Circadian regulation of cellular physiology
Open accessAbstract
The circadian clock synchronizes behavioral and physiological processes on a daily basis in anticipation of the light-dark cycle. In mammals, molecular clocks are present in both the central pacemaker neurons and in nearly all peripheral tissues. Clock transcription factors in metabolic tissues coordinate metabolic fuel utilization and storage with alternating periods of feeding and fasting corresponding to the rest-activity cycle. In vitro and in vivo biochemical approaches have led to the discovery of mechanisms underlying the interplay between the molecular clock and the metabolic networks. For example, recent studies have demonstrated that the circadian clock controls rhythmic synthesis of the cofactor nicotinamide adenine dinucleotide (NAD(+)) and activity of NAD(+)-dependent sirtuin deacetylase enzymes to regulate mitochondrial function across the circadian cycle. In this chapter, we review current state-of-the-art methods to analyze circadian cycles in mitochondrial bioenergetics, glycolysis, and nucleotide metabolism in both cell-based and animal models.
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CLOCK-BMAL1 heterodimers drive rhythmic expression of nicotinamide phosphoribosyltransferase, a rate-limiting enzyme in the NAD+ salvage pathway; NAD+ acts as a cofactor for SIRT1, which regulates the activity of CLOCK-BMAL1.
“For example, CLOCK-BMAL1 heterodimers drive rhythmic expression of nicotinamide phosphoribosyltransferase, which is a rate-limiting enzyme involved in the NAD+ salvage pathway; NAD+ acts as a cofactor for Sirtuin (SIRT1), which regulates the activity of CLOCK-BMAL1 among its other metabolic functions (23,24).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [24]
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Circadian rhythms, metabolism, and chrononutrition in rodents and humans
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“Several metabolites, such as AMP, ADP, ATP, and NAD + , with different abundances in GF and SPF mice, are known modifiers of core clock gene activity in hepatocytes 24,25 .”
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Self-citation
- Authors
- Peek, C. B., Ramsey, K. M., Levine, D. C., Marcheva, B., Perelis, M., & Bass, J.
- Affiliations
- Northwestern University (US)
- Venue
- Methods in Enzymology
- Publisher
- Elsevier
- Published
- 2015
- Volume
- 552
- Pages
- 165-184
- ISSN
- 0076-6879 (ISSN-L)
- PMC
- PMC4690540
- OpenAlex
- W118453116
- Cited by
- 35
- References
- 37
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 1
- FWCI
- 16.38
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (T32 HL-07909, T32HL007909)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60DK020595, K01DK105137, R01DK090625, P30DK020595)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- circadian clock, circadian rhythm, metabolic rhythms, feeding-fasting cycle, NAD+ synthesis, sirtuin deacetylase, mitochondrial function, mitochondrial bioenergetics, glycolysis, nucleotide metabolism
- MeSH terms
- Animals, Cell Line, Circadian Rhythm, Mice, Inbred C57BL, Muscle Fibers, Skeletal, Mice
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