Brown adipose tissue thermogenesis and obesity

Thermogenic mechanisms in brown fat.

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Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain

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Diet, Obesity and Hypertension: An Hypothesis Involving Insulin, the Sympathetic Nervous System, and Adaptive Thermogenesis

LANDSBERG, L. (1986) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068066 · Cited by 373

Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression

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Brown adipose tissue uncoupling protein content in human infants, children and adults

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Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus

Ravussin, E., Bogardus, C., Schwartz, R. S., Robbins, D. C., Wolfe, R. R., Horton, E. S., Danforth, E., & Sims, E. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111060 · Cited by 172

Evidence that insulin resistance is responsible for the decreased thermic effect of glucose in human obesity

Ravussin, E., Acheson, K. J., Vernet, O., Danforth, E., & Jéquier, E. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112083 · Cited by 151

The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings

Thurlby, P. L., & Trayhurn, P. (1979) · British Journal of Nutrition · doi:10.1079/bjn19790127 · Cited by 135

Metabolic relationships between lipolysis and respiration in rat brown adipocytes. The role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis

Bukowiecki, L. J., Folléa, N., Lupien, J., & Paradis, A. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42972-9 · Cited by 122

Full Expression of Uncoupling Protein Gene Requires the Concurrence of Norepinephrine and Triiodothyronine

Silva, J. E., & Matthews, P. S. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-8-706 · Cited by 100

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

Physiological and Molecular Basis of Thyroid Hormone Action

Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011

Towards a molecular understanding of adaptive thermogenesis

Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553

Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat

Xue, B., Rim, J.-S., Hogan, J. C., Coulter, A. A., Koza, R. A., & Kozak, L. P. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600287-jlr200 · Cited by 288

BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY

Lowell, M., & Flier, M. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.307 · Cited by 237

Thyroid Hormone Effects on Mitochondrial Energetics

Harper, M.-E., & Seifert, E. L. (2008) · Thyroid · doi:10.1089/thy.2007.0250 · Cited by 194

Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194

Norepinephrine Is Required for Leptin Effects on Gene Expression in Brown and White Adipose Tissue1

Commins, S. P., Marsh, D. J., Thomas, S. A., Watson, P. M., Padgett, M. A., Palmiter, R., & Gettys, T. W. (1999) · Endocrinology · doi:10.1210/endo.140.10.7043 · Cited by 107

Immunohistochemical identification of the β3-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine

De Matteis, R., Arch, J., Petroni, M., Ferrari, D., Cinti, S., & Stock, M. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802148 · Cited by 85

Regulation of UCP gene expression in brown adipocytes differentiated in primary culture. Effects of a new β-adrenoceptor agonist

Champigny, O., Holloway, B. R., & Ricquier, D. (1992) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(92)90177-8 · Cited by 51

The mitochondrial uncoupling protein: structural and genetic studies.

Ricquier, D., & Bouillaud, F. (1997) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)61003-x · Cited by 52

Metabolic Effects of Ketogenic Diets: Exploring Whole-Body Metabolism in Connection with Adipose Tissue and Other Metabolic Organs

Ahmad, Y., Seo, D. S., & Jang, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137076 · Cited by 49