The hypocretins as sensors for metabolism and arousal
Open accessAbstract
Sleep disturbances are associated with hormonal imbalances and may result in metabolic disorders including obesity and diabetes. Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions. The hypocretin (Hcrt) system is a strong candidate for mediating both sleep and metabolic imbalances because Hcrt neurons are sensitive to metabolic hormones, including leptin and ghrelin, and modulate arousal and goal‐orientated behaviours. This review discusses the role of Hcrt neurons as a sensors of energy balance and arousal and proposes new ways of probing local hypothalamic circuits regulating sleep and metabolism with unprecedented cellular specificity and temporal resolution.
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Orexin neurons can integrate metabolic state signals such as leptin, insulin, and glucose.
“Orexin neurons can integrate various metabolic state signals such as leptin, insulin, and glucose”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [2]
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- Authors
- Adamantidis, A., & De Lecea, L.
- Affiliations
- Stanford Medicine (US)
- ORCID
- Adamantidis, Antoine
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 587
- Issue
- 1
- Pages
- 33-40
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2670020
- OpenAlex
- W1509650655
- Cited by
- 112
- References
- 53
- Citations by year
- 2025: 6 · 2024: 3 · 2022: 15 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 7 · 2012: 10
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Fonds De La Recherche Scientifique - FNRS
- Defense Advanced Research Projects Agency
- National Institute on Drug Abuse
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- orexin, hypocretin neurons, sleep regulation, energy balance, arousal, leptin, ghrelin, hypothalamic circuits, obesity, diabetes mellitus, sleep disorders, metabolic hormones
- MeSH terms
- Orexins, Animals, Arousal, Humans, Hypothalamus, Metabolism, Models, Neurological, Neurons, Neuropeptides, Sleep, Leptin, Intracellular Signaling Peptides and Proteins, Ghrelin
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