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Cited by 234Memory and Neural MechanismsStress Responses and CortisolMemory Processes and Influences

Corticosterone enhances long-term retention in one-day-old chicks trained in a weak passive avoidance learning paradigm

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Sandi, Carmen, Rose, Steven P.R.·1994·Brain Research
DOI 10.1016/0006-8993(94)91404-4
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Abstract

Glucocorticoids are released during learning situations and can trigger neural actions through binding to receptors in different brain areas. The possible role of a glucocorticoid action in long-term memory formation was studied, in day-old chicks, by using a passive avoidance task which chicks otherwise only retain for a few hours (< 10) after training. Thus, we examined the effects of intracerebral corticosterone administration on retention 24 h posttraining. The results showed that chicks injected with corticosterone (1 microgram) at either 15 min pretraining or at 5, 30, 60 min (but not 120, 180, or 360 min) posttraining retained the passive avoidance response when tested 24 h posttraining. Studies with specific mineralocorticoid or glucocorticoid receptor antagonists (RU 28318 or RU 38486, respectively) indicated that this increase in retention by corticosterone might be mediated through glucocorticoid receptors. In order to assess whether the facilitatory effect of corticosterone was mediated through an effect on protein synthesis mechanisms, the protein synthesis inhibitor anisomycin was administered prior to corticosterone. However, this treatment only partially attenuated the effect of the steroid, suggesting that corticosterone may influence other cellular processes involved in the formation of long-term memory for the avoidance behaviour.

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  • The use of exogenous corticosteroids is not always associated with deleterious effects on cognition; some studies in animals and humans have failed to demonstrate an association, while some provide evidence of corticosteroid-induced cognitive enhancement.

    “Furthermore, the use of exogenous corticosteroids is not always associated with deleterious effects on cognition, and some studies in animals and humans have failed to demonstrate an association, while some provide evidence of corticosteroid-induced cognitive enhancement (438–443).”

    From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [441]

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Authors
Sandi, C., & Rose, S. P. R.
Affiliations
The Open University (GB)
Corresponding author
Sandi, Carmen
ORCID
Sandi, Carmen
Venue
Brain Research
Publisher
Elsevier BV
Published
1994-05
Volume
647
Issue
1
Pages
106-112
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(94)91404-4
OpenAlex
W2008175050
Cited by
234
References
42
Citations by year
2025: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 8 · 2012: 8
FWCI
7.51
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
corticosterone, long-term memory retention, passive avoidance learning, chicks, glucocorticoid receptor, mineralocorticoid receptor antagonists, mifepristone, anisomycin, protein synthesis, memory consolidation
MeSH terms
Animals, Animals, Newborn, Anisomycin, Avoidance Learning, Chickens, Corticosterone, Drug Interactions, Female, Injections, Intraventricular, Male, Memory, Microspheres, Osmolar Concentration, Receptors, Steroid, Retention, Psychology, Taste, Time Factors, ortho-Aminobenzoates

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