Bacteroides Vulgatus Protects against Escherichia Coli-Induced Colitis in Gnotobiotic Interleukin-2-Deficient Mice

Waidmann, Marc; Bechtold, Oliver; Frick, Julia-stefanie; Lehr, Hans-anton; Schubert, Sören; Dobrindt, Ulrich; Loeffler, Jürgen; Bohn, Erwin; Autenrieth, Ingo B

doi:10.1016/s0016-5085(03)00672-3

Cited by 234Gut microbiota and healthInflammatory Bowel DiseaseProbiotics and Fermented Foods

Bacteroides Vulgatus Protects against Escherichia Coli-Induced Colitis in Gnotobiotic Interleukin-2-Deficient Mice

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Waidmann, Marc, Bechtold, Oliver, Frick, Julia-stefanie, Lehr, Hans-anton, Schubert, Sören, Dobrindt, Ulrich, Loeffler, Jürgen, Bohn, Erwin +1 more·2003·Gastroenterology

DOI 10.1016/s0016-5085(03)00672-3

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Abstract

Background & aims The microflora plays a crucial role in inflammatory bowel diseases (IBDs). Specific pathogen-free (SPF), but not germ-free, interleukin (IL)-2-deficient (IL-2-/-) mice develop colitis. The colitogenicity of commensal bacteria was determined.Methods Gnotobiotic IL-2-/- and IL-2+/+ mice were colonized with Escherichia coli mpk, Bacteroides vulgatus mpk, or both bacterial strains, or with E. coli strain Nissle 1917. DNA arrays were used to characterize E. coli mpk. Colitis was analyzed by histology and real-time reverse-transcription polymerase chain reaction (RT-PCR) for interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-10, and CD14 messenger RNA (mRNA) expression. Bacterial numbers in feces and bacterial localization in the colon was determined by culture and fluorescence in situ hybridization (FISH).Results IL-2-/- but not IL-2+/+ mice monocolonized with E. coli mpk developed colitis, whereas mono-association with B. vulgatus mpk, or E. coli Nissle, or co-colonization with E. coli mpk and B. vulgatus mpk, did not induce colitis. DNA array experiments and cellular studies revealed that E. coli mpk is a nonpathogenic strain. FISH and culture methods revealed that the anticolitogenic effect of B. vulgatus mpk on E. coli mpk cannot be explained by a significant reduction in numbers of E. coli in the colon. E. coli mpk-induced colitis was associated with increased IFN-gamma, TNF-alpha, CD14, and IL-10 mRNA expression in the colon.Conclusions In IL-2-/- mice, B. vulgatus mpk protects against E. coli mpk-triggered colitis by an unknown mechanism. E. coli Nissle does not induce colitis. Various bacterial species common to the microflora differ in their ability to trigger IBD.

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Bacteroides vulgatus has contradictory effects: it can reduce inflammation in some conditions and promote inflammatory bowel disorders in others.
“B. vulgatus specifically has shown contradictory effects: it can both reduce inflammation in some conditions [120] and promote inflammatory bowel disorders in others [121].”
From Unraveling the Connections: Eating Issues, Microbiome, and Gastrointestinal Symptoms in Autism Spectrum Disorder (2025) · cites this paper as [120]

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Collins MT, Lisby G, Moser C, Chicks D, Christensen S, Reich- elderfer M, Hoiby N, Harms BA, Thomsen OO, Skibsted U, Binder V. Results of multiple diagnostic tests for Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel dis- ease and in controls. J Clin Microbiol 2000;38:4373-4381.

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Authors: Waidmann, M., Bechtold, O., Frick, J.-S., Lehr, H.-A., Schubert, S., Dobrindt, U., Loeffler, J., Bohn, E., & Autenrieth, I. B.
Affiliations: University of Tübingen (DE)
Johannes Gutenberg University Mainz (DE)
Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie (DE)
University of Würzburg (DE)
Corresponding author: Autenrieth, Ingo B
ORCID: Frick, Julia-stefanie
Lehr, Hans-anton
Schubert, Sören
Dobrindt, Ulrich
Bohn, Erwin
Autenrieth, Ingo B
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2003-07
Volume: 125
Issue: 1
Pages: 162-177
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/s0016-5085(03)00672-3
OpenAlex: W2002432312
Cited by: 234
References: 75
Citations by year: 2026: 4 · 2025: 10 · 2024: 7 · 2023: 13 · 2022: 16 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 12 · 2017: 15 · 2016: 12 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 12
FWCI: 3.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: Bacteroides vulgatus, Escherichia coli, colitis, interleukin-2 deficiency, inflammatory bowel disease, commensal bacteria, gnotobiotic mice, interferon-gamma, TNF-α, IL-10, CD14, gut microbiota, bacterial colonization
MeSH terms: Animals, Bacteroides, Colitis, Escherichia coli, Escherichia coli Infections, Feces, Female, Germ-Free Life, Interleukin-2, Intestines, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Specific Pathogen-Free Organisms, Gene Expression, Mice

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Bacteroides Vulgatus Protects against Escherichia Coli-Induced Colitis in Gnotobiotic Interleukin-2-Deficient Mice

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