Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

Mello, C. C., Kramer, J. M., Stinchcomb, D. T., & Ambros, V. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04966.x · Cited by 3,095

Regulating the fate of mRNA: the control of cellular iron metabolism

Klausner, R. D., Rouault, T. A., & Harford, J. B. (1993) · Cell · doi:10.1016/0092-8674(93)90046-s · Cited by 1,210

Heterochronic Mutants of the Nematode Caenorhabditis elegans

Ambros, V., & Horvitz, H. R. (1984) · Science · doi:10.1126/science.6494891 · Cited by 797

RNA Structure Prediction

Turner, D. H., Sugimoto, N., & Freier, S. M. (1988) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.17.060188.001123 · Cited by 647

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

Fire, A. Z., Harrison, S. M. W., & Dixon, D. (1990) · Gene · doi:10.1016/0378-1119(90)90224-f · Cited by 603

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

Sachs, A. B., & Davis, R. W. (1989) · Cell · doi:10.1016/0092-8674(89)90938-0 · Cited by 552

Mutations that lead to reiterations in the cell lineages of C. elegans.

Chalfie, M., Horvitz, H., & Sulston, J. (1981) · Cell · doi:10.1016/0092-8674(81)90501-8 · Cited by 541

RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos

Wharton, R. P., & Struhl, G. (1991) · Cell · doi:10.1016/0092-8674(91)90368-9 · Cited by 386

A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans

Ambros, V. (1989) · Cell · doi:10.1016/0092-8674(89)90171-2 · Cited by 361

Sequence-specific inhibition of small RNA function

Hutvágner, G., Simard, M. J., Mello, C. C., & Zamore, P. D. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020098 · Cited by 584

Negative Feedback Regulation of Dicer-Like1 in Arabidopsis by microRNA-Guided mRNA Degradation

Xie, Z., Kasschau, K. D., & Carrington, J. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00281-1 · Cited by 594

Canalization of development by microRNAs

Hornstein, E., & Shomron, N. (2006) · Nature Genetics · doi:10.1038/ng1803 · Cited by 578

MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues

Barad, O., Meiri, E., Avniel, A., Aharonov, R., Barzilai, A., Bentwich, I., Einav, U., Gilad, S., Hurban, P., Karov, Y., et al. (2004) · Genome Research · doi:10.1101/gr.2845604 · Cited by 582

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

Ishizuka, A., Siomi, M. C., & Siomi, H. (2002) · Genes & Development · doi:10.1101/gad.1022002 · Cited by 581

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

Kim, J., Krichevsky, A. M., Grad, Y. H., Hayes, G. D., Kosik, K. S., Church, G. M., & Ruvkun, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2333854100 · Cited by 586

microRNA biogenesis and function in plants

Chen, X. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.071 · Cited by 571

Circulating microRNAs as novel biomarkers for diabetes mellitus

Guay, C., & Regazzi, R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.86 · Cited by 563

Structural basis for microRNA targeting

Schirle, N. T., Sheu‐Gruttadauria, J., & MacRae, I. J. (2014) · Science · doi:10.1126/science.1258040 · Cited by 575

Inhibition of microRNA function by antimiR oligonucleotides

Stenvang, J., Petri, A., Lindow, M., Obad, S., & Kauppinen, S. (2012) · Silence · doi:10.1186/1758-907x-3-1 · Cited by 571

C. elegans dauer formation and the molecular basis of plasticityPreprint

Fielenbach, N., & Antebi, A. (2008) · Genes & Development · doi:10.1101/gad.1701508 · Cited by 587

MicroRNAs and their regulatory roles in animals and plants

Zhang, B., Wang, Q., & Pan, X. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20869 · Cited by 555

Genomic analysis of human microRNA transcripts

Saini, H. K., Griffiths‐Jones, S., & Enright, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703890104 · Cited by 583

Antisense Oligonucleotides: An Emerging Area in Drug Discovery and Development

Dhuri, K., Bechtold, C., Quijano, E., Pham, H. T. T., Gupta, A., Vikram, A., & Bahal, R. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9062004 · Cited by 586

microRNAs join the p53 network — another piece in the tumour-suppression puzzle

He, L., He, X., Lowe, S. W., & Hannon, G. J. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2232 · Cited by 551

Insulin/insulin-like growth factor signaling in C. elegans

Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 544

Intracellular Signaling by the Unfolded Protein Response

Bernales, S., Papa, F. R., & Walter, P. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120200 · Cited by 543

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

Tabara, H., Yigit, E., Siomi, H., & Mello, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00793-6 · Cited by 539

The Art of MicroRNA Research

van Rooij, E. (2011) · Circulation Research · doi:10.1161/circresaha.110.227496 · Cited by 548

Dicing and slicing: The core machinery of the RNA interference pathway

Hammond, S. M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.08.079 · Cited by 545

The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation

Han, M.-H., Goud, S., Song, L., & Fedoroff, N. V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307969100 · Cited by 522

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

Kumar, P., Kuscu, C., & Dutta, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.004 · Cited by 511

A Small, Stable RNA Induced by Oxidative Stress: Role as a Pleiotropic Regulator and Antimutator

Altuvia, S., Weinstein‐Fischer, D., Zhang, A., Postow, L., & Storz, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80312-8 · Cited by 510

miRNAs and apoptosis: RNAs to die for

Jovanović, M., & Hengartner, M. O. (2006) · Oncogene · doi:10.1038/sj.onc.1209912 · Cited by 511

MicroRNA in autoimmunity and autoimmune diseases

Pauley, K. M., Cha, S., & Chan, E. K. L. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.02.012 · Cited by 516

MicroRNA silencing through RISC recruitment of eIF6

Chendrimada, T. P., Finn, K. J., Ji, X., Baillat, D., Gregory, R. I., Liebhaber, S. A., Pasquinelli, A. E., & Shiekhattar, R. (2007) · Nature · doi:10.1038/nature05841 · Cited by 570

The Evolution of Controlled Multitasked Gene Networks: The Role of Introns and Other Noncoding RNAs in the Development of Complex Organisms

Mattick, J. S., & Gagen, M. J. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003951 · Cited by 508

CONTROL OF TRANSLATION INITIATION IN ANIMALS

Gray, N. K., & Wickens, M. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.399 · Cited by 500

Developing MicroRNA Therapeutics

van Rooij, E., Purcell, A. L., & Levin, A. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247916 · Cited by 449

Cloning and Characterization of MicroRNAs from Rice

Sunkar, R., Girke, T., Jain, P. K., & Zhu, J. (2005) · The Plant Cell · doi:10.1105/tpc.105.031682 · Cited by 501

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

Eichhorn, S. W., Guo, H., McGeary, S. E., Rodriguez-Mias, R. A., Shin, C., Baek, D., Hsu, S.-H., Ghoshal, K., Villén, J., & Bartel, D. P. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.028 · Cited by 503

MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart

Cheng, Y., Ji, R., Yue, J., Yang, J., Liu, X., Chen, H., Dean, D. B., & Zhang, C. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061170 · Cited by 492

The biological functions of miRNAs: lessons from in vivo studies

Vidigal, J. A., & Ventura, A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.004 · Cited by 507

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

岡田, 千., Yamashita, E., Lee, S. J., Shibata, S., Katahira, J., Nakagawa, A., Yoneda, Y., & Tomitake Tsukihara, A. (2009) · Science · doi:10.1126/science.1178705 · Cited by 525

Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability

Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484

miRNA Profiling of Naïve, Effector and Memory CD8 T Cells

Wu, H., Neilson, J. R., Kumar, P., Manocha, M., Shankar, P., Sharp, P. A., & Manjunath, N. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001020 · Cited by 490

Desperately seeking microRNA targets

Thomas, M., Lieberman, J., & Lal, A. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1921 · Cited by 487

Direct Regulation of an Oncogenic Micro-RNA Cluster by E2F Transcription Factors

Woods, K., Thomson, J. M., & Hammond, S. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600252200 · Cited by 479

Vive la différence: biogenesis and evolution of microRNAs in plants and animals

Axtell, M. J., Westholm, J. O., & Lai, E. C. (2011) · Genome biology · doi:10.1186/gb-2011-12-4-221 · Cited by 496

The Micro-Ribonucleic Acid (miRNA) miR-206 Targets the Human Estrogen Receptor-α (ERα) and Represses ERα Messenger RNA and Protein Expression in Breast Cancer Cell Lines

Adams, B. D., Furneaux, H., & White, B. A. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0022 · Cited by 484

How Do MicroRNAs Regulate Gene Expression?

Jackson, R. J., & Standart, N. (2007) · Science s STKE · doi:10.1126/stke.3672007re1 · Cited by 487

Identification of novel and candidate miRNAs in rice by high throughput sequencing

Sunkar, R., Zhou, X., Zheng, Y., Zhang, W., & Zhu, J. (2008) · BMC Plant Biology · doi:10.1186/1471-2229-8-25 · Cited by 471

New class of microRNA targets containing simultaneous 5′-UTR and 3′-UTR interaction sitesPreprint

Lee, I., Ajay, S. S., Yook, J. I., Kim, H. S., Hong, S. H., Kim, N. H., Dhanasekaran, S. M., Chinnaiyan, A. M., & Athey, B. D. (2009) · Genome Research · doi:10.1101/gr.089367.108 · Cited by 510

MicroRNA (miRNA) Transcriptome of Mouse Retina and Identification of a Sensory Organ-specific miRNA Cluster

Xu, S., Witmer, P. D., Lumayag, S., Kovacs, B., & Valle, D. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700501200 · Cited by 481

Regulation of the Adenomatous Polyposis Coli Gene by the miR-135 Family in Colorectal Cancer

Nagel, R., le Sage, C., Diosdado, B., van der Waal, M. S., Vrielink, J. A. F. O., Bolijn, A. S., Meijer, G. A., & Agami, R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0951 · Cited by 475

Small RNAs: Classification, Biogenesis, and Function

Kim, V. N. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)13130-x · Cited by 484

Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways

Schwarz, D. S., Hutvágner, G., Haley, B., & Zamore, P. D. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00651-2 · Cited by 478

A Parsimonious Model for Gene Regulation by miRNAs

Djuranović, S., Nahvi, A., & Green, R. (2011) · Science · doi:10.1126/science.1191138 · Cited by 476

The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans

Abbott, A. L., Alvarez-Saavedra, E., Miska, E. A., Lau, N. C., Bartel, D. P., Horvitz, H. R., & Ambros, V. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.009 · Cited by 467

Common features of microRNA target prediction tools

Peterson, S. M., Thompson, J. A., Ufkin, M. L., Sathyanarayana, P., Liaw, L., & Congdon, C. B. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00023 · Cited by 484

mir-17-92, a cluster of miRNAs in the midst of the cancer network

Olive, V., Jiang, I., & He, L. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.03.004 · Cited by 476

Approaches to microRNA discovery

Berezikov, E., Cuppen, E. P. J. G., & Plasterk, R. H. A. (2006) · Nature Genetics · doi:10.1038/ng1794 · Cited by 462

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer

Tsang, W. P., Ng, E. K. O., Ng, S. S. M., Jin, H., Yu, J. Q., Sung, J. J. �., & Kwok, T. T. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp181 · Cited by 462

Detection of 91 potential conserved plant microRNAs in Arabidopsis thaliana and Oryza sativa identifies important target genes

Bonnet, É., Wuyts, J., Rouzé, P., & de Peer, Y. V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404025101 · Cited by 456

The Centrality of RNA

Sharp, P. A. (2009) · Cell · doi:10.1016/j.cell.2009.02.007 · Cited by 462

MicroRNA Expression Signature and the Role of MicroRNA-21 in the Early Phase of Acute Myocardial Infarction

Dong, S., Cheng, Y., Yang, J., Li, J., Liu, X., Wang, X., Wang, D., Krall, T. J., Delphin, E. S., & Zhang, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.027896 · Cited by 454

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans

Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 451

MicroRNAs: Novel regulators in the hallmarks of human cancer

Ruan, K., Fang, X., & Ouyang, G. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.031 · Cited by 454

The Role of miRNAs in Regulating Gene Expression Networks

Gurtan, A. M., & Sharp, P. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.007 · Cited by 456

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTRPreprint

Vella, M. C., Choi, E.-Y., Lin, S.-Y., Reinert, K. L., & Slack, F. J. (2004) · Genes & Development · doi:10.1101/gad.1165404 · Cited by 442

MicroRNAs and cancer

McManus, M. T. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(03)00038-5 · Cited by 441

MicroRNA—implications for cancer

Sassen, S., Miska, E. A., & Caldas, C. (2007) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-007-0532-2 · Cited by 446

MicroRNA history: Discovery, recent applications, and next frontiers

Almeida, M. I., Reis, R. M., & Calin, G. A. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.03.009 · Cited by 466

Micromanagement of the immune system by microRNAs

Lodish, H. F., Zhou, B., Liu, G., & Chen, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2252 · Cited by 452

Micro RNAs in Animal Development

Plasterk, R. H. A. (2006) · Cell · doi:10.1016/j.cell.2006.02.030 · Cited by 437

Small and long non-coding RNAs: Past, present, and future

Chen, L., & Kim, V. N. (2024) · Cell · doi:10.1016/j.cell.2024.10.024 · Cited by 461

Tools for Sequence-Based miRNA Target Prediction: What to Choose?

Riffo‐Campos, Á. L., Riquelme, I., & Brebi, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121987 · Cited by 450

Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions

Didiano, D., & Hobert, O. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1138 · Cited by 435

MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor

Li, J., Huang, H., Sun, L., Yang, M., Pan, C., Chen, W., Wu, D., Lin, Z., Zeng, C., Yao, Y., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3053 · Cited by 431

Prediction and identification of Arabidopsis thaliana microRNAs and their mRNA targets

Wang, X., Reyes, J. L., Chua, N., & Gaasterland, T. (2004) · Genome biology · doi:10.1186/gb-2004-5-9-r65 · Cited by 432

Role of microRNAs in translation regulation and cancer

Oliveto, S., Mancino, M., Manfrini, N., & Biffo, S. (2017) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v8.i1.45 · Cited by 440

Deadenylation is a widespread effect of miRNA regulation

Eulálio, A., Huntzinger, E., Nishihara, T., Rehwinkel, J., Fauser, M., & Izaurralde, E. (2008) · RNA · doi:10.1261/rna.1399509 · Cited by 429

microRNAs in Vertebrate Physiology and Human Disease

Chang, T.-C., & Mendell, J. T. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.8.080706.092351 · Cited by 437

MicroRNA-206: The skeletal muscle-specific myomiR

McCarthy, J. J. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.03.001 · Cited by 433

Potent effect of target structure on microRNA function

Long, D., Lee, R., Williams, P., Chan, C. Y., Ambros, V., & Ding, Y. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1226 · Cited by 429

A Genome-Wide Map of Conserved MicroRNA Targets in C. elegans

Lall, S., Grün, D., Krek, A., Chen, K., Wang, Y.-L., Dewey, C. N., Sood, P., Colombo, T., Bray, N., MacMenamin, P., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.050 · Cited by 422

Circulating MicroRNAs in Cancer: Potential and Challenge

Cui, M., Wang, H., Yao, X., Zhang, D., Xie, Y., Cui, R., & Zhang, X. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00626 · Cited by 434

daf-12encodes a nuclear receptor that regulates the dauer diapause and developmental age inC. elegansPreprint

Antebi, A., Yeh, W.-H., Tait, D. S., Hedgecock, E. M., & Riddle, D. L. (2000) · Genes & Development · doi:10.1101/gad.14.12.1512 · Cited by 418

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

Hendrickson, D. G., Hogan, D. J., McCullough, H. L., Myers, J. W., Herschlag, D., Ferrell, J. E., & Brown, P. O. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000238 · Cited by 418

Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles

Yuan, A., Farber, E. L., Rapoport, A. L., Tejada, D., Deniskin, R., Akhmedov, N. B., & Farber, D. B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004722 · Cited by 416

MicroRNAs As Novel Regulators of Angiogenesis

Suárez, Y., & Sessa, W. C. (2009) · Circulation Research · doi:10.1161/circresaha.108.191270 · Cited by 416

MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies

Kim, T., & Croce, C. M. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01050-9 · Cited by 432

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in drosophila embryos

Murata, Y., & Wharton, R. P. (1995) · Cell · doi:10.1016/0092-8674(95)90353-4 · Cited by 414

Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs

Wu, L., & Belasco, J. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.010 · Cited by 409

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406

The roles of microRNA in cancer and apoptosis

Lynam‐Lennon, N., Maher, S. G., & Reynolds, J. V. (2008) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2008.00061.x · Cited by 412

How do microRNAs regulate gene expression?

Cannell, I. G., Kong, Y. W., & Bushell, M. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361224 · Cited by 412

MicroRNAs as oncogenes

Hammond, S. M. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.005 · Cited by 407

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

Seggerson, K., Tang, L., & Moss, E. G. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0563 · Cited by 421

RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges

Yu, A., Choi, Y. H., & Tu, M. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019554 · Cited by 421

MicroRNA control of protein expression noise

Schmiedel, J. M., Klemm, S. L., Zheng, Y., Sahay, A., Blüthgen, N., Marks, D. S., & van Oudenaarden, A. (2015) · Science · doi:10.1126/science.aaa1738 · Cited by 395

Translational regulation in development

Curtis, D., Lehmann, R., & Zamore, P. D. (1995) · Cell · doi:10.1016/0092-8674(95)90325-9 · Cited by 395

Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties

Wee, L. M., Flores-Jasso, C. F., Salomon, W. E., & Zamore, P. D. (2012) · Cell · doi:10.1016/j.cell.2012.10.036 · Cited by 398

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

Pillai, R. S., Artus-Revel, C. G., & Filipowicz, W. (2004) · RNA · doi:10.1261/rna.7131604 · Cited by 390

MicroRNAs: From Mechanism to Organism

Dexheimer, P. J., & Cochella, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00409 · Cited by 405

Cloning and characterization of microRNAs from wheat (Triticum aestivum L.)

Yao, Y., Guo, G., Ni, Z., Sunkar, R., Du, J., Zhu, J., & Sun, Q. (2007) · Genome biology · doi:10.1186/gb-2007-8-6-r96 · Cited by 386

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs

Nielsen, C. B., Shomron, N., Sandberg, R., Hornstein, E., Kitzman, J. O., & Burge, C. B. (2007) · RNA · doi:10.1261/rna.768207 · Cited by 404

MicroRNAs activate gene transcription epigenetically as an enhancer trigger

Xiao, M., Li, J., Li, W., Wang, Y., Wu, F., Xi, Y., Zhang, L., Ding, C., Luo, H., Li, Y., et al. (2016) · RNA Biology · doi:10.1080/15476286.2015.1112487 · Cited by 396

PBMDA: A novel and effective path-based computational model for miRNA-disease association prediction

You, Z., Huang, Z.-A., Zhu, Z., Yan, G., Li, Z., Wen, Z., & Chen, X. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005455 · Cited by 386

Trials and Tribulations of MicroRNA Therapeutics

Seyhan, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031469 · Cited by 381

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.Preprint

Ha, I., Wightman, B., & Ruvkun, G. (1996) · Genes & Development · doi:10.1101/gad.10.23.3041 · Cited by 235

Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes

Ruvkun, G., Wightman, B., Bürglin, T., & Arasu, P. (1991) · Development · doi:10.1242/dev.113.supplement_1.47 · Cited by 25

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.Preprint

Wightman, B., Bürglin, T. R., Gatto, J., Arasu, P., & Ruvkun, G. (1991) · Genes & Development · doi:10.1101/gad.5.10.1813 · Cited by 210

Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.Preprint

Arasu, P., Wightman, B., & Ruvkun, G. (1991) · Genes & Development · doi:10.1101/gad.5.10.1825 · Cited by 120

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948