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Cited by 1,605

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension

Open access
Ganau, Antonello, Devereux, Richard B., Roman, Mary J., de Simone, Giovanni, Pickering, Thomas G., Saba, Pier Sergio, Vargiu, Paolo, Simongini, Isabella, Laragh, John H.·1992·Journal of the American College of Cardiology
DOI 10.1016/0735-1097(92)90617-v
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Abstract

The spectrum of left ventricular geometric adaptation to hypertension was investigated in 165 patients with untreated essential hypertension and 125 age- and gender-matched normal adults studied by two-dimensional and M-mode echocardiography. Among hypertensive patients, left ventricular mass index and relative wall thickness were normal in 52%, whereas 13% had increased relative wall thickness with normal ventricular mass ("concentric remodeling"), 27% had increased mass with normal relative wall thickness (eccentric hypertrophy) and only 8% had "typical" hypertensive concentric hypertrophy (increase in both variables). Systemic hemodynamics paralleled ventricular geometry, with the highest peripheral resistance in the groups with concentric remodeling and hypertrophy, whereas cardiac index was super-normal in those with eccentric hypertrophy and low normal in patients with concentric remodeling. The left ventricular short-axis/long-axis ratio was positively related to stroke volume (r = 0.45, p less than 0.001), with cavity shape most elliptic in patients with concentric remodeling and most spheric in those with eccentric hypertrophy. Normality of left ventricular mass in concentric remodeling appeared to reflect offsetting by volume "underload" of the effects of pressure overload, whereas eccentric hypertrophy was associated with concomitant pressure and volume overload. Thus, arterial hypertension is associated with a spectrum of cardiac geometric adaptation matched to systemic hemodynamics and ventricular load. Concentric left ventricular remodeling and eccentric hypertrophy are more common than the typical pattern of concentric hypertrophy in untreated hypertensive patients.

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Metadata

Authors
Ganau, A., Devereux, R. B., Roman, M. J., de Simone, G., Pickering, T. G., Saba, P. S., Vargiu, P., Simongini, I., & Laragh, J. H.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
1992-06
Volume
19
Issue
7
Pages
1550-1558
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/0735-1097(92)90617-v
OpenAlex
W2035822743
Cited by
1,605
References
2
FWCI
14.23
Type
journal article
Language
en
Open access
bronze

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