Gut microbiota composition is associated with temperament traits in infants
Open accessAbstract
BACKGROUND: One of the key behavioral phenotypes in infancy are different temperament traits, and certain early life temperament traits have been shown to precede later mental health problems. Differences in the gut microbiota composition (GMC) have been suggested to link with neurodevelopment. For example, toddler temperament traits have been found to associate with differences in GMC; however, studies in infants are lacking although infancy is a rapid period of neurodevelopment as well as GM development. Thus, we aimed to investigate association between infant GMC and temperament. METHODS: The study population (n = 301, 53% boys) was drawn from the FinnBrain Birth Cohort Study. Stool samples were collected from the 2.5-month-old infants and sequenced with 16S Illumina MiSeq platform. GMC taxonomic composition (at Genus and OTU level), observed sample clusters, diversity and richness were investigated in relation to the maternal reports of Infant Behavior Questionnaire -Revised (IBQ-R) at the age of 6 months. RESULTS: Three sample clusters (Bifidobacterium/Enterobacteriaceae, Bacteroides, V. Dispar) based on GMC were identified, of which Bifidobacterium/Enterobacteriaceae-cluster presented with higher scores on the IBQ-R main dimension regulation and its subscale duration of orienting compared to Bacteroides-cluster. The clusters associated with temperament in a sex-dependent manner. The IBQ-R main dimension surgency (positive emotionality) was associated positively both with genus Bifidobacterium and Streptococcus. Alpha diversity had a negative association with negative emotionality and fear reactivity. CONCLUSION: This is the first study demonstrating associations, but not causal connections, between GMC and temperament in young infants in a prospective design.
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The composition of the infant gut microbiota at a young age has been associated with subsequent cognitive development and behavioral outcomes later in infancy.
“While the composition of the infant gut microbiota at a young age has been associated with subsequent cognitive development and behavioral outcomes later in infancy (266, 267), whether these relations are mediated by breast-feeding and early dietary intake is still being investigated.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [267]
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R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,013 · see citing works
<b>mice</b>: Multivariate Imputation by Chained Equations in<i>R</i>
Buuren, S. V., & Groothuis-Oudshoorn, K. (2011) · Journal of Statistical Software · doi:10.18637/jss.v045.i03 · Cited by 13,870 · see citing works
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891 · see citing works
(2010) · University of Twente Research Information · Cited by 6,037 · see citing works
Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing
Bokulich, N. A., Subramanian, S., Faith, J. J., Gevers, D., Gordon, J. I., Knight, R. D., Mills, D. A., & Caporaso, J. G. (2012) · Nature Methods · doi:10.1038/nmeth.2276 · Cited by 4,409 · see citing works
Associations between species and groups of sites: indices and statistical inference
Cáceres, M. D., & Legendre, P. (2009) · Ecology · doi:10.1890/08-1823.1 · Cited by 4,037 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Self-citationTemporal development of the gut microbiome in early childhood from the TEDDY study
Stewart, C. J., Ajami, N. J., O’Brien, J. L., Hutchinson, D. S., Smith, D. P., Wong, M. C., Ross, M. C., Lloyd, R. E., Doddapaneni, H., Metcalf, G., et al. (2018) · Nature · doi:10.1038/s41586-018-0617-x · Cited by 1,996 · see citing works
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968 · see citing works
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Behavioral manifestations of autism in the first year of life
Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.001 · Cited by 1,602 · see citing works
Human gut microbiome: Hopes, threats and promises
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386 · see citing works
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
Gender differences in temperament: A meta-analysis.
Else-Quest, N. M., Hyde, J. S., Goldsmith, H. H., & Van Hulle, C. A. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.1.33 · Cited by 1,169 · cited 1× · see citing works
“However, boys typically show more surgency and its subscales (Else-Quest et al., 2006; Willoughby et al., 2015) as reported by parents and observed in laboratory settings (Gagne et al.”
Control of brain development, function, and behavior by the microbiome
Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089 · see citing works
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works
Temperament, Development, and Personality
Rothbart, M. K. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00505.x · Cited by 910 · see citing works
Rutayisire, E., Huang, K., Liu, Y., & Tao, F. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0498-0 · Cited by 669 · see citing works
Using QIIME to Analyze 16S rRNA Gene Sequences from Microbial Communities
Kuczynski, J., Stombaugh, J., Walters, W. A., González, A., Caporaso, J. G., & Knight, R. D. (2012) · Current Protocols in Microbiology · doi:10.1002/9780471729259.mc01e05s27 · Cited by 661 · see citing works
The development of self-regulation across early childhood.
Montroy, J. J., Bowles, R. P., Skibbe, L. E., McClelland, M. M., & Morrison, F. J. (2016) · Developmental Psychology · doi:10.1037/dev0000159 · Cited by 629 · see citing works
Putnam, S. P., Helbig, A. L., Gartstein, M. A., Rothbart, M. K., & Leerkes, E. M. (2013) · Journal of Personality Assessment · doi:10.1080/00223891.2013.841171 · Cited by 581 · see citing works
Vantage sensitivity: Individual differences in response to positive experiences.
Pluess, M., & Belsky, J. (2012) · Psychological Bulletin · doi:10.1037/a0030196 · Cited by 577 · see citing works
Infant gut microbiome associated with cognitive development
Carlson, A. L., Xia, K., Azcarate-Peril, M. A., Goldman, B. D., Ahn, M., Styner, M. A., Thompson, A. L., Geng, X., Gilmore, J. H., & Knickmeyer, R. C. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.021 · Cited by 541 · see citing works
Maternal prenatal stress is associated with the infant intestinal microbiota
Zijlmans, M. A. C., Korpela, K., Riksen-Walraven, J. M., de Vos, W. M., & de Weerth, C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.006 · Cited by 438 · see citing works
Leclercq, S., Mian, F. M., Stanisz, A. M., Bindels, L. B., Cambier, E., Ben-Amram, H., Koren, O., Forsythe, P., & Bienenstock, J. (2017) · Nature Communications · doi:10.1038/ncomms15062 · Cited by 434 · see citing works
Dantzer, R., Konsman, J.-P., Bluthé, R.-M., & Kelley, K. W. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00220-4 · Cited by 400 · see citing works
Nigg, J. T., Goldsmith, H. H., & Sachek, J. (2004) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3301_5 · Cited by 383 · see citing works
Pauw, S. S. W. D., & Mervielde, I. (2010) · Child Psychiatry & Human Development · doi:10.1007/s10578-009-0171-8 · Cited by 364 · see citing works
Temperament, stress reactivity, and coping: implications for depression in childhood and adolescence
Compas, B. E., Connor-Smith, J., & Jaser, S. S. (2004) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3301_3 · Cited by 361 · see citing works
Gut microbiome in ADHD and its relation to neural reward anticipation
Aarts, E., Ederveen, T. H. A., Naaijen, J., Zwiers, M. P., Boekhorst, J., Timmerman, H. M., Smeekens, S. P., Netea, M. G., Buitelaar, J. K., Franke, B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183509 · Cited by 352 · see citing works
van Dam, A.-M., Brouns, M., Louisse, S., & Berkenbosch, F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91588-6 · Cited by 333 · see citing works
Sex differences in the gut microbiome–brain axis across the lifespan
Jašarević, E., Morrison, K. E., & Bale, T. L. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0122 · Cited by 294 · see citing works
Cohort Profile: The FinnBrain Birth Cohort Study (FinnBrain)
Karlsson, L., Tolvanen, M., Scheinin, N. M., Uusitupa, H., Korja, R., Ekholm, E. M. K., Tuulari, J. J., Pajulo, M., Huotilainen, M., Paunio, T., et al. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyx173 · Cited by 256 · see citing works
Self-citationThe Microbiome in Psychology and Cognitive Neuroscience
Sarkar, A., Harty, S., Lehto, S. M., Moeller, A. H., Dinan, T. G., Dunbar, R., Cryan, J. F., & Burnet, P. W. J. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.04.006 · Cited by 231 · see citing works
Gut microbiome composition is associated with temperament during early childhood
Christian, L. M., Galley, J. D., Hade, E. M., Schoppe-Sullivan, S., Kamp Dush, C., & Bailey, M. T. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.10.018 · Cited by 191 · see citing works
Gut microbiota profiles in treatment-naïve children with attention deficit hyperactivity disorder
Jiang, H.-Y., Zhou, Y.-Y., Zhou, G.-L., Li, Y.-C., Yuan, J., Li, X.-H., & Ruan, B. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.036 · Cited by 164 · see citing works
Lahti, L. (2017) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.18129/b9.bioc.microbiome · Cited by 162 · see citing works
Self-citationVisser, J. C., Rommelse, N. N. J., Greven, C. U., & Buitelaar, J. K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.019 · Cited by 160 · see citing works
Current Protocols in Microbiology
(2018) · Current Protocols in Microbiology · doi:10.1002/(issn)1934-8533 · Cited by 154 · see citing works
ADHD and personality: a meta-analytic review
Gomez, R., & Corr, P. J. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.05.002 · Cited by 151 · see citing works
Maternal prenatal stress and infant emotional reactivity six months postpartum
Nolvi, S., Karlsson, L., Bridgett, D. J., Korja, R., Huizink, A. C., Kataja, E., & Karlsson, H. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.020 · Cited by 135 · see citing works
Self-citationGao, W., Salzwedel, A., Carlson, A. L., Xia, K., Azcárate-Peril, M. A., Styner, M. A., Thompson, A. L., Geng, X., Goldman, B. D., Gilmore, J. H., et al. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5161-8 · Cited by 127 · see citing works
Continuity of temperament from infancy to middle childhood
Komsi, N., Räikkönen, K., Pesonen, A., Heinonen, K., Keskivaara, P., Järvenpää, A., & Strandberg, T. E. (2006) · Infant Behavior and Development · doi:10.1016/j.infbeh.2006.05.002 · Cited by 124 · see citing works
Positive emotionality at age 3 predicts cognitive styles in 7-year-old children
Hayden, E. P., Klein, D. N., Durbin, C. E., & Olino, T. M. (2006) · Development and Psychopathology · doi:10.1017/s0954579406060226 · Cited by 117 · see citing works
Xu, J., Chen, X., Yu, S., Su, Y., & Zhu, W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162461 · Cited by 99 · see citing works
A longitudinal analysis of anger and inhibitory control in twins from 12 to 36 months of age
Gagne, J. R., & Goldsmith, H. H. (2010) · Developmental Science · doi:10.1111/j.1467-7687.2010.00969.x · Cited by 95 · see citing works
Fearful temperament and stress reactivity among preschool‐aged children
Talge, N. M., Donzella, B., & Gunnar, M. R. (2008) · Infant and Child Development · doi:10.1002/icd.585 · Cited by 84 · see citing works
Behavioral Inhibition: Temperament or Prodrome?
Pérez‐Edgar, K. E., & Guyer, A. E. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0019-9 · Cited by 78 · see citing works
Kopala‐Sibley, D. C., Danzig, A. P., Kotov, R., Bromet, E. J., Carlson, G. A., Olino, T. M., Bhatia, V., Black, S. R., & Klein, D. N. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000152 · Cited by 71 · see citing works
Genetic and Environmental Contributions to the Development of Positive Affect in Infancy
Planalp, E. M., Hulle, C. V. V., Lemery-Chalfant, K., & Goldsmith, H. (2017) · Emotion · doi:10.1037/emo0000238 · Cited by 62 · see citing works
Turner‐Cobb, J. M., Rixon, L., & Jessop, D. S. (2008) · Developmental Psychobiology · doi:10.1002/dev.20298 · Cited by 61 · see citing works
Canals, J., Hernández‐Martínez, C., Esparó, G., & Fernandez-Ballart, J. D. (2011) · Acta Paediatrica · doi:10.1111/j.1651-2227.2011.02306.x · Cited by 54 · see citing works
Infant temperament and childhood psychiatric disorder: longitudinal study
Sayal, K. S., Heron, J., Maughan, B., Rowe, R., & Ramchandani, P. G. (2013) · Child Care Health and Development · doi:10.1111/cch.12054 · Cited by 54 · see citing works
Early—but modest—gender differences in focal aspects of childhood temperament
Gagne, J. R., Miller, M. M., & Goldsmith, H. H. (2013) · Personality and Individual Differences · doi:10.1016/j.paid.2013.02.006 · Cited by 53 · see citing works
Nolvi, S., Uusitupa, H., Bridgett, D. J., Pesonen, H., Aatsinki, A., Kataja, E., Korja, R., Karlsson, H., & Karlsson, L. (2017) · Developmental Science · doi:10.1111/desc.12625 · Cited by 49 · see citing works
Self-citationRintala, A., Riikonen, I., Toivonen, A., Pietilä, S., Munukka, E., Pursiheimo, J., Elo, L. L., Arikoski, P., Luopajärvi, K., Schwab, U., et al. (2018) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2018.1444788 · Cited by 48 · see citing works
Self-citationMother's and father's reports on their child's temperament: Does gender matter?
Bayly, B. L., & Gartstein, M. A. (2012) · Infant Behavior and Development · doi:10.1016/j.infbeh.2012.10.008 · Cited by 27 · see citing works
Hanford, L. C., Schmithorst, V. J., Panigrahy, A., Lee, V., Ridley, J., Bonar, L. K., Versace, A., Hipwell, A. E., & Phillips, M. L. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01968 · Cited by 12 · see citing works
The epidemiology of observed temperament: Factor structure and demographic group differences
Willoughby, M. T., Stifter, C. A., & Gottfredson, N. C. (2015) · Infant Behavior and Development · doi:10.1016/j.infbeh.2015.02.001 · Cited by 10 · see citing works
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Cowan, C. S. M., Dinan, T. G., & Cryan, J. F. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13156 · Cited by 176 · see citing works
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Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127 · see citing works
Kelsey, C. M., Prescott, S., McCulloch, J. A., Trinchieri, G., Valladares, T. L., Dreisbach, C., Alhusen, J., & Grossmann, T. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.003 · Cited by 116 · see citing works
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Loughman, A., Ponsonby, A.-L., O'Hely, M., Symeonides, C., Collier, F., Tang, M. L. K., Carlin, J., Ranganathan, S., Allen, K., Pezic, A., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102640 · Cited by 120 · see citing works
Ou, Y., Belzer, C., Smidt, H., & de Weerth, C. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2038853 · Cited by 54 · see citing works
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- Authors
- Aatsinki, A.-K., Lahti, L., Uusitupa, H.-M., Munukka, E., Keskitalo, A., Nolvi, S., O'Mahony, S., Pietilä, S., Elo, L. L., Eerola, E., Karlsson, H., & Karlsson, L.
- Affiliations
- University of Turku (FI)
- Åbo Akademi University (FI)
- Corresponding author
- Aatsinki, Anna-Katariina
- ORCID
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 80
- Pages
- 849-858
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2945924223
- Cited by
- 148
- References
- 71
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 26 · 2023: 23 · 2022: 22 · 2021: 18 · 2020: 16 · 2019: 5
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- UTUPub (University of Turku) (submittedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-nd)
- Funders
- Waterloo Foundation
- Academy of Finland
- Yrjö Jahnssonin Säätiö
- Signe ja Ane Gyllenbergin Säätiö
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- gut microbiota, infant temperament, brain development, Bifidobacterium, Enterobacteriaceae, Bacteroides, Streptococcus, positive affectivity, negative affectivity, fear reactivity, alpha diversity, sex differences, stool microbiome
- MeSH terms
- Gastrointestinal Microbiome, Adult, Feces, Female, Finland, Humans, Infant, Male, Mothers, Prospective Studies, Surveys and Questionnaires, Temperament, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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