Co-delivery of chemotherapeutics and proteins for synergistic therapy

He, Chaoliang; Tang, Zhaohui; Tian, Huayu; Chen, Xuesi

doi:10.1016/j.addr.2015.10.021

Cited by 231Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsRNA Interference and Gene Delivery

Co-delivery of chemotherapeutics and proteins for synergistic therapy

He, Chaoliang, Tang, Zhaohui, Tian, Huayu, Chen, Xuesi·2016·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2015.10.021

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Abstract

Combination therapy with chemotherapeutics and protein therapeutics, typically cytokines and antibodies, has been a type of crucial approaches for synergistic cancer treatment. However, conventional approaches by simultaneous administration of free chemotherapeutic drugs and proteins lead to limitations for further optimizing the synergistic effects, due to the distinct in vivo pharmacokinetics and distribution of small drugs and proteins, insufficient tumor selectivity and tumor accumulation, unpredictable drug/protein ratios at tumor sites, short half-lives, and serious systemic adverse effects. Consequently, to obtain optimal synergistic anti-tumor efficacy, considerable efforts have been devoted to develop the co-delivery systems for co-incorporating chemotherapeutics and proteins into a single carrier system and subsequently releasing the dual or multiple payloads at desired target sites in a more controllable manner. The co-delivery systems result in markedly enhanced blood stability and in vivo half-lives of the small drugs and proteins, elevated tumor accumulation, as well as the capability of delivering the multiple agents to the same target sites with rational drug/protein ratios, which may facilitate maximizing the synergistic effects and therefore lead to optimal antitumor efficacy. This review emphasizes the recent advances in the co-delivery systems for chemotherapeutics and proteins, typically cytokines and antibodies, for systemic or localized synergistic cancer treatment. Moreover, the proposed mechanisms responsible for the synergy of chemotherapeutic drugs and proteins are discussed.

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Smart nanoparticles for ratiometric delivery of synergistic drug combinations have many potential benefits in clinical applications for cancer treatment.
“There are many potential benefits of using smart nanoparticles for ratio-metric delivery of synergistic drug combination for cancer treatment in clinical applications.332,333”
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Authors: He, C., Tang, Z., Tian, H., & Chen, X.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Chen, Xuesi
ORCID: He, Chaoliang
Tang, Zhaohui
Tian, Huayu
Chen, Xuesi
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2016-03
Volume: 98
Pages: 64-76
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2015.10.021
OpenAlex: W2165372444
Cited by: 231
References: 137
Citations by year: 2026: 15 · 2025: 21 · 2024: 20 · 2023: 20 · 2022: 28 · 2021: 35 · 2020: 21 · 2019: 23 · 2018: 23 · 2017: 14 · 2016: 11
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (21574127, 51233004, 51390484, 51321062)
Ministry of Science and Technology of China (2011DFR51090)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: co-delivery system, combination cancer therapy, synergistic drug delivery, chemotherapeutics, therapeutic proteins, cytokines, immunoglobulins, tumor accumulation, tumor selectivity, pharmacokinetics
MeSH terms: Animals, Antineoplastic Agents, Drug Combinations, Drug Synergism, Humans, Neoplasms, Proteins, Drug Delivery Systems

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