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Multiple roles for orexin/hypocretin in addiction
Open accessAbstract
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but also play a critical role in drug addiction and reward-related behaviors. Here, we review the roles played by orexins in a variety of animal models of drug addiction, emphasizing both commonalities and differences for orexin's involvement in seeking of the major classes of abused drugs, as well as food. One common theme that emerges is an involvement of orexins in drug seeking triggered by external stimuli (e.g., cues, contexts or stressors). We also discuss the functional neuronal circuits in which orexins are embedded, and how these circuits mediate addiction-related behaviors, with particular focus on the role of orexin and glutamate interactions within the ventral tegmental area. Finally, we attempt to contextualize the role of orexins in reward by discussing ways in which these peptides, expressed in only a few thousand neurons in the brain, can have such wide-ranging effects on behavior.
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Items 201–320 of 320
Dumont, É. C., Mark, G. P., Mader, S. L., & Williams, J. T. (2005) · Nature Neuroscience · doi:10.1038/nn1414 · Cited by 136
Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system
Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21604 · Cited by 135
Nair, S. G., Golden, S. A., & Shaham, Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.3 · Cited by 133
Orexin/hypocretin is necessary for context-driven cocaine-seeking
Smith, R. J., Tahsili‐Fahadan, P., & Aston‐Jones, G. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.042 · Cited by 131
Self-citationBaldo, B. A., Gual‐Bonilla, L., Sijapati, K. S., Daniel, R. A., Landry, C. F., & Kelley, A. E. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03093.x · Cited by 130
Zhou, Y., Bendor, J., Hofmann, L., Randesi, M., Ho, A., & Kreek, M. J. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06960 · Cited by 130
Moorman, D. E., & Aston‐Jones, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2871-10.2010 · Cited by 129
Self-citationHcrtr1 and 2 signaling differentially regulates depression-like behaviors
Scott, M. M., Marcus, J., Pettersen, A., Birnbaum, S. G., Mochizuki, T., Scammell, T. E., Nestler, E. J., Elmquist, J. K., & Lutter, M. L. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.044 · Cited by 129
Conditioned and sensitized responses to stimulant drugs in humans
Leyton, M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.027 · Cited by 127
Amphetamine-Induced Place Preference in Humans
Childs, E., & de Wit, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.016 · Cited by 127
Franklin, T. R., & Druhan, J. P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00071.x · Cited by 126
Direct and Indirect Inhibition by Catecholamines of Hypocretin/Orexin Neurons
Li, Y., & van den Pol, A. N. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4015-04.2005 · Cited by 125
Smith, R. J., & Aston‐Jones, G. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08013.x · Cited by 123
Self-citationNicotine Up-Regulates Expression of Orexin and Its Receptors in Rat Brain
Kane, J. K., Parker, S. L., Matta, S. G., Fu, Y., Sharp, B. M., & Li, M. D. (2000) · Endocrinology · doi:10.1210/endo.141.10.7707 · Cited by 123
Stewart, J., & Vezina, P. (1991) · Behavioural Pharmacology · doi:10.1097/00008877-199102000-00009 · Cited by 119
Henny, P., & Jones, B. E. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21131 · Cited by 118
Huang, H., Acuna, C., Li, Y., Cheng, H. M., Obrietan, K. H., & van den Pol, A. N. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0732-07.2007 · Cited by 115
Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction
Pierce, R. C., & Vanderschuren, L. J. M. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.007 · Cited by 115
Bayer, L., Eggermann, E., Serafin, M., Grivel, J., Machard, D., Mühlethaler, M., & Jones, B. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.032 · Cited by 113
The hypocretins as sensors for metabolism and arousal
Adamantidis, A., & De Lecea, L. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164400 · Cited by 112
Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking
Marchant, N. J., Hamlin, A. S., & McNally, G. P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5194-08.2009 · Cited by 112
Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., & Weiss, F. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.027 · Cited by 112
Hirose, M., Egashira, S., Goto, Y., Hashihayata, T., Ohtake, N., Iwaasa, H., Hata, M., Fukami, T., Kanatani, A., & Yamada, K. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.08.038 · Cited by 112
A ventral tegmental CRF–glutamate–dopamine interaction in addiction
Wise, R. A., & Morales, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.101 · Cited by 111
Oleson, E. B., & Roberts, D. C. S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.195 · Cited by 110
Sartor, G. C., & Aston-Jones, G. S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4561-11.2012 · Cited by 109
Self-citationJupp, B., Krstew, E., Dezsi, G., & Lawrence, A. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01088.x · Cited by 107
Sekiguchi, M., Fleck, M. W., Mayer, M. L., Takeo, J., Chiba, Y., Yamashita, S., & Wada, K. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05760.1997 · Cited by 106
Gozzi, A., Turrini, G., Piccoli, L., Massagrande, M., Amantini, D., Antolini, M., Martinelli, P., Cesari, N., Montanari, D., Tessari, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016406 · Cited by 106
Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement
Sharf, R., Sarhan, M., Brayton, C. E., Guarnieri, D. J., Taylor, J. R., & Dileone, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.035 · Cited by 104
Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons
Vittoz, N. M., Schmeichel, B. E., & Berridge, C. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06453.x · Cited by 104
Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference
Risinger, F. O., Dickinson, S. D., & Cunningham, C. L. (1992) · Psychopharmacology · doi:10.1007/bf02245175 · Cited by 104
Orexin receptors as therapeutic drug targets
Gotter, A. L., Roecker, A. J., Hargreaves, R. J., Coleman, P. J., Winrow, C. J., & Renger, J. J. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00010-0 · Cited by 102
Accumbens Shell–Hypothalamus Interactions Mediate Extinction of Alcohol Seeking
Millan, E. Z., Furlong, T. M., & McNally, G. P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4933-09.2010 · Cited by 102
The Number of Hypothalamic Hypocretin (Orexin) Neurons Is Not Affected in Prader-Willi Syndrome
Fronczek, R., Lammers, G. J., Balesar, R. A., Unmehopa, U. A., & Swaab, D. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0296 · Cited by 102
Zushida, K., Sakurai, M., Wada, K., & Sekiguchi, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3842-06.2007 · Cited by 101
Addiction and arousal: The hypocretin connection
Boutrel, B., & de Lecea, L. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.022 · Cited by 101
μ-Opioid Receptor-Mediated Depression of the Hypothalamic Hypocretin/Orexin Arousal System
Li, Y., & van den Pol, A. N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5447-07.2008 · Cited by 100
Neuropeptide Y in Central Control
Niimi, M., Sato, M., & Taminato, T. (2001) · Endocrine · doi:10.1385/endo:14:2:269 · Cited by 97
Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization
Sharf, R., Guarnieri, D. J., Taylor, J. R., & Dileone, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.12.035 · Cited by 97
Cannella, N., Economidou, D., Kallupi, M., Stopponi, S., Heilig, M. A., Massi, M., & Ciccocioppo, R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.37 · Cited by 96
Neurobiology of overeating and obesity: The role of melanocortins and beyond
Pandit, R., de Jong, J. W., Vanderschuren, L. J. M. J., & Adan, R. A. H. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.01.034 · Cited by 95
Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity
Gompf, H. S., & Aston‐Jones, G. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.060 · Cited by 91
Self-citationMalherbe, P., Borroni, E., Gobbi, L. B., Knust, H., Nettekoven, M. H., Pinard, E., Roche, O., Rogers‐Evans, M., Wettstein, J. G., & Moreau, J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00127.x · Cited by 91
Orexin Receptor Antagonists: Medicinal Chemistry and Therapeutic Potential
Roecker, A. J., & Coleman, P. J. (2008) · Current Topics in Medicinal Chemistry · doi:10.2174/156802608784936746 · Cited by 91
Zavala, A. R., Weber, S. M., Rice, H. J., Alleweireldt, A. T., & Neisewander, J. L. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03452-8 · Cited by 90
Brown, Z. J., Tribe, E., D’souza, N. A., & Erb, S. M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1376-4 · Cited by 90
Activation of orexin neurons by acute nicotine
Pasumarthi, R. K., Reznikov, L. R., & Fadel, J. R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.02.021 · Cited by 90
Richardson, K. A., & Aston‐Jones, G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3917-11.2012 · Cited by 87
Self-citationBuffalari, D. M., & See, R. E. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2008-3 · Cited by 87
Orexin and leptin are associated with nicotine craving: A link between smoking, appetite and reward
von der Goltz, C., Koopmann, A., Dinter, C., Richter, A., Rockenbach, C., Grosshans, M., Nakovics, H., Wiedemann, K., Mann, K. F., Winterer, G., et al. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.005 · Cited by 87
Kallupi, M., Cannella, N., Economidou, D., Ubaldi, M., Ruggeri, B., Weiss, F., Massi, M., Marugán, J., Heilig, M. A., Bonnavion, P., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004100107 · Cited by 87
Chester, J. A., & Cunningham, C. L. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00253-6 · Cited by 87
McGregor, R., Wu, M., Barber, G., Ramanathan, L., & Siegel, J. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4017-11.2011 · Cited by 86
Hypocretins and the neurobiology of sleep–wake mechanisms
de Lecea, L. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00003-3 · Cited by 86
LeSage, M. G., Perry, J. L., Kotz, C. M., Shelley, D., & Corrigall, W. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1792-0 · Cited by 85
Plaza‐Zabala, A., Flores, Á., Maldonado, R. J., & Berrendero, F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.025 · Cited by 81
Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats
Akanmu, M. A., & Honda, K. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.064 · Cited by 81
Harris, G. C. M., & Aston‐Jones, G. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.10.012 · Cited by 79
Self-citationMorganstern, I., Chang, G., Barson, J. R., Ye, Z., Karatayev, O., & Leibowitz, S. F. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01161.x · Cited by 79
Yun, I. A., & Fields, H. L. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00531-1 · Cited by 78
Winrow, C. J., Tanis, K. Q., Reiss, D. R., Rigby, A. M., Uslaner, J. M., Uebele, V. N., Doran, S. M., Fox, S. V., Garson, S. L., Gotter, A. L., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.008 · Cited by 77
Whitman, D. B., Cox, C. D., Breslin, M. J., Brashear, K. M., Schreier, J. D., Bogusky, M. J., Bednar, R. A., Lemaire, W., Bruno, J. G., Hartman, G. D., et al. (2009) · ChemMedChem · doi:10.1002/cmdc.200900069 · Cited by 74
Orexin-1 Receptor Mediation of Cocaine Seeking in Male and Female Rats
Zhou, L., Ghee, S. M., Chan, C. H., Lin, L., Cameron, M. D., Kenny, P. J., & See, R. E. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.187567 · Cited by 73
Harris, G. C., & Aston‐Jones, G. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300122 · Cited by 72
Self-citationZellner, M. R., & Ranaldi, R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.011 · Cited by 71
Sano, H., & Yokoi, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0514-07.2007 · Cited by 71
Hutcheson, D. M., Quarta, D., Halbout, B., Rigal, A., Valerio, E., & Heidbreder, C. A. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328343d761 · Cited by 71
α2 Adrenergic and Imidazoline Receptor Agonists Prevent Cue-Induced Cocaine Seeking
Smith, R. J., & Aston‐Jones, G. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.010 · Cited by 69
Self-citationZhou, Y., Cui, C., Schlussman, S. D., Choi, J. C., Ho, A., Han, J., & Kreek, M. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.023 · Cited by 67
ISHII, Y., Blundell, J. E., Halford, J. C. G., Upton, N., Porter, R. A., Johns, A., Jeffrey, P. D., Summerfield, S. G., & Rodgers, R. J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.07.012 · Cited by 66
Li, Y., Wang, H., Qi, K., Chen, X., Li, S., Sui, N., & Kirouac, G. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.10.006 · Cited by 65
Ciano, P. D., & Everitt, B. J. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.024 · Cited by 64
Overview of orexin/hypocretin system
Mieda, M., & Sakurai, T. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00002-1 · Cited by 64
Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat
Kane, J. K., Parker, S. L., & Li, M. D. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01730-4 · Cited by 63
Stimulant-induced psychosis: an evaluation of animal methods.
Segal, D. S., Geyer, M. A., & Schuckit, M. A. (1981) · PubMed · Cited by 63
Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence
von der Goltz, C., Koopmann, A., Dinter, C., Richter, A., Grosshans, M., Fink, T., Wiedemann, K., & Kiefer, F. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.017 · Cited by 62
Quarta, D., Valerio, E., Hutcheson, D. M., Hédou, G., & Heidbreder, C. A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.08.012 · Cited by 62
Taslimi, Z., Haghparast, A., Hassanpour-Ezatti, M., & Safari, M.-S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.007 · Cited by 62
Narita, M., Nagumo, Y., Miyatake, M., Ikegami, D., Kurahashi, K., & Suzuki, T. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05403.x · Cited by 61
Dhaher, R., Hauser, S. R., Getachew, B., Bell, R. L., McBride, W. J., McKinzie, D. L., & Rodd, Z. A. (2010) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e3181bd893f · Cited by 61
Suto, N., Ecke, L. E., You, Z., & Wise, R. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1890-z · Cited by 58
Bayerlein, K., Kraus, T., Leinonen, I., et al. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.02.306 · Cited by 57
Lê, A. D., Funk, D. R., Harding, S. E., Juzytsch, W., & Fletcher, P. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1481-z · Cited by 56
Zhang, G., Mao, L., Liu, X., & Wang, J. Q. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04748.x · Cited by 56
Involvement of the orexin/hypocretin system in ethanol conditioned place preference
Voorhees, C. M., & Cunningham, C. L. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2082-6 · Cited by 55
The hippocampus, context, and information processing
Winocur, G., & Gilbert, M. E. (1984) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(84)90146-8 · Cited by 54
Fabio, R. D., Pellacani, A., Faedo, S., Roth, A. L., Piccoli, L., Gerrard, P. A., Porter, R. A., Johnson, C. N., Thewlis, K. M., Donati, D., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.06.086 · Cited by 53
Jacobs, E. H., Smit, A. B., Vries, T. J. D., & Schoffelmeer, A. N. M. (2004) · Addiction Biology · doi:10.1080/13556210412331284748 · Cited by 52
Azizi, H., Mirnajafi‐Zadeh, J., Rohampour, K., & Semnanian, S. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.050 · Cited by 52
Food-elicited increases in cortical acetylcholine release require orexin transmission
Frederick-Duus, D., Guyton, M., & Fadel, J. R. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.061 · Cited by 51
Mukai, K., Kim, J., Nakajima, K., Oomura, Y., Wayner, M. J., & Sasaki, K. (2009) · Peptides · doi:10.1016/j.peptides.2009.04.018 · Cited by 51
Regulation of alcohol-seeking by orexin (hypocretin) neurons
Lawrence, A. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.072 · Cited by 50
Zellner, M. R., Kest, K., & Ranaldi, R. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.013 · Cited by 50
Peters, Y. M., O’Donnell, P., & Carelli, R. M. (2005) · Synapse · doi:10.1002/syn.20129 · Cited by 49
Lesions of orexin neurons block conditioned place preference for sexual behavior in male rats
Sebastiano, A. R. D., Wilson, H., Lehman, M. N., & Coolen, L. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.09.006 · Cited by 48
Cholinergic Regulation of Orexin/Hypocretin Neurons Through M3 Muscarinic Receptor in Mice
Ohno, K., Hondo, M., & Sakurai, T. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0071986 · Cited by 47
Use of vivo-morpholinos for control of protein expression in the adult rat brain
Reissner, K. J., Sartor, G. C., Vazey, E. M., Dunn, T. E., Aston‐Jones, G., & Kalivas, P. W. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.10.009 · Cited by 45
Self-citationDrug Self-Administration Viewed as Ingestive Behaviour
Wise, R. A. (1997) · Appetite · doi:10.1006/appe.1996.0059 · Cited by 43
Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus
Suzuki, R., Shimojima, H., Funahashi, H., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00140-4 · Cited by 41
Hypocretin modulation of drug-induced synaptic plasticity
Baimel, C., & Borgland, S. L. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00008-2 · Cited by 40
Sebastiano, A. R. D., Yong-Yow, S., Wagner, L., Lehman, M. N., & Coolen, L. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.004 · Cited by 38
Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat
Murphy, J. A., Deurveilher, S., & Semba, K. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00461-5 · Cited by 37
Mori, K., Kim, J., & Sasaki, K. (2010) · Peptides · doi:10.1016/j.peptides.2010.10.023 · Cited by 37
Root, D. H., Fabbricatore, A. T., Barker, D. J., Ma, S., Pawlak, A. P., & West, M. O. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007170 · Cited by 36
See, R. E., & Waters, R. P. (2010) · PubMed Central · Cited by 35
Ranaldi, R., Kest, K., Zellner, M. R., Lubelski, D., Muller, J., Cruz, Y., & Saliba, M. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.026 · Cited by 35
Bickel, W. K., Yi, R., Mueller, E. T., Jones, B. A., & Christensen, D. R. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_22 · Cited by 33
Roles of orexins in the regulation of feeding and arousal
Sakurai, T. (2002) · Sleep Medicine · doi:10.1016/s1389-9457(02)00156-9 · Cited by 30
McPherson, C. S., Featherby, T. J., Krstew, E., & Andrew, J. L. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125732 · Cited by 29
Coleman, P. J., Schreier, J. D., Roecker, A. J., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.05.047 · Cited by 27
Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1
Nakajima, M., Shimizu, T., & Shirasawa, T. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20001015)62:2 · Cited by 27
Ciano, P. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301542 · Cited by 25
Hata, T., Chen, J., Ebihara, K., Date, Y., Ishida, Y., & Nakahara, D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07808.x · Cited by 25
Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators
Kessler, M., & Arai, A. (2005) · Brain Research · doi:10.1016/j.brainres.2005.09.024 · Cited by 21
Gifford, A. N., Gatley, S. J., & Ashby, C. R. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199603)22:3 · Cited by 20
Simms, D., & Gallagher, J. P. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12407-5 · Cited by 19
Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss–Webster mice
Riday, T. T., Fish, E. W., Robinson, J. E., Jarrett, T. M., McGuigan, M. M., & Malanga, C. J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.003 · Cited by 18
Lesse, H., & Harper, R. K. (1985) · Brain Research · doi:10.1016/0006-8993(85)90272-0 · Cited by 14
Shoji, S., Simms, D., Yamada, K., et al. (1998) · PubMed · Cited by 12
Research works printed but not linked: 3
- Downs, 1932, The effect of repeated doses of cocaine on the rat, The Journal of Pharmacology and Experimental Therapeutics, 46, 199
- McDonald, 2011, Summary of the probe development effort to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [Summary], Ed. S. R. I. M. S. Center. PubChem.
- NIDA, 2009, (2009). Principals of Drug Addiction Treatment: A Research-Based Guide, Ed. D. o. H. a. H. S. National Institutes of Health. NIH.
Cited by
Sorted by citations
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Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
The contribution of brain reward circuits to the obesity epidemic
Stice, E., Figlewicz, D. P., Gosnell, B. A., Levine, A. S., & Pratt, W. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.001 · Cited by 274
Brown, R. M., Khoo, S. Y.-S., & Lawrence, A. J. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000333 · Cited by 101
Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.293 · Cited by 79
Lopez, M. F., Moorman, D. E., Aston-Jones, G., & Becker, H. C. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.049 · Cited by 62
Self-citation
Metadata
- Authors
- Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Aston-Jones, Gary
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2012
- Volume
- 198
- Pages
- 79-121
- ISSN
- 0079-6123 (ISSN-L)
- PMC
- PMC3643893
- OpenAlex
- W4211199394
- Cited by
- 215
- References
- 320
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 13 · 2021: 14 · 2020: 14 · 2019: 15 · 2018: 20 · 2017: 17 · 2016: 22 · 2015: 19 · 2014: 26 · 2013: 17 · 2012: 3
- FWCI
- 23.33
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (P50AA010761)
- National Institute on Drug Abuse (F32DA031519, R37DA006214, R21DA032005, F32DA026692, P50DA015369)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- orexin, drug addiction, drug-seeking behavior, reward, food reward, contextual cues, stress, neural circuits, ventral tegmental area, glutamate, arousal, wakefulness
- MeSH terms
- Orexins, Animals, Brain, Humans, Motivation, Neuropeptides, Substance-Related Disorders, Intracellular Signaling Peptides and Proteins
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