The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
Open accessAbstract
During C. elegans development, the temporal pattern of many cell lineages is specified by graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple elements in the lin-14 3'UTR that are regulated by the heterochronic gene Lin-4. The lin-14 3'UTR is both necessary and sufficient to confer lin-4-mediated posttranscriptional temporal regulation. The function of the lin-14 3'UTR is conserved between C. elegans and C. briggsae. Among the conserved sequences are seven elements that are each complementary to the lin-4 RNAs. A reporter gene bearing three of these elements shows partial temporal gradient activity. These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and thus act as important regulators of cellular phenotype and function.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [2]
In the citing paper
“Two C. elegans miRNAs, lin-4 and let-7, control developmental timing by forming imperfect base pairing with elements within the 3Ј UTR of target mRNAs and attenuating their translation (Lee et al. 1993;Wightman et al. 1993;Olsen and Ambros 1999;Reinhart et al. 2000;Slack et al. 2000).”
From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Wightman et al. 1993
Citations
Cites
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Mello, C. C., Kramer, J. M., Stinchcomb, D. T., & Ambros, V. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04966.x · Cited by 3,095
Regulating the fate of mRNA: the control of cellular iron metabolism
Klausner, R. D., Rouault, T. A., & Harford, J. B. (1993) · Cell · doi:10.1016/0092-8674(93)90046-s · Cited by 1,210
Heterochronic Mutants of the Nematode Caenorhabditis elegans
Ambros, V., & Horvitz, H. R. (1984) · Science · doi:10.1126/science.6494891 · Cited by 797
Turner, D. H., Sugimoto, N., & Freier, S. M. (1988) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.17.060188.001123 · Cited by 647
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans
Fire, A. Z., Harrison, S. M. W., & Dixon, D. (1990) · Gene · doi:10.1016/0378-1119(90)90224-f · Cited by 603
Sachs, A. B., & Davis, R. W. (1989) · Cell · doi:10.1016/0092-8674(89)90938-0 · Cited by 552
Mutations that lead to reiterations in the cell lineages of C. elegans.
Chalfie, M., Horvitz, H., & Sulston, J. (1981) · Cell · doi:10.1016/0092-8674(81)90501-8 · Cited by 541
RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos
Wharton, R. P., & Struhl, G. (1991) · Cell · doi:10.1016/0092-8674(91)90368-9 · Cited by 386
A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans
Ambros, V. (1989) · Cell · doi:10.1016/0092-8674(89)90171-2 · Cited by 361
Cited by
Sorted by citations
Items 801–900 of 1,015
microRNA expression in the eyes and their significance in relation to functions
Xu, S. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.11.003 · Cited by 110
A computational view of microRNAs and their targets
Brown, J. R., & Sanséau, P. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03399-4 · Cited by 110
Tanaka, Y., Tsuda, S., Kunikata, H., Sato, J., Kokubun, T., Yasuda, M., Nishiguchi, K. M., Inada, T., & Nakazawa, T. (2014) · Scientific Reports · doi:10.1038/srep05089 · Cited by 109
Differential Expression of MicroRNAs in Normal and Inflamed Human Pulps
Zhong, S., Zhang, S., Bair, E., Nares, S., & khan, A. W. A. (2012) · Journal of Endodontics · doi:10.1016/j.joen.2012.02.020 · Cited by 109
Role of virus-encoded microRNAs in herpesvirus biology
Boss, I. W., Plaisance‐Bonstaff, K., & Renne, R. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2009.09.002 · Cited by 108
Emerging functions of microRNAs in glioblastoma
Lawler, S. E., & Chiocca, E. A. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-9843-2 · Cited by 108
The emerging roles of microRNAs in cancer metabolism
Chan, B., Manley, J., Lee, J., & Singh, S. R. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.10.011 · Cited by 107
MicroRNA in central nervous system trauma and degenerative disorders
Liu, N., & Xu, X. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00168.2010 · Cited by 114
A CHOP-regulated microRNA controls rhodopsin expression
Behrman, S. L., Acosta‐Alvear, D., & Walter, P. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010055 · Cited by 113
Peng, Y., & Gao, Z. (2011) · Analytical Chemistry · doi:10.1021/ac102370s · Cited by 109
What Can We Learn About Human Disease from the Nematode C. elegans?
Apfeld, J., & Alper, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7471-9_4 · Cited by 116
The Network of Non-coding RNAs in Cancer Drug Resistance
Corrà, F., Agnoletto, C., Minotti, L., Baldassari, F., & Volinia, S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00327 · Cited by 109
Ciphers and Executioners: How 3′-Untranslated Regions Determine the Fate of Messenger RNAs
Mayya, V. K., & Duchaîne, T. F. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00006 · Cited by 113
The role of miR‐29 family in disease
Horita, M., Farquharson, C., & Stephen, L. A. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29896 · Cited by 113
Zhu, S., Cao, L., Zhu, J., Kong, L., Jin, J., Qian, L., Zhu, C., Hu, X., Li, M., Guo, X., et al. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.05.010 · Cited by 116
Chapter 20 Transcription and Translation
Krause, M. (1995) · Methods in cell biology · doi:10.1016/s0091-679x(08)61400-4 · Cited by 113
Everything you wanted to know about small RNA but were afraid to ask
Boyd, S. D. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.32 · Cited by 108
Small RNAs – secrets and surprises of the genome
Chen, X. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2009.04089.x · Cited by 115
MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease
Zacharewicz, E., Lamon, S., & Russell, A. P. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00266 · Cited by 115
The 20 years it took to recognize the importance of tiny RNAs
Ruvkun, G., Wightman, B., & Ha, I. (2004) · Cell · doi:10.1016/s0092-8674(04)00034-0 · Cited by 108
Self-citationBettinger, J. C., Lee, K., & Rougvie, A. E. (1996) · Development · doi:10.1242/dev.122.8.2517 · Cited by 108
The full-length transcriptome of C. elegans using direct RNA sequencingPreprint
Roach, N. P., Sadowski, N., Alessi, A. F., Timp, W., Taylor, J., & Kim, J. K. (2020) · Genome Research · doi:10.1101/gr.251314.119 · Cited by 107
MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer.
Pal, M. K., Jaiswar, S. P., Dwivedi, V. N., Tripathi, A. K., Dwivedi, A., & Sankhwar, P. (2015) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2015.0024 · Cited by 107
Regulation of translation by specific protein/mRNA interactions
Standart, N., & Jackson, R. J. (1994) · Biochimie · doi:10.1016/0300-9084(94)90189-9 · Cited by 107
Kuge, H., & Richter, J. D. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00320.x · Cited by 107
Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players
Deng, G., & Sui, G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918319 · Cited by 106
Mirnas and Their Potential For Use Against Cancer and Other Diseases
Tili, E., Michaille, J., Gandhi, V. V., Plunkett, W. K., Sampath, D., & Calin, G. A. (2007) · Future Oncology · doi:10.2217/14796694.3.5.521 · Cited by 105
Ko, J., Prassinos, C., & Han, K. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2005.01623.x · Cited by 106
Sexually Dimorphic MicroRNA Expression During Chicken Embryonic Gonadal Development1
Bannister, S. C., Tizard, M. L., Doran, T. J., Sinclair, A. H., & Smith, C. A. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.074005 · Cited by 103
MicroRNA: A new player in stem cells
Zhang, B., Pan, X., & Anderson, T. A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20713 · Cited by 106
Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules.
Schumacher, J. M., Lee, K., Edelhoff, S., & Braun, R. E. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.4.1023 · Cited by 105
Podshivalova, K., & Salomon, D. R. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013006858 · Cited by 105
Role of miRNAs in the progression of malignant melanoma
Mueller, D. W., & Bosserhoff, A. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605204 · Cited by 104
HHMMiR: efficient de novo prediction of microRNAs using hierarchical hidden Markov models
Kadri, S., Hinman, V. F., & Benos, P. V. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-s1-s35 · Cited by 101
Circulating microRNAs in acute and chronic exercise: more than mere biomarkers
Sapp, R. M., Shill, D. D., Roth, S. M., & Hagberg, J. M. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00982.2016 · Cited by 109
Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
Kang, Y., He, W., Ren, C., Qiao, J., Guo, Q., Hu, J., Xu, H., Jiang, X., & Wang, L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00340-2 · Cited by 104
Alkan, A. H., & Akgül, B. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1170-8_5 · Cited by 108
Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori
Zhang, Y., Zhou, X., Ge, X., Jiang, J., Li, M., Jia, S., Yang, X., Kan, Y., Miao, X., Zhao, G., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004677 · Cited by 103
Designing a Polycationic Probe for Simultaneous Enrichment and Detection of MicroRNAs in a Nanopore
Tian, K., He, Z., Wang, Y., Chen, S., & Gu, L. (2013) · ACS Nano · doi:10.1021/nn305789z · Cited by 104
Isolation of translationally controlled mRNAs by differential screening
Mikulits, W., Pradet‐Balade, B., Habermann, B., Beug, H., Garcia‐SANZ, J. A., & Müllner, E. W. (2000) · The FASEB Journal · doi:10.1096/fj.14.11.1641 · Cited by 104
A Comparative Review of microRNA Expression Patterns in Autism Spectrum Disorder
Hicks, S. D., & Middleton, F. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00176 · Cited by 103
MicroRNAs and their implications in toxicological research
Lema, C., & Cunningham, M. J. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.06.019 · Cited by 103
The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells
Masri, S., Liu, Z., Phung, S., Wang, E., Yuan, Y., & Chen, S. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0716-3 · Cited by 106
Role of Deregulated microRNAs in Breast Cancer Progression Using FFPE Tissue
Chen, L., Li, Y., Fu, Y., Jin, P., Mo, M.-H., Stamatakos, M., Teal, C. B., Brem, R. F., Stojadinovic, A., Grinkemeyer, M. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054213 · Cited by 104
Prognostic Significance of miR-205 in Endometrial Cancer
Karaayvaz, M., Zhang, C., Liang, S. X., Shroyer, K. R., & Ju, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035158 · Cited by 103
Circulating miRNAs as New Blood-Based Biomarkers for Solid Cancers
Rédová, M., Šáňa, J., & Slabý, O. (2013) · Future Oncology · doi:10.2217/fon.12.192 · Cited by 103
miR-155 as a novel clinical target for hematological malignancies
Witten, L., & Slack, F. J. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz183 · Cited by 104
Estimating the number of diseases – the concept of rare, ultra-rare, and hyper-rare
Smith, C. I. E., Bergman, P., & Hagey, D. W. (2022) · iScience · doi:10.1016/j.isci.2022.104698 · Cited by 115
Plant Genome Diversity Volume 1
Wendel, J. F., Greilhuber, J., Doležel, J., & Leitch, I. J. (2012) · Springer eBooks · doi:10.1007/978-3-7091-1130-7 · Cited by 119
Fordham, J. B., Naqvi, A. R., & Nares, S. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a1014-519rr · Cited by 101
Molecular Mechanisms of RNA-Triggered Gene Silencing Machineries
Li, Z., & Rana, T. M. (2012) · Accounts of Chemical Research · doi:10.1021/ar200253u · Cited by 108
RNAi: a potential new class of therapeutic for human genetic disease
Seyhan, A. A. (2011) · Human Genetics · doi:10.1007/s00439-011-0995-8 · Cited by 104
Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review)
Νikolouzakis, Τ. Κ., Vassilopoulou, L., Fragkiadaki, P., Sapsakos, T. M., Papadakis, G., Spandidos, D. A., Tsatsakis, A. M., & Tsiaoussis, J. (2018) · Oncology Reports · doi:10.3892/or.2018.6330 · Cited by 105
The Implications of the Long Non-Coding RNA NEAT1 in Non-Cancerous Diseases
Prinz, F., Kapeller, A., Pichler, M., & Klec, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030627 · Cited by 102
Das, S., Shah, R. V., Dimmeler, S., Freedman, J. E., Holley, C. L., Lee, J., Moore, K. J., Musunuru, K., Wang, D., Xiao, J., et al. (2020) · Circulation Genomic and Precision Medicine · doi:10.1161/hcg.0000000000000062 · Cited by 106
MicroRNA Dysregulation in Parkinson’s Disease: A Narrative Review
Nies, Y. H., Najib, N. H. M., Lim, W. L., Kamaruzzaman, M. A., Yahaya, M. F., & Teoh, S. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.660379 · Cited by 105
Hayes, G. D., Frand, A. R., & Ruvkun, G. (2006) · Development · doi:10.1242/dev.02655 · Cited by 99
Self-citationTaliaferro, J. M., Aspden, J. L., Bradley, T., Marwha, D., Blanchette, M., & Rio, D. C. (2013) · Genes & Development · doi:10.1101/gad.210708.112 · Cited by 102
Inferring MicroRNA Activities by Combining Gene Expression with MicroRNA Target Prediction
Cheng, C., & Li, L. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001989 · Cited by 100
The perfect storm of tiny RNAs
Ruvkun, G. (2008) · Nature Medicine · doi:10.1038/nm1008-1041 · Cited by 102
Self-citationmicroRNAs in the onset and development of cardiovascular disease
Vickers, K. C., Rye, K., & Tabet, F. (2013) · Clinical Science · doi:10.1042/cs20130203 · Cited by 102
Wei, R., Huang, G., Zhang, M.-Y., Li, B., Zhang, H.-Z., Shi, M., Chen, X.-Q., Huang, L., Zhou, Q.-M., Jia, W.-H., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2728 · Cited by 101
MicroRNAs in platelet production and activation
Edelstein, L. C., McKenzie, S. E., Shaw, C. A., Holinstat, M. A., Kunapuli, S. P., & Bray, P. F. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12214 · Cited by 103
Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart
Queirós, A. M., Eschen, C., Fliegner, D., Kararigas, G., Dworatzek, E., Westphal, C., Sanchez‐Ruderisch, H., & Regitz‐Zagrosek, V. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.09.002 · Cited by 102
microRNAs in cardiovascular development
Chen, J., & Wang, D. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.01.012 · Cited by 100
Dogini, D. B., Pascoal, V., Avansini, S. H., Vieira, A. S., Pereira, T. C., & Lopes‐Cendes, Í. (2014) · Genetics and Molecular Biology · doi:10.1590/s1415-47572014000200014 · Cited by 104
Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets
Schirle, N. T., Sheu‐Gruttadauria, J., Chandradoss, S. D., Joo, C., & MacRae, I. J. (2015) · eLife · doi:10.7554/elife.07646 · Cited by 104
Let-7 microRNA as a potential therapeutic target with implications for immunotherapy
Gilles, M.-E., & Slack, F. J. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1535594 · Cited by 99
Nata, T., Fujiya, M., Ueno, N., Moriichi, K., Konishi, H., Tanabe, H., Ohtake, T., Ikuta, K., & Kohgo, Y. (2013) · The Journal of Gene Medicine · doi:10.1002/jgm.2717 · Cited by 104
Kawase‐Koga, Y., Low, R., Otaegi, G., Pollock, A., Deng, H., Eisenhaber, F., Maurer‐Stroh, S., & Sun, T. (2010) · Journal of Cell Science · doi:10.1242/jcs.059659 · Cited by 101
MicroRNAs and glioblastoma; the stem cell connection
Godlewski, J., Newton, H. B., Chiocca, E. A., & Lawler, S. E. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.71 · Cited by 86
MicroRNAs and Diabetic Complications
Natarajan, R. D., Putta, S., & Kato, M. V. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9368-5 · Cited by 100
A myriad of roles of miR-25 in health and disease
Sárközy, M., Kahán, Z., & Csont, T. (2018) · Oncotarget · doi:10.18632/oncotarget.24662 · Cited by 99
PSoL: a positive sample only learning algorithm for finding non-coding RNA genes
Wang, C., Ding, C. H. Q., Meraz, R. F., & Holbrook, S. R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl441 · Cited by 99
A miRacle in plant development: Role of microRNAs in cell differentiation and patterning
Garcia, D. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.013 · Cited by 104
β-Cell MicroRNAs: Small but Powerful
Filios, S. R., & Shalev, A. (2015) · Diabetes · doi:10.2337/db15-0831 · Cited by 106
Ren, Z., & Ambros, V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422858112 · Cited by 97
Kolbert, C. P., Feddersen, R. M., Rakhshan, F., Grill, D. E., Simon, G., Middha, S., Jang, J. S., Simon, V. A., Schultz, D. A., Zschunke, M. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052517 · Cited by 98
Smorag, L., Zheng, Y., Nolte, J., Zechner, U., Engel, W., & Pantakani, D. V. K. (2012) · Biology of the Cell · doi:10.1111/boc.201200014 · Cited by 98
A Whole-Genome RNAi Screen for C. elegans miRNA Pathway Genes
Parry, D. H., Xu, J., & Ruvkun, G. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.058 · Cited by 98
Self-citationCamels and zebrafish, viruses and cancer: a microRNA update
Berezikov, E., & Plasterk, R. H. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi271 · Cited by 97
MicroRNAs: tiny molecules with a significant role in mammalian follicular and oocyte development
Tesfaye, D., Gebremedhn, S., Salilew‐Wondim, D., Hailay, T., Hoelker, M., Große‐Brinkhaus, C., & Schellander, K. (2017) · Reproduction · doi:10.1530/rep-17-0428 · Cited by 97
The Role of miRNA in the Diagnosis, Prognosis, and Treatment of Osteosarcoma
Wang, J., Liu, S., Shi, J., Li, J., Wang, S., Liu, H., Zhao, S., Duan, K., Pan, X., & Zhi, Y. (2019) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.2939 · Cited by 97
A Novel Method to Monitor the Expression of microRNAs
Fu, H.-J., Zhu, J., Yang, M., Zhang, Z., Tie, Y., Jiang, H. F., Sun, Z., & Zheng, X. (2006) · Molecular Biotechnology · doi:10.1385/mb:32:3:197 · Cited by 98
Role of miRNA in carcinogenesis and biomarker selection: a methodological view
Ahmed, F. (2007) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.7.5.569 · Cited by 95
Hausser, J., Landthaler, M., Jaśkiewicz, Ł., Gaidatzis, D., & Zavolan, M. (2009) · Genome Research · doi:10.1101/gr.091181.109 · Cited by 99
microRNAs in cardiac development and regeneration
Porrello, E. R. (2013) · Clinical Science · doi:10.1042/cs20130011 · Cited by 100
Mandli, J., Mohammadi, H., & Amine, A. (2017) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2017.03.002 · Cited by 97
Advancements in clinical RNA therapeutics: Present developments and prospective outlooks
Saw, P. E., & Song, E. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101555 · Cited by 97
MicroRNA epigenetic alterations in human cancer: One step forward in diagnosis and treatment
Yang, N., Coukos, G., & Zhang, L. (2007) · International Journal of Cancer · doi:10.1002/ijc.23325 · Cited by 96
Horwich, M. D., & Zamore, P. D. (2008) · Nature Protocols · doi:10.1038/nprot.2008.145 · Cited by 95
Zhang, H., & Li, L. (2013) · The Plant Journal · doi:10.1111/tpj.12107 · Cited by 97
Li, M., Jones-Rhoades, M. W., Lau, N. C., Bartel, D. P., & Rougvie, A. E. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.08.002 · Cited by 96
Diversity in translational regulation
Macdonald, P. M. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00215-5 · Cited by 96
Function and Localization of MicroRNAs in Mammalian CellsPreprint
Leung, A. K. L., & Sharp, P. A. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.049 · Cited by 95
Nuclear receptor signal transduction in C. elegans
Antebi, A. (2015) · WormBook · doi:10.1895/wormbook.1.64.2 · Cited by 93
MicroRNAs activate natural killer cells through Toll-like receptor signaling
He, S., Chu, J., Wu, L., Mao, H. C., Peng, Y., Alvarez-Breckenridge, C. A., Hughes, T. L., Wei, M., Zhang, J., Yuan, S., et al. (2013) · Blood · doi:10.1182/blood-2012-07-441360 · Cited by 97
MicroRNA-regulated viral vectors for gene therapy
Geisler, A., & Fechner, H. (2016) · World Journal of Experimental Medicine · doi:10.5493/wjem.v6.i2.37 · Cited by 100
A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer
Chan, J. J., Kwok, Z. H., Chew, X. H., Zhang, B., Liu, C., Soong, T. W., Yang, H. H., & Tay, Y. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1248 · Cited by 98
Fridrich, A., Hazan, Y., & Moran, Y. (2019) · BioEssays · doi:10.1002/bies.201800169 · Cited by 96
Metadata
- Authors
- Wightman, B., Ha, I., & Ruvkun, G.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-12
- Volume
- 75
- Issue
- 5
- Pages
- 855-862
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2160467221
- Cited by
- 4,292
- References
- 27
- Citations by year
- 2026: 86 · 2025: 189 · 2024: 151 · 2023: 164 · 2022: 171 · 2021: 193 · 2020: 177 · 2019: 172 · 2018: 189 · 2017: 235 · 2016: 193 · 2015: 227 · 2014: 224 · 2013: 281 · 2012: 231
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM44619, R01GM044619)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- lin-14, lin-4, post-transcriptional regulation, 3' untranslated region, heterochronic genes, RNA duplex, protein synthesis inhibition, Caenorhabditis elegans, Caenorhabditis briggsae, developmental timing, cell lineage specification
- MeSH terms
- Animals, Base Sequence, Caenorhabditis, Gene Expression Regulation, Molecular Sequence Data, Morphogenesis, RNA, Messenger, Sequence Homology, Nucleic Acid, Species Specificity, Time Factors, Protein Biosynthesis, Helminth Proteins, RNA, Antisense, Sequence Alignment, Genes, Helminth
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review