Circadian transcription from beta cell function to diabetes pathophysiology

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302 · see citing works

Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works

The mammalian circadian timing system: organization and coordination of central and peripheral clocks

Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421 · see citing works

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes &amp; Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works

Adverse metabolic and cardiovascular consequences of circadian misalignment

Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works

A circadian gene expression atlas in mammals: Implications for biology and medicine

Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304 · see citing works

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works

Resetting of circadian time in peripheral tissues by glucocorticoid signaling

Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859 · see citing works

Mutagenesis and Mapping of a Mouse Gene, <i>Clock</i> , Essential for Circadian Behavior

Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632 · see citing works

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works

Extensive and divergent circadian gene expression in liver and heart

Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464 · see citing works

Molecular architecture of the mammalian circadian clock

Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449 · see citing works

Health disorders of shift workers

Knutsson, A. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg048 · Cited by 1,218 · see citing works

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2327 · Cited by 1,177 · see citing works

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

Stoffers, D. A., Zinkin, N. T., Stanojevic, V., Clarke, W. L., & Habener, J. F. (1997) · Nature Genetics · doi:10.1038/ng0197-106 · Cited by 1,103 · see citing works

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works

Physiological significance of a peripheral tissue circadian clock

Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953 · see citing works

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917 · see citing works

Peroxiredoxins are conserved markers of circadian rhythms

Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915 · see citing works

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

Mojsov, S., Weir, G. C., & Habener, J. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112855 · Cited by 882 · see citing works

A transcription factor response element for gene expression during circadian night

Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 850 · see citing works

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

Polonsky, K. S., Given, B. D., & Van Cauter, E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113339 · Cited by 763 · see citing works

Reprogramming of the Circadian Clock by Nutritional Challenge

Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 711 · see citing works

Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Peek, C. B., Affinati, A. H., Ramsey, K. M., Kuo, H.-Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., et al. (2013) · Science · doi:10.1126/science.1243417 · Cited by 658 · see citing works

System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658 · see citing works

Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation

Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 611 · see citing works

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611 · see citing works

Circadian topology of metabolism

Bass, J. T. (2012) · Nature · doi:10.1038/nature11704 · Cited by 610 · see citing works

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567 · see citing works

A map of open chromatin in human pancreatic islets

Gaulton, K. J., Nammo, T., Pasquali, L., Simon, J. M., Giresi, P. G., Fogarty, M. P., Panhuis, T. M., Mieczkowski, P. A., Secchi, A., Bosco, D., et al. (2010) · Nature Genetics · doi:10.1038/ng.530 · Cited by 530 · see citing works

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523 · see citing works

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

He, B., Nohara, K., Park, N., Park, Y.-S., Guillory, B., Zhao, Z., Garcia, J. M., Koike, N., Lee, C. C., Takahashi, J. S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.007 · Cited by 505 · see citing works

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Pasquali, L., Gaulton, K. J., Rodríguez‐Seguí, S. A., Mularoni, L., Miguel-Escalada, I., Akerman, İ., Tena, J. J., Morán, I., Gómez-Marín, C., van de Bunt, M., et al. (2014) · Nature Genetics · doi:10.1038/ng.2870 · Cited by 502 · see citing works

Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes

Gunton, J. E., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W. J., Tseng, Y., Roberson, R. S., Ricordi, C., O’Connell, P. J., Gonzalez, F. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.027 · Cited by 489 · see citing works

Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts

Balsalobre, A., Marcacci, L., & Schibler, U. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00758-2 · Cited by 485 · see citing works

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

Rey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M., & Naef, F. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000595 · Cited by 473 · see citing works

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

Fadista, J., Vikman, P. J., Ottosson-Laakso, E., Mollet, I. G., Esguerra, J. L. S., Taneera, J., Storm, P., Osmark, P., Ladenvall, C., Prasad, R. B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402665111 · Cited by 470 · see citing works

Glucocorticoid hormones inhibit food‐induced phase‐shifting of peripheral circadian oscillators

Minh, N. L., Damiola, F., Tronche, F., Schütz, G., & Schibler, U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7128 · Cited by 467 · see citing works

Obesity in mice with adipocyte-specific deletion of clock component Arntl

Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465 · see citing works

Mammalian melatonin receptors: molecular biology and signal transduction

von Gall, C., Stehle, J. H., & Weaver, D. R. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0581-4 · Cited by 455 · see citing works

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes

Woon, P. Y., Kaisaki, P. J., Bragança, J., Bihoreau, M., Lévy, J., Farrall, M., & Gauguier, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703247104 · Cited by 410 · see citing works

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Gaulton, K. J., Ferreira, T. C., Lee, Y., Raimondo, A., Mägi, R., Reschen, M. E., Mahajan, A., Locke, A. E., Rayner, N. W., Robertson, N., et al. (2015) · Nature Genetics · doi:10.1038/ng.3437 · Cited by 390 · see citing works

Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., et al. (2015) · Science · doi:10.1126/science.aac4250 · Cited by 377 · see citing works

Melatonin secretion and the incidence of type 2 diabetes

McMullan, C. J., Schernhammer, E. S., Rimm, E. B., Hu, F. B., & Forman, J. P. (2013) · JAMA · doi:10.1001/jama.2013.2710 · Cited by 369 · see citing works

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

Seino, S., Shibasaki, T., & Minami, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45680 · Cited by 364 · see citing works

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

The Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC), Bonnefond, A., Clément, N., Fawcett, K., Yengo, L., Vaillant, E., Guillaume, J.-L., Dechaume, A., Payne, F., Roussel, R., et al. (2012) · Nature Genetics · doi:10.1038/ng.1053 · Cited by 363 · see citing works

The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons

Buijs, R. M., la Fleur, S. E., Wortel, J., van Heyningen, C., Zuiddam, L., Mettenleiter, T. C., Kalsbeek, A., Nagai, K., & Niijima, A. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10765 · Cited by 356 · see citing works

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

Menet, J. S., Rodriguez, J., Abruzzi, K. C., & Rosbash, M. (2012) · eLife · doi:10.7554/elife.00011 · Cited by 321 · see citing works

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

Yang, G., Chen, L., Grant, G. R., Paschos, G. K., Song, W., Musiek, E. S., Lee, V., McLoughlin, S. C., Großer, T., Cotsarelis, G., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3305 · Cited by 317 · see citing works

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

Sadacca, L. A., Lamia, K. A., deLemos, A. S., Blum, B., & Weitz, C. J. (2011) · Diabetologia · doi:10.1007/s00125-010-1920-8 · Cited by 314 · see citing works

Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in MammalsPreprint

Schibler, U., Gotić, I., Saini, C., Gos, P., Curie, T., Emmenegger, Y., Sinturel, F., Gosselin, P., Gerber, A., Fleury-Olela, F., et al. (2015) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2015.80.027490 · Cited by 313 · see citing works

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

Rodriguez‐Diaz, R., Dando, R., Jacques-Silva, M. C., Fachado, A., Molina, J., Abdulreda, M. H., Ricordi, C., Roper, S. D., Berggren, P., & Caicedo, A. (2011) · Nature Medicine · doi:10.1038/nm.2371 · Cited by 305 · see citing works

Diurnal pattern to insulin secretion and insulin action in healthy individuals

Saad, A., Dalla Man, C., Nandy, D. K., Levine, J. A., Bharucha, A. E., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., Kudva, Y. C., et al. (2012) · Diabetes · doi:10.2337/db11-1478 · Cited by 297 · see citing works

Cold-Inducible RNA-Binding Protein Modulates Circadian Gene Expression Posttranscriptionally

Morf, J., Rey, G., Schneider, K., Stratmann, M., Fujita, J., Naef, F., & Schibler, U. (2012) · Science · doi:10.1126/science.1217726 · Cited by 263 · see citing works

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

Fang, B., Everett, L. J., Jager, J., Briggs, E. R., Armour, S. M., Feng, D., Roy, A., Gerhart‐Hines, Z., Sun, Z., & Lazar, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.10.022 · Cited by 262 · see citing works

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

Gerhart‐Hines, Z., Feng, D., Emmett, M. J., Everett, L. J., Loro, E., Briggs, E. R., Bugge, A. K., Hou, C., Ferrara, C., Seale, P., et al. (2013) · Nature · doi:10.1038/nature12642 · Cited by 261 · see citing works

Anticipatory physiological regulation in feeding biology: Cephalic phase responses

Power, M. L., & Schulkin, J. (2008) · Appetite · doi:10.1016/j.appet.2007.10.006 · Cited by 258 · see citing works

Circadian Oscillations of Protein-Coding and Regulatory RNAs in a Highly Dynamic Mammalian Liver Epigenome

Vollmers, C., Schmitz, R. J., Nathanson, J. L., Yeo, G. W.-M., Ecker, J. R., & Panda, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.004 · Cited by 253 · see citing works

Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillatorsPreprint

Saini, C., Morf, J., Stratmann, M., Gos, P., & Schibler, U. (2012) · Genes & Development · doi:10.1101/gad.183251.111 · Cited by 248 · see citing works

Diurnal Variation in Glucose Tolerance and in Insulin Secretion in Man

Carroll, K. F., & Nestel, P. J. (1973) · Diabetes · doi:10.2337/diab.22.5.333 · Cited by 231 · see citing works

Bmal1 and β-Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced β-Cell Failure in Mice

Lee, J., Moulik, M., Fang, Z., Saha, P., Zou, F., Xu, Y., Nelson, D. L., Ma, K., Moore, D. D., & Yechoor, V. K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01421-12 · Cited by 224 · see citing works

Altered sleep regulation in leptin-deficient mice

Laposky, A. D., Shelton, J., Bass, J., Dugovic, C., Perrino, N., & Turek, F. W. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00304.2005 · Cited by 203 · see citing works

SCN Efferents to Peripheral Tissues: Implications for Biological Rhythms

Bartness, T. J., Song, C. K., & Demas, G. E. (2001) · Journal of Biological Rhythms · doi:10.1177/074873040101600302 · Cited by 197 · see citing works

The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

Hodge, B. A., Wen, Y., Riley, L. A., Zhang, X., England, J. H., Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0039-5 · Cited by 175 · see citing works

The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity

Coomans, C. P., van den Berg, S. A. A., Lucassen, E. A., Houben, T., Pronk, A. C. M., van der Spek, R. D., Kalsbeek, A., Biermasz, N. R., Willems van Dijk, K., Romijn, J. A., et al. (2013) · Diabetes · doi:10.2337/db12-0507 · Cited by 173 · see citing works

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

Mulder, H., Nagorny, C. L. F., Lyssenko, V., & Groop, L. (2009) · Diabetologia · doi:10.1007/s00125-009-1359-y · Cited by 169 · see citing works

Impairment of Peripheral Circadian Clocks Precedes Metabolic Abnormalities in ob/ob Mice

Ando, H., Kumazaki, M., Motosugi, Y., Ushijima, K., Maekawa, T., Ishikawa, E., & Fujimura, A. (2011) · Endocrinology · doi:10.1210/en.2010-1068 · Cited by 164 · see citing works

Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver

la Fleur, S. E., Kalsbeek, A., Wortel, J., & Buijs, R. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02423-9 · Cited by 160 · see citing works

Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity

Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013) · Cell · doi:10.1016/j.cell.2012.12.027 · Cited by 160 · see citing works

Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets

Peschke, E., & Peschke, D. (1998) · Diabetologia · doi:10.1007/s001250051034 · Cited by 150 · see citing works

Intrinsic muscle clock is necessary for musculoskeletal health

Schroder, E. A., Harfmann, B. D., Zhang, X., Srikuea, R., England, J. H., Hodge, B. A., Wen, Y., Riley, L. A., Yu, Q., Christie, A., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271436 · Cited by 145 · see citing works

Consequences of Exposure to Light at Night on the Pancreatic Islet Circadian Clock and Function in Rats

Qian, J., Block, G. D., Colwell, C. S., & Matveyenko, A. V. (2013) · Diabetes · doi:10.2337/db12-1543 · Cited by 138 · see citing works

Diurnal Variation of Oral Glucose Tolerance: a Possible Pointer to the Evolution of Diabetes Mellitus

Jarrett, R. J., & KEEN, H. (1969) · BMJ · doi:10.1136/bmj.2.5653.341 · Cited by 136 · see citing works

Sleep-wake regulation is altered in leptin-resistant ( <i>db/db</i> ) genetically obese and diabetic mice

Laposky, A. D., Bradley, M. A., Williams, D. L., Bass, J., & Turek, F. W. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00026.2008 · Cited by 135 · see citing works

Oscillations in Insulin Secretion During Constant Glucose Infusion in Normal Man: Relationship to Changes in Plasma Glucose*

Shapiro, E. T., TILLIL, H., Polonsky, K. S., Fang, V. S., Rubenstein, A. H., & Cauter, E. V. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-307 · Cited by 131 · see citing works

Circadian Secretion of the Intestinal Hormone GLP-1 by the Rodent L Cell

Gil‐Lozano, M., Mingomataj, E., Wu, W. K., Ridout, S. A., & Brubaker, P. L. (2014) · Diabetes · doi:10.2337/db13-1501 · Cited by 130 · see citing works

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

Lee, J., Kim, M.-S., Li, R., Liu, V. Y., Fu, L., Moore, D. D., Ma, K., & Yechoor, V. K. (2011) · Islets · doi:10.4161/isl.3.6.18157 · Cited by 124 · see citing works

Identification and functional characterization of melatonin Mel 1a receptors in pancreatic β cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling

Kemp, D. M., Ubeda, M., & Habener, J. F. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00064-3 · Cited by 122 · see citing works

Diet and cephalic phase insulin responses.

Powley, T., & Berthoud, H. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.5.991 · Cited by 119 · see citing works

Diurnal Variation in Glucose Tolerance

Bowen, A. J. (1967) · Archives of Internal Medicine · doi:10.1001/archinte.1967.00290210093007 · Cited by 117 · see citing works

Brain-Specific Rescue of Clock Reveals System-Driven Transcriptional Rhythms in Peripheral Tissue

Hughes, M. E., Hong, H., Chong, J. L., Indacochea, A. A., Lee, S. S., Han, M., Takahashi, J., & Hogenesch, J. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002835 · Cited by 116 · see citing works

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

Staiger, H., Machicao, F. E., Schäfer, S., Kirchhoff, K., Kantartzis, K., Guthoff, M., Silbernagel, G., Stefan, N., Häring, H., & Fritsche, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003962 · Cited by 116 · see citing works

Circadian Variation of the Blood Glucose, Plasma Insulin and Human Growth Hormone Levels in Response to an Oral Glucose Load in Normal Subjects

Aparicio, N. J., Puchulu, F., Gagliardino, J. J., Ruiz, M., Llorens, J. M. C., Ruiz, J., Lamas, A., & Miguel, R. D. (1974) · Diabetes · doi:10.2337/diab.23.2.132 · Cited by 112 · see citing works

Receptor (MT1) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS‐1

Peschke, E., Mühlbauer, E., Mußhoff, U., CSERNUS, V. J., Chankiewitz, E., & Peschke, D. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.02919.x · Cited by 109 · see citing works

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Pulimeno, P., Mannic, T., Sage, D., Giovannoni, L., Salmon, P., Lemeille, S., Giry-Laterrière, M., Unser, M. A., Bosco, D., Bauer, C., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2779-7 · Cited by 106 · see citing works

Altered β-Cell Distribution of pdx-1 and GLUT-2 After a Short-Term Challenge With a High-Fat Diet in C57BL/6J Mice

Reimer, M. K., & Åhrén, B. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s138 · Cited by 104 · see citing works

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

Boesgaard, T. W., Grarup, N., Jørgensen, T., Borch‐Johnsen, K., Hansen, T. F., & Pedersen, O. B. (2010) · Diabetologia · doi:10.1007/s00125-010-1753-5 · Cited by 99 · see citing works

Regulation of core clock genes in human islets

Stamenkovic, J., Olsson, A. H., Nagorny, C. L. F., Malmgren, S., Nitert, M. D., Ling, C., & Mulder, H. (2012) · Metabolism · doi:10.1016/j.metabol.2011.11.013 · Cited by 98 · see citing works

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 Are Associated with Glucose Metabolism in the Chinese

Hu, C., Zhang, R., Wang, C., Wang, J., Ma, X., Hou, X., Lu, J., Yu, W., Jiang, F., Bao, Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015542 · Cited by 96 · see citing works

Circadian Rhythms in the Zucker Obese Rat: Assessment and Intervention

Mistlberger, R. E., Lukman, H., & Nadeau, B. G. (1998) · Appetite · doi:10.1006/appe.1997.0134 · Cited by 91 · see citing works

A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells

Saini, C., Petrenko, V., Pulimeno, P., Giovannoni, L., Berney, T., Hebrok, M., Howald, C., Dermitzakis, E. T., & Dibner, C. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12616 · Cited by 91 · see citing works

Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription

Chaves, I., van der Horst, G. T. J., Schellevis, R. D., Nijman, R., Koerkamp, M. J. A. G., Holstege, F. C. P., Smidt, M. P., & Hoekman, M. F. M. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.018 · Cited by 89 · see citing works

Circadian redox oscillations and metabolism

Milev, N. B., & Reddy, A. B. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.05.012 · Cited by 84 · see citing works

Activation of melatonin signaling promotes β-cell survival and function

Costes, S., Boss, M., Thomas, A. P., & Matveyenko, A. V. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1293 · Cited by 84 · see citing works

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice

Rakshit, K., Hsu, T. W., & Matveyenko, A. V. (2016) · Diabetologia · doi:10.1007/s00125-015-3859-2 · Cited by 77 · see citing works

AFTERNOON GLUCOSE TOLERANCE TESTING: A KEY TO THE PATHOGENESIS, EARLY DIAGNOSIS AND PROGNOSIS OF DIABETOGENIC HYPERINSULINISM

Roberts, H. J. (1964) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1964.tb05730.x · Cited by 71 · see citing works

24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.

Sturis, J., Scheen, A. J., Leproult, R., Polonsky, K. S., & Cauter, E. V. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117817 · Cited by 69 · see citing works

Loss of<i>mPer2</i>increases plasma insulin levels by enhanced glucose‐stimulated insulin secretion and impaired insulin clearance in mice

Zhao, Y., Zhang, Y., Zhou, M., Wang, S., Hua, Z., & Zhang, J. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.034 · Cited by 57 · see citing works

Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications

de Azúa, I. R., Gautam, D., Guettier, J., & Wess, J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.10.004 · Cited by 56 · see citing works

Mechanism controlling sleep organization of the obese Zucker rats

Megirian, D., Dmochowski, J., & Farkas, G. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.1.253 · Cited by 37 · see citing works

Circadian regulation of cellular physiology

Peek, C. B., Ramsey, K. M., Levine, D. C., Marcheva, B., Perelis, M., & Bass, J. (2015) · Methods in Enzymology · doi:10.1016/bs.mie.2014.10.006 · Cited by 35 · see citing works

The Melatonin Agonist Ramelteon Induces Duration-Dependent Clock Gene Expression through cAMP Signaling in Pancreatic INS-1 β-Cells

Nishiyama, K., & Hirai, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102073 · Cited by 35 · see citing works

Chronobiological aspects of blood glucose regulation: a new scope for the study of diabetes mellitus.

Gagliardino, J. J., Hernandez, R. E., & Rebolledo, O. R. (1985) · PubMed · Cited by 19 · see citing works

Targeting Time in Metabolic Therapeutics

Bass, J. T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.011 · Cited by 10 · see citing works

Nerve growth factor induces light adaptive cellular and synaptic plasticity in the outer retina of fish

Haamedi, S. N., Karten, H. J., & Djamgoz, M. B. A. (2001) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010319)431:4 · Cited by 8 · see citing works

Mental health in elite athletes: International Olympic Committee consensus statement (2019)

Reardon, C. L., Hainline, B., Aron, C. M., Baron, D., Baum, A. L., Bindra, A., Budgett, R., Campriani, N., Castaldelli-Maia, J. M., Currie, A., et al. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-100715 · Cited by 1,277 · see citing works

Sleep, Health, and Society

Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720 · see citing works

Rethinking the clockwork: redox cycles and non-transcriptional control of circadian rhythms

Wu, L., & Reddy, A. B. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130169 · Cited by 20 · see citing works

Kernel mechanism of the cyanobacterial circadian clock is a relaxation oscillator

Ma, L., & Ranganathan, R. (2011) · doi:10.1109/cdc.2011.6161040 · Cited by 1 · see citing works

Molecular Connections Between Circadian Clocks and Aging

Welz, P.-S., & Benitah, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.036 · Cited by 87 · see citing works

Circadian clocks and cell division

Johnson, C. H. (2010) · Cell Cycle · doi:10.4161/cc.9.19.13205 · Cited by 98 · see citing works

Molecular analysis of mammalian circadian rhythms

Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works