Increased extracellular dopamine in the nucleus accumbens of the rat elicited by a conditional stimulus for food: an electrochemical study
Abstract
Stearate-modified graphite paste electrodes were implanted chronically into dopamine terminal regions in the nucleus accumbens or caudate nucleus of the rat. Reverse dialysis was used to demonstrate a selective response of these electrodes to dopamine, but not 3,4-dihydroxyphenylacetic acid or ascorbic acid. In a separate behavioural experiment, a significant increase in the chronoamperometric response was observed during presentation of a conditional stimulus predictive of food, and the electrochemical response remained elevated during and following consumption of the meal. Similar trends were observed from electrodes in the caudate nucleus. These data confirm the activation of mesolimbic dopamine neurons by incentive stimuli predictive of food and possibly by consumption of food. Together with other recent data on sex- and thirst-related increases in dopamine levels in the nucleus accumbens, these findings are consistent with a role for the nucleus accumbens as an interface between motivation and activation of the motor system.Key words: dopamine, nucleus accumbens, electrochemistry, feeding, conditional response.
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There is an increase in DA release in the NAc in response to unexpected food rewards or stimuli that predict food rewards.
“There is an increase in DA release (measured in awake, behaving animals by microdialysis or by fastscanning cyclic voltammetry) in the NAc in response to unexpected food rewards or stimuli that predict food rewards [72,308-310].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [308]
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- Authors
- Phillips, A. G., Atkinson, L. J., Blackburn, J. R., & Blaha, C. D.
- Affiliations
- University of British Columbia (CA)
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 1993-05-01
- Volume
- 71
- Issue
- 5-6
- Pages
- 387-393
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W2035923484
- Cited by
- 113
- References
- 18
- Citations by year
- 2024: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Physiology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- extracellular dopamine, nucleus accumbens, caudate nucleus, food reward, mesolimbic dopamine neurons, meal ingestion, motivation
- MeSH terms
- Animals, Caudate Nucleus, Conditioning, Classical, Dopamine, Electrochemistry, Extracellular Space, Feeding Behavior, Homovanillic Acid, Male, Membrane Potentials, Nucleus Accumbens, Oxidation-Reduction, Rats, Inbred Strains, Time Factors, Rats
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