Role of the amygdala and periaqueductal gray in anxiety and panic.

Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822

Handbook of Psychopharmacology

Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,756

The rat brain in stereotaxic coordinates (2nd edn)

Herman, J. P., & Watson, S. J. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90017-8 · Cited by 1,751

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

Pellow, S., & File, S. E. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90552-6 · Cited by 1,534

The use of c-fos as a metabolic marker in neuronal pathway tracing

Dragunow, M., & Faull, R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90150-7 · Cited by 1,416

Expression of C‐fos‐like protein as a marker for neuronal activity following noxious stimulation in the rat

Bullitt, E. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960402 · Cited by 1,059

5-HT and mechanisms of defence

Deakin, J. F. W., & Graeff, F. G. (1991) · Journal of Psychopharmacology · doi:10.1177/026988119100500414 · Cited by 1,011

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

Handley, S. L., & Mithani, S. (1984) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00504983 · Cited by 974

A perceptual-defensive-recuperative model of fear and pain

Bolles, R. C., & Fanselow, M. S. (1980) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0000491x · Cited by 840

Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites

Engel, G., G�thert, M., Hoyer, D., Schlicker, E., & Hillenbrand, K. (1986) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00633189 · Cited by 677

The induction of pain: an integrative review

Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774

The neurobiology and control of anxious states

Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 978

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

Cartmell, J., & Schoepp, D. D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750889.x · Cited by 883

Role of 5-HT in stress, anxiety, and depression

Graeff, F. G., Guimarães, F. S., De Andrade, T. G. C. S., & Deakin, J. F. W. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02135-3 · Cited by 984

Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice

Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., & Nishimori, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5593-08.2009 · Cited by 608

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

McEwen, B. S., Eiland, L., Hunter, R. G., & Miller, M. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.014 · Cited by 596

Neurobiology of fear responses: the role of the amygdala

Davis, M. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.382 · Cited by 577

Role of GABA in anxiety and depression

Kalueff, A. V., & Nutt, D. (2006) · Depression and Anxiety · doi:10.1002/da.20262 · Cited by 563

Effect of nicotine and nicotinic receptors on anxiety and depression

Picciotto, M. R., Brunzell, D. H., & Caldarone, B. J. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00006 · Cited by 483

Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic

Blanchard, D. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00009-4 · Cited by 461

The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y

Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358

The HPA and immune axes in stress: the involvement of the serotonergic system

Leonard, B. E. (2005) · European Psychiatry · doi:10.1016/s0924-9338(05)80180-4 · Cited by 317

Serotonin, the periaqueductal gray and panic

Graeff, F. G. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.12.004 · Cited by 285

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255

5HT drugs in animal models of anxiety

Handley, S. L., & McBlane, J. W. (1993) · Psychopharmacology · doi:10.1007/bf02247358 · Cited by 253

The Role of the Dorsal Hippocampal Serotonergic and Cholinergic Systems in the Modulation of Anxiety

File, S. E., Kenny, P. J., & Cheeta, S. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00198-2 · Cited by 239

Anxiety and cardiovascular reactivity: the basal forebrain cholinergic link

Berntson, G. G., Sarter, M. F., & Cacioppo, J. T. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00041-2 · Cited by 225

Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat

Amat, J., Matus-Amat, P., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00960-3 · Cited by 222

Transmitter systems involved in neural plasticity undelying increased anxiety and defense— Implications for understanding anxiety following traumatic stress

Adamec, R. E. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00055-3 · Cited by 216

The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease

MICHELSEN, K., PRICKAERTS, J., & STEINBUSCH, H. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00912-6 · Cited by 196

Dual role of 5-HT in defense and anxiety

Graeff, F. G., Viana, M. D. B., & Mora, P. O. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00059-0 · Cited by 195

Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray

Samineni, V. K., Grajales‐Reyes, J. G., Copits, B. A., O’Brien, D. E., Trigg, S. L., Gomez, A. M., Bruchas, M. R., & Gereau, R. W. (2017) · eNeuro · doi:10.1523/eneuro.0129-16.2017 · Cited by 188

Dorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats

Kim, E. J., Horovitz, O., Pellman, B. A., Tan, L. M., Li, Q., Richter‐Levin, G., & Kim, J. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310845110 · Cited by 204

Interactions between NPY and CRF in the amygdala to regulate emotionality

Sajdyk, T. J., Shekhar, A., & Gehlert, D. R. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.006 · Cited by 183

5-HT1A receptor knockout mouse as a genetic model of anxiety

Tóth, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01280-9 · Cited by 177

Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65

Stork, O., Ji, F.-Y., Kaneko, K., Stork, S., Yoshinobu, Y., Moriya, T., Shibata, S., & Obata, K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02206-x · Cited by 177

The distributed auditory cortex

Winer, J. A., & Lee, C. C. (2007) · Hearing Research · doi:10.1016/j.heares.2007.01.017 · Cited by 169

The periaqueductal gray and primal emotional processing critical to influence complex defensive responses, fear learning and reward seeking

Motta, S. C., Carobrez, A. P., & Canteras, N. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.012 · Cited by 167

8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.

Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.3.404 · Cited by 167

Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety

Dhonnchadha, B. Á. N., Bourin, M., & Hascoët, M. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00311-x · Cited by 165

Exercise, Learned Helplessness, and the Stress-Resistant Brain

Greenwood, B. N., & Fleshner, M. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8029-y · Cited by 168

Biological bases of anxiety

Clément, Y. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00058-4 · Cited by 155

Conditioned fear to context is associated with increased Fos expression in the caudal ventrolateral region of the midbrain periaqueductal gray.

Carrive, P., Leung, P., Harris, J. A., & Paxinos, G. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)83047-3 · Cited by 156

Targeting ASIC1a Reduces Innate Fear and Alters Neuronal Activity in the Fear Circuit

Coryell, M. W., Ziemann, A. E., Westmoreland, P., Haenfler, J. M., Kurjakovic, Z., Zha, X., Price, M. P., Schnizler, M. K., & Wemmie, J. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.008 · Cited by 146

Functions of the caudal periaqueductal gray in lactating rats: Kyphosis, lordosis, maternal aggression, and fearfulness.

Lonstein, J. S., Simmons, D. A., & Stern, J. M. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1502 · Cited by 145

Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry

Singewald, N., & Sharp, T. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00177-9 · Cited by 145

The consequences of uncontrollable stress are sensitive to duration of prior wheel running

Greenwood, B. N., Foley, T. E., Burhans, D., Maier, S. F., & Fleshner, M. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.037 · Cited by 143

Improved Behavior and Neuropathology in the Mouse Model of Sanfilippo Type IIIB Disease after Adeno-Associated Virus-Mediated Gene Transfer in the Striatum

Cressant, A., Desmaris, N., Vérot, L., Bréjot, T., Froissart, R., Vanier, M.-T., Maire, I., & Heard, J. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3558-04.2004 · Cited by 137

The psychobiology of anxiolytic drugs

Sandford, J. J., Argyropoulos, S. V., & Nutt, D. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00082-6 · Cited by 137

Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion

Nogueira, R. L., & Graeff, F. G. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00402-5 · Cited by 132

Dorsolateral and ventral regions of the periaqueductal gray matter are involved in distinct types of fear

Vianna, D. M. L., Landeira-Fernández, J., & Brandão, M. L. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00052-5 · Cited by 129

Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy

Bonne, O. B., Grillon, C., Vythilingam, M., Neumeister, A., & Charney, D. S. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.12.001 · Cited by 128

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors

Bey, A. L., Wang, X., Yan, H., Kim, N., Passman, R. L., Yang, Y., Cao, X., Towers, A. J., Hulbert, S. W., Duffney, L. J., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0142-6 · Cited by 120

Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test

Faria, M. S., Muscará, M. N., Moreno, H., Teixeira, S. A., Dias, H. B., Oliveira, B., Graeff, F. G., & Nucci, G. D. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00027-7 · Cited by 115

Evidence that the lateral septum is involved in the antidepressant-like effects of the vasopressin V1b receptor antagonist, SSR149415

Stemmelin, J., Lukovic, L., Salome, N., & Griebel, G. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300562 · Cited by 112

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors

Soares, V. D. P., Campos, A. C., Bortoli, V. C. D., Zangrossi, H., Guimarães, F. S., & Zuardi, A. W. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.004 · Cited by 112

Neural Systems Involved in Fear Inhibition: Extinction and Conditioned Inhibition

Davis, M., Falls, W. A., & Gewirtz, J. C. (2000) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4757-4860-4_8 · Cited by 116

Behavioral analysis of CREB αΔ mutation on a B6/129 F1 hybrid background

Graves, L. A., Dalvi, A., Lucki, I., Blendy, J. A., & Abel, T. G. (2002) · Hippocampus · doi:10.1002/hipo.10003 · Cited by 108

Presynaptic serotonergic inhibition of GABAergic synaptic transmission in mechanically dissociated rat basolateral amygdala neurons

Koyama, S., Kubo, C., Rhee, J., & Akaike, N. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0525p.x · Cited by 108

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor

Linden, A.-M., Johnson, B. G., Peters, S. C., Shannon, H. E., Tian, M., Wang, Y., Yu, J., Koster, A. M., Baez, M., & Schoepp, D. D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00079-5 · Cited by 108

Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice

Risbrough, V. B., Hauger, R. L., Pelleymounter, M. A., & Geyer, M. A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1535-6 · Cited by 107

Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

Linden, A.-M., Greene, S. J., Bergeron, M., & Schoepp, D. D. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300321 · Cited by 106

2,3,5-Trimethyl-3-thiazoline (TMT), a component of fox odor – Just repugnant or really fear-inducing?

Fendt, M., & Endres, T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.010 · Cited by 107

Activation of 5-HT 2B Receptors in the Medial Amygdala causes Anxiolysis in the Social Interaction Test in the Rat

Duxon, M. S., Kennett, G. A., Lightowler, S., Blackburn, T. P., & Fone, K. C. F. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00042-7 · Cited by 103

Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders

Shekhar, A., McCann, U., Meaney, M. J., Blanchard, D. C., Davis, M., Frey, K. A., Liberzon, I., Overall, K. L., Shear, M., Tecott, L. H., et al. (2001) · Psychopharmacology · doi:10.1007/s002130100859 · Cited by 101

Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam

Nunes‐de‐Souza, R. L., Canto‐de‐Souza, A., da-Costa, M., Fornari, R. V., Graeff, F. G., & Pelá, I. R. (2000) · Psychopharmacology · doi:10.1007/s002130000428 · Cited by 96

Neurobiological mechanisms by which nicotine mediates different types of anxiety

File, S. E., Cheeta, S., & Kenny, P. J. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00889-4 · Cited by 110

Reduced γ-Aminobutyric AcidA–Benzodiazepine Binding Sites in Insular Cortex of Individuals With Panic Disorder

Cameron, O. G., Huang, G., Nichols, T. E., Koeppe, R. A., Minoshima, S., Rose, D. S., & Frey, K. A. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.793 · Cited by 89

Brain mechanisms of aggressive behavior: an updated review.

Adams, D. B. (2006) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.09.004 · Cited by 97

The 5-HT 1A receptor knockout mouse and anxiety

Olivier, B., Pattij, T., Wood, S. J., Oosting, R. S., Sarnyai, Z., & Tóth, M. (2001) · Behavioural Pharmacology · doi:10.1097/00008877-200111000-00004 · Cited by 89

Agmatine induces anxiolysis in the elevated plus maze task in adult rats

Lavinsky, D., Arteni, N. S., & Netto, C. A. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00326-1 · Cited by 89

Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

Cheeta, S., Kenny, P. J., & File, S. E. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00129-9 · Cited by 88

Opposed regulation by dorsal raphe nucleus 5-HT pathways of two types of fear in the elevated T-maze

Graeff, F. G. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02012-8 · Cited by 87

Anxiolytic-like effects of AP7 injected into the dorsolateral or ventrolateral columns of the periaqueductal gray of rats

Molchanov, M. L., & es, F. G. X. E. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0941-x · Cited by 85

Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino)tetralin in the elevated T-maze

Zangrossi, H., Viana, M. D. B., & Graeff, F. G. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00075-8 · Cited by 83

Role of 5-HT2A and 5-HT2C Receptor Subtypes in the Two Types of Fear Generated by the Elevated T-Maze

Mora, P. O., Netto, C. F., & Graeff, F. G. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00057-9 · Cited by 83

The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray

Terpou, B. A., Harricharan, S., McKinnon, M. C., Frewen, P., Jetly, R., & Lanius, R. A. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24447 · Cited by 82

Behavioral and c-fos expression changes induced by nitric oxide donors microinjected into the dorsal periaqueductal gray

de Oliveira, R. W., Bel, E. A. D., & Guimarães, F. S. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00248-8 · Cited by 80

Anxiolytic effects of 5-HT1A receptors and anxiogenic effects of 5-HT2C receptors in the amygdala of mice

Li, Q., Luo, T., Jiang, X. X., & Wang, J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.002 · Cited by 81

Role of Gq protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane

Garcia, E. E., Smith, R. L., & Sanders‐Bush, E. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.03.013 · Cited by 78

Alterations in stress-associated behaviors and neurochemical markers in adult rats after neonatal short-lasting local inflammatory insult

Anseloni, V. C. Z., He, F., Novikova, S. I., Robbins, M. T., Lidow, I. A., Ennis, M. J., & Lidow, M. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.039 · Cited by 77

Conditioned antinociception and freezing using electrical stimulation of the dorsal periaqueductal gray or inferior colliculus as unconditioned stimulus are differentially regulated by 5-HT2A receptors in rats

Castilho, V. M., & Brandão, M. L. (2001) · Psychopharmacology · doi:10.1007/s002130100697 · Cited by 77

Angiotensin-II Is a Putative Neurotransmitter in Lactate-Induced Panic-Like Responses in Rats with Disruption of GABAergic Inhibition in the Dorsomedial Hypothalamus

Shekhar, A., Johnson, P. L., Sajdyk, T. J., Fitz, S. D., Keim, S. R., Kelley, P. E., Gehlert, D. R., & DiMicco, J. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2491-06.2006 · Cited by 77

Human behavioral assessments in current research of Parkinson’s disease

Asakawa, T., Fang, H., Sugiyama, K., Nozaki, T., Kobayashi, S. S., Hong, Z., Suzuki, K., Mori, N., Yang, Y., Hua, F., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.036 · Cited by 75

Pain Perception and Response: Central Nervous System Mechanisms

Hudson, A. J. (2000) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100051908 · Cited by 72

5 -HT, antidepressant drugs and the psychosocial origins of depression

Deakin, J. F. W. (1996) · Journal of Psychopharmacology · doi:10.1177/026988119601000106 · Cited by 72

Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception

Jurik, A., Auffenberg, E., Klein, S., Deussing, J. M., Schmid, R. M., Wotjak, C. T., & Thoeringer, C. K. (2015) · Pain · doi:10.1097/j.pain.0000000000000318 · Cited by 75

Persistence of the interictal emotionality produced by long-term amygdala kindling in rats

Kalynchuk, L. E., Pinel, J. P. J., Treitj, D., Barnes, S. J., McEachern, J. C., & Kippin, T. E. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00003-7 · Cited by 68

SEROTONERGIC SYSTEMS

Graeff, F. G. (1997) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70342-7 · Cited by 68

Animal behavioral assessments in current research of Parkinson’s disease

Asakawa, T., Fang, H., Sugiyama, K., Nozaki, T., Hong, Z., Yang, Y., Hua, F., Ding, G., Chao, D., Fenoy, A. J., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.016 · Cited by 68

Animal models of anxiety disorders

Uys, J. D. K., Stein, D. J., Daniels, W. M. U., & Harvey, B. H. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0056-7 · Cited by 67

Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray

de Bortoli, V. C., Nogueira, R. L., & Zangrossi, H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0189-y · Cited by 64

The relation between fearfulness in young and stress-response in adult laying hens, on individual and group level

Haas, E. N. D., Kops, M. S., Bolhuis, J. E., Groothuis, T. G. G., Ellen, E. D., & Rodenburg, T. B. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.08.002 · Cited by 64

The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour

Beckett, S. R. G., & Marsden, C. A. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100111 · Cited by 64

Role of benzodiazepine and serotonergic mechanisms in conditioned freezing and antinociception using electrical stimulation of the dorsal periaqueductal gray as unconditioned stimulus in rats

Castilho, V. C., Macedo, C. E., & o, M. B. X. E. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1246-4 · Cited by 64

Lesions of the central gray block conditioned fear as measured with the potentiated startle paradigm

Fendt, M., Koch, M., & Schnitzler, H. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)82984-6 · Cited by 62

Altered conditioned fear behavior in glutamate decarboxylase 65 null mutant mice

Stork, O., Yamanaka, H., Stork, S., Kume, N., & Obata, K. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00008.x · Cited by 63

Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test

MARTINEZ, G., ROPERO, C., FUNES, A., FLORES, E., BLOTTA, C., Landa, A. I., & Gargiulo, P. Á. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00704-7 · Cited by 62

Involvement of the dorsal periaqueductal gray in the loss of fear-potentiated startle accompanying high footshock training.

Walker, D. L., & Davis, M. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.692 · Cited by 61

Anxiolytic-like effects induced by nitric oxide synthase inhibitors microinjected into the medial amygdala of rats

Forestiero, D., Manfrim, C. M., Guimarães, F. S., & de Oliveira, R. M. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0270-6 · Cited by 62

Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression

Weinstock, M., Poltyrev, T., Bejar, C., & Youdim, M. B. H. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0978-x · Cited by 61

MRI Temporal Lobe Volume Measures and Neuropsychologic Function in Alzheimer's Disease

Smith, C. D., Malcein, M., Meurer, K., Schmitt, F. A., Markesbery, W. R., & Pettigrew, L. C. (1999) · Journal of Neuroimaging · doi:10.1111/jon1999912 · Cited by 63

Behavioral Effects of Systemic, Infralimbic and Prelimbic Injections of a Serotonin 5-HT2A Antagonist in Carioca High- and Low-Conditioned Freezing Rats

León, L. A., Gomes, V. D. C., Zárate-Guerrero, S., Corredor, K., Cruz, A. P. D. M., Brandão, M. L., Cárdenas, F. P., & Landeira-Fernández, J. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00117 · Cited by 60

Hypothalamic vasopressin system regulation by maternal separation: Its impact on anxiety in rats

Zhang, L., Hernández, V. S., Liu, B., Medina‐Pizarro, M., Nava-Kopp, A. T., Irles, C., & Morales, M. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.046 · Cited by 60

Escape-related behaviours in an unstable elevated and exposed environment

King, S. M. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00062-x · Cited by 60

Psychotropic and neurotropic activity

Vogel, H. G., & Vogel, W. H. (1997) · Springer eBooks · doi:10.1007/978-3-662-03333-3_5 · Cited by 61

Effects of diazepam on BOLD activation during the processing of aversive faces

Del‐Ben, C. M., Ferreira, C. A., Sanchez, T. A., Alves-Neto, W. C., Guapo, V. G., de Araújo, D. B., & Graeff, F. G. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110389092 · Cited by 59

Facilitation of 5-HT1A-mediated neurotransmission in dorsal periaqueductal grey matter accounts for the panicolytic-like effect of chronic fluoxetine

Zanoveli, J. M., Pobbe, R. L. H., de Bortoli, V. C., de Carvalho, M. C., Brandão, M. L., & Zangrossi, H. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570999099x · Cited by 55

Comparison of the Effects of Partial- or Whole-Body Exposures to16O Particles on Cognitive Performance in Rats

Rabin, B. M., Shukitt‐Hale, B., Carrihill-Knoll, K. L., & Gomes, S. M. (2014) · Radiation Research · doi:10.1667/rr13469.1 · Cited by 54

Pharmacological manipulation of ultrasound induced defence behaviour in the rat

Beckett, S. R. G., Aspley, S., Graham, M. D., & Marsden, C. A. (1996) · Psychopharmacology · doi:10.1007/bf02806019 · Cited by 54

Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats

DEPAULASOARES, V., & ZANGROSSIJR, H. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.027 · Cited by 27

Activation of 5-HT1A receptors in the rat basolateral amygdala induces both anxiolytic and antipanic-like effects

Strauss, C. V. D. A., Vicente, M. A., & Zangrossi, H. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.005 · Cited by 39

Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze

Moraes, C. L. K., Bertoglio, L. J., & Carobrez, A. P. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.07.005 · Cited by 27

Role of 5-HT1A and 5-HT2C receptors of the dorsal periaqueductal gray in the anxiety- and panic-modulating effects of antidepressants in rats

Vilela‐Costa, H. H., Maraschin, J. C., Casarotto, P. C., Sant’Ana, A. B., de Bortoli, V. C., Vicente, M. A., Campos, A. C., Guimarães, F. S., & Zangrossi, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113159 · Cited by 10

Blockade of 5-HT2 receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT1A receptor antagonism in the median raphe nucleus in mice

Nunes-de-Souza, V., Nunes‐de‐Souza, R. L., Rodgers, R. J., & Canto‐de‐Souza, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.056 · Cited by 11