Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex

Oda, Satoko; Tsuneoka, Yousuke; Yoshida, Sachine; Adachi‐Akahane, Satomi; Ito, Masanori; Kuroda, Masaru; Funato, Hiromasa

doi:10.1002/cne.24409

Cited by 28Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on Behavior

Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex

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Oda, Satoko, Tsuneoka, Yousuke, Yoshida, Sachine, Adachi‐Akahane, Satomi, Ito, Masanori, Kuroda, Masaru, Funato, Hiromasa·2018·Journal of Comparative Neurology

DOI 10.1002/cne.24409PMC PMC5900831

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Abstract

The medial prefrontal cortex (mPFC) has been considered to participate in many higher cognitive functions, such as memory formation and spatial navigation. These cognitive functions are modulated by cholinergic afferents via muscarinic acetylcholine receptors. Previous pharmacological studies have strongly suggested that the M1 receptor (M1R) is the most important subtype among muscarinic receptors to perform these cognitive functions. Actually, M1R is abundant in mPFC. However, the proportion of somata containing M1R among cortical cellular types, and the precise intracellular localization of M1R remain unclear. In this study, to clarify the precise immunolocalization of M1R in rat mPFC, we examined three major cellular types, pyramidal neurons, inhibitory neurons, and astrocytes. M1R immunopositivity signals were found in the majority of the somata of both pyramidal neurons and inhibitory neurons. In pyramidal neurons, strong M1R immunopositivity signals were usually found throughout their somata and dendrites including spines. On the other hand, the signal strength of M1R immunopositivity in the somata of inhibitory neurons significantly varied. Some neurons showed strong signals. Whereas about 40% of GAD67‐immunopositive neurons and 30% of parvalbumin‐immunopositive neurons (PV neurons) showed only weak signals. In PV neurons, M1R immunopositivity signals were preferentially distributed in somata. Furthermore, we found that many astrocytes showed substantial M1R immunopositivity signals. These signals were also mainly distributed in their somata. Thus, the distribution pattern of M1R markedly differs between cellular types. This difference might underlie the cholinergic modulation of higher cognitive functions subserved by mPFC.

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In rat and primate PFC, the α2-adrenoceptor and muscarinic M1 receptor modulate working memory via KCNQ potassium channels.
“Recent studies of rat and primate PFC showed that the α2-adrenoceptor and muscarinic M1 receptor modulate working memory via KCNQ potassium channel [148–151].”
From Development of prefrontal cortex (2022) · cites this paper as [149]
The Discussion (‘M1R in excitatory neurons’; page unavailable) links M1R-mediated neuronal firing to Kv7 channels, the components of M-channels. Another Discussion passage (‘M1R in GABAergic interneurons’; page unavailable) links M1R activity to working memory. The paper does not establish that working memory is modulated through those channels, or address the claimed α2-adrenoceptor mechanism in rat and primate PFC. (LLM, conf=0.86)
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Authors: Oda, S., Tsuneoka, Y., Yoshida, S., Adachi‐Akahane, S., Ito, M., Kuroda, M., & Funato, H.
Affiliations: Toho University (JP)
Corresponding author: Oda, Satoko
ORCID: Oda, Satoko
Tsuneoka, Yousuke
Yoshida, Sachine
Adachi‐Akahane, Satomi
Ito, Masanori
Funato, Hiromasa
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2018-02-28
Volume: 526
Issue: 8
Pages: 1329-1350
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.24409
PMC: PMC5900831
OpenAlex: W2793078608
Cited by: 27
References: 126
Citations by year: 2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 1 · 2018: 2
FWCI: 1.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: The Journal of Comparative Neurology (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology (15K08160)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: M1 muscarinic receptor, medial prefrontal cortex, cholinergic modulation, pyramidal neurons, inhibitory interneurons, parvalbumin neurons, astrocytes, dendritic localization, cognitive function, rats
MeSH terms: Animals, Astrocytes, Glial Fibrillary Acidic Protein, Glutamate Decarboxylase, Glutamate-Ammonia Ligase, Male, Microtubule-Associated Proteins, Neurons, Parvalbumins, Rats, Sprague-Dawley, Prefrontal Cortex, Microscopy, Confocal, Receptor, Muscarinic M1, Vesicular Glutamate Transport Protein 2, Rats

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Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex

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