness
Demitrack, M. A., & Gold, P. W. (1988) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(88)90072-3 · Cited by 26 · see citing works
Neonatal administration of oxytocin increases novelty-induced grooming in the adult rat
Noonan, L. R., Continella, G., & Pedersen, C. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90386-9 · Cited by 24 · see citing works
Ventral tegmental oxytocin induces grooming
Stivers, J. A., Kaltwasser, M.-T., Hill, P. S., Hruby, V. J., & Crawley, J. N. (1988) · Peptides · doi:10.1016/0196-9781(88)90248-3 · Cited by 23 · see citing works
Acute cocaine treatment decreases oxytocin levels in the rat hippocampus
Johns, J. M., Caldwell, J. D., & Pedersen, C. A. (1993) · Neuropeptides · doi:10.1016/0143-4179(93)90081-k · Cited by 24 · see citing works
Self-citationTan, O., Martin, L. J., & Bowen, M. T. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120913150 · Cited by 20 · see citing works
“This finding is consistent with previous work in rodents demonstrating OXT increases grooming via actions at the OXTR (Drago et al., 1986, 1991) and, specifically, through acting within various parts of a grooming circuit, including the PVN and central amygdala (Marroni et al., 2007; Van Erp et…”
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Self-citationIs oxytocin-induced grooming mediated by uterine-like receptors?
Caldwell, J. D., Hruby, V. J., Hill, P., Prange, A. J., & Pedersen, C. A. (1986) · Neuropeptides · doi:10.1016/0143-4179(86)90068-5 · Cited by 21 · see citing works
Self-citationIn Search of an Adult Attachment Stress Provocation to Measure Effect on the Oxytocin System
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“Actually, pre-test administration of oxytocin significantly increased the rate of self-grooming in all subjects, which is in accordance with the reported oxytocin augmented rate following intracerebral injections in rats [85,86].”
ResultThe inhibition of oxytocin-induced grooming by a specific receptor antagonist
Drago, F., Sarnyai, Z., & D’Agata, V. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90541-u · Cited by 16 · see citing works
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The Season for Peace: Reconciliation in a Despotic Species (Lemur catta)
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Intranasal Oxytocin Failed to Affect Chimpanzee (Pan troglodytes) Social Behavior
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Effects of oxytocin on emotional stress and stress-induced gastric lesions
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Social impairments among children perinatally exposed to oxytocin or oxytocin receptor antagonist
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- Authors
- Drago, F., Pedersen, C. A., Caldwell, J. D., & Prange, A. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Drago, Filippo
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 368
- Issue
- 2
- Pages
- 287-295
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2005322248
- Cited by
- 134
- References
- 48
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, grooming, dopamine, haloperidol, naloxone, intracerebroventricular administration, dose-response relationship, rats
- MeSH terms
- Animals, Female, Grooming, Haloperidol, Injections, Intraperitoneal, Injections, Intraventricular, Injections, Subcutaneous, Male, Naloxone, Oxytocin, Rats, Inbred Strains, Sex Characteristics, Time Factors, Rats
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