Circadian rhythms in mitochondrial respiration

de Goede, Paul; Wefers, Jakob; Brombacher, Eline Constance; Schrauwen, Patrick; Kalsbeek, Andries

doi:10.1530/jme-17-0196

Cited by 219Circadian rhythm and melatoninMitochondrial Function and PathologySleep and Work-Related Fatigue

Circadian rhythms in mitochondrial respiration

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de Goede, Paul, Wefers, Jakob, Brombacher, Eline Constance, Schrauwen, Patrick, Kalsbeek, Andries·2018·Journal of Molecular Endocrinology

DOI 10.1530/jme-17-0196PMC PMC5854864

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Abstract

Many physiological processes are regulated with a 24-h periodicity to anticipate the environmental changes of daytime to nighttime and vice versa. These 24-h regulations, commonly termed circadian rhythms, among others control the sleep-wake cycle, locomotor activity and preparation for food availability during the active phase (daytime for humans and nighttime for nocturnal animals). Disturbing circadian rhythms at the organ or whole-body level by social jetlag or shift work, increases the risk to develop chronic metabolic diseases such as type 2 diabetes mellitus. The molecular basis of this risk is a topic of increasing interest. Mitochondria are essential organelles that produce the majority of energy in eukaryotes by converting lipids and carbohydrates into ATP through oxidative phosphorylation. To adapt to the ever-changing environment, mitochondria are highly dynamic in form and function and a loss of this flexibility is linked to metabolic diseases. Interestingly, recent studies have indicated that changes in mitochondrial morphology (i.e., fusion and fission) as well as generation of new mitochondria are dependent on a viable circadian clock. In addition, fission and fusion processes display diurnal changes that are aligned to the light/darkness cycle. Besides morphological changes, mitochondrial respiration also displays diurnal changes. Disturbing the molecular clock in animal models leads to abrogated mitochondrial rhythmicity and altered respiration. Moreover, mitochondrial-dependent production of reactive oxygen species, which plays a role in cellular signaling, has also been linked to the circadian clock. In this review, we will summarize recent advances in the study of circadian rhythms of mitochondria and how this is linked to the molecular circadian clock.

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Many of the molecular processes that regulate mitochondrial content, function, and dynamics are regulated in a circadian manner.
“As many of the molecular processes that regulate mitochondrial content, function, and dynamics are regulated in a circadian manner [60,61] and considering that molecular markers of circadian rhythm are altered by a night of sleep deprivation [7,8], we also examined aspects of diurnal rhythmicity using the measures of peripheral skin temperature (obtained over 48 h, pre- and post-intervention) and”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [61]

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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works
Circadian rhythms and exercise — re-setting the clock in metabolic disease
Gabriel, B. M., & Zierath, J. R. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0150-x · Cited by 382 · see citing works
Feeding Rhythms and the Circadian Regulation of Metabolism
Pickel, L., & Sung, H. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00039 · Cited by 261 · see citing works
The molecular athlete: exercise physiology from mechanisms to medals
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Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders
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Circadian rhythms and mood disorders: Time to see the light
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Circadian Control of Mitochondria in Reactive Oxygen Species Homeostasis
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Circadian Rhythms and Mitochondria: Connecting the Dots
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Impact of Melatonin on Skeletal Muscle and Exercise
Stacchiotti, A., Favero, G., & Rodella, L. F. (2020) · Cells · doi:10.3390/cells9020288 · Cited by 115 · see citing works
At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications
Bae, S.-A., Fang, M., Rustgi, V. K., Zarbl, H., & Androulakis, I. P. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00132 · Cited by 100 · see citing works
Coupled network of the circadian clocks: a driving force of rhythmic physiology
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Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy
Springer, C., Humayun, D., & Skouta, R. (2024) · Cancers · doi:10.3390/cancers16030647 · Cited by 88 · see citing works
Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder
Scaini, G., Andrews, T., Lima, C. N. D. C., Benevenuto, D., STRECK, E. L., & Quevedo, J. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.12.002 · Cited by 77 · see citing works
The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10
Cai, T., Hua, B., Luo, D., Xu, L., Cheng, Q., Yuan, G., Yan, Z., Sun, N., Hua, L., & Lü, C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.03.016 · Cited by 74 · see citing works
Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin
Marón, F. J. M., Ferder, L., Reiter, R. J., & Manucha, W. A. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105595 · Cited by 74 · see citing works
Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
Wang, X., & Li, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.696554 · Cited by 74 · see citing works
Is REDD1 a metabolic double agent? Lessons from physiology and pathology
Britto, F. A., Dumas, K., Giorgetti‐Peraldi, S., Ollendorff, V., & Favier, F. B. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2020 · Cited by 70 · see citing works
NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson’s Disease
Curtis, W. M., Seeds, W. A., Mattson, M. P., & Bradshaw, P. C. (2022) · Cells · doi:10.3390/cells11152416 · Cited by 70 · see citing works
Exercise timing and circadian rhythms
Wolff, C. A., & Esser, K. A. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.04.020 · Cited by 69 · see citing works
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms
Saner, N. J., Lee, M. J.-C., Kuang, J., Pitchford, N. W., Roach, G. D., Garnham, A., Genders, A. J., Stokes, T., Schroder, E. A., Huo, Z., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101110 · Cited by 68 · see citing works
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity
Aguilar‐López, B. A., Moreno‐Altamirano, M. M. B., Dockrell, H. M., Duchen, M. R., & Sánchez‐García, F. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00051 · Cited by 71 · see citing works
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 68 · see citing works
Roles of clock genes in the pathogenesis of Parkinson's disease
Shkodina, A. D., Tan, S. C., Hasan, M. M., Abdelgawad, M., Chopra, H., Bilal, M., Boiko, D. I., Tarianyk, K. А., & Alexiou, A. T. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101554 · Cited by 65 · see citing works
Mitochondria and immunity in chronic fatigue syndrome
Anderson, G., & Maes, M. H. J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109976 · Cited by 64 · see citing works
Circadian Clocks Make Metabolism Run
Sinturel, F., Petrenko, V., & Dibner, C. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.018 · Cited by 64 · see citing works
Mood‐related central and peripheral clocks
Ketchesin, K. D., Becker‐Krail, D. D., & McClung, C. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14253 · Cited by 60 · see citing works
Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?
López‐Lluch, G., Hernández‐Camacho, J. D., Fernández‐Ayala, D. J. M., & Navas, P. (2018) · Biogerontology · doi:10.1007/s10522-018-9768-2 · Cited by 57 · see citing works
Daily mitochondrial dynamics in cone photoreceptors
Giarmarco, M. M., Brock, D. C., Robbings, B. M., Cleghorn, W. M., Tsantilas, K. A., Kuch, K. C., Ge, W., Rutter, K. M., Parker, E. D., Hurley, J. B., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007827117 · Cited by 55 · see citing works
Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles
Richardson, R. B., & Mailloux, R. J. (2023) · Antioxidants · doi:10.3390/antiox12030674 · Cited by 55 · see citing works
Re-Setting the Circadian Clock Using Exercise against Sarcopenia
Choi, Y., Cho, J., No, M., Heo, J., Cho, E., Chang, E., Park, D., Kang, J., & Kwak, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093106 · Cited by 52 · see citing works
Mitochondria as the Essence of Yang Qi in the Human Body
Luo, J., Shiwei, S., Xia, J., Wang, J., & Gu, Z. (2022) · Phenomics · doi:10.1007/s43657-022-00060-3 · Cited by 50 · see citing works
Yoga improves mitochondrial health and reduces severity of autoimmune inflammatory arthritis: A randomized controlled trial
Gautam, S., Kumar, U., Kumar, M., Rana, D., & Dada, R. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.03.004 · Cited by 53 · see citing works
Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day
Basti, A., Yalçın, M., Herms, D., Hesse, J., Aboumanify, O., Li, Y., Aretz, Z. E. H., Garmshausen, J., El‐Athman, R., Hastermann, M., et al. (2021) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2020-000876 · Cited by 49 · see citing works
Genetic risk factors for ME/CFS identified using combinatorial analysis
Das, S., Taylor, K., Kozubek, J. A., Sardell, J. M., & Gardner, S. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03815-8 · Cited by 49 · see citing works
Circadian regulation of cardiac metabolism
Zhang, L., & Jain, M. K. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148276 · Cited by 49 · see citing works
PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress
Sun, Q., Yang, Y., Wang, Z., Yang, X., Gao, Y., Zhao, Y., Ge, W., Liu, J.-H., Xu, X., Guan, W., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101694 · Cited by 48 · see citing works
Understanding circadian regulation of mammalian cell function, protein homeostasis, and metabolism
Stangherlin, A., Seinkmane, E., & O'Neill, J. S. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.100391 · Cited by 46 · see citing works
Role of mitochondrial dysfunction on rheumatic diseases
Vaamonde‐García, C., & López-Armada, M. J. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.03.008 · Cited by 45 · see citing works
Do not neglect the role of circadian rhythm in muscle atrophy
Zhang, H., Liang, J., & Chen, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101155 · Cited by 46 · see citing works
Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis
Taylor, K., Pearson, M. W., Das, S., Sardell, J. M., Chocian, K., & Gardner, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04588-4 · Cited by 45 · see citing works
Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism
Pacelli, C., Rotundo, G., Lecce, L., Menga, M., Bidollari, E., Scrima, R., Cela, O., Piccoli, C., Cocco, T., Vescovi, A. L., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112772 · Cited by 44 · see citing works
Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis
Salmina, A. B., Gorina, Y. V., Komleva, Y. K., Panina, Y. A., Malinovskaya, N. A., & Lopatina, O. L. (2021) · Biomedicines · doi:10.3390/biomedicines9091092 · Cited by 41 · see citing works
Urolithin A Prevents Sleep-deprivation-induced Neuroinflammation and Mitochondrial Dysfunction in Young and Aged Mice
Misrani, A. A., Tabassum, S., Zhang, Z.-Y., Tan, S.-H., & Long, C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03651-x · Cited by 38 · see citing works
Circadian regulated control of myocardial ischemia-reperfusion injury
Rabinovich-Nikitin, I., & Kirshenbaum, L. A. (2022) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2022.09.003 · Cited by 38 · see citing works
Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock
Colombini, B., Dinu, M., Murgo, E., Lotti, S., Tarquini, R., Sofi, F., & Mazzoccoli, G. (2022) · Antioxidants · doi:10.3390/antiox11112228 · Cited by 38 · see citing works
Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions
Tiwari, S., Phoolmala, Goyal, S., Yadav, R. K., & Chaturvedi, R. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04160-1 · Cited by 37 · see citing works
Integration of Melatonin Related Redox Homeostasis, Aging, and Circadian Rhythm
Yanar, K., Simsek, B., & Çakatay, U. (2018) · Rejuvenation Research · doi:10.1089/rej.2018.2159 · Cited by 37 · see citing works
Time‐restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle
de Goede, P., Wüst, R. C. I., Schomakers, B. V., Denis, S. W., Vaz, F. M., Pras‐Raves, M. L., van Weeghel, M., Yi, C., Kalsbeek, A., & Houtkooper, R. H. (2022) · The FASEB Journal · doi:10.1096/fj.202100707r · Cited by 36 · see citing works
Self-citation
The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development
Zhao, B., Nepovimová, E., & Wu, Q. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02040-2 · Cited by 38 · see citing works
A day in the life of mitochondria reveals shifting workloads
Weinrich, T. W., Kam, J. H., Ferrara, B., Thompson, E. P., Mitrofanis, J., & Jeffery, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-48383-y · Cited by 30 · see citing works
What is bipolar disorder? A disease model of dysregulated energy expenditure
Mansur, R. B., Lee, Y. L., McIntyre, R. S., & Brietzke, E. M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.006 · Cited by 33 · see citing works
Potential Circadian Rhythms in Oligodendrocytes? Working Together Through Time
Colwell, C. S., & Ghiani, C. A. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02778-5 · Cited by 31 · see citing works
Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review
Inyushkin, A. N., Полетаев, В., Михайловна, И. Е., Сергеевич, К. И., & Inyushkin, A. A. (2023) · Journal of Biomedical Research · doi:10.7555/jbr.37.20230133 · Cited by 30 · see citing works
Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models
Hao, S., Chen, Z., Gu, Y., Chen, L., Sheng, F., Xu, Y., Wu, D., Han, Y., Lu, B., Chen, S., et al. (2023) · Particle and Fibre Toxicology · doi:10.1186/s12989-023-00540-y · Cited by 28 · see citing works
Mitochondrial calcium drives clock gene-dependent activation of pyruvate dehydrogenase and of oxidative phosphorylation
Scrima, R., Cela, O., Agriesti, F., Piccoli, C., Tataranni, T., Pacelli, C., Mazzoccoli, G., & Capitanio, N. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118815 · Cited by 28 · see citing works
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus
Goyal, S., Tiwari, S., Seth, B., Tandon, A., Shankar, J., Sinha, M., Singh, S. J., Priya, S., & Chaturvedi, R. K. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.04.001 · Cited by 27 · see citing works
Zeitgebers of skeletal muscle and implications for metabolic health
Gabriel, B. M., & Zierath, J. R. (2021) · The Journal of Physiology · doi:10.1113/jp280884 · Cited by 27 · see citing works
Light/Dark and Temperature Cycling Modulate Metabolic Electron Flow in Pseudomonas aeruginosa Biofilms
Kahl, L. J., Eckartt, K. N., Morales, D. K., Price‐Whelan, A., & Dietrich, L. E. P. (2022) · mBio · doi:10.1128/mbio.01407-22 · Cited by 26 · see citing works
Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings
Groennebaek, T., Nielsen, J., Jespersen, N. R., Bøtker, H. E., de Paoli, F. V., Miller, B. F., & Vissing, K. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00101.2020 · Cited by 25 · see citing works
Circadian clocks' interactions with oxygen sensing and signalling
Adamovich, Y., Dandavate, V., & Asher, G. (2022) · Acta Physiologica · doi:10.1111/apha.13770 · Cited by 26 · see citing works
Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice
Escalante‐Covarrubias, Q., Mendoza-Viveros, L., González-Suárez, M., Sitten-Olea, R., Velázquez‐Villegas, L. A., Becerril-Pérez, F., Pacheco-Bernal, I., Carreño‐Vázquez, E., Sanchez, P. B. M., Bustamante-Zepeda, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37286-2 · Cited by 24 · see citing works
Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet
Nohara, K., Kim, E., Wirianto, M., Mileykovskaya, E., Dowhan, W., Chen, Z., & Yoo, S. H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5304768 · Cited by 24 · see citing works
Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions
Madhamanchi, K., Zhang, J., & Melkani, G. C. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.011 · Cited by 30 · see citing works
From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin
Fernández‐Martínez, J., Ramírez‐Casas, Y., Yang, Y., Aranda‐Martínez, P., Martínez-Ruiz, L., Escames, G., & Acuña-Castroviejo, D. (2023) · Biomolecules · doi:10.3390/biom13121779 · Cited by 21 · see citing works
Enhancing the metabolic benefits of exercise: Is timing the key?
Bennett, S. E., & Sato, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.987208 · Cited by 22 · see citing works
Environmental and behavioral regulation of HIF-mitochondria crosstalk
Burtscher, J., Hohenauer, E., Burtscher, M., Millet, G. P., & Egg, M. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.06.015 · Cited by 23 · see citing works
Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice
Hardee, J. P., Caldow, M. K., Chan, A. S. M., Plenderleith, S. K., Trieu, J., Koopman, R., & Lynch, G. S. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00188.2021 · Cited by 20 · see citing works
Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania
Gardea‐Resendez, M., Coombes, B. J., Veldić, M., Tye, S. J., Romo‐Nava, F., Özerdem, A., Prieto, M. L., Barboza, A. B. C., Núñez, N. A., Singh, B., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01888-x · Cited by 21 · see citing works
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease
Yalçın, M., El‐Athman, R., Ouk, K., Priller, J., & Relógio, A. (2020) · Cancers · doi:10.3390/cancers12040963 · Cited by 21 · see citing works
Evolutionary conservations, changes of circadian rhythms and their effect on circadian disturbances and therapeutic approaches
Palm, D., Uzoni, A., Simon, F., Fischer, M., Coogan, A., Tucha, O., Thome, J., & Faltraco, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.007 · Cited by 20 · see citing works
Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity
Mir, F. A., Lark, A. R. S., & Nehs, C. J. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1605070 · Cited by 21 · see citing works
The Preventive Effects of Pterostilbene on the Exercise Intolerance and Circadian Misalignment of Mice Subjected to Sleep Restriction
Yang, L., Lang, H., Zhou, M., Huang, L., Hui, S., Wang, X., Chen, K., & Mi, M. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900991 · Cited by 20 · see citing works
Increased expression of fragmented tRNA promoted neuronal necrosis
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Authors: de Goede, P., Wefers, J., Brombacher, E. C., Schrauwen, P., & Kalsbeek, A.
Affiliations: 1Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
Maastricht University Medical Centre (NL)
Amsterdam UMC Location University of Amsterdam (NL)
Netherlands Institute for Neuroscience (NL)
Corresponding author: Kalsbeek, Andries
ORCID: Wefers, Jakob
Brombacher, Eline Constance
Schrauwen, Patrick
Kalsbeek, Andries
Venue: Journal of Molecular Endocrinology
Publisher: Bioscientifica
Published: 2018-04
Volume: 60
Issue: 3
Pages: R115-R130
ISSN: 0952-5041 (ISSN-L)
1479-6813
DOI: 10.1530/jme-17-0196
PMC: PMC5854864
OpenAlex: W2789456434
Cited by: 211
References: 91
Citations by year: 2026: 24 · 2025: 31 · 2024: 27 · 2023: 30 · 2022: 30 · 2021: 22 · 2020: 26 · 2019: 13 · 2018: 8
FWCI: 2.41
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Journal of Molecular Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
Pure Amsterdam UMC (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Research Publications (Maastricht University) (submittedVersion, cc-by)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (40-00812-98-1404, 40-00812-98-14047)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian rhythm, mitochondrial respiration, circadian clock, mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, mitochondrial biogenesis, oxidative phosphorylation, reactive oxygen species, type 2 diabetes, metabolic disorders, shift work, social jetlag, light-dark cycle
MeSH terms: Animals, Circadian Rhythm, Humans, Mitochondria, Models, Biological, Reactive Oxygen Species, Cell Respiration, Mitophagy

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