Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

Sadlack, Benjamin, Merz, Hartmut, Schorle, Hubert, Schimpl, Anneliese, Feller, Alfred C., Horak, Ivan·1993·Cell

DOI 10.1016/0092-8674(93)80067-o

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(93)80067-o

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Fontenot, J. D., Rasmussen, J. P., Gavin, M. A., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1263 · Cited by 1,819
Inflammatory bowel disease
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146
The Biology of Interleukin-2
Malek, T. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090357 · Cited by 1,079
Synbiotic therapy ( Bifidobacterium longum /Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766
Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.
Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
Yang, X.-P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H.-W., Wei, L., Vahedi, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.1995 · Cited by 583
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551
Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models
Seril, D. N. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.353 · Cited by 467
Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414
T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.
Davidson, N. J., Leach, M. W., Fort, M. M., Thompson-Snipes, L., Kühn, R., Müller, W., Berg, D. J., & Rennick, D. M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.1.241 · Cited by 402
Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family
Bour‐Jordan, H., Esensten, J. H., Martinez‐Llordella, M., Penaranda, C., Stumpf, M., & Bluestone, J. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01011.x · Cited by 391
Inflammatory Bowel Disease as a Model for Translating the Microbiome
Huttenhower, C., Kostic, A. D., & Xavier, R. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.013 · Cited by 332
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
Jabri, B., & Abadie, V. (2015) · Nature Reviews Immunology · doi:10.1038/nri3919 · Cited by 315
Developmental and Functional Control of Natural Killer Cells by Cytokines
Wu, Y., Tian, Z., & Wei, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00930 · Cited by 269
Th17 cells: from precursors to players in inflammation and infection
Awasthi, A., & Kuchroo, V. K. (2009) · International Immunology · doi:10.1093/intimm/dxp021 · Cited by 241
Bacteroides Vulgatus Protects against Escherichia Coli-Induced Colitis in Gnotobiotic Interleukin-2-Deficient Mice
Waidmann, M., Bechtold, O., Frick, J.-S., Lehr, H.-A., Schubert, S., Dobrindt, U., Loeffler, J., Bohn, E., & Autenrieth, I. B. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00672-3 · Cited by 234
Dietary Inulin Improves Distal Colitis Induced by Dextran Sodium Sulfate in the Rat
Videla, S., Vilaseca, J., Antolín, M., García-Lafuente, A., Guarner, F., Crespo, E., Casalots, J., Salas, A., & Malagelada, J. R. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03802.x · Cited by 209
Commensal Bacteria Can Enter Colonic Epithelial Cells and Induce Proinflammatory Cytokine Secretion: A Possible Pathogenic Mechanism of Ulcerative Colitis
Ohkusa, T., Yoshida, T., Sato, N., Watanabe, S., Tajiri, H., & Okayasu, I. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.005801-0 · Cited by 167
Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial
Ohkusa, T., Kato, K., Terao, S., Chiba, T., Mabe, K., Murakami, K., Mizokami, Y., Sugiyama, T., Yanaka, A., Takeuchi, Y., et al. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.84 · Cited by 138
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
Jung, K. B., Lee, H., Son, Y. S., Lee, M.-O., Kim, Y.-D., Oh, S. J., Kwon, O., Cho, S., Cho, H.-S., Kim, D.-S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05450-8 · Cited by 125
Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells
MATSUMOTO, S., NAGAOKA, M., HARA, T., KIMURA-TAKAGI, I., MISTUYAMA, K., & UEYAMA, S. (2004) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2004.02462.x · Cited by 113
Modulation of cytokine release by differentiated CACO-2 cells in a compartmentalized coculture model with mononuclear leucocytes and nonpathogenic bacteria
Parlesak, A., Haller, D., Brinz, S., Baeuerlein, A., & Bode, C. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01495.x · Cited by 109
Mast cells and nerves tickle in the tummy
Rijnierse, A., Nijkamp, F. P., & Kraneveld, A. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.008 · Cited by 105
Time to include the gut microbiota in the hygienic standardisation of laboratory rodents
Bleich, A., & Hansen, A. K. (2012) · Comparative Immunology, Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2011.12.006 · Cited by 82
Interleukin-15 and the regulation of lymphoid homeostasis
Lodolce, J., Burkett, P., Koka, R., Boone, D., Chien, M., Chan, F., Madonia, M., Chai, S., & Ma, A. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00211-0 · Cited by 71
Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells
Pender, S. L. F., Quinn, J. J., Sanderson, I. R., & MacDonald, T. T. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g918 · Cited by 55
Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies
Hünig, T. (2007) · Advances in Immunology · doi:10.1016/s0065-2776(07)95004-x · Cited by 57
Dendritic Cells and T Cells in the Regulation of Cutaneous Immunity
Loser, K., & Beissert, S. (2007) · Advances in Dermatology · doi:10.1016/j.yadr.2007.07.014 · Cited by 52
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool
Permanyer, M., Bošnjak, B., Glage, S., Friedrichsen, M., Floess, S., Huehn, J., Patzer, G. E., Odak, I., Eckert, N., Zargari, R., et al. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00599-z · Cited by 46
Spaceflight impairs antigen‐specific tolerance induction in vivo and increases inflammatory cytokines
Chang, T. T., Spurlock, S. M., Candelario, T. L. T., Grenon, S. M., & Hughes‐Fulford, M. (2015) · The FASEB Journal · doi:10.1096/fj.15-275073 · Cited by 42
Epithelial-specific Toll-like receptor (TLR)5 activation mediates barrier dysfunction in experimental ileitis
Lopetuso, L. R., Jia, R., Wang, X.-M., Jia, L.-G., Petito, V., Goodman, W. A., Meddings, J. B., Cominelli, F., Reuter, B. K., & Pizarro, T. T. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001035 · Cited by 28
Role of Cytokines in Thymic Regulatory T Cell Generation: Overview and Updates
Tang, M., Jia, F., Nan, F., Zuo, F., Yuan, Z., & Zhang, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.883560 · Cited by 11

Authors: Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., & Horak, I.
Venue: Cell
Publisher: Elsevier BV
Published: 1993-10
Volume: 75
Issue: 2
Pages: 253-261
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(93)80067-o
OpenAlex: W2000208875
Cited by: 1,744
References: 0
FWCI: 37.63
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review