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Electrospun silk biomaterial scaffolds for regenerative medicine

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Zhang, Xiaohui, Reagan, Michaela R., Kaplan, David L.·2009·Advanced Drug Delivery Reviews
DOI 10.1016/j.addr.2009.07.005
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Abstract

Electrospinning is a versatile technique that enables the development of nanofiber-based biomaterial scaffolds. Scaffolds can be generated that are useful for tissue engineering and regenerative medicine since they mimic the nanoscale properties of certain fibrous components of the native extracellular matrix in tissues. Silk is a natural protein with excellent biocompatibility, remarkable mechanical properties as well as tailorable degradability. Integrating these protein polymer advantages with electrospinning results in scaffolds with combined biochemical, topographical and mechanical cues with versatility for a range of biomaterial, cell and tissue studies and applications. This review covers research related to electrospinning of silk, including process parameters, post treatment of the spun fibers, functionalization of nanofibers, and the potential applications for these material systems in regenerative medicine. Research challenges and future trends are also discussed.

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Research works printed but not linked: 145

  1. R. Skalak, C.F. Fox (Eds.), Tissue Engineering, Alan R Liss, Inc., New York.
  2. Koh, 2004, Tissue engineering, stem cells, and cloning: opportunities for regenerative medicine, J. Am. Soc. Nephrol., 15, 1113, 10.1097/01.ASN.0000119683.59068.F0 · DOI
  3. Langer, 1993, Tissue engineering, Science, 260, 920, 10.1126/science.8493529 · DOI · Paper page
  4. Murugan, 2006, Nano-featured scaffolds for tissue engineering: a review of spinning methodologies, Tissue Eng., 12, 435, 10.1089/ten.2006.12.435 · DOI · Paper page
  5. Barnes, 2007, Nanofiber technology: designing the next generation of tissue engineering scaffolds, Adv. Drug Deliv. Rev., 59, 1413, 10.1016/j.addr.2007.04.022 · DOI · Paper page
  6. Kidoaki, 2005, Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques, Biomaterials, 26, 37, 10.1016/j.biomaterials.2004.01.063 · DOI · Paper page
  7. Murugan, 2007, Design strategies of tissue engineering scaffolds with controlled fiber orientation, Tissue Eng., 13, 1845, 10.1089/ten.2006.0078 · DOI · Paper page
  8. Liao, 2006, Biomimetic electrospun nanofibers for tissue regeneration, Biomed Mater., 1, R45, 10.1088/1748-6041/1/3/R01 · DOI · Paper page
  9. Rho, 2006, Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing, Biomatrials, 27, 1452, 10.1016/j.biomaterials.2005.08.004 · DOI · Paper page
  10. Laurencin, 1999, Tissue engineering: orthopedic applications, Annu. Rev. Biomed. Eng., 1, 19, 10.1146/annurev.bioeng.1.1.19 · DOI · Paper page
  11. Jayaraman, 2004, Recent advances in polymer nanofibers, J. Nanosci. Nanotechnol., 4, 52
  12. Ma, 2005, Potential of nanofiber matrix as tissue-engineering scaffolds, Tissue Eng., 11, 101, 10.1089/ten.2005.11.101 · DOI · Paper page
  13. Smith, 2004, Nano-fibrous scaffolds for tissue engineering, Colloids Surf. B Biointerfaces, 39, 125, 10.1016/j.colsurfb.2003.12.004 · DOI · Paper page
  14. Sill, 2008, Electrospinning: applications in drug delivery and tissue engineering, Biomaterials, 29, 1989, 10.1016/j.biomaterials.2008.01.011 · DOI · Paper page
  15. Zhang, 2008, In vitro evaluation of electrospun silk fibroin scaffolds for vascular cell growth, Biomaterials, 29, 2217, 10.1016/j.biomaterials.2008.01.022 · DOI · Paper page
  16. Vendrely, 2007, Biotechnological production of spider-silk proteins enables new applications, Macromol. Biosci., 7, 401, 10.1002/mabi.200600255 · DOI · Paper page
  17. Wang, 2008, In vivo degradation of three-dimensional silk fibroin scaffolds, Biomaterials, 29, 3415, 10.1016/j.biomaterials.2008.05.002 · DOI · Paper page
  18. Cunniff, 1994, Mechanical and thermal properties of dragline silk from the spider, Nephila clavipes, Polym. Adv. Technol., 5, 401, 10.1002/pat.1994.220050801 · DOI · Paper page
  19. Magoshi, 1977, Physical properties and structure of silk. V. Thermal behavior of silk fibroin in the random-coil conformation, J. Polym. Sci. Japan, 15, 1675
  20. Zeleny, 1914, The electrical discharge from liquid points and ahydrostatic method of measuring the electric intensity at their surfaces, J. Phy. Rev., 3, 69, 10.1103/PhysRev.3.69 · DOI · Paper page
  21. Formhals, 1934, U. S. Patent, 975, 504
  22. Formhals, 1939, U. S. Patent, 160, 962
  23. Formhals, 1940, U. S. Patent, 187, 306
  24. Formhals, 1943, U. S. Patent, 323, 025
  25. Formhals, 1944, U. S. Patent, 349, 950
  26. Baumgarten, 1971, Electrostatic spinning of acrylic microfibers, J. Colloid Interface Sci., 36, 71, 10.1016/0021-9797(71)90241-4 · DOI · Paper page
  27. Simons, 1966, U.S. Patent, 280, 229
  28. Taylor, 1969, Electrically driven jets, Proc. R. Soc. London, 313A, 453, 10.1098/rspa.1969.0205 · DOI · Paper page
  29. Annis, 1978, An elastomeric vascular prosthesis, Trans. Am. Soc. Artif. Intern. Organs, 24, 209
  30. Fisher, 1985, Long term in-vivo performance of an electrostatically-spun small bore arterial prosthesis: the contribution of mechanical compliance and anti-platelet therapy, Life Support Syst., 1, 462
  31. Huang, 2003, A review on polymer nanofibers by electrospinning and their applications in nanocomposites, Compos. Sci. Technol., 63, 2223, 10.1016/S0266-3538(03)00178-7 · DOI · Paper page
  32. Schreuder-Gibson, 2002, Protective textile based on electrospun nanofibers, J. Adv. Mater., 34, 44
  33. Tsaia, 2002, Different electrostatic methods for making electret filters, J. Electrostatic, 54, 333, 10.1016/S0304-3886(01)00160-7 · DOI · Paper page
  34. Peneker, 1996, Nanometer diameter fibers of polymer produced by electrospinning, Nanotechnology, 7, 216, 10.1088/0957-4484/7/3/009 · DOI · Paper page
  35. Megelski, 2002, Micro- and nanostructured surface morphology on electrospun polymer fibers, Macromolecules, 35, 8456, 10.1021/ma020444a · DOI · Paper page
  36. Nair, 2004, Development of novel tissue engineering scaffolds via electrospinning, Expert Opin. Biol. Ther., 4, 659, 10.1517/14712598.4.5.659 · DOI
  37. Hohman, 2001, Electrospinning and electrically forced jets I. Stability theory, Phys. Fluids, 13, 2201, 10.1063/1.1383791 · DOI
  38. Hohman, 2001, Electrospinning and electrically forced jets. II Applications, Phys. Fluids, 13, 2221, 10.1063/1.1384013 · DOI · Paper page
  39. Fang, 1997, DNA fibers by electrospinning, J. Macromol. Sci., Phys., B36, 169, 10.1080/00222349708220422 · DOI · Paper page
  40. Deitzel, 2001, The effect of processing variables on the morphology of electrospun nanofibers and textiles, Polymer, 42, 261, 10.1016/S0032-3861(00)00250-0 · DOI · Paper page
  41. Yarin, 2001, Bending instability in electrospinning nanofibers, J. Appl. Phys., 89, 3018, 10.1063/1.1333035 · DOI · Paper page
  42. Reneker, 2000, Bending instability of electrically charged liquid jets of polymer solutions in electrospinning, J. appl. Phys., 87, 4531, 10.1063/1.373532 · DOI · Paper page
  43. Doshi, 1995, Electrospinning process and applications of electrospun fibers, J. Electrostat., 35, 151, 10.1016/0304-3886(95)00041-8 · DOI · Paper page
  44. Warner, 1998, Nano fibers, Natl. Text, Cent. Annu. Rep., 83
  45. Shin, 2001, Electrospinning: a whipping fluid jet generates submicron polymer fibers, Appl. Phys. Lett., 78, 1149, 10.1063/1.1345798 · DOI · Paper page
  46. Ramakrishna, 2006, Electrospun nanofibers: solving global issues, Materials Today, 9, 40, 10.1016/S1369-7021(06)71389-X · DOI · Paper page
  47. Hayati, 1987, Investigation into the mechanism of electrohydrodynamic spraying of liquids, I. Effect of electric field the environment on pendant drops and factors affecting the formation of stable jets and atomization, J. Colloid Interf. Sci., 117, 205, 10.1016/0021-9797(87)90185-8 · DOI · Paper page
  48. Dietzel, 2001, The effect of processing variables on the morphology of electrospun nanofibers and textiles, Polymer, 42, 261, 10.1016/S0032-3861(00)00250-0 · DOI · Paper page
  49. Subbiah, 2005, Electrospinning of nanofibers, J. Appl. Polym. Sci., 96, 557, 10.1002/app.21481 · DOI · Paper page
  50. Kameoka, 2003, A scanning tip electrospinning source for deposition of oriented nanofibres, Nanotechnology, 14, 1124, 10.1088/0957-4484/14/10/310 · DOI
  51. Zong, 2002, Structure and process relationship of electrospun bioabsorbable nanofiber membranes, Polymer, 43, 4403, 10.1016/S0032-3861(02)00275-6 · DOI · Paper page
  52. Kim, 2005, Morphological characterization of electrospun nano-fibrous membranes of biodegradable poly(l-lactide) and poly(lactideco-glycolide), Macromol. Symp., 224, 145, 10.1002/masy.200550613 · DOI
  53. Deitzel, 2001, The effect of processing variables on the morphology of electrospun nanofibers and textiles, Polymer, 42, 261, 10.1016/S0032-3861(00)00250-0 · DOI · Paper page
  54. Son, 2004, The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly(ethylene oxide) fibers, Polymer, 45, 2959, 10.1016/j.polymer.2004.03.006 · DOI · Paper page
  55. Zhang, 2005, Study on morphology of electrospun poly(vinyl alcohol) mats, Eur. Polym. J., 41, 423, 10.1016/j.eurpolymj.2004.10.027 · DOI · Paper page
  56. Gupta, 2005, Electrospinning of linear homopolymers of poly(methyl methacrylate): exploring relationships between fiber formation, viscosity, molecular weight and concentration in a good solvent, Polymer, 46, 4799, 10.1016/j.polymer.2005.04.021 · DOI · Paper page
  57. Jarusuwannapoom, 2005, Effect of solvents on electro-spinnability of polystyrene solutions and morphological appearance of resulting electrospun polystyrene fibers, Eur. Polym. J., 41, 409, 10.1016/j.eurpolymj.2004.10.010 · DOI · Paper page
  58. Koski, 2004, Effect of molecular weight on fibrous PVA produced by electrospinning, Mater. Lett., 58, 493, 10.1016/S0167-577X(03)00532-9 · DOI · Paper page
  59. Lee, 2004, Role of molecular weight of atactic poly(vinyl alcohol) (PVA) in the structure and properties of PVA nanofabric prepared by electrospinning, J. Appl. Polym. Sci., 93, 1638, 10.1002/app.20602 · DOI · Paper page
  60. Ohgo, 2003, Preparation of non-woven nanofibers of Bombyx mori silk, Samia Cynthia ricini silk and recombinant hybrid silk with electrospinning method, Polymer, 44, 841, 10.1016/S0032-3861(02)00819-4 · DOI · Paper page
  61. Jeong, 2007, Effect of solvent on the characteristics of electrospun regenerated silk fibroin nanofibers, Key Eng. Mater., 342–343, 813, 10.4028/www.scientific.net/KEM.342-343.813 · doi:10.4028/www.scientific.net/kem.342-343.813
  62. Wang, 2006, Structure of silk fibroin fibers made by an electrospun process from a silk fibroin aqueous solution, J. Appl. Polym. Sci., 101, 961, 10.1002/app.24024 · doi:10.1002/app.24024
  63. Wang, 2005, Electrospun ultra-fine silk fibroin fiber from aqueous solutions, J. Mater. Sci., 40, 5359, 10.1007/s10853-005-4332-2 · DOI
  64. Jin, 2002, Electrospinning Bombyx mori silk with poly(ethylene oxide), Biomacromolecules, 3, 1233, 10.1021/bm025581u · DOI · Paper page
  65. Zhu, 2007, Morphology and structure of electrospun mats from regenerated silk fibroin aqueous solutions with adjusting pH, Int. J. Biol. Macromol., 41, 469, 10.1016/j.ijbiomac.2007.06.006 · DOI
  66. Zhu, 2008, Electorspinning and rheology of regenerated Bombyx mori silk fibroin aqueous solutions: the effects of pH and concentration, Polymer, 49, 2880, 10.1016/j.polymer.2008.04.049 · doi:10.1016/j.polymer.2008.04.049
  67. Katti, 2004, Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters, J. Biomed. Mater. Res., 70b, 286, 10.1002/jbm.b.30041 · DOI · Paper page
  68. Lu, 2006, Computer simulation of electrospinning. Part I. Effect of solvent in electrospinning, Polymer, 47, 915, 10.1016/j.polymer.2005.11.090 · doi:10.1016/j.polymer.2005.11.090
  69. Sukigara, 2003, Regeneration of Bombyx mori silk by electrospinning—part 1: processing parameters and geometric properties, Polymer, 44, 5721, 10.1016/S0032-3861(03)00532-9 · DOI · Paper page
  70. Meechaisue, 2007, Preparation of electrospun silk fibroin fiber mats as bone scaffolds: a preliminary study, Biomed. Mater., 2, 181, 10.1088/1748-6041/2/3/003 · DOI
  71. Choi, 2004, Effect of organosoluble salts on the nanofibrous structure of electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate), Int. J. Biol. Macromol., 34, 249, 10.1016/j.ijbiomac.2004.06.001 · DOI
  72. Reneker, 1996, Nanometre diameter fibres of polymer, produced by electrospinning, Nanotechnology, 7, 216, 10.1088/0957-4484/7/3/009 · DOI · Paper page
  73. Ki, 2005, Characterization of gelatin nanofiber prepared from gelatin–formic acid solution, Polymer, 46, 5094, 10.1016/j.polymer.2005.04.040 · DOI · Paper page
  74. Lee, 2004, Role of molecular weight of atactic poly(vinyl alcohol) (PVA) in the structure and properties of PVA nanofabric prepared by electrospinning, J. Appl. Polym. Sci., 93, 1638, 10.1002/app.20602 · DOI · Paper page
  75. Sukigara, 2004, Regeneration of Bombyx mori silk by electrospinning. Part 2. Process optimization and empirical modeling using response surface methodology, Polymer, 45, 3701, 10.1016/j.polymer.2004.03.059 · DOI
  76. Ayutsede, 2005, Regeneration of Bombyx mori silk by electrospinning. Part 3: characterization of electrospun nonwoven mat, Polymer, 46, 1625, 10.1016/j.polymer.2004.11.029 · DOI · Paper page
  77. Peng, 2004, Investigation on the conformation transition of regenerated silk fibroin films under thermal treatment by two-dimensional (2D) correlation FT-IR spectroscopy, Acta Chim. Sin., 62, 2127
  78. Wilson, 2000, Conformational transitions in model silk peptides, Biophys. J., 78, 2690, 10.1016/S0006-3495(00)76813-5 · DOI · Paper page
  79. Ishida, 1990, Solvent- and mechanical-treatment-induced conformational transition of silk fibroins studies by high-resolution solid-state carbon-13 NMR spectroscopy, Macromolecules, 23, 88, 10.1021/ma00203a017 · DOI · Paper page
  80. Tsukada, 1994, Structural changes of silk fibroin membranes induced by immersion in methanol aqueous solutions, J. Polym. Sci., Part B: Polym. Phys., 32, 961, 10.1002/polb.1994.090320519 · DOI · Paper page
  81. Kim, 2003, Silk fibroin nanofiber. Electrospinning, properties, and structure, Polym. J., 35, 185, 10.1295/polymj.35.185 · DOI · Paper page
  82. Jin, 2005, Water-stable silk films with reduced-sheet content, Adv. Funct. Mater., 15, 1241, 10.1002/adfm.200400405 · DOI · Paper page
  83. Asakura, 1992, 1H pulsed NMR study of Bombyx mori silk fibroin: dynamics of fibroin and of absorbed water, J. Polym. Sci., Part B: Polym. Phys., 30, 693, 10.1002/polb.1992.090300706 · doi:10.1002/polb.1992.090300706
  84. Min, 2006, Regenerated silk fibroin nanofibers: water vapor-induced structural changes and their effects on the behavior of normal human cells, Macromol. Biosci., 6, 285, 10.1002/mabi.200500246 · DOI
  85. Jeong, 2006, Time-resolved structural investigation of regenerated silk fibroin nanofibers treated with solvent vapor, Int. J. Biol. Macromol., 38, 140, 10.1016/j.ijbiomac.2006.02.009 · DOI
  86. Gupta, 2003, Some investigations on the fiber formation by utilizing a side-by-side bicomponent electrospinning approach, Polymer, 44, 6353, 10.1016/S0032-3861(03)00616-5 · DOI · Paper page
  87. Park, 2004, Biomimetic nanofibrous scaffolds: preparation and characterization of chitin/silk fibroin blend nanofibers, Polymer, 45, 7151, 10.1016/j.polymer.2004.08.045 · DOI · Paper page
  88. Yoo, 2008, Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes, Int. J. Biol. Macromol., 42, 324, 10.1016/j.ijbiomac.2007.12.004 · DOI
  89. Yeo, 2008, Collagen-based biomimetic nanofibrous scaffolds: preparation and characterization of collagen/silk fibroin bicomponent nanofibrous structures, Biomacromolecules, 9, 1106, 10.1021/bm700875a · DOI
  90. Wang, 2006, Production of submicron diameter silk fibers under benign processing conditions by two-fluid electrospinning, Macromolecules, 39, 1102, 10.1021/ma0517749 · DOI
  91. Ki, 2008, Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration, Biotechnol. Lett., 30, 405, 10.1007/s10529-007-9581-5 · DOI
  92. Zhang, 2005, Characterization of the surface biocompatibility of the electrospun PCL-collagen nanofibers using fibroblast, Biomacromolecules, 6, 2583, 10.1021/bm050314k · DOI · Paper page
  93. Venugopa, 2007, Interaction of cell and nanofiber scaffolds in tissue engineering, J. Biomed. Mater. Res., 84B, 34, 10.1002/jbm.b.30841 · DOI · Paper page
  94. Lee, 2005, Application of electrospun silk fibroin nanofibers as an immobilization support of enzyme, Fibers Polym., 6, 181, 10.1007/BF02875641 · DOI
  95. Li, 2006, Electrospun silk-BMP-2 scaffolds for bone tissue engineering, Biomaterials, 27, 3115, 10.1016/j.biomaterials.2006.01.022 · DOI · Paper page
  96. Kang, 2007, Silver nanoparticles incorporated electrospun silk fibers, J. Nanosci. Nanotechnol., 7, 3888, 10.1166/jnn.2007.056 · doi:10.1166/jnn.2007.056
  97. Kang, 2007, Electrically conducting electrospun silk membranes fabricated by adsorption of carbon nanotubes, Colloid. Polym. Sci., 285, 1163, 10.1007/s00396-007-1668-y · doi:10.1007/s00396-007-1668-y
  98. S.H. Saw, K. Wang, T. Yong, S. Ramakrishna, Polymeric Nanofibers for Tissue Engineering, in: C.S.S.R. Kumar (Ed.), Nanotechnologies for the Life Sciences, vol. 9, Wiley-VCH, Weinheim, Germany, 2007, pp. 66–134. · DOI
  99. Li, 2002, Electrospun nanofibrous structure: a novel scaffold for tissue engineering, J. Biomed. Mater. Res., 60, 613, 10.1002/jbm.10167 · DOI · Paper page
  100. Bhattarai, 2002, Novel biodegradable electrospun membrane: scaffold for tissue engineering, Biomaterials, 25, 2595, 10.1016/j.biomaterials.2003.09.043 · DOI · Paper page
  101. Xu, 2004, Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering, Biomaterials, 25, 877, 10.1016/S0142-9612(03)00593-3 · DOI · Paper page
  102. Zhang, 2005, Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds, J. Biomed. Mater. Res. Part B: App. Biomaterials, 72, 156, 10.1002/jbm.b.30128 · DOI · Paper page
  103. Boland, 2004, Electrospinning collagen and elastin: preliminary vascular tissue engineering, Front. Biosci., 9, 1422, 10.2741/1313 · DOI · Paper page
  104. Matthews, 2003, Electrospinning of collagen type II: a feasibility study, J. Bioact. Compat. Polym., 18, 125, 10.1177/0883911503018002003 · DOI · Paper page
  105. Huang, 2001, Engineered collagen-PEO nanofibers and fabrics, J. Biomater. Sci., Polym. Ed., 12, 979, 10.1163/156856201753252516 · DOI · Paper page
  106. Yannas, 1980, Design of an artificial skin. II. Control of chemical composition, J. Biomed. Mater. Res., 14, 107, 10.1002/jbm.820140203 · DOI · Paper page
  107. Almany, 2005, Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures, Biomaterials, 26, 2467, 10.1016/j.biomaterials.2004.06.047 · DOI · Paper page
  108. Altman, 2002, Silk matrix for tissue engineered anterior cruciate ligaments, Biomaterials, 23, 4131, 10.1016/S0142-9612(02)00156-4 · DOI · Paper page
  109. Horan, 2005, In vitro degradation of silk fibroin, Biomaterials, 26, 3385, 10.1016/j.biomaterials.2004.09.020 · DOI · Paper page
  110. Steinthorsson, 1999, Clinical and biological relevance of vein cuff anastomosis, Acta Chir. Belg., 99, 282, 10.1080/00015458.1999.12098497 · DOI
  111. Yokoyama, 1978, Aorta–coronary artery revascularization with an expanded polytetrafluoroethylene vascular graft. A preliminary report, J. Thorac. Cardiovasc. Surg., 76, 552, 10.1016/S0022-5223(19)41087-8 · doi:10.1016/s0022-5223(19)41087-8
  112. Sapsford, 1981, Early and late patency of expanded polytetrafluoroethylene vascular grafts in aorta–coronary bypass, J. Thorac. Cardiovasc. Surg., 81, 860, 10.1016/S0022-5223(19)39420-6 · DOI
  113. Veith, 1986, Six year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions, J. Vasc. Surg., 3, 104, 10.1067/mva.1986.avs0030104 · doi:10.1067/mva.1986.avs0030104
  114. Bondara, 2008, Functionality of endothelial cells on silk fibroin nets: comparative study of micro- and nanometric fibre size, Biomaterials, 29, 561, 10.1016/j.biomaterials.2007.10.002 · DOI
  115. Soffer, 2008, Silk-based electrospun tubular scaffolds for tissue-engineered vascular grafts, J. Biomater. Sci. Polymer Edn., 19, 653, 10.1163/156856208784089607 · DOI · Paper page
  116. Orban, 2004, Crosslinking of collagen gels by transglutaminase, J. Biomed. Mater. Res. A, 68, 756, 10.1002/jbm.a.20110 · DOI · Paper page
  117. Nishibe, 2007, Optimal prosthetic graft design for small diameter vascular grafts, Vascular., 15, 356, 10.2310/6670.2007.00053 · DOI
  118. Rouabhia, 1997, Skin substitute production by tissue engineering, Landes Bioscience
  119. Min, 2004, Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro, Biomaterials, 25, 1289, 10.1016/j.biomaterials.2003.08.045 · DOI · Paper page
  120. Min, 2004, Formation of silk fibroin matrices with different texture and its cellular response to normal human keratinocytes, Int. J. Biol. Macromol., 34, 281, 10.1016/j.ijbiomac.2004.08.004 · DOI · Paper page
  121. Min, 2006, Regenerated silk fibroin nanofibers: water vapor-induced structural changes and their effects on the behavior of normal human cells, Macromol. Biosci., 6, 285, 10.1002/mabi.200500246 · DOI
  122. Okamoto, 2002, Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium, Biomaterials, 23, 1975, 10.1016/S0142-9612(01)00324-6 · DOI
  123. Park, 2006, Biomimetic nanofibrous scaffolds: preparation and characterization of chitin/silk fibroin blend nanofibers, Int. J. Biol. Macromol., 38, 165, 10.1016/j.ijbiomac.2006.03.003 · DOI
  124. Yoo, 2008, Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes, Int. J. Biol. Macromol., 42, 324, 10.1016/j.ijbiomac.2007.12.004 · DOI
  125. Griffith, 2002, Tissue engineering—current challenges and expanding opportunities, Science, 295, 1009, 10.1126/science.1069210 · DOI · Paper page
  126. Liao, 2006, Biomimetic electrospun nanofibers for tissue regeneration, Biomed. Mater., 1, R45, 10.1088/1748-6041/1/3/R01 · DOI · Paper page
  127. Jin, 2004, Human bone marrow stromal cell responses on electrospun silk fibroin mats, Biomaterials, 25, 1039, 10.1016/S0142-9612(03)00609-4 · DOI · Paper page
  128. Kim, 2005, Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration, J. Biotechnol., 120, 327, 10.1016/j.jbiotec.2005.06.033 · DOI · Paper page
  129. Li, 2005, A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells, Biomaterials, 26, 599, 10.1016/j.biomaterials.2004.03.005 · DOI · Paper page
  130. Baek, 2008, Enhanced chondrogenic responses of articular chondrocytes onto porous silk fibroin scaffolds treated with microwave-induced argon plasma, Surf. Coat. Technol., 202, 5794, 10.1016/j.surfcoat.2008.06.154 · DOI
  131. Yang, 2005, Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering, Biomaterials, 26, 2603, 10.1016/j.biomaterials.2004.06.051 · DOI · Paper page
  132. Eichhorn, 2005, Statistical geometry of pores and statistics of porous nanofibrous assemblies, J R. Soc. Interface, 22, 309, 10.1098/rsif.2005.0039 · DOI · Paper page
  133. Stitzel, 2006, Controlled fabrication of a biological vascular substitute, Biomaterials, 27, 1088, 10.1016/j.biomaterials.2005.07.048 · DOI · Paper page
  134. Ma, 2005, Grafting of gelatin on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell orientation, Tissue Eng., 11, 1149, 10.1089/ten.2005.11.1149 · DOI · Paper page
  135. Schnell, 2007, Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-epsilon-caprolactone and a collagen/poly-epsilon-caprolactone blend, Biomaterials, 28, 3012, 10.1016/j.biomaterials.2007.03.009 · DOI · Paper page
  136. Inoguchi, 2007, The effect of gradually graded shear stress on the morphological integrity of a huvec-seeded compliant small-diameter vascular graft, Biomaterials, 28, 486, 10.1016/j.biomaterials.2006.09.020 · DOI
  137. Zhong, 2006, An aligned nanofibrous collagen scaffold by electrospinning and its effects on in vitro fibroblast culture, J. Biomed. Mater. Res., 79A, 456, 10.1002/jbm.a.30870 · DOI · Paper page
  138. Song, 2007, Production of electrospun gelatin nanofiber by water-based co-solvent approach, J. Mater. Sci.: Mater. Med., 19, 95, 10.1007/s10856-007-3169-4 · DOI
  139. Um, 2004, Electro-spinning and electro-blowing of hyaluronic acid, Biomacromolecules, 5, 1428, 10.1021/bm034539b · DOI · Paper page
  140. Ayres, 2006, Modulation of anisotropy in electrospun tissue-engineering scaffolds: analysis of fiber alignment by the fast Fourier transform, Biomaterials, 27, 5524, 10.1016/j.biomaterials.2006.06.014 · DOI · Paper page
  141. McManus, 2007, Electrospun fibrinogen: feasibility as a tissue engineering scaffold in a rat cell culture model, J. Biomed. Mater. Res., 81A, 299, 10.1002/jbm.a.30989 · DOI
  142. Zarkoob, 2004, Structure and morphology of electrospun silk nanofibers, Polymer, 45, 3973, 10.1016/j.polymer.2003.10.102 · DOI · Paper page
  143. Wong Po Foo, 2006, Novel nanocomposites from spider silk–silica fusion (chimeric) proteins, Proc. Natl. Acad. Sci. U.S.A., 103, 9428, 10.1073/pnas.0601096103 · DOI
  144. Silva, 2008, Genipin-modified silk-fibroin nanometric nets, Macromol. Biosci., 8, 766, 10.1002/mabi.200700300 · DOI
  145. Zhou, 2008, Preparation and characterization of a novel electrospun spider silk fibroin/poly(d,l-lactide) composite fiber, J. Phys. Chem. B, 36, 11209, 10.1021/jp800913k · doi:10.1021/jp800913k

Cited by

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Metadata

Authors
Zhang, X., Reagan, M. R., & Kaplan, D. L.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2009-10
Volume
61
Issue
12
Pages
988-1006
ISSN
0169-409X (ISSN-L)
DOI
10.1016/j.addr.2009.07.005
OpenAlex
W2027339181
Cited by
432
References
3
FWCI
0.90
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Electrospun silk biomaterial scaffolds for regenerative medicine. https://app.cochat.ai/papers/10.1016/j.addr.2009.07.005
The paper
Zhang, X., Reagan, M. R., & Kaplan, D. L. (2009). Electrospun silk biomaterial scaffolds for regenerative medicine. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2009.07.005

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.