Cited by 295Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

The DOI matches its Crossref record; 270 of the 272 references it cites were found in a registry or an index.

Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy

Open access

Buford, Thomas W., Anton, Stephen D., Judge, Andrew R., Marzetti, Emanuele, Wohlgemuth, Stephanie E., Carter, Christy S., Leeuwenburgh, Christiaan, Pahor, Marco, Manini, Todd M.·2010·Ageing Research Reviews

DOI 10.1016/j.arr.2010.04.004PMC PMC3788572

Open this paper in CoChat — free account

Abstract

Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population ages. Certain conditions have the strong potential to coincide with sarcopenia to accelerate the progression of muscle atrophy in older adults. Among these conditions are co-morbid diseases common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease. Furthermore, behaviors such as poor nutrition and physical inactivity are well-known to contribute to sarcopenia development. However, we argue that these behaviors are not inherent to the development of sarcopenia but rather accelerate its progression. In the present review, we discuss how these factors affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy. In addition, we describe gaps in the literature concerning the role of these factors in accelerating sarcopenia progression. Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.arr.2010.04.004

Cites

270 of 270 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600
Retracted
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection
Palella, F. J., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., & Holmberg, S. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381301 · Cited by 9,393
Cancer Statistics, 2007
Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Chronic Health Conditions in Adult Survivors of Childhood Cancer
Oeffinger, K. C., Mertens, A. C., Sklar, C. A., Kawashima, T. I., Hudson, M. M., Meadows, A. T., Friedman, D. L., Marina, N. M., Hobbie, W. L., Kadan‐Lottick, N. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmsa060185 · Cited by 3,597
Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · cited 1×
“These changes contribute to declines in functional capacity of the muscle that contribute to functional disability (Evans, 1997; Janssen et al., 2002; Muhlberg and Sieber, 2004; Rolland et al., 2008; Visser et al., 2005).”
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.-P., & Colette, C. (2006) · JAMA · doi:10.1001/jama.295.14.1681 · Cited by 2,444
Prognostic effect of weight loss prior tochemotherapy in cancer patients
DeWys, W. D., Begg, C. B., Lavin, P. T., Band, P. R., Bennett, J. M., Bertino, J. R., Cohen, M. H., Douglass, H. O., Engstrom, P. F., Ezdinli, E. Z., et al. (1980) · The American Journal of Medicine · doi:10.1016/s0149-2918(05)80001-3 · Cited by 2,350
Cachexia: a new definition.
Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102 · cited 1×
“Along with the well-characterized effects of insulin resistance on muscle (DeFronzo and Tripathy, 2009), sarcopenia and type 2 DM share a common set of lifestyle factors, including physical inactivity and a poor diet that contribute to accelerated muscle atrophy.”
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
Lauretani, F., Russo, C. R., Bandinelli, S., Bartali, B., Cavazzini, C., Di Iorio, A., Corsi, A. M., Rantanen, T., Guralnik, J. M., & Ferrucci, L. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00246.2003 · Cited by 1,946
Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies.
(2008) · The Lancet · doi:10.1016/s0140-6736(08)61113-7 · Cited by 1,661
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,561
The healthcare costs of sarcopenia in the United States
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
The Look AHEAD Research Group (2007) · Diabetes Care · doi:10.2337/dc07-0048 · Cited by 1,522
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489
Polymyositis and dermatomyositis
Dalakas, M. C., & Hohlfeld, R. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14368-1 · Cited by 1,425
Muscle Mass, Muscle Strength, and Muscle Fat Infiltration as Predictors of Incident Mobility Limitations in Well-Functioning Older Persons
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403
Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging
Lemasters, J. J. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.3 · Cited by 1,342
Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226
Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
Houston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211
Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment
Prado, C. M. M., Baracos, V. E., McCargar, L. J., Reiman, T., Mourtzakis, M., Tonkin, K. S., Mackey, J. R., Koski, S. L., Pituskin, E., & Sawyer, M. B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2242 · Cited by 1,125
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Polymyositis and Dermatomyositis
Hohlfeld, R., Hofmann, W. W., & Hanley, D. F. (1994) · Neurocritical Care · doi:10.1007/978-3-642-87602-8_72 · Cited by 1,084
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives
Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071
Peripheral Muscle Weakness Contributes to Exercise Limitation in COPD
Gosselink, R., Troosters, T., & Decramer, M. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630582 · Cited by 1,024
Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly
Baumgartner, R. N., Wayne, S. J., Waters, D. L., Janssen, I., Gallagher, D., & Morley, J. E. (2004) · Obesity Research · doi:10.1038/oby.2004.250 · Cited by 937
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Sarcopenia != Dynapenia
Clark, B. C., & Manini, T. M. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.8.829 · Cited by 876
Self-citation
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1305 · Cited by 856
Midthigh Muscle Cross-Sectional Area Is a Better Predictor of Mortality than Body Mass Index in Patients with Chronic Obstructive Pulmonary Disease
Marquis, K., Debigaré, R., Lacasse, Y., Leblanc, P., Jobin, J., Carrier, G., & Maltais, F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107031 · Cited by 840
Dietary protein recommendations and the prevention of sarcopenia
Paddon-Jones, D., & Rasmussen, B. B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef8b · Cited by 823
AGE‐RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLES
Faulkner, J. A., Larkin, L. M., Claflin, D. R., & Brooks, S. V. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04752.x · Cited by 802
Autophagy and aging: The importance of maintaining "clean" cells
Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792
Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes
Park, S. W., Goodpaster, B. H., Lee, J. S., Kuller, L. H., Boudreau, R., de Rekeneire, N., Harris, T. B., Kritchevsky, S., Tylavsky, F. A., Nevitt, M., et al. (2009) · Diabetes Care · doi:10.2337/dc09-0264 · Cited by 778
Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States
Lecker, S. H., Solomon, V., Mitch, W. E., & Goldberg, A. L. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.227s · Cited by 742
Sarcopenia: Current Concepts
Roubenoff, R., & HUGHES, V. A. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.12.m716 · Cited by 698
Age-related decline in chaperone-mediated autophagy
Cuervo, A. M., & Dice, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002102200 · Cited by 665
Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.
Kolterman, O. G., Insel, J., Saekow, M., & Olefsky, J. M. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109790 · Cited by 664
COPD as a Disease of Accelerated Lung Aging
Ito, K., & Barnes, P. J. (2009) · CHEST Journal · doi:10.1378/chest.08-1419 · Cited by 634
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1
Sacheck, J. M., Ohtsuka, A., McLary, S. C., & Goldberg, A. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2004 · Cited by 606
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases
Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585 · cited 1×
“, 1996), or denervation (Sacheck et al., 2007).”
Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90027-v · Cited by 577
Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis
Brenner, H. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11199-8 · Cited by 543
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
Acharyya, S., Ladner, K. J., Nelsen, L., Damrauer, J. S., Reiser, P. J., Swoap, S. J., & D, D. C. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20174 · Cited by 541
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans
Balagopal, P., Rooyackers, O., Adey, D., Ades, P. A., & Nair, K. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e790 · Cited by 541
Postprandial Hyperglycemia/Hyperlipidemia (Postprandial Dysmetabolism) Is a Cardiovascular Risk Factor
O’Keefe, J. H., & Bell, D. S. H. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.03.107 · Cited by 538
Review Article: Sarcopenia: Causes, Consequences, and Preventions
Marcell, T. J. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.10.m911 · Cited by 536
Skeletal muscle satellite cells
Schultz, E., & McCormick, K. M. (1994) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0030904 · Cited by 526
Mechanisms of glucocorticoid-induced myopathy
Schakman, O., Gilson, H., & Thissen, J. P. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0606 · Cited by 521
Skeletal muscle weakness in old age
Brooks, S. V., & Faulkner, J. A. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199404000-00006 · Cited by 511
Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults
Kosek, D. J., Kim, J.-S., Petrella, J. K., Cross, J. M., & Bamman, M. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01474.2005 · Cited by 503
Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α
Li, Y., Schwartz, R. J., Waddell, I. D., Holloway, B. R., & Reid, M. B. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.871 · Cited by 502
Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years
Larsson, L., Sjödin, B., & Karlsson, J. (1978) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1978.tb06187.x · Cited by 500
Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
Verdijk, L. B., Koopman, R., Schaart, G., Meijer, K., Savelberg, H. H. C. M., & van Loon, L. J. C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2006 · Cited by 489
Tumor Necrosis Factor-Alpha Levels and Weight Loss in Chronic Obstructive Pulmonary Disease
Di Francia, M., Barbier, D., Mège, J. L., & OREHEK, J. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.5.7952575 · Cited by 480
The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly1
Volpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464
A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets
Arsham, A. M., Howell, J. J., & Simon, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212770200 · Cited by 463
Skeletal muscle weakness in old age: underlying mechanisms.
Brooks, S. V., & Faulkner, J. A. (1994) · PubMed · Cited by 463
Physical frailty and body composition in obese elderly men and women
Villareal, D. T., Banks, M., Siener, C., Sinacore, D. R., & Klein, S. (2004) · Obesity Research · doi:10.1038/oby.2004.111 · Cited by 459
The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.
Bailey, J. L., Wang, X., England, B. K., Price, S. R., Ding, X., & Mitch, W. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118566 · Cited by 455
Natural history of HIV infection in the_era of combination antiretroviral therapy
Moore, R. D., & Chaisson, R. E. (1999) · AIDS · doi:10.1097/00002030-199910010-00017 · Cited by 454
Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans
GREIWE, J. S., CHENG, B., RUBIN, D. C., YARASHESKI, K. E., & SEMENKOVICH, C. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0274com · Cited by 454 · cited 1×
“Resistance exercise provides a host of physiological benefits to muscle including, but not limited to, reduced inflammation (Greiwe et al., 2001), increased mitochondrial function (Melov et al.”
NF-κB mediates the protein loss induced by TNF-α in differentiated skeletal muscle myotubes
Li, Y.-P., & Reid, M. B. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1165 · Cited by 451
Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial
Goodpaster, B. H., Chomentowski, P., Ward, B. K., Rossi, A., Glynn, N. W., Delmonico, M. J., Kritchevsky, S. B., Pahor, M., & Newman, A. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90425.2008 · Cited by 446
Self-citation
The Association Between Obesity and the Frailty Syndrome in Older Women: The Women's Health and Aging Studies
Blaum, C. S., Xue, Q., Michelon, E., Semba, R. D., & Fried, L. P. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53300.x · Cited by 444
Psychological and metabolic stress: A recipe for accelerated cellular aging?
Epel, E. S. (2009) · HORMONES · doi:10.14310/horm.2002.1217 · Cited by 424
Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.
Tsujinaka, T., Fujita, J., Ebisui, C., Yano, M., Kominami, E., Suzuki, K., Tanaka, K., Katsume, A., Ohsugi, Y., Shiozaki, H., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118398 · Cited by 421 · cited 1×
“, 2003), pro-inflammatory cytokines (Li and Reid, 2000; Tsujinaka et al., 1996), or denervation (Sacheck et al.”
Basal Muscle Amino Acid Kinetics and Protein Synthesis in Healthy Young and Older Men
Volpi, E. (2001) · JAMA · doi:10.1001/jama.286.10.1206 · Cited by 421
Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction
Volpi, E., Mittendorfer, B., Wolf, S. E., & Wolfe, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.3.e513 · Cited by 418
Muscle transplantation between young and old rats: age of host determines recovery
Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417
Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression
Ma, K., Mallidis, C., Bhasin, S., Mahabadi, V., Artaza, J., González-Cadavid, N. F., Arias, J., & Salehian, B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00487.2002 · Cited by 416
Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans
Guillet, C., Prod'homme, M., Balage, M., Gachon, P., Giraudet, C., Morin, L., Grizard, J., & Boirie, Y. (2004) · The FASEB Journal · doi:10.1096/fj.03-1341fje · Cited by 412
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging
Drummond, M. J., Dreyer, H. C., Pennings, B., Fry, C. S., Dhanani, S., Dillon, E. L., Sheffield‐Moore, M., Volpi, E., & Rasmussen, B. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00021.2008 · Cited by 410
Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women
Yarasheski, K. E., Zachwieja, J. J., & Bier, D. M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.2.e210 · Cited by 406
Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure
Anker, S. D. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1446 · Cited by 374
Oxidative Stress, Accumulation of Biological 'Garbage', and Aging
Terman, A., & Brunk, U. T. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.197 · Cited by 363
Resistance Exercise Reverses Aging in Human Skeletal Muscle
Melov, S., Tarnopolsky, M. A., Beckman, K. B., Felkey, K., & Hubbard, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000465 · Cited by 360
Functional consequences of sarcopenia and dynapenia in the elderly
Clark, B. C., & Manini, T. M. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328337819e · Cited by 359
Self-citation
Skeletal muscle apoptosis, sarcopenia and frailty at old age
Marzetti, E., & Leeuwenburgh, C. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.011 · Cited by 353
Self-citation
S ARCOPENIA , W EIGHT L OSS , AND N UTRITIONAL F RAILTY IN THE E LDERLY
Bales, C. W., & Ritchie, C. S. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102715 · Cited by 350
Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men
McNeil, C. J., Doherty, T. J., Stashuk, D. W., & Rice, C. L. (2005) · Muscle & Nerve · doi:10.1002/mus.20276 · Cited by 346
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men
Sinha-Hikim, I., Roth, S. M., Lee, M. I., & Bhasin, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00370.2002 · Cited by 344
Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease
Sietsema, K. E., Amato, A., Adler, S. G., & Brass, E. P. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00411.x · Cited by 342
Do the Differences between the Amino Acid Compositions of Acute-Phase and Muscle Proteins Have a Bearing on Nitrogen Loss in Traumatic States?
Reeds, P. J., Fjeld, C. R., & Jahoor, F. (1994) · Journal of Nutrition · doi:10.1093/jn/124.6.906 · Cited by 338
Skeletal muscle satellite cells: Changes in proliferation potential as a function of age
Schultz, E., & Lipton, B. H. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90105-1 · Cited by 335
Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes
Li, Y.-P., Chen, Y., Li, A. S., & Reid, M. B. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00129.2003 · Cited by 334
Reduced physical activity increases intermuscular adipose tissue in healthy young adults
Manini, T. M., Clark, B. C., Nalls, M. A., Goodpaster, B. H., Ploutz-Snyder, L. L., & Harris, T. B. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.377 · Cited by 332
Self-citation
EFFECTS OF ACUTE AEROBIC AND ANAEROBIC EXERCISE ON BLOOD MARKERS OF OXIDATIVE STRESS
Bloomer, R. J., Goldfarb, A. H., Wideman, L., MCKENZIE, M. J., & Consitt, L. A. (2005) · The Journal of Strength and Conditioning Research · doi:10.1519/14823.1 · Cited by 328
Age‐related differences in absolute numbers of skeletal muscle satellite cells
Gibson, M. C., & Schultz, E. (1983) · Muscle & Nerve · doi:10.1002/mus.880060807 · Cited by 327
Functional and Metabolic Consequences of Sarcopenia
Vandervoort, A. A., & Symons, T. B. (2001) · Canadian Journal of Applied Physiology · doi:10.1139/h01-007 · Cited by 326
In Vivo Body Composition Studies
Yasumura, S., Harrison, J. E., McNeill, K. G., Woodhead, A. D., & Dilmanian, F. A. (1990) · Springer eBooks · doi:10.1007/978-1-4613-1473-8 · Cited by 317
Sarcopenic/Obesity and Physical Capacity in Older Men and Women: Data From the Nutrition as a Determinant of Successful Aging (NuAge)—the Quebec Longitudinal Study
Bouchard, D. R., Dionne, I. J., & Brochu, M. (2009) · Obesity · doi:10.1038/oby.2009.109 · Cited by 314
Expression and Splicing of the Insulin‐Like Growth Factor Gene in Rodent Muscle is Associated with Muscle Satellite (stem) Cell Activation following Local Tissue Damage
Hill, M., & Goldspink, G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.035832 · Cited by 313
Aging successfully until death in old age: opportunities for increasing active life expectancy
Leveille, S. G., Guralnik, J. M., Ferrucci, L., & Langlois, J. A. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009866 · Cited by 301
Satellite cells and myonuclei in young and elderly women and men
Kadi, F., Charifi, N., Denis, C., & Lexell, J. E. (2003) · Muscle & Nerve · doi:10.1002/mus.10510 · Cited by 298
Physical activity and maintaining physical function in older adults
Manini, T. M., & Pahor, M. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.053736 · Cited by 294
Self-citation
II. Morphological Adaptations of Human Skeletal Muscle to Chronic Hypoxia*
Hoppeler, H., Kleinert, E., Schlegel, C., Claassen, H., Howald, H., Kayar, S., & Cerretelli, P. (1990) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024846 · Cited by 290
Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.
Verhoeven, S., Vanschoonbeek, K., Verdijk, L., Koopman, R., Wodzig, W., Dendale, P., & van Loon, L. V. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26668 · Cited by 286
Muscle satellite (stem) cell activation during local tissue injury and repair
Hill, M., Wernig, A., & Goldspink, G. (2003) · Journal of Anatomy · doi:10.1046/j.1469-7580.2003.00195.x · Cited by 286
Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women
Dillon, E. L., Sheffield‐Moore, M., Paddon‐Jones, D., Gilkison, C. R., Sanford, A. P., Casperson, S. L., Jiang, J., Chinkes, D. L., & Urban, R. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1564 · Cited by 284
Muscle fiber‐specific apoptosis and TNF‐α signaling in sarcopenia are attenuated by life‐long calorie restriction
Phillips, T., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2870fje · Cited by 283
Self-citation
Myofibrillar protein synthesis in young and old men
Welle, S. L., Thornton, C. A., Józefowicz, R. F., & Statt, M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.5.e693 · Cited by 280
Chronic changes in skeletal muscle histology and function in peripheral arterial disease.
Regensteiner, J. G., Wolfel, E. E., Brass, E. P., Carry, M. R., Ringel, S. P., Hargarten, M. E., Stamm, E. R., & Hiatt, W. R. (1993) · Circulation · doi:10.1161/01.cir.87.2.413 · Cited by 276
Body Fat and Skeletal Muscle Mass in Relation to Physical Disability in Very Old Men and Women of the Framingham Heart Study
Visser, M., Harris, T. B., Langlois, J. A., Hannan, M. T., Roubenoff, R., Felson, D. T., Wilson, P. W. F., & Kiel, D. P. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.3.m214 · Cited by 259
The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging
HIONA, A. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.001 · Cited by 247
Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting
Grinspoon, S. K., Corcoran, C. P., Lee, K., Burrows, B. A., Hubbard, J. L., Katznelson, L. J., Walsh, M. J., Guccione, A. A., Cannan, J., Heller, H. M., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923860 · Cited by 241
Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle.
Adhihetty, P. J., O'Leary, M. F. N., Chabi, B., Wicks, K. L., & Hood, D. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00768.2006 · Cited by 240
Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle
Clavel, S., Coldefy, A.-S., Kurkdjian, E., Salles, J., Margaritis, I., & Dérijard, B. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.07.005 · Cited by 233
Mitochondrial defects and oxidative damage in patients with peripheral arterial disease
Pipinos, I. I., Judge, A. R., Zhu, Z. H., Selsby, J. T., Swanson, S. A., Johanning, J. M., Baxter, B. T., Lynch, T. G., & DODD, S. L. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.003 · Cited by 233
Self-citation
Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites
Mantovani, G., Macciò, A., Mura, L., Massa, E., Mudu, M. C., Mulas, C., Lusso, M. R., Madeddu, C., & Dessì, A. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000137 · Cited by 232
Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men ≥76 yr old
Yarasheski, K. E., Pak-Loduca, J., Hasten, D. L., Obert, K. A., Brown, M. B., & Sinacore, D. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e118 · Cited by 226
Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion
Douyon, L., & SCHTEINGART, D. E. (2002) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(01)00023-8 · Cited by 222
Functional and Metabolic Consequences of Sarcopenia
Evans, W. J. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.998s · Cited by 218
The pediatric cancer quality of life inventory-32 (PCQL-32)
Varni, J. W., Katz, E. R., Seid, M., Quiggins, D. J. L., & Friedman-Bender, A. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980315)82:6 · Cited by 217
Human immunodeficiency virus—associated myopathy: Analysis of 11 patients
Simpson, D. M., & Bender, A. N. (1988) · Annals of Neurology · doi:10.1002/ana.410240114 · Cited by 208
Apoptosis in muscle atrophy: Relevance to sarcopenia
Dupont‐Versteegden, E. E. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.003 · Cited by 207
Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus
Lee, H. K., Song, J., Shin, C. S., Park, D. J., Park, K. S., Lee, K. U., & Koh, C.-S. (1998) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(98)00110-7 · Cited by 206
Cancer anorexia-cachexia syndrome: cytokines and neuropeptides
Ramos, E. J., Suzuki, S., Marks, D. L., Inui, A., Asakawa, A., & Meguid, M. M. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000134363.53782.cb · Cited by 196
Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats
Rieu, I., Magne, H., Savary‐Auzeloux, I., Avérous, J., Bos, C., Peyron, M., Combaret, L., & Dardevet, D. P. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178319 · Cited by 193
Minireview: Mechano-Growth Factor: A Putative Product of IGF-I Gene Expression Involved in Tissue Repair and Regeneration
Matheny, R. W., Nindl, B. C., & Adamo, M. L. (2010) · Endocrinology · doi:10.1210/en.2009-1217 · Cited by 187
Myofibrillar protein synthesis in young and old human subjects after three months of resistance training
Welle, S. L., Thornton, C. A., & Statt, M. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.3.e422 · Cited by 186
Diabetes, Sarcopenia, and Frailty
Morley, J. E. (2008) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2008.03.004 · Cited by 186
Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis
Sood, N. A., Baker, W. L., & Coleman, C. I. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1167 · Cited by 184
Muscle function in elite master weightlifters
PEARSON, S. J., YOUNG, A., MACALUSO, A., DEVITO, G., NIMMO, M. A., COBBOLD, M., & HARRIDGE, S. D. R. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200207000-00023 · Cited by 184
Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism
Koves, T. R., Noland, R. C., Bates, A. L., Henes, S. T., Muoio, D. M., & Cortright, R. N. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00391.2004 · Cited by 184
TNF Can Directly Induce the Expression of Ubiquitin-Dependent Proteolytic System in Rat Soleus Muscles
Llovera, M., Garcia‐Martínez, C., Agell, N., López-Soriano, F. J., & Argilés, J. M. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.5827 · Cited by 184
Human Immunodeficiency Virus in an Aging Population, a Complication of Success
Kirk, J. B., & Goetz, M. B. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02494.x · Cited by 181
Skeletal muscle metabolism in patients with malignant tumor
Lundholm, K., Bylund, A., Holm, J., & Scherstén, T. (1976) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(76)90036-0 · Cited by 180
Skeletal muscle regeneration and the mitotic clock
Renault, V. M., Piron-Hamelin, G., Forestier, C.-L., Donna, S. D., Decary, S., Hentati, F., Saillant, G., Butler-Browne, G. S., & Mouly, V. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00151-0 · Cited by 179
The Role of Cytokines in Regulating Protein Metabolism and Muscle Function
Zoico, E., & Roubenoff, R. (2002) · Nutrition Reviews · doi:10.1301/00296640260085949 · Cited by 179
Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 Phosphorylation
Anthony, J. C., Reiter, A. K., Anthony, T. G., Crozier, S. J., Lang, C. H., MacLean, D. A., Kimball, S. R., & Jefferson, L. S. (2002) · Diabetes · doi:10.2337/diabetes.51.4.928 · Cited by 177
Cancer cachexia
Tisdale, M. J. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283347e77 · Cited by 176
Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy
Marzetti, E., Hwang, J. C. Y., Lees, H. A., Wohlgemuth, S. E., Dupont-Versteegden, E. E., Carter, C. S., Bernabei, R., & Leeuwenburgh, C. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.05.007 · Cited by 174
Self-citation
Growth Delay in Postburn Pediatric Patients
Rutan, R. L. (1990) · Archives of Surgery · doi:10.1001/archsurg.1990.01410150114021 · Cited by 174
A leucine‐supplemented diet restores the defective postprandial inhibition of proteasome‐dependent proteolysis in aged rat skeletal muscle
Combaret, L., Dardevet, D. P., Rieu, I., Pouch-Pélissier, M.-N., Béchet, D., Taillandier, D., Grizard, J., & Attaix, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098004 · Cited by 173
Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle
Marzetti, E., Wohlgemuth, S. E., Lees, H. A., Chung, H.-Y., Giovannini, S., & Leeuwenburgh, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.05.005 · Cited by 172
Self-citation
Lower Extremity Ischemia, Calf Skeletal Muscle Characteristics, and Functional Impairment in Peripheral Arterial Disease
McDermott, M. M., Hoff, F. L., Ferrucci, L., Pearce, W. H., Guralnik, J. M., Tian, L., Liu, K., Schneider, J. R., Sharma, L., Tan, J. R., et al. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01092.x · Cited by 170
Managing Cancer-Related Anorexia/Cachexia
Mantovani, G., Macci??, A., Massa, E., & Madeddu, C. (2001) · Drugs · doi:10.2165/00003495-200161040-00004 · Cited by 169
The mechanisms and treatment of weight loss in cancer
Fearon, K. C. H. (1992) · Proceedings of The Nutrition Society · doi:10.1079/pns19920036 · Cited by 165
Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism
Fujita, S., Glynn, E. L., Timmerman, K. L., Rasmussen, B. B., & Volpi, E. (2009) · Diabetologia · doi:10.1007/s00125-009-1430-8 · Cited by 164
Protein turnover and requirements in the healthy and frail elderly.
Morais, J. A., Chevalier, S., & Gougeon, R. (2006) · PubMed · Cited by 162
Skeletal muscle proteolysis in aging
Combaret, L., Dardevet, D. P., Béchet, D., Taillandier, D., Mosoni, L., & Attaix, D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831b9c31 · Cited by 162
Prospective study of physical activity and physical function in early old age
Hillsdon, M. M., Brunner, E. J., Guralnik, J. M., & Marmot, M. G. (2005) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2004.12.008 · Cited by 162
Reduced synthesis of muscle proteins in chronic renal failure
Adey, D., Kumar, R., McCarthy, J. T., & Nair, K. S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.2.e219 · Cited by 159
Body Mass Index, Physical Activity, and the Risk of Decline in Overall Health and Physical Functioning in Late Middle Age
He, X. Z., & Baker, D. W. (2004) · American Journal of Public Health · doi:10.2105/ajph.94.9.1567 · Cited by 158
Exercise and the Master Athlete--A Model of Successful Aging?
Hawkins, S. A. C., WISWELL, R. A., & MARCELL, T. J. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.11.m1009 · Cited by 157
Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age
Whitman, S. A., Wacker, M. J., Richmond, S. R., & Godard, M. P. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1473-8 · Cited by 156
Skeletal muscle myocytes undergo protein loss and reactive oxygen‐mediated NF‐κB activation in response to tumor necrosis factorα
Li, Y., Schwartz, R. J., Waddell, I. D., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.971 · Cited by 154
Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia.
Bing, C., Brown, M., King, P., Collins, P., Tisdale, M. J., & Williams, G. (2000) · PubMed · Cited by 152
Maintenance of Whole Muscle Strength and Size Following Resistance Training in Older Men
Trappe, S. W., Williamson, D., & Godard, M. P. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.4.b138 · Cited by 152
Enhanced satellite cell proliferation with resistance training in elderly men and women
Mackey, A. L., Esmarck, B., Kadi, F., Koskinen, S. O. A., Kongsgaard, M., Sylvestersen, A., Hansen, J., Larsen, G. S., & Kjær, M. (2006) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2006.00534.x · Cited by 151
Age-related changes in collagen gene expression in the muscles of mdx dystrophic and normal mice
Goldspink, G., Fernandes, K., WILLIAMS, P. E., & Wells, D. J. (1994) · Neuromuscular Disorders · doi:10.1016/0960-8966(94)90019-1 · Cited by 149
Signaling pathways weigh in on decisions to make or break skeletal muscle
Guttridge, D. C. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/01.mco.0000134364.61406.26 · Cited by 149
Diabetes prevalence and diagnosis in US states: analysis of health surveys
Danaei, G., Friedman, A. B., Oza, S., Murray, C. J. L., & Ezzati, M. (2009) · Population Health Metrics · doi:10.1186/1478-7954-7-16 · Cited by 149
Satellite cell depletion in degenerative skeletal muscle
Jejurikar, S. S., & Kuzon, W. M. (2003) · APOPTOSIS · doi:10.1023/a:1026127307457 · Cited by 148
Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia
Ness, K. K., Baker, K. S., Dengel, D. R., Youngren, N. M., Sibley, S. D., Mertens, A. C., & Gurney, J. G. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.21091 · Cited by 146
Exercise-Induced Systemic Effects in Muscle-Wasted Patients with COPD
van Helvoort, H. A. C., Heijdra, Y. F., Thijs, H. M. H., Viña, J., Wanten, G. J. A., & Dekhuijzen, P. N. R. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000228331.13123.53 · Cited by 141
Pathogenesis of cancer cachexia.
Tisdale, M. J. (2004) · PubMed · Cited by 140
Skeletal muscle dysfunction in chronic renal failure: effects of exercise
Adams, G. R., & Vaziri, N. D. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00296.2005 · Cited by 138
Moderate exercise attenuates the loss of skeletal muscle mass that occurs with intentional caloric restriction-induced weight loss in older, overweight to obese adults
Chomentowski, P., Dube, J. J., Amati, F., Stefanovic-Racic, M., Zhu, S., Toledo, F. G. S., & Goodpaster, B. H. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp007 · Cited by 137
The istituto rizzoli-beretta experience with osteosarcoma of the jaw
Bertoni, F., Dallera, P., Bacchini, P., Marchetti, C., & Campobassi, A. (1991) · Cancer · doi:10.1002/1097-0142(19911001)68:7 · Cited by 137
Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus
Venables, M. C., & Jeukendrup, A. E. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.983 · Cited by 137
High circulating levels of cytokines (IL-6 and TNFa), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test
Signorelli, S. S., Mazzarino, M. C., Pino, L. D., Malaponte, G., Porto, C., Pennisi, G., Marchese, G., Costa, M. P., Digrandi, D., Celotta, G., et al. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm466oa · Cited by 135
Sarcopenia and frailty in geriatric patients: Implications for training and prevention
M�hlberg, W., & Sieber, C. C. (2004) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-004-0203-8 · Cited by 134
Anorectic Effects of the Cytokine, Ciliary Neurotropic Factor, Are Mediated by Hypothalamic Neuropeptide Y: Comparison with Leptin
Xu, B., Dube, M. G., Kalra, P. S., Farmerie, W. G., Kaibara, A., Moldawer, L. L., Martin, D., & Kalra, S. P. (1998) · Endocrinology · doi:10.1210/endo.139.2.5723 · Cited by 134
Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosis
Jejurikar, S. S., Henkelman, E., Cederna, P. S., Marcelo, C. L., Urbanchek, M. G., & Kuzon, W. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.053 · Cited by 133
Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women
Arsenault, B. J., Rana, J. S., Lemieux, I., Després, J., Kastelein, J. J. P., Boekholdt, S. M., Wareham, N. J., & Khaw, K. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.229 · Cited by 124
Fibrinogen Synthesis Is Elevated in Fasting Cancer Patients with an Acute Phase Response
Preston, T., Slater, C., McMillan, D. C., Falconer, J. S., Shenkin, A., & Fearon, K. C. H. (1998) · Journal of Nutrition · doi:10.1093/jn/128.8.1355 · Cited by 124
Skeletal Muscle Mitochondrial DNA Injury in Patients With Unilateral Peripheral Arterial Disease
Bhat, H. K., Hiatt, W. R., Hoppel, C. L., & Brass, E. P. (1999) · Circulation · doi:10.1161/01.cir.99.6.807 · Cited by 116
The impact of malnutrition on the quality of life in the elderly
Vetta, F., Ronzoni, S., Taglieri, G., & Bollea, M. R. (1999) · Clinical Nutrition · doi:10.1016/s0261-5614(98)80022-8 · Cited by 116
Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure
Hambrecht, R., Schulze, P. C., Gielen, S., Linke, A., Möbius‐Winkler, S., Erbs, S., Kratzsch, J., Schubert, A., Adams, V., & Schuler, G. C. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000173106.68485.b7 · Cited by 114
Frailty and the aging male
Morley, J. E., Kim, M. J., Haren, M. T., Kevorkian, R. T., & Banks, W. A. (2005) · The Aging Male · doi:10.1080/13685530500277232 · Cited by 113
Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction
Marzetti, E., Carter, C. S., Wohlgemuth, S. E., Lees, H. A., Giovannini, S., Anderson, B., Quinn, L. S., & Leeuwenburgh, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.008 · Cited by 113
Self-citation
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle
Marzetti, E., Lawler, J. M., Hiona, A., Manini, T., Seo, A. Y., & Leeuwenburgh, C. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.028 · Cited by 113
Self-citation
Death receptor-associated pro-apoptotic signaling in aged skeletal muscle
Pistilli, E. E., Jackson, J. R., & Alway, S. E. (2006) · APOPTOSIS · doi:10.1007/s10495-006-0194-6 · Cited by 113
Altered Growth Hormone, Cortisol, and Leptin Secretion in Healthy Elderly Persons With Sarcopenia and Mixed Body Composition Phenotypes
Waters, D. L., Qualls, C. R., Dorin, R. I., Veldhuis, J. D., & Baumgartner, R. N. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.5.536 · Cited by 112
Muscular adaptations to resistance exercise in the elderly.
Narici, M. V., Reeves, N. D., Morse, C. I., & Maganaris, C. N. (2004) · PubMed · Cited by 111
Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes
Donati, A., Cavallini, G., Paradiso, C., Vittorini, S., Pollera, M., Gori, Z., & Bergamini, E. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.7.b288 · Cited by 110
Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16
Imae, M., Fu, Z., Yoshida, A., Noguchi, T., & Kato, H. (2003) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0300253 · Cited by 110
Elevated tumour interleukin-1β is associated with systemic inflammation: a marker of reduced survival in gastro-oesophageal cancer
Deans, D. A. C., Wigmore, S. J., Gilmour, H. M., Paterson‐Brown, S., Ross, J. A., & Fearon, K. C. H. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603446 · Cited by 110
Presence of low-grade inflammation impaired postprandial stimulation of muscle protein synthesis in old rats
Balage, M., Avérous, J., Rémond, D., Bos, C., Pujos‐Guillot, E., Papet, I., Mosoni, L., Combaret, L., & Dardevet, D. P. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.005 · Cited by 106
Postprandial myofibrillar and whole body protein synthesis in young and old human subjects
Welle, S. L., Thornton, C. A., Statt, M., & McHenry, B. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.4.e599 · Cited by 105
Atrophy of non-locomotor muscle in patients with end-stage renal failure
Sakkas, G. K. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg325 · Cited by 102
Impaired Recovery of Strength in Older Patients After Major Abdominal Surgery
Watters, J. M., Clancey, S. M., Moulton, S. B., Brière, K. M., & Zhu, J.-M. (1993) · Annals of Surgery · doi:10.1097/00000658-199309000-00017 · Cited by 96
Towards a definition of sarcopenia — results from epidemiologic studies
Visser, M. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0202-y · Cited by 95
Protein metabolism in liver cirrhosis: from albumin to muscle myofibrils
Tessari, P. (2003) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200301000-00012 · Cited by 93
Cancer cachexia: Its correlations and causes
Rubin, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931260100 · Cited by 89
Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
Roubenoff, R., Grinspoon, S. K., Skolnik, P. R., Tchetgen, E. T., Abad, L. W., Spiegelman, D. L., Knox, T. A., & Gorbach, S. L. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00426.2001 · Cited by 86
Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia
Hepple, R. T., Qin, M., Nakamoto, H., & Goto, S. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90478.2008 · Cited by 86
Undernutrition and Anorexia in the Older Person
Visvanathan, R., & Chapman, I. M. (2009) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2009.06.009 · Cited by 85
Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat
Kim, J.-H., Kwak, H., Leeuwenburgh, C., & Lawler, J. M. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.012 · Cited by 83
Self-citation

Flagged first, then by citations

2 of the 272 references couldn’t be matched to a known paper.

Sorted by citations

Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases
Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70034-8 · Cited by 1,102
The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size
Nilwik, R., Snijders, T., Leenders, M., Groen, B. B. L., van Kranenburg, J., Verdijk, L. B., & van Loon, L. J. C. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.012 · Cited by 776
Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting
Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2017) · Obesity · doi:10.1002/oby.22065 · Cited by 822
Self-citation
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627
Self-citation
Hypertension and aging
Buford, T. W. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.007 · Cited by 622
Self-citation

See all 295

Authors: Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M.
Affiliations: University of Florida (US)
Corresponding author: Buford, Thomas W.
Manini, Todd M.
ORCID: Buford, Thomas W.
Anton, Stephen D.
Judge, Andrew R.
Marzetti, Emanuele
Wohlgemuth, Stephanie E.
Carter, Christy S.
Leeuwenburgh, Christiaan
Manini, Todd M.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2010-10
Volume: 9
Issue: 4
Pages: 369-383
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2010.04.004
PMC: PMC3788572
OpenAlex: W1967880601
Cited by: 295
References: 272
Citations by year: 2026: 4 · 2025: 10 · 2024: 17 · 2023: 22 · 2022: 16 · 2021: 24 · 2020: 19 · 2019: 12 · 2018: 20 · 2017: 24 · 2016: 21 · 2015: 25 · 2014: 17 · 2013: 17 · 2012: 29
FWCI: 2.04
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P30AG028740)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: sarcopenia, age-related muscle loss, skeletal muscle, comorbidities, cancer, kidney disease, diabetes mellitus, peripheral arterial disease, nutrition, physical inactivity, therapeutic target
MeSH terms: Acceleration, Aged, Aged, 80 and over, Aging, Diabetes Mellitus, Feeding Behavior, Humans, Kidney Diseases, Health Knowledge, Attitudes, Practice, Models, Biological, Motor Activity, Neoplasms, Nutritional Requirements, Comorbidity, Apoptosis, Muscle, Skeletal, Sarcopenia, Peripheral Arterial Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks