Cited by 134Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

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Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer’s type

Bassani, Taysa B., Turnes, Joelle M., Moura, Eric L.R., Bonato, Jéssica M., Cóppola-Segovia, Valentín, Zanata, Silvio M., Oliveira, Rúbia M.M.W., Vital, Maria A.B.F.·2017·Behavioural Brain Research

DOI 10.1016/j.bbr.2017.08.014

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Abstract

Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and neuroprotective properties. Recent evidence also suggests that curcumin increases cognitive performance in animal models of dementia, and this effect would be related to its capacity to enhance adult neurogenesis. The aim of this study was to test the hypothesis that curcumin treatment would be able to preserve cognition by increasing neurogenesis and decreasing neuroinflammation in the model of dementia of Alzheimer's type induced by an intracerebroventricular injection of streptozotocin (ICV-STZ) in Wistar rats. The animals were injected with ICV-STZ or vehicle and curcumin treatments (25, 50 and 100mg/kg, gavage) were performed for 30days. Four weeks after surgery, STZ-lesioned animals exhibited impairments in short-term spatial memory (Object Location Test (OLT) and Y maze) and short-term recognition memory (Object Recognition Test - ORT), decreased cell proliferation and immature neurons (Ki-67- and doublecortin-positive cells, respectively) in the subventricular zone (SVZ) and dentate gyrus (DG) of hippocampus, and increased immunoreactivity for the glial markers GFAP and Iba-1 (neuroinflammation). Curcumin treatment in the doses of 50 and 100mg/kg prevented the deficits in recognition memory in the ORT, but not in spatial memory in the OLT and Y maze. Curcumin treatment exerted only slight improvements in neuroinflammation, resulting in no improvements in hippocampal and subventricular neurogenesis. These results suggest a positive effect of curcumin in object recognition memory which was not related to hippocampal neurogenesis.

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Authors: Bassani, T. B., Turnes, J. M., Moura, E. L. R., Bonato, J. M., Cóppola-Segovia, V., Zanata, S. M., Oliveira, R. M. M. W., & Vital, M. A. B. F.
Affiliations: Universidade Federal do Paraná (BR)
Universidade Estadual de Maringá (BR)
Corresponding author: Bassani, Taysa B.
ORCID: Bassani, Taysa B.
Bonato, Jéssica M.
Cóppola-Segovia, Valentín
Vital, Maria A.B.F.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2017-09
Volume: 335
Pages: 41-54
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2017.08.014
OpenAlex: W2742647283
Cited by: 134
References: 72
Citations by year: 2026: 6 · 2025: 14 · 2024: 13 · 2023: 20 · 2022: 18 · 2021: 16 · 2020: 18 · 2019: 14 · 2018: 15
FWCI: 4.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: curcumin, Alzheimer's disease, spatial memory, recognition memory, adult neurogenesis, neuroinflammation, hippocampus, subventricular zone, dentate gyrus, glial fibrillary acidic protein, Iba1, object recognition memory, object location memory, neuroprotection
MeSH terms: Doublecortin Protein, Alzheimer Disease, Animals, Behavior, Animal, Brain, Cognition, Curcumin, Dementia, Disease Models, Animal, Hippocampus, Male, Memory, Short-Term, Neuroimmunomodulation, Rats, Wistar, Neuroprotective Agents, Maze Learning, Dentate Gyrus, Rats, Neurogenesis, Spatial Memory

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Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer’s type

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