Quality of life in patients with atrial fibrillation: a systematic review
Abstract
The impact of atrial fibrillation (AF) on patients' quality of life (QoL) has yet to be fully elucidated in a systematic manner. This article examines QoL in "general" patients with AF as well as the effects that rate and/or rhythm-control interventions have on QoL. Patients with AF have significantly poorer QoL compared with healthy controls, the general population, and other patients with coronary heart disease. Studies examining rate or rhythm-control strategies alone demonstrate improved QoL after intervention. Three of the four large randomized control trials (STAF, PIAF, RACE) comparing rate versus rhythm control demonstrated a greater improvement in QoL in patients receiving rate control. However, the AFFIRM trial revealed a similar improvement in QoL for both rate and rhythm-control groups. The data, although frequently compromised by various methodologic weaknesses, suggest that patients with AF have impaired QoL, and that QoL can be significantly improved through rate or rhythm-control strategies.
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Patients with AF have significantly poorer quality of life than healthy controls.
“Patients with AF have significantly poorer quality of life than healthy controls, experiencing a variety of symptoms including lethargy, palpitations, dyspnoea, chest tightness, sleeping difficulties, and psychosocial distress.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [32]
Patients with AF experience symptoms including lethargy, palpitations, dyspnoea, chest tightness, sleeping difficulties, and psychosocial distress.
“Patients with AF have significantly poorer quality of life than healthy controls, experiencing a variety of symptoms including lethargy, palpitations, dyspnoea, chest tightness, sleeping difficulties, and psychosocial distress.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [32]
There are limited data to compare the benefit of different treatments on quality of life.
“Improved quality of life has been noted with both pharmacological and interventional therapies, [181][182][183][184][185] but there are limited data to compare the benefit of different treatments.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [32]
Lack of AF-related knowledge in patients is common, even in those who have received verbal and written information.
“However, lack of AFrelated knowledge in patients is common, even in those who have received verbal and written information, 32,1011,1012”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [32]
In adjusted models, atrial fibrillation is associated with increased morbidity, especially stroke and heart failure, as well as increased mortality.
“In adjusted models, AF is associated with increased morbidity, especially stroke and heart failure, as well as increased mortality.2–5”
From Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study (2014) · cites this paper as [4]
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- Authors
- Thrall, G., Lane, D., Carroll, D., & Lip, G. Y. H.
- Affiliations
- Birmingham City Hospital (GB)
- Corresponding author
- Lip, Gregory Y.H.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 119
- Issue
- 5
- Pages
- 448.e1-448.e19
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W1973633212
- Cited by
- 697
- References
- 62
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 44 · 2023: 37 · 2022: 45 · 2021: 49 · 2020: 64 · 2019: 40 · 2018: 41 · 2017: 46 · 2016: 36 · 2015: 40 · 2014: 35 · 2013: 37 · 2012: 26
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- atrial fibrillation, quality of life, rate control, rhythm control, anticoagulation, AFFIRM trial, coronary artery disease
- MeSH terms
- Anti-Arrhythmia Agents, Atrial Fibrillation, Health Status, Humans, Quality of Life, Randomized Controlled Trials as Topic, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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