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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
Open accessAbstract
During C. elegans development, the temporal pattern of many cell lineages is specified by graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple elements in the lin-14 3'UTR that are regulated by the heterochronic gene Lin-4. The lin-14 3'UTR is both necessary and sufficient to confer lin-4-mediated posttranscriptional temporal regulation. The function of the lin-14 3'UTR is conserved between C. elegans and C. briggsae. Among the conserved sequences are seven elements that are each complementary to the lin-4 RNAs. A reporter gene bearing three of these elements shows partial temporal gradient activity. These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation.
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“MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and thus act as important regulators of cellular phenotype and function.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [2]
In the citing paper
“Two C. elegans miRNAs, lin-4 and let-7, control developmental timing by forming imperfect base pairing with elements within the 3Ј UTR of target mRNAs and attenuating their translation (Lee et al. 1993;Wightman et al. 1993;Olsen and Ambros 1999;Reinhart et al. 2000;Slack et al. 2000).”
From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Wightman et al. 1993
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Cites
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Mello, C. C., Kramer, J. M., Stinchcomb, D. T., & Ambros, V. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04966.x · Cited by 3,095
Regulating the fate of mRNA: the control of cellular iron metabolism
Klausner, R. D., Rouault, T. A., & Harford, J. B. (1993) · Cell · doi:10.1016/0092-8674(93)90046-s · Cited by 1,210
Heterochronic Mutants of the Nematode Caenorhabditis elegans
Ambros, V., & Horvitz, H. R. (1984) · Science · doi:10.1126/science.6494891 · Cited by 797
Turner, D. H., Sugimoto, N., & Freier, S. M. (1988) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.17.060188.001123 · Cited by 647
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans
Fire, A. Z., Harrison, S. M. W., & Dixon, D. (1990) · Gene · doi:10.1016/0378-1119(90)90224-f · Cited by 603
Sachs, A. B., & Davis, R. W. (1989) · Cell · doi:10.1016/0092-8674(89)90938-0 · Cited by 552
Mutations that lead to reiterations in the cell lineages of C. elegans.
Chalfie, M., Horvitz, H., & Sulston, J. (1981) · Cell · doi:10.1016/0092-8674(81)90501-8 · Cited by 541
RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos
Wharton, R. P., & Struhl, G. (1991) · Cell · doi:10.1016/0092-8674(91)90368-9 · Cited by 386
A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans
Ambros, V. (1989) · Cell · doi:10.1016/0092-8674(89)90171-2 · Cited by 361
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Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb
Xiao, C., Calado, D. P., Galler, G. R., Thai, T., Patterson, H. C., Wang, J., Rajewsky, N., Bender, T. P., & Rajewsky, K. (2007) · Cell · doi:10.1016/j.cell.2007.07.021 · Cited by 1,061
A microRNA array reveals extensive regulation of microRNAs during brain development
KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040
Noncoding RNA:RNA Regulatory Networks in Cancer
Chan, J. J., & Tay, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051310 · Cited by 1,032
Therapeutic targeting of microRNAs: current status and future challenges
Li, Z., & Rana, T. M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4359 · Cited by 1,052
The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila
Okamura, K., Hagen, J. W., Duan, H., Tyler, D. M., & Lai, E. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.028 · Cited by 1,089
MicroRNA Control in the Immune System: Basic Principles
Xiao, C., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2008.12.027 · Cited by 1,020
Molecular mechanisms of translational control
Gebauer, F., & Hentze, M. W. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1488 · Cited by 991
Vaucheret, H., Vazquez, F., Crété, P., & Bartel, D. P. (2004) · Genes & Development · doi:10.1101/gad.1201404 · Cited by 982
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Suh, M. R., Lee, Y., Kim, J. Y., Kim, S.-K., Moon, S., Lee, J. Y., Cha, K., Chung, H., Yoon, H. S., Moon, S. Y., et al. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.02.019 · Cited by 974
Kasschau, K. D., Xie, Z., Allen, E., Llave, C., Chapman, E. J., Krizan, K. A., & Carrington, J. C. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00025-x · Cited by 968
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Aravin, A. A., Lagos-Quintana, M., Yalcin, A., Zavolan, M., Marks, D., Snyder, B., Gaasterland, T., Meyer, J., & Tuschl, T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00228-4 · Cited by 802
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Jackson, A. L., Burchard, J., Schelter, J. M., Chau, B. N., Cleary, M. A., Lim, L. P., & Linsley, P. S. (2006) · RNA · doi:10.1261/rna.25706 · Cited by 979
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
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Small RNAs as big players in plant abiotic stress responses and nutrient deprivation
Sunkar, R., Chinnusamy, V., Zhu, J., & Zhu, J.-K. (2007) · Trends in Plant Science · doi:10.1016/j.tplants.2007.05.001 · Cited by 935
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
Zeng, Y., Yi, R., & Cullen, B. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1630797100 · Cited by 741
Ji, R., Cheng, Y., Yue, J., Yang, J., Liu, X., Chen, H., Dean, D. B., & Zhang, C. (2007) · Circulation Research · doi:10.1161/circresaha.106.141986 · Cited by 918
Endogenous and Silencing-Associated Small RNAs in Plants[W]
Llave, C., Kasschau, K. D., Rector, M. A., & Carrington, J. C. (2002) · The Plant Cell · doi:10.1105/tpc.003210 · Cited by 927
Mallory, A. C., Bartel, D. P., & Bartel, B. (2005) · The Plant Cell · doi:10.1105/tpc.105.031716 · Cited by 921
siRNAs: applications in functional genomics and potential as therapeutics
Dorsett, Y., & Tuschl, T. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1345 · Cited by 917
Non-coding RNAs in disease: from mechanisms to therapeutics
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MicroRNAs: Synthesis, mechanism, function, and recent clinical trials
Wahid, F., Shehzad, A., Khan, T., & Kim, Y. Y. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.06.013 · Cited by 929
microRNAs in action: biogenesis, function and regulation
Shang, R., Lee, S., Senavirathne, G., & Lai, E. C. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00611-y · Cited by 897
Farazi, T. A., Spitzer, J., Morozov, P. S., & Tuschl, T. (2010) · The Journal of Pathology · doi:10.1002/path.2806 · Cited by 903
New microRNAs from mouse and human
LAGOS-QUINTANA, M., RAUHUT, R., MEYER, J., BORKHARDT, A., & TUSCHL, T. (2003) · RNA · doi:10.1261/rna.2146903 · Cited by 909
MicroRNAs and Cancer: Short RNAs Go a Long Way
Ventura, A., & Jacks, T. (2009) · Cell · doi:10.1016/j.cell.2009.02.005 · Cited by 898
Mogilyansky, E., & Rigoutsos, I. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.125 · Cited by 889
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Extensive post-transcriptional regulation of microRNAs and its implications for cancer
Thomson, J. M., Newman, M., Parker, J. S., Morin-Kensicki, E. M., Wright, T., & Hammond, S. M. (2006) · Genes & Development · doi:10.1101/gad.1444406 · Cited by 877
Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability
Jing, Q., Huang, S., Guth, S., Zarubin, T., Motoyama, A. B., Chen, J., Padova, F. D., Lin, S., Gram, H., & Han, J. (2005) · Cell · doi:10.1016/j.cell.2004.12.038 · Cited by 849
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysPreprint
岡村, 勝., Ishizuka, A., Siomi, H., & Siomi, M. C. (2004) · Genes & Development · doi:10.1101/gad.1210204 · Cited by 866
Moss, E. G., Lee, R. C., & Ambros, V. (1997) · Cell · doi:10.1016/s0092-8674(00)81906-6 · Cited by 850
Zeng, Y., Wagner, E. J., & Cullen, B. R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00541-5 · Cited by 839
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782
MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions.
Shukla, G. C., Singh, J., & Barik, S. (2011) · PubMed · Cited by 822
How microRNAs control cell division, differentiation and death
Miska, E. A. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.08.005 · Cited by 821
MicroRNA function in animal development
Wienholds, E., & Plasterk, R. H. A. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.070 · Cited by 823
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Braunwald, E. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61889-4 · Cited by 818
microPrimer: the biogenesis and function of microRNA
Du, T., & Zamore, P. D. (2005) · Development · doi:10.1242/dev.02070 · Cited by 832
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T., Goodman, R. H., & Impey, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508448102 · Cited by 696
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Vazquez, F., Vaucheret, H., Rajagopalan, R. M., Lepers-Blassiau, C., Gasciolli, V., Mallory, A. C., Hilbert, J., Bartel, D. P., & Crété, P. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.028 · Cited by 797
Microarray analysis of microRNA expression in the developing mammalian brain
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Rybak‐Wolf, A., Fuchs, H. R., Smirnova, L., Brandt, C., Pohl, E. E., Nitsch, R., & Wulczyn, F. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1759 · Cited by 811
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Garzon, R., Fabbri, M., Cimmino, A., Calin, G. A., & Croce, C. M. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.006 · Cited by 791
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Non-coding RNAs as regulators of gene expression and epigenetics
Kaikkonen, M. U., Lam, M. T. Y., & Glass, C. K. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr097 · Cited by 764
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Kiriakidou, M., Nelson, P. T., Kouranov, A., Fitziev, P., Bouyioukos, C., Mourelatos, Z., & Hatzigeorgiou, A. G. (2004) · Genes & Development · doi:10.1101/gad.1184704 · Cited by 774
Novel small RNA-encoding genes in the intergenic regions of Escherichia coli
Argaman, L., Hershberg, R., Vogel, J., Bejerano, G., Wagner, E. G. H., Margalit, H., & Altuvia, S. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00270-6 · Cited by 764
Slack, F. J., Basson, M., Liu, Z., Ambros, V., Horvitz, H. R., & Ruvkun, G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80245-2 · Cited by 751
Self-citationThe Functions of MicroRNAs: mRNA Decay and Translational Repression
Iwakawa, H., & Tomari, Y. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.011 · Cited by 764
Biomarkers of Acute Kidney Injury
Vaidya, V. S., Ferguson, M. A., & Bonventre, J. V. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094615 · Cited by 741
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Zhang, B., Pan, X., Cannon, C. H., Cobb, G. P., & Anderson, T. A. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02697.x · Cited by 717
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Kent, O. A., & Mendell, J. T. (2006) · Oncogene · doi:10.1038/sj.onc.1209913 · Cited by 715
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Sethupathy, P., CORDA, B., & Hatzigeorgiou, A. G. (2005) · RNA · doi:10.1261/rna.2239606 · Cited by 718
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Schickel, R., Boyerinas, B. M., Sm, P., & Peter, M. E. (2008) · Oncogene · doi:10.1038/onc.2008.274 · Cited by 721
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Tham, Y. K., Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., & McMullen, J. R. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1477-x · Cited by 732
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Mattie, M. D., Benz, C. C., Bowers, J., Sensinger, K., Wong, L., Scott, G. K., Fedele, V., Ginzinger, D. G., Getts, R. C., & Haqq, C. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-24 · Cited by 711
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Argonaute proteins: mediators of RNA silencing
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Mallory, A. C., Reinhart, B. J., Jones-Rhoades, M. W., Tang, G., Zamore, P. D., Barton, M. K., & Bartel, D. P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600340 · Cited by 681
Myogenic factors that regulate expression of muscle-specific microRNAs
Rao, P. K., Kumar, R., Farkhondeh, M., Baskerville, S., & Lodish, H. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602831103 · Cited by 703
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Schetter, A. J., Heegaard, N. H. H., & Harris, C. C. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp272 · Cited by 671
Biological functions of microRNAs: a review
Huang, Y., Shen, X. J., Zou, Q., Wang, S. P., Tang, S. M., & Zhang, G. Z. (2010) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-010-0050-6 · Cited by 659
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
Harfe, B. D., McManus, M. T., Mansfield, J. H., Hornstein, E., & Tabin, C. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504834102 · Cited by 656
MicroRNA and cancer – A brief overview
Acunzo, M., Romano, G., Wernicke, D., & Croce, C. M. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.09.013 · Cited by 638
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He, B., Zhao, Z., Cai, Q., Zhang, Y., Zhang, P., Shi, S., Xie, H., Peng, X., Yin, W., Tao, Y., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.47203 · Cited by 651
Identification and consequences of miRNA–target interactions — beyond repression of gene expression
Hausser, J., & Zavolan, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3765 · Cited by 633
Non-coding RNAs as regulators of embryogenesis
Pauli, A., Rinn, J. L., & Schier, A. F. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2904 · Cited by 637
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van Rooij, E., & Kauppinen, S. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201100899 · Cited by 625
Vitale, A. V., Tan, H., & Jin, P. (2011) · Journal of Nucleic Acids Investigation · doi:10.4081/jnai.2011.2236 · Cited by 626
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
Meister, G., Landthaler, M., Dorsett, Y., & Tuschl, T. (2004) · RNA · doi:10.1261/rna.5235104 · Cited by 626
Real-time PCR quantification of precursor and mature microRNA
Schmittgen, T. D., Lee, E. J., Jiang, J., Sarkar, A., Yang, L., Elton, T. S., & Chen, C. (2008) · Methods · doi:10.1016/j.ymeth.2007.09.006 · Cited by 616
let-7 microRNAs in development, stem cells and cancer
Büssing, I., Slack, F. J., & Großhans, H. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.07.001 · Cited by 615
Ratti, M., Lampis, A., Ghidini, M., Salati, M., Mirchev, M. B., Valeri, N., & Hahne, J. C. (2020) · Targeted Oncology · doi:10.1007/s11523-020-00717-x · Cited by 632
Bhaskaran, M., & Mohan, M. (2013) · Veterinary Pathology · doi:10.1177/0300985813502820 · Cited by 642
A Transparent Window into Biology: A Primer on Caenorhabditis elegans
Corsi, A. K., Wightman, B., & Chalfie, M. (2015) · Genetics · doi:10.1534/genetics.115.176099 · Cited by 670
Self-citationZhang, Y., Wang, Z., & Gemeinhart, R. A. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.09.015 · Cited by 535
Ruby, J. G., Stark, E., Johnston, W. K., Kellis, M., Bartel, D. P., & Lai, E. C. (2007) · Genome Research · doi:10.1101/gr.6597907 · Cited by 602
Kuwabara, Y., Ono, K., Horie, T., Nishi, H., Nagao, K., Kinoshita, M., Watanabe, S., Baba, O., Kojima, Y., Shizuta, S., et al. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.958975 · Cited by 601
microRNA Modulation of Circadian-Clock Period and Entrainment
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Metadata
- Authors
- Wightman, B., Ha, I., & Ruvkun, G.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-12
- Volume
- 75
- Issue
- 5
- Pages
- 855-862
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2160467221
- Cited by
- 4,292
- References
- 27
- Citations by year
- 2026: 86 · 2025: 189 · 2024: 151 · 2023: 164 · 2022: 171 · 2021: 193 · 2020: 177 · 2019: 172 · 2018: 189 · 2017: 235 · 2016: 193 · 2015: 227 · 2014: 224 · 2013: 281 · 2012: 231
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM44619, R01GM044619)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- lin-14, lin-4, post-transcriptional regulation, 3' untranslated region, heterochronic genes, RNA duplex, protein synthesis inhibition, Caenorhabditis elegans, Caenorhabditis briggsae, developmental timing, cell lineage specification
- MeSH terms
- Animals, Base Sequence, Caenorhabditis, Gene Expression Regulation, Molecular Sequence Data, Morphogenesis, RNA, Messenger, Sequence Homology, Nucleic Acid, Species Specificity, Time Factors, Protein Biosynthesis, Helminth Proteins, RNA, Antisense, Sequence Alignment, Genes, Helminth
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