CoChat
Sign Up
Cited by 294Attention Deficit Hyperactivity DisorderBehavioral and Psychological StudiesDevelopmental and Educational Neuropsychology

Methylphenidate and dextroamphetamine treatments of hyperactivity: Are there true nonresponders?

Elia, Josephine, Borcherding, Breck G., Rapoport, Judith L., Keysor, Cynthia S.·1991·Psychiatry Research
DOI 10.1016/0165-1781(91)90126-a
Open this paper in CoChat — free account

Abstract

The response to stimulant drugs of 48 boys with attention deficit/hyperactivity disorder was measured following dextroamphetamine, methylphenidate, and placebo in a double-blind crossover study. To distinguish lack of behavioral improvement from adverse drug effects, a day hospital setting and a wide dose range were used. Both drugs were highly and equally efficacious for the group as a whole, and frequently one drug or the other was superior for an individual child, or adverse effects occurred only on one of the stimulants. Only one of the 48 boys (2%) was discharged without the recommendation for continued stimulant drug treatment. "Nonresponse" appears to be extremely rare when both stimulants and a wide range of doses are given.

Integrity signals

Registry

Crossref · 10.1016/0165-1781(91)90126-a

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Most people with ADHD will respond favorably to pharmacological interventions, but optimal functioning may not be attained.

    “Although most people with ADHD will respond favorably to pharmacological interventions [126], optimal functioning may not be attained.”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [126]

  • In two separate crossover studies comparing the efficacy of methylphenidate and dextroamphetamine, most children with ADHD who did not respond to one stimulant responded to the other.

    “In 2 separate crossover studies [31,32] comparing the efficacy of MPH and dextroamphetamine, most children with ADHD who did not respond to 1 stimulant responded to the other.”

    From Efficacy of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder previously treated with methylphenidate: a post hoc analysis (2011) · cites this paper as [32]

  • Arnold (2000), Swanson et al. (1998), and others (Elia et al., 1991) have stated that head-to-head comparisons of amphetamine agents versus methylphenidate suggest nearly equivalent group effects, although Arnold (2000) has raised the question of differential benefits in some symptom domains.

    “Arnold (2000), Swanson et al. (1998), and others (Elia et al., 1991) have stated that head-to-head comparisons of amphetamine agents versus methylphenidate suggest nearly equivalent group effects, although Arnold (2000) has raised the question of differential benefits in some symptom domains.”

    From Analog Classroom Assessment of a Once-Daily Mixed Amphetamine Formulation, SLI381 (ADDERALL XR), in Children With ADHD (2003) · cites this paper as Elia et al., 1991

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Elia, J., Borcherding, B. G., Rapoport, J. L., & Keysor, C. S.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Rapoport, Judith L.
ORCID
Elia, Josephine
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1991-02
Volume
36
Issue
2
Pages
141-155
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/0165-1781(91)90126-a
OpenAlex
W2074521517
Cited by
294
References
36
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 10 · 2015: 10 · 2014: 6 · 2013: 10 · 2012: 9
FWCI
4.64
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords
methylphenidate, d-amphetamine, attention deficit hyperactivity disorder, hyperactivity, stimulant medication, treatment non-responders, drug efficacy, adverse drug reactions, dose range, boys
MeSH terms
Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Day Care, Medical, Dextroamphetamine, Double-Blind Method, Humans, Male, Methylphenidate, Placebos, Research Design

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review