Extending possible applications of an episodic-like memory task in rats
Abstract
Recently, an object recognition episodic-like memory task was proposed in rodents. However, the short retention delay of the task narrows its applications. This study verifies whether this task can be evoked after 24h. Additionally, the effect of a classical amnestic agent (scopolamine) on episodic-like memory consolidation was investigated. Rats showed increased exploration of old over recent objects and spent more time exploring displaced over stationary object. Both old over recent and displaced over stationary objects preferences were abolished by pos-training scopolamine administration (1mg/kg i.p.), indicating impaired spatiotemporal retrieval. In conclusion, the object recognition task that accomplishes the what, where and when components of episodic-like memory in rats can persist for 24h.
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Rats retain 'what-where-when' memory for up to 24 hours in the ELM2-1 test.
“Other studies have shown rats to retain “what-where-when” memory for up to 24 hours in the ELM2–1 test (Barbosa et al., 2010; Barbosa et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Barbosa et al., 2010
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Barbosa, F. F., Santos, J. R., Meurer, Y. S. R., Macêdo, P. T., Ferreira, L. M. S., Pontes, I. M. O., Ribeiro, A. M., & Silva, R. H. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00112 · Cited by 79 · see citing works
“Recently, we have adapted this protocol using a 24-h retention delay (Barbosa et al., 2010), in order to study separately the acquisition, consolidation, and retrieval mnemonic Frontiers in Behavioral Neuroscience www.frontiersin.org August 2013 | Volume 7 | Article 112 | 1 processes.”
MethodResultBarbosa, F. F., de Oliveira Pontes, I. M., Ribeiro, S., Ribeiro, A. M., & Silva, R. H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.022 · Cited by 71 · see citing works
Self-citationCastilla-Ortega, E., Pedraza, C., Chun, J., Fonseca, F. R. D., Estivill-Torrús, G., & Santín, L. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.018 · Cited by 50 · see citing works
Castilla-Ortega, E., Rosell-Valle, C., Pedraza, C., Rodríguez de Fonseca, F., Estivill-Torrús, G., & Santín, L. J. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.001 · Cited by 41 · see citing works
Belblidia, H., Abdelouadoud, A., Jozet-Alves, C., Dumas, H., Freret, T., Leger, M., & Schumann-Bard, P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.043 · Cited by 17 · see citing works
- Authors
- Barbosa, F. F., Pontes, I. M. D. O., Ribeiro, A. M., & Silva, R. H.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Corresponding author
- Silva, Regina Helena
- ORCID
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 215
- Issue
- 2
- Pages
- 326-331
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2122391906
- Cited by
- 23
- References
- 29
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tekes
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- episodic-like memory, object recognition memory, memory consolidation, scopolamine, amnesia
- MeSH terms
- Animals, Exploratory Behavior, Male, Mental Recall, Scopolamine, Time Factors, Rats, Wistar, Rats
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