Cited by 113Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Increased extracellular dopamine in the nucleus accumbens of the rat elicited by a conditional stimulus for food: an electrochemical study

Phillips, A. G., Atkinson, L. J., Blackburn, J. R., Blaha, C. D.·1993·Canadian Journal of Physiology and Pharmacology

Abstract

Stearate-modified graphite paste electrodes were implanted chronically into dopamine terminal regions in the nucleus accumbens or caudate nucleus of the rat. Reverse dialysis was used to demonstrate a selective response of these electrodes to dopamine, but not 3,4-dihydroxyphenylacetic acid or ascorbic acid. In a separate behavioural experiment, a significant increase in the chronoamperometric response was observed during presentation of a conditional stimulus predictive of food, and the electrochemical response remained elevated during and following consumption of the meal. Similar trends were observed from electrodes in the caudate nucleus. These data confirm the activation of mesolimbic dopamine neurons by incentive stimuli predictive of food and possibly by consumption of food. Together with other recent data on sex- and thirst-related increases in dopamine levels in the nucleus accumbens, these findings are consistent with a role for the nucleus accumbens as an interface between motivation and activation of the motor system.Key words: dopamine, nucleus accumbens, electrochemistry, feeding, conditional response.

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Crossref · 10.1139/y93-059

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Authors
Phillips, A. G., Atkinson, L. J., Blackburn, J. R., & Blaha, C. D.
Affiliations
University of British Columbia (CA)
Venue
Canadian Journal of Physiology and Pharmacology
Published
1993-05-01
Volume
71
Issue
5-6
Pages
387-393
ISSN
  • 0008-4212 (ISSN-L)
  • 1205-7541
OpenAlex
W2035923484
Cited by
113
References
18
Citations by year
2024: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
2.29
Type
journal article
Language
en
Open access
closed
Locations
  • Canadian Journal of Physiology and Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
extracellular dopamine, nucleus accumbens, caudate nucleus, food reward, mesolimbic dopamine neurons, meal ingestion, motivation
MeSH terms
Animals, Caudate Nucleus, Conditioning, Classical, Dopamine, Electrochemistry, Extracellular Space, Feeding Behavior, Homovanillic Acid, Male, Membrane Potentials, Nucleus Accumbens, Oxidation-Reduction, Rats, Inbred Strains, Time Factors, Rats

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