The advantage of social living: Brain neuropeptides mediate the beneficial consequences of sex and motherhood
Abstract
Living in social groups is clearly beneficial for many species, often resulting in increased survival, enhanced fitness of the group, and progression of brain development and cognitive abilities. The development of the social brain has been promoted on the basis (i) of activation of reward centres by social stimuli, (ii) of positive consequences of close social interactions on emotionality (which is reinforcing by itself) and on general fitness, and (iii) of negative health consequences in the absence or as a result of sudden interruption of social interactions. For example, social interactions as seen between mother and child or between mating partners have beneficial effects on the mental and physical health state, in particular on adaptive processes related to emotional and physiological stress coping in both sexes. Here, the neurobiological basis of social behaviour, in particular the involvement of the brain neuropeptides, oxytocin and prolactin, in mediating such positive health effects will be discussed.
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Social effects of oxytocin in humans: context and person matter
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“There is some evidence that OT may play a role in mediating these effects but more research is needed in this area, particularly with respect to immune function (for a review see Neumann in this Issue [84]).”
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REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
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Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids
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Marital behavior, oxytocin, vasopressin, and wound healing
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Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence
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Brain oxytocin: how puzzle stones from animal studies translate into psychiatry
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Self-citationBrain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
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Self-citationReduced plasma oxytocin levels in female patients with borderline personality disorder
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Effects of Adverse Early‐Life Events on Aggression and Anti‐Social Behaviours in Animals and Humans
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Oxytocin, feeding, and satiety
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Low CSF oxytocin reflects high intent in suicide attempters
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Evolving nonapeptide mechanisms of gregariousness and social diversity in birds
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Self-citationRoles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
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The orgasmic history of oxytocin: Love, lust, and labor
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Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100 · see citing works
Self-citationDisplays of paternal mouse pup retrieval following communicative interaction with maternal mates
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Slattery, D. A., & Neumann, I. D. (2010) · Pharmaceuticals · doi:10.3390/ph3030702 · Cited by 94 · see citing works
Self-citationKalamatianos, T., Faulkes, C. G., Oosthuizen, M. K., Poorun, R., Bennett, N. C., & Coen, C. W. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22302 · Cited by 92 · see citing works
Salubrious effects of oxytocin on social stress-induced deficits
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Lonstein, J. S., Maguire, J. L., Meinlschmidt, G., & Neumann, I. D. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12188 · Cited by 83 · see citing works
Self-citationCalcagnoli, F., de Boer, S. F., Beiderbeck, D. I., Althaus, M., Koolhaas, J. M., & Neumann, I. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.050 · Cited by 84 · see citing works
Self-citationMuttenthaler, M., Andersson, Å., Vetter, I., Menon, R., Busnelli, M., Ragnarsson, L. K. N., Bergmayr, C., Arrowsmith, S., Deuis, J. R., Chiu, H. S., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aan3398 · Cited by 79 · see citing works
Self-citationTransient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat
Slattery, D. A., Neumann, I. D., & Cryan, J. F. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110368873 · Cited by 77 · see citing works
Self-citationCardoso, C., Ellenbogen, M. A., Serravalle, L., & Linnen, A. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.006 · Cited by 76 · see citing works
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Nyuyki, K. D., Waldherr, M., Baeuml, S., & Neumann, I. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023599 · Cited by 74 · see citing works
Self-citationSong, Z., Tai, F., Yu, C., Wu, R., Zhang, X., Broders, H. G., He, F., & Guo, R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.045 · Cited by 73 · see citing works
Torner, L., Plotsky, P. M., Neumann, I. D., & A, T. R. D. J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.006 · Cited by 70 · see citing works
Self-citationThe endocrinology of human caregiving and its intergenerational transmission
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Effects of group housing on stress induced emotional and neuroendocrine alterations
Liu, X., Wu, R., Tai, F., Ma, L., Wei, B. K., Yang, X., Zhang, X., & Jia, R. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.044 · Cited by 68 · see citing works
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Neuropeptidergic regulation of pair-bonding and stress buffering: Lessons from voles
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Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 63 · see citing works
Self-citationSelectively Bred Rodents as Models of Depression and Anxiety
Wegener, G., Mathé, A. A., & Neumann, I. D. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_192 · Cited by 64 · see citing works
Self-citationOxytocin and vasopressin modulate the social response to threat: a preclinical study
Bowen, M. T., & McGregor, I. S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000388 · Cited by 63 · see citing works
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Rault, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.015 · Cited by 63 · see citing works
Oxytocin and Memory of Emotional Stimuli: Some Dance to Remember, Some Dance to Forget
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Nonapeptides and the Evolution of Social Group Sizes in Birds
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“Given that OXT has broader implications beyond pair bonding, intranasal OXT ’ s effects were also examined concerning maternal and paternal bonding with their offspring (Neumann, 2009; Yoshihara et al., 2018).”
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Animal models of social stress: the dark side of social interactions
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Autism - A Neurodevelopmental Journey from Genes to Behaviour
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Potential Neurochemical and Neuroendocrine Effects of Social Distancing Amidst the COVID-19 Pandemic
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The neuroendocrinology of the social brain
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- Authors
- Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Neumann, Inga D.
- ORCID
- Neumann, Inga D.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 30
- Issue
- 4
- Pages
- 483-496
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2061566303
- Cited by
- 162
- References
- 222
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 12 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 6 · 2014: 20 · 2013: 12 · 2012: 13
- FWCI
- 21.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- group living, social brain, brain neuropeptides, oxytocin, prolactin, sex differences, motherhood, social interaction, stress coping, emotional well-being, mother-infant interaction
- MeSH terms
- Animals, Brain, Biological Evolution, Humans, Interpersonal Relations, Maternal Behavior, Neuropeptides, Oxytocin, Prolactin, Sexual Behavior, Social Behavior, Stress, Psychological
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