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Synaptic plasticity in the hippocampus: LTP and LTD
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“Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-D-aspartate (NMDA)-type glutamate receptors, typically by the coincident activity of pre-and postsynaptic neurons.”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Malenka 1994
In the citing paper
“LTP and LTD are induced by specific patterns of activity (Malenka 1994).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Malenka 1994
In the citing paper
“Indeed, it is now fairly well accepted that modest activation of NMDARs leading to modest increases in postsynaptic calcium are optimal for triggering LTD, whereas much stronger activation of NMDARs leading to much larger increases in postsynaptic calcium are required to trigger LTP (Malenka 1994).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Malenka 1994
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“via LTD, and AMPAR insertion or removal from the postsynaptic membrane is the conduit for this change in synaptic strength.(81,82) Importantly, LTP and LTD do not just”
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Metadata
- Authors
- Malenka, R. C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Malenka, Robert C.
- ORCID
- Malenka, Robert C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-08
- Volume
- 78
- Issue
- 4
- Pages
- 535-538
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2070094949
- Cited by
- 655
- References
- 26
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 13 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 13 · 2016: 18 · 2015: 19 · 2014: 18 · 2013: 17 · 2012: 15
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, long-term depression, synaptic plasticity, hippocampus, NMDA receptor, calcium buffering, calcium-dependent protein kinase, CaMKII, CaMKI, CaMKIV
- MeSH terms
- Animals, Hippocampus, Humans, Memory, Models, Neurological, Neuronal Plasticity, Signal Transduction, Long-Term Potentiation
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