Cited by 295Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

The DOI matches its Crossref record; 270 of the 272 references it cites were found in a registry or an index.

Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy

Open access

Buford, Thomas W., Anton, Stephen D., Judge, Andrew R., Marzetti, Emanuele, Wohlgemuth, Stephanie E., Carter, Christy S., Leeuwenburgh, Christiaan, Pahor, Marco, Manini, Todd M.·2010·Ageing Research Reviews

DOI 10.1016/j.arr.2010.04.004PMC PMC3788572

Open this paper in CoChat — free account

Abstract

Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population ages. Certain conditions have the strong potential to coincide with sarcopenia to accelerate the progression of muscle atrophy in older adults. Among these conditions are co-morbid diseases common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease. Furthermore, behaviors such as poor nutrition and physical inactivity are well-known to contribute to sarcopenia development. However, we argue that these behaviors are not inherent to the development of sarcopenia but rather accelerate its progression. In the present review, we discuss how these factors affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy. In addition, we describe gaps in the literature concerning the role of these factors in accelerating sarcopenia progression. Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.arr.2010.04.004

Cites

270 of 270 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600
Retracted
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection
Palella, F. J., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., & Holmberg, S. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381301 · Cited by 9,393
Cancer Statistics, 2007
Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Chronic Health Conditions in Adult Survivors of Childhood Cancer
Oeffinger, K. C., Mertens, A. C., Sklar, C. A., Kawashima, T. I., Hudson, M. M., Meadows, A. T., Friedman, D. L., Marina, N. M., Hobbie, W. L., Kadan‐Lottick, N. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmsa060185 · Cited by 3,597
Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · cited 1×
“These changes contribute to declines in functional capacity of the muscle that contribute to functional disability (Evans, 1997; Janssen et al., 2002; Muhlberg and Sieber, 2004; Rolland et al., 2008; Visser et al., 2005).”
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.-P., & Colette, C. (2006) · JAMA · doi:10.1001/jama.295.14.1681 · Cited by 2,444

Flagged first, then by citations

Show all 272 references

2 of the 272 references couldn’t be matched to a known paper.

Sorted by citations

Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases
Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70034-8 · Cited by 1,102
The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size
Nilwik, R., Snijders, T., Leenders, M., Groen, B. B. L., van Kranenburg, J., Verdijk, L. B., & van Loon, L. J. C. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.012 · Cited by 776
Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting
Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2017) · Obesity · doi:10.1002/oby.22065 · Cited by 822
Self-citation
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627
Self-citation
Hypertension and aging
Buford, T. W. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.007 · Cited by 622
Self-citation
Sarcopenia: Definition, Epidemiology, and Pathophysiology
Kim, T. N., & Choi, K. M. (2013) · Journal of Bone Metabolism · doi:10.11005/jbm.2013.20.1.1 · Cited by 523
Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis
Šteffl, M., Bohannon, R. W., Sontáková, L., Tufano, J. J., Shiells, K. R., & Holmerová, I. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s132940 · Cited by 510
Cellular senescence: a link between cancer and age-related degenerative disease?
Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.001 · Cited by 421
Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia
Wall, B. T., Dirks, M. L., & van Loon, L. J. C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.07.003 · Cited by 400
Atrogin-1, MuRF-1, and sarcopenia
Gumucio, J. P., & Mendias, C. L. (2012) · Endocrine · doi:10.1007/s12020-012-9751-7 · Cited by 378
Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention
Panza, F., Lozupone, M., Solfrizzi, V., Sardone, R., Dibello, V., Lena, L. D., D’Urso, F., Stallone, R., Petruzzi, M., Giannelli, G., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170963 · Cited by 355
Sarcopenia in the elderly: Diagnosis, physiopathology and treatment
Malafarina, V., Úriz‐Otano, F., Iniesta, R. R., & Gil‐Guerrero, L. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.11.012 · Cited by 298
Successful aging: Advancing the science of physical independence in older adults
Anton, S. D., Woods, A. J., Ashizawa, T., Barb, D., Buford, T. W., Carter, C. S., Clark, D. J., Cohen, R. A., Corbett, D. B., Cruz-Almeida, Y., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.005 · Cited by 292
Self-citation
Loss of motor function in preclinical Alzheimer's disease
Buchman, A. S., & Bennett, D. A. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.57 · Cited by 311
Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort
Bijlsma, A. Y., Meskers, C. G. M., Ling, C. H. Y., Narici, M. V., Kurrle, S. E., Cameron, I. D., Westendorp, R. G. J., & Maier, A. B. (2012) · AGE · doi:10.1007/s11357-012-9384-z · Cited by 275
Sarcopenia and menopause: The role of estradiol
Geraci, A., Calvani, R., Ferri, E., Marzetti, E., Arosio, B., & Cesari, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.682012 · Cited by 238
Self-citation
The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease
Kim, T. N., & Choi, K. M. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25077 · Cited by 225
Sarcopenia During Androgen-Deprivation Therapy for Prostate Cancer
Smith, M. R., Fred Saad, C., Egerdie, B., SIEBER, P. R., Tammela, T. L. J., Ke, C., Leder, B. Z., & Goessl, C. D. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.8850 · Cited by 202
Association between Sarcopenia and Metabolic Syndrome in Middle-Aged and Older Non-Obese Adults: A Systematic Review and Meta-Analysis
Zhang, H., Lin, S., Gao, T., Zhong, F., Cai, J., Sun, Y., & Ma, A. (2018) · Nutrients · doi:10.3390/nu10030364 · Cited by 193
Motor dysfunction in diabetes
Andersen, H. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2257 · Cited by 198
Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle
Birbrair, A., Zhang, T., Wang, Z.-M., Messi, M. L., Mintz, A., & Delbono, O. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00171.2013 · Cited by 180
Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging
Solfrizzi, V., Scafato, E., Seripa, D., Lozupone, M., Imbimbo, B. P., D'Amato, A., Tortelli, R., Schilardi, A., Galluzzo, L., Gandin, C., et al. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.10.012 · Cited by 176
CURRENT NUTRITIONAL RECOMMENDATIONS AND NOVEL DIETARY STRATEGIES TO MANAGE SARCOPENIA
Calvani, R., Miccheli, A., Landi, F., Bossola, M., Cesari, M., Leeuwenburgh, C., Sieber, C. C., Bernabei, R., & Marzetti, E. (2013) · The Journal of Frailty & Aging · doi:10.14283/jfa.2013.7 · Cited by 164
Self-citation
Time‐restricted eating and concurrent exercise training reduces fat mass and increases lean mass in overweight and obese adults
Kotarsky, C. J., Johnson, N., Mahoney, S. J., Mitchell, S. L., Schimek, R. L., Stastny, S., & Hackney, K. J. (2021) · Physiological Reports · doi:10.14814/phy2.14868 · Cited by 155
Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting
Jo, E., Lee, S.-R., Park, B., & Kim, J. (2012) · Aging Clinical and Experimental Research · doi:10.1007/bf03654825 · Cited by 150
Cognitive Frailty: A Systematic Review of Epidemiological and Neurobiological Evidence of an Age-Related Clinical Condition
Panza, F., Solfrizzi, V., Barulli, M. R., Santamato, A., Seripa, D., Pilotto, A., & Logroscino, G. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1637 · Cited by 148
Exercise, Amino Acids, and Aging in the Control of Human Muscle Protein Synthesis
Walker, D. K., Dickinson, J. M., Timmerman, K. L., Drummond, M. J., Reidy, P. T., Fry, C. S., Gundermann, D. M., & Rasmussen, B. B. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318223b037 · Cited by 143
Sarcopenia Is Associated With Lower Skeletal Muscle Capillarization and Exercise Capacity in Older Adults
Prior, S. J., Ryan, A. S., Blumenthal, J. B., Watson, J. M., Katzel, L. I., & Goldberg, A. P. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw017 · Cited by 146
Reduced stress and improved physical functional ability in elderly with mental health problems following a horticultural therapy program
Han, A.-R., Park, S.-A., & Ahn, B.-E. (2018) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2018.03.011 · Cited by 133
The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies
Qiao, Y.-S., Chai, Y.-H., Gong, H.-J., Zhuldyz, Z., Stehouwer, C. D. A., Zhou, J.-B., & Simó, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.782391 · Cited by 132
Lifestyle and Sarcopenia – Etiology, Prevention and Treatment
Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z. (2012) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10091 · Cited by 131
Frailty phenotype and chronic kidney disease: a review of the literature
Musso, C. G., Jáuregui, J. R., & Núñez, J. F. M. (2015) · International Urology and Nephrology · doi:10.1007/s11255-015-1112-z · Cited by 126
Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan
Regmi, S. G., Rolland, S. G. M., & Conradt, B. (2014) · Aging · doi:10.18632/aging.100639 · Cited by 126
Functional impact of sarcopenia in respiratory muscles
Elliott, J. E., Greising, S. M., Mantilla, C. B., & Sieck, G. C. (2015) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2015.10.001 · Cited by 124
Targeting Cognitive Frailty: Clinical and Neurobiological Roadmap for a Single Complex Phenotype
Panza, F., Seripa, D., Solfrizzi, V., Tortelli, R., Greco, A., Pilotto, A., & Logroscino, G. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150358 · Cited by 120
The Effect of Physiological Stimuli on Sarcopenia; Impact of Notch and Wnt Signaling on Impaired Aged Skeletal Muscle Repair
Arthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 131
Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats
Bársony, J., Manigrasso, M. B., Xu, Q., Tam, H., & Verbalis, J. G. (2012) · AGE · doi:10.1007/s11357-011-9347-9 · Cited by 116
The musculoskeletal syndrome of menopause
Wright, V. J., Schwartzman, J. D., Itinoche, R., & Wittstein, J. R. (2024) · Climacteric · doi:10.1080/13697137.2024.2380363 · Cited by 141
Sarcopenia and smoking: A possible cellular model of cigarette smoke effects on muscle protein breakdown
Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06532.x · Cited by 112
Effect of nano- and micro-scale topological features on alignment of muscle cells and commitment of myogenic differentiation
Jana, S., Leung, M. C., Chang, J., & Zhang, M. (2014) · Biofabrication · doi:10.1088/1758-5082/6/3/035012 · Cited by 114
Pathology of mouse models of accelerated aging
Harkema, L., Youssef, S. A., & de Bruin, A. (2016) · Veterinary Pathology · doi:10.1177/0300985815625169 · Cited by 105
Sarcopenia, Obesity, and Mortality in US Adults With and Without Chronic Kidney Disease
Androga, L. A., Sharma, D., Amodu, A., & Abramowitz, M. K. (2016) · Kidney International Reports · doi:10.1016/j.ekir.2016.10.008 · Cited by 113
The Instrumented Sit-to-Stand Test (iSTS) Has Greater Clinical Relevance than the Manually Recorded Sit-to-Stand Test in Older Adults
van Lummel, R. C., Walgaard, S., Maier, A. B., Ainsworth, E., Beek, P. J., & van Dieën, J. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157968 · Cited by 114
Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age
Lisco, G., Disoteo, O., Tullio, A. D., Geronimo, V. D., Giagulli, V. A., Monzani, F., Jirillo, E., Cozzi, R. C., Guastamacchia, E., Pergola, G. D., et al. (2023) · Nutrients · doi:10.3390/nu16010063 · Cited by 111
Muscle weakness in the elderly: role of sarcopenia, dynapenia, and possibilities for rehabilitation
Seene, T., & Kaasik, P. (2012) · European Review of Aging and Physical Activity · doi:10.1007/s11556-012-0102-8 · Cited by 111
Chronology of age-related disease definitions: Osteoporosis and sarcopenia
Bijlsma, A. Y., Meskers, C. G. M., Westendorp, R. G. J., & Maier, A. B. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.001 · Cited by 109
Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy
Zhu, S., Tian, Z., Torigoe, D., Zhao, J., Xie, P., Sugizaki, T., Sato, M., Horiguchi, H., Terada, K., Kadomatsu, T., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0221366 · Cited by 100
Obesity and diabetes as accelerators of functional decline: Can lifestyle interventions maintain functional status in high risk older adults?
Anton, S. D., Karabetian, C., Naugle, K., & Buford, T. W. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.007 · Cited by 100
Self-citation
METTL21C Is a Potential Pleiotropic Gene for Osteoporosis and Sarcopenia Acting Through the Modulation of the NF-κB Signaling Pathway
Huang, J. M., Hsu, Y., Mo, C., de Abreu, E. L., Kiel, D. P., Bonewald, L. F., Brotto, M., & Karasik, D. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2200 · Cited by 99
Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions
Jun, L., Robinson, M., Geetha, T., Broderick, T. L., & Babu, J. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032973 · Cited by 107
Association between sarcopenia with lifestyle and family function among community-dwelling Chinese aged 60 years and older
Hai, S., Wang, H., Cao, L., Liu, P., Zhou, J., Yang, Y., & Dong, B. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0587-0 · Cited by 96
Sarcopenia and the New ICD-10-CM Code: Screening, Staging, and Diagnosis Considerations.
Falcon, L. J., & Harris‐Love, M. O. (2017) · Europe PMC (PubMed Central) · Cited by 93
Preoperative low skeletal muscle mass as a risk factor for pharyngocutaneous fistula and decreased overall survival in patients undergoing total laryngectomy
Bril, S. I., Pézier, T. F., Tijink, B. M., Janssen, L. M., Braunius, W. W., & de Bree, R. (2019) · Head & Neck · doi:10.1002/hed.25638 · Cited by 92
Sarcopenia predicts poor long-term survival in patients undergoing endovascular aortic aneurysm repair
Newton, D. H., Kim, C., Lee, N., Wolfe, L. G., Pfeifer, J. R., & Amendola, M. F. (2017) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2017.06.092 · Cited by 89
Sarcopenia in heart failure: mechanisms and therapeutic strategies.
Collamati, A., Marzetti, E., Calvani, R., Tosato, M., D’Angelo, E., Sisto, A. N., & Landi, F. (2016) · PubMed Central · doi:10.11909/j.issn.1671-5411.2016.07.004 · Cited by 88
Self-citation
Higher Muscle Strength Is Associated with Prolonged Survival in Older Patients with Advanced Cancer
Versteeg, K. S., Blauwhoff-Buskermolen, S., Buffart, L. M., de van der Schueren, M. A. E., Langius, J. A. E., Verheul, H. M. W., Maier, A. B., & Konings, I. R. H. M. (2017) · The Oncologist · doi:10.1634/theoncologist.2017-0193 · Cited by 85
Handgrip strength cutoff points to identify mobility limitation in community-dwelling older people and associated factors
Vasconcelos, K. S. D. S., Dias, J. M. D., Bastone, A. D. C., Vieira, R. A., Andrade, A. C. D. S., Perracini, M. R., Guerra, R. O., & Dias, R. C. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0584-y · Cited by 90
A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
Jo, D., Yoon, G., Kim, O. Y., & Song, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112636 · Cited by 86
Muscle mass gain is positively associated with functional recovery in patients with sarcopenia after stroke
Nagano, F., Yoshimura, Y., Bise, T., Shimazu, S., & Shiraishi, A. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105017 · Cited by 82
Functional impact of diaphragm muscle sarcopenia in both male and female mice
Greising, S. M., Mantilla, C. B., Medina-Martinez, J. S., Stowe, J. M., & Sieck, G. C. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00064.2015 · Cited by 81
Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice
Sayed, R. K. A., de Leonardis, E. C., Guerrero-Martinez, J. A., Rahim, I., Mokhtar, D. M., Saleh, A. M., Abdalla, K. E. H., Pozo, M. J., Escames, G., López, L. C., et al. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.007 · Cited by 81
Physical Activity and Sarcopenia
Pillard, F., Laoudj‐Chenivesse, D., Carnac, G., Mercier, J. G., RAMI, J., Rivière, D., & Rolland, Y. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.009 · Cited by 79
Identification of possible cigarette smoke constituents responsible for muscle catabolism
Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z. (2012) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-012-9299-4 · Cited by 75
Gardening Intervention for Physical and Psychological Health Benefits in Elderly Women at Community Centers
Park, S.-A., Lee, A.-Y., Son, K.-C., Lee, W.-L., & Kim, D. S. (2016) · HortTechnology · doi:10.21273/horttech.26.4.474 · Cited by 73
Association of muscle wasting with mortality risk among adults: A systematic review and meta‐analysis of prospective studies
Zhou, H., Liao, Y., Peng, Z., Liu, F., Wang, Q., & Yang, W. Q. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13263 · Cited by 77
Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia
Marzetti, E., Lorenzi, M., Landi, F., Picca, A., Rosa, F., Tanganelli, F., Galli, M., Doglietto, G. B., Pacelli, F., Cesari, M., et al. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.10.003 · Cited by 71
Self-citation
Diagnostic measures for sarcopenia and bone mineral density
Bijlsma, A. Y., Meskers, C. G. M., Molendijk, M. L., Westendorp, R. G. J., Sipilä, S., Stenroth, L., Sillanpää, E., McPhee, J. S., Jones, D. A., Narici, M. V., et al. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2376-8 · Cited by 70
Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging
Endo, Y., Nourmahnad, A., & Sinha, I. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00874 · Cited by 77
Excess Glucose Impedes the Proliferation of Skeletal Muscle Satellite Cells Under Adherent Culture Conditions
Furuichi, Y., Kawabata, Y., Aoki, M., Mita, Y., FUJII, N. L., & Manabe, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640399 · Cited by 69
Endurance Training Per Se Increases Metabolic Health in Young, Moderately Overweight Men
Nordby, P., Auerbach, P., Rosenkilde, M., Kristiansen, L., Thomasen, J. R., Rygaard, L., Groth, R., Brandt, N., Helge, J. W., Richter, E. A., et al. (2012) · Obesity · doi:10.1038/oby.2012.70 · Cited by 69
Determinants of Adherence in Time-Restricted Feeding in Older Adults: Lessons from a Pilot Study
Lee, S. A., Sypniewski, C., Bensadon, B. A., McLaren, C., Donahoo, W. T., Sibille, K. T., & Anton, S. D. (2020) · Nutrients · doi:10.3390/nu12030874 · Cited by 72
Self-citation
Lipotoxicity, aging, and muscle contractility: does fiber type matter?
Carter, C. S., Justice, J. N., & Thompson, L. (2019) · GeroScience · doi:10.1007/s11357-019-00077-z · Cited by 66
Self-citation
Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia
Damanti, S., Azzolino, D., Roncaglione, C., Arosio, B., Rossi, P. D., & Cesari, M. (2019) · Nutrients · doi:10.3390/nu11091991 · Cited by 72
Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass
Looijaard, S. M. L. M., Hekkert, M. L. T. L., Wüst, R. C. I., Otten, R. H. J., Meskers, C. G. M., & Maier, A. B. (2020) · Acta Physiologica · doi:10.1111/apha.13516 · Cited by 69
Review on aging, unloading and reloading: Changes in skeletal muscle quantity and quality
Seene, T., Kaasik, P., & Riso, E. (2011) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2011.05.002 · Cited by 65
Changes in frailty-related characteristics of the hip fracture population and their implications for healthcare services: evidence from Quebec, Canada
Auais, M. A., Morin, S. N., Nadeau, L., Finch, L. E., & Mayo, N. E. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2390-x · Cited by 64
Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats
Javadov, S. A., Jang, S., Rodriguez, N., Rodríguez‐Zayas, A. E., Hernández, J. S., Krainz, T., Wipf, P., & Frontera, W. R. (2015) · Oncotarget · doi:10.18632/oncotarget.5783 · Cited by 67
Leukocyte telomere length is related to appendicular lean mass: cross-sectional data from the Berlin Aging Study II (BASE-II)
Meyer, A., Salewsky, B., Spira, D., Steinhagen‐Thiessen, E., Norman, K., & Demuth, I. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116806 · Cited by 61
Framework for Considering Productive Aging and Work
Schulte, P. A., Grosch, J. W., Scholl, J. C., & Tamers, S. L. (2018) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001295 · Cited by 69
Muscoloskeletal aging, sarcopenia and cancer
Colloca, G. A., Capua, B. D., Bellieni, A., Cesari, M., Marzetti, E., Valentini, V., & Calvani, R. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.11.007 · Cited by 65
Self-citation
Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males
Cooke, M. B., Brabham, B., Buford, T. W., Shelmadine, B. D., McPheeters, M., Hudson, G. M., Stathis, C., Greenwood, M., Kreider, R., & Willoughby, D. S. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2866-1 · Cited by 58
Self-citation
Sexual dimorphism in skeletal muscle protein turnover
Smith, G. I., & Mittendorfer, B. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00625.2015 · Cited by 65
Dietary protein considerations to support active aging
Wall, B. T., Cermak, N. M., & van Loon, L. J. C. (2014) · Sports Medicine · doi:10.1007/s40279-014-0258-7 · Cited by 56
Docosahexaenoic Acid, a Potential Treatment for Sarcopenia, Modulates the Ubiquitin–Proteasome and the Autophagy–Lysosome Systems
Lee, J. H., Jeon, J. H., & Lee, M. J. (2020) · Nutrients · doi:10.3390/nu12092597 · Cited by 62
Socioeconomic differences in handgrip strength and its association with measures of intrinsic capacity among older adults in six middle-income countries
Perianayagam, A., Selvamani, Y., Thiyagarajan, J. A., & Sadana, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-99047-9 · Cited by 55
Effects of loaded voluntary wheel exercise on performance and muscle hypertrophy in young and old male C 57 B l/6 J mice
Soffe, Z., Radley‐Crabb, H. G., McMahon, C., Grounds, M. D., & Shavlakadze, T. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12416 · Cited by 54
Age-related loss of muscle fibres is highly variable amongst mouse skeletal muscles
Sheard, P. W., & Anderson, R. D. (2011) · Biogerontology · doi:10.1007/s10522-011-9365-0 · Cited by 54
Factors associated with 36-month loss to follow-up and mortality outcomes among HIV-infected adults on antiretroviral therapy in Central Kenya
Wekesa, P., McLigeyo, A., Owuor, K. O., Mwangi, J., Ng'ang'a, E., & Masamaro, K. (2020) · BMC Public Health · doi:10.1186/s12889-020-8426-1 · Cited by 52
Analysis of muscle fiber clustering in the diaphragm muscle of sarcopenic mice
Greising, S. M., Medina-Martinez, J. S., Vasdev, A. K., Sieck, G. C., & Mantilla, C. B. (2015) · Muscle & Nerve · doi:10.1002/mus.24641 · Cited by 51
Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age
Venturelli, M., Morgan, G. R., Donato, A. J., Reese, V., Bottura, R., Tarperi, C., Milanese, C., Schena, F., Reggiani, C., Naro, F., et al. (2014) · Clinical Science · doi:10.1042/cs20140051 · Cited by 50
Age related skeletal muscle atrophy and upregulation of autophagy in dogs
Pagano, T. B., Wojcik, S. P., Costagliola, A., Biase, D. D., Iovino, S., Iovane, V., Russo, V., Papparella, S., & Paciello, O. (2015) · The Veterinary Journal · doi:10.1016/j.tvjl.2015.07.005 · Cited by 50
Association of Body Shape Index (ABSI) with Hand Grip Strength
Krakauer, N. Y., & Krakauer, J. C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186797 · Cited by 50
Monotropein Improves Dexamethasone-Induced Muscle Atrophy via the AKT/mTOR/FOXO3a Signaling Pathways
Wang, P., Kang, S. Y., Kim, S. J., Park, Y., & Jung, H. W. (2022) · Nutrients · doi:10.3390/nu14091859 · Cited by 49
Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition
Wandrag, L., Siervo, M., Riley, H. L., Khosravi, M., Fernandez, B. O., Leckstrom, C. A., Martín, D., Mitchell, K., Levett, D. Z. H., Montgomery, H., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.004 · Cited by 52
ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle
Fuqua, J. D., Mere, C. P., Kronemberger, A., Blomme, J., Bae, D., Turner, K. D., Harris, M. P., Scudese, E., Edwards, M., Ebert, S. M., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900766r · Cited by 47
Acute Sarcopenia: Mechanisms and Management
Damanti, S., Senini, E., LORENZO, R. D., Merolla, A., Santoro, S., Festorazzi, C., Messina, M., Vitali, G., Sciorati, C., & Rovere, P. Q. (2024) · Nutrients · doi:10.3390/nu16203428 · Cited by 53
Development of Evidence-Based Exercise Recommendations for Older HIV-Infected Patients
Yahiaoui, A., McGough, E. L., & Voss, J. G. (2011) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/j.jana.2011.06.001 · Cited by 47
Sarcopenia: A Novel Clinical Condition or Still a Matter for Research?
Cesari, M., & Vellas, B. J. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.07.020 · Cited by 46
The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes
Sayed, R. K. A., Fernández-Ortiz, M., Diaz-Casado, M. E., Rusanova, I., Rahim, I., Escames, G., López, L. C., Mokhtar, D. M., & Acuña-Castroviejo, D. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly059 · Cited by 45
Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation
Mogi, M., Kohara, K., Nakaoka, H., Kan‐no, H., Tsukuda, K., Wang, X., Chisaka, T., Bai, H., Shan, B., Kukida, M., et al. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12044 · Cited by 44

Authors: Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M.
Affiliations: University of Florida (US)
Corresponding author: Buford, Thomas W.
Manini, Todd M.
ORCID: Buford, Thomas W.
Anton, Stephen D.
Judge, Andrew R.
Marzetti, Emanuele
Wohlgemuth, Stephanie E.
Carter, Christy S.
Leeuwenburgh, Christiaan
Manini, Todd M.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2010-10
Volume: 9
Issue: 4
Pages: 369-383
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2010.04.004
PMC: PMC3788572
OpenAlex: W1967880601
Cited by: 295
References: 272
Citations by year: 2026: 4 · 2025: 10 · 2024: 17 · 2023: 22 · 2022: 16 · 2021: 24 · 2020: 19 · 2019: 12 · 2018: 20 · 2017: 24 · 2016: 21 · 2015: 25 · 2014: 17 · 2013: 17 · 2012: 29
FWCI: 2.04
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P30AG028740)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: sarcopenia, age-related muscle loss, skeletal muscle, comorbidities, cancer, kidney disease, diabetes mellitus, peripheral arterial disease, nutrition, physical inactivity, therapeutic target
MeSH terms: Acceleration, Aged, Aged, 80 and over, Aging, Diabetes Mellitus, Feeding Behavior, Humans, Kidney Diseases, Health Knowledge, Attitudes, Practice, Models, Biological, Motor Activity, Neoplasms, Nutritional Requirements, Comorbidity, Apoptosis, Muscle, Skeletal, Sarcopenia, Peripheral Arterial Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks