The DOI matches its Crossref record; 41 of the 45 references it cites were found in a registry or an index.
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
Abstract
IL-6 has emerged as an important cytokine upregulated in states of insulin resistance such as type 2 diabetes. We evaluated the chronic effect of IL-6 on insulin signaling in 3T3-F442A and 3T3-L1 adipocytes. First, cells responded to a chronic treatment with IL-6 by initiating an autoactivation process that increased IL-6 secretion. Second, IL-6-treated adipocytes showed a decreased protein expression of IR-beta subunit and IRS-1 but also an inhibition of the insulin-induced activation of IR-beta, Akt/PKB, and ERK1/2. Moreover, IL-6 suppressed the insulin-induced lipogenesis and glucose transport consistent with a diminished expression of GLUT4. IL-6-treated adipocytes failed to maintain their adipocyte phenotype as shown by the downregulation of the adipogenic markers FAS, GAPDH, aP2, PPAR-gamma, and C/EBP-alpha. IL-6 also induced the expression of SOCS-3, a potential inhibitor of insulin signaling. Finally, the effects of IL-6 could be prevented by rosiglitazone, an insulin-sensitizing agent. Thus, IL-6 may play an important role in the set-up of insulin resistance in adipose cell.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Gene expression studies with human adipose tissue have demonstrated that the levels of expression of MCP-1, colony-stimulating factor-3 and the urokinase plasminogen activator CD87 increase significantly in the adipose tissue of subjects with morbid obesity (31) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [31]
In the citing paper
“In obese subjects, these macrophages typically aggregate in crowns around apoptotic adipocytes (31) (Figs. 1 and 2).”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [31]
In the citing paper
“Hypoxia-inducible factor-1a, a transcription factor normally induced by hypoxia, is overexpressed in the subcutaneous adipose tissue of obese subjects and its expression is decreased during weight reduction (31) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [31]
In the citing paper
“In this study, the protein expression of IL-10 increased, suggesting a possible M1 to M2 (pro-inflammatory to anti-inflammatory) switch of macrophage phenotypes (31) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [31]
In the citing paper
“On the other hand, it seems likely that reduced secretion of pro-inflammatory mediators from adipocytes or activated macrophages of adipose tissue contributes to the effect of weight loss (31,36,65,67,142) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [31]
In the citing paper
“The parallelism between the down-regulation of these genes and the reduction in adiposity and adipocyte diameter by n-3 PUFA treatment suggests a positive relationship between adipose cell size and adipose tissue inflammation, agreeing with other observations (31,66) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [31]
Citations
Cites
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Spiegelman, B. M. (1998) · Diabetes · doi:10.2337/diabetes.47.4.507 · Cited by 1,730
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Cited by
Sorted by citations
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,090
Self-citationInflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912
Picon‐Ruiz, M., Morata‐Tarifa, C., Valle‐Goffin, J. J., Friedman, E. R., & Slingerland, J. M. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21405 · Cited by 932
Hypoxia and Adipose Tissue Function and Dysfunction in Obesity
Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 932
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 966
Lipolysis and lipid mobilization in human adipose tissue
Lafontan, M., & Langin, D. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.05.001 · Cited by 884
Arsenic-induced oxidative stress and its reversibility
Flora, S. J. S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.008 · Cited by 841
Adipokines: The missing link between insulin resistance and obesity
Antuna-Puente, B., Fève, B., Fellahi, S., & Bastard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.09.004 · Cited by 760
Self-citationDavidovici, B. B., Sattar, N. A., Prinz, J. C., Puig, L., Emery, P., Barker, J. N., van de Kerkhof, P., Ståhle, M., Nestle, F. O., Girolomoni, G., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.103 · Cited by 717
Jager, J., Grémeaux, T., Cormont, M., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2006) · Endocrinology · doi:10.1210/en.2006-0692 · Cited by 727
Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes
Scheithauer, T. P. M., Rampanelli, E., Nieuwdorp, M., Vallance, B. A., Verchere, C. B., van Raalte, D. H., & Herrema, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571731 · Cited by 715
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668
Adipogenesis and WNT signalling
Christodoulides, C., Lagathu, C., Sethi, J. K., & Vidal‐Puig, A. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.09.002 · Cited by 614
Self-citationIncreased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis
Wieckowska, A., Papouchado, B. G., Li, Z., Lopez, R., Zein, N. N., & Feldstein, A. E. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01774.x · Cited by 597
IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
Neurath, M. F., & Finotto, S. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.02.003 · Cited by 584
Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update
Su, H., Lei, C., & Zhang, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00405 · Cited by 554
Kristiansen, O. P., & Mandrup-Poulsen, T. R. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s114 · Cited by 529
Maachi, M., Piéroni, L., Bruckert, É., Jardel, C., Fellahi, S., Hainque, B., Capeau, J., & Jp, B. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802718 · Cited by 379
Self-citationDietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y., & Wang, Y. (2014) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2014.03.001 · Cited by 360
Tremellen, K., & Pearce, K. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.04.016 · Cited by 359
The role of interleukins in insulin resistance and type 2 diabetes mellitus
Fève, B., & Bastard, J.-P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.62 · Cited by 343
Self-citationSarjeant, K., & Stephens, J. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008417 · Cited by 328
Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes
Lagathu, C., Yvan‐Charvet, L., Bastard, J., Maachi, M., Quignard‐Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 328
Self-citationLipid and lipoprotein dysregulation in insulin resistant states
Avramoglu, R. K., Basciano, H., & Adeli, K. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.026 · Cited by 326
Petersen, E. W., Carey, A. L., Sacchetti, M., Steinberg, G. R., Macaulay, S. L., Febbraio, M. A., & Pedersen, B. K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2004 · Cited by 311
Inflammatory Process in Type 2 Diabetes: The Role of Cytokines
ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309
IL-6 signalling pathways and the development of type 2 diabetes
Akbari, M., & Hassan‐Zadeh, V. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0458-0 · Cited by 315
The potential biological mechanisms of arsenic-induced diabetes mellitus
Tseng, C. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.02.009 · Cited by 311
Matsubara, T., Mita, A., Minami, K., Hosooka, T., Kitazawa, S., Takahashi, K., Tamori, Y., Yokoi, N., Watanabe, M., Matsuo, E., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.002 · Cited by 287
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282
Leal, V. D. O., & Mafra, D. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.02.003 · Cited by 287
Insulin signalling mechanisms for triacylglycerol storage
Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 289
Interleukin-6 depletion selectively improves hepatic insulin action in obesity.
Klover, P. J., Clementi, A. H., & Mooney, R. A. (2005) · Endocrinology · doi:10.1210/en.2004-1468 · Cited by 273
From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation
Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.16 · Cited by 258
The JAK / STAT pathway in obesity and diabetes
Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016) · The FEBS Journal · doi:10.1111/febs.13709 · Cited by 249
Adipose cell size: importance in health and disease
Stenkula, K. G., & Erlanson‐Albertsson, C. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00257.2017 · Cited by 266
Perry, B. D., Caldow, M. K., Brennan‐Speranza, T. C., Sbaraglia, M., Jerums, G., GARNHAM, A. P., Wong, C. Y., Levinger, P., Haq, M. A. U., Hare, D. L., et al. (2016) · PubMed · Cited by 239
The autocrine and paracrine roles of adipokines
Karastergiou, K., & Mohamed-Ali, V. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.11.011 · Cited by 233
Wang, B., Jenkins, J. R., & Trayhurn, P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00475.2004 · Cited by 235
Neilson, H. K., Friedenreich, C. M., Brockton, N. T., & Millikan, R. C. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0756 · Cited by 232
Physiological roles of muscle-derived interleukin-6 in response to exercise
Pedersen, B. K., & Fischer, C. P. (2007) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3280ebb5b3 · Cited by 227
Chapter 21 Interleukin‐6 and Insulin Resistance
Kim, J., Bachmann, R. A., & Chen, J. (2009) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)00621-3 · Cited by 224
Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines
Pedersen, B. K. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00734.2009 · Cited by 221
Gehrke, N., & Schattenberg, J. M. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.02.020 · Cited by 216
Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
Nieto-Vazquez, I., Fernández-Veledo, S., de Alvaro, C., & Lorenzo, M. (2008) · Diabetes · doi:10.2337/db07-1062 · Cited by 209
RetractedRieusset, J., Bouzakri, K., Chevillotte, E., Ricard, N., Jacquet, D., Bastard, J.-P., Laville, M., & Vidal, H. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2232 · Cited by 200
Self-citationCancer Drug Discovery and Development
Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195
FAT CELLS: Afferent and Efferent Messages Define New Approaches to Treat Obesity
Lafontan, M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095843 · Cited by 191
IL-6 signalling in exercise and disease
Pedersen, B. K. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351295 · Cited by 193
Anty, R., Bekri, S., Luciani, N., Saint‐Paul, M., Dahman, M., Iannelli, A., Amor, I. B., Staccini-Myx, A., Huet, P., Gugenheim, J., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00724.x · Cited by 196
Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice
Lee, Y., Cha, B., Saito, K., Yamakawa, H., Choi, S., Yamaguchi, K., Yonezawa, T., Teruya, T., Nagai, K., & Woo, J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.01.034 · Cited by 189
Kang, J., Kim, C.-S., Han, I., Kawada, T., & Yu, R. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.082 · Cited by 188
Lagathu, C., Eustace, B. K., Prot, M., Frantz, D., Gu, Y., Bastard, J., Maachi, M., Azoulay, S., Briggs, M., Caron, M., et al. (2007) · Antiviral Therapy · doi:10.1177/135965350701200407 · Cited by 185
Self-citationInfluence of TNF-α and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans
Krogh‐Madsen, R., Plomgaard, P., Møller, K., Mittendorfer, B., & Pedersen, B. K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00471.2005 · Cited by 185
Badawi, A. F. (2010) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmsott.s9089 · Cited by 228
Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice
Lee, Y., Cha, B., Choi, S., Choi, B., Yonezawa, T., Teruya, T., Nagai, K., & Woo, J. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.03.014 · Cited by 182
Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
Pedersen, B. K., & Febbraio, M. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01208.2006 · Cited by 181
Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity
Wunderlich, C. M., Hövelmeyer, N., & Wunderlich, F. T. (2013) · JAK-STAT · doi:10.4161/jkst.23878 · Cited by 176
Ye, Z., Wang, S., Zhang, C., & Zhao, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00617 · Cited by 178
Conjugated Linoleic Acid Induces Human Adipocyte Delipidation
Brown, J. M., Sandberg, M. B., Chung, S., Fabiyi, O., Morrison, R. F., Mandrup, S., & McIntosh, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401766200 · Cited by 173
Jan, V., Cervera, P., Maachi, M., Baudrimont, M., Kim, M. J., Vidal, H., Girard, P., Levan, P., Rozenbaum, W., Lombès, A., et al. (2004) · Antiviral Therapy · doi:10.1177/135965350400900412 · Cited by 169
Self-citationOverexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice
Franckhauser, S., Elias, I., Sopasakis, V. R., Ferré, T., Nagaev, I., Andersson, C. X., Agudo, J., Ruberte, J., Bosch, F., & Smith, U. (2008) · Diabetologia · doi:10.1007/s00125-008-0998-8 · Cited by 175
Wang, B., & Trayhurn, P. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0055-8 · Cited by 163
Inflammatory markers and bariatric surgery: a meta-analysis
Rao, S. R. (2012) · Inflammation Research · doi:10.1007/s00011-012-0473-3 · Cited by 162
Association between Inadequate Sleep and Insulin Resistance in Obese Children
Flint, J. K., Kothare, S. V., Zihlif, M., Suarez, E. A., Adams, R., Legido, A., & Luca, F. D. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.08.063 · Cited by 164
Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine
Sommer, G., Garten, A., Petzold-Quinque, S., Beck‐Sickinger, A. G., Blüher, M., Stümvoll, M., & Faßhauer, M. (2008) · Clinical Science · doi:10.1042/cs20070226 · Cited by 161
Inflammation, physical activity, and chronic disease: An evolutionary perspective
Burini, R. C., Anderson, E., Durstine, J. L., & Carson, J. A. (2020) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2020.03.004 · Cited by 173
Chung, S., Brown, J. M., Provo, J. N., Hopkins, R. G., & McIntosh, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508159200 · Cited by 160
Kunz, H., Hart, C. R., Gries, K. J., Parvizi, M., LAURENTI, M. C., Man, C. D., Moore, N., Zhang, X., Ryan, Z., Polley, E. C., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2021 · Cited by 170
Caër, C., Rouault, C., Roy, T. L., Poitou, C., Aron‐Wisnewsky, J., Torcivia, A., Bichet, J.-C., Clément, K., Guerre-Millo, M., & André, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02660-w · Cited by 165
Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes
Kralisch, S., Klein, J. C., Lössner, U., Blüher, M., Paschke, R., Stümvoll, M., & Faßhauer, M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00090.2005 · Cited by 161
Interleukin-1 Receptor Antagonist: A New Therapy for Type 2 Diabetes Mellitus
Akash, M. S. H., Shen, Q., Rehman, K., & Chen, S. (2012) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23057 · Cited by 158
Roles of IL-6-gp130 Signaling in Vascular Inflammation
Hou, T., Tieu, B. C., Ray, S., Recinos, A., Cui, R., Tilton, R. G., & Brasier, A. R. (2008) · Current Cardiology Reviews · doi:10.2174/157340308785160570 · Cited by 149
Interleukin-6 and insulin sensitivity: friend or foe?
Carey, A. L., & Febbraio, M. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1447-y · Cited by 143
Association of Short and Long Sleep Durations with Insulin Sensitivity in Adolescents
Javaheri, S., Storfer-Isser, A., Rosen, C. L., & Redline, S. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.09.080 · Cited by 139
Appetite and energy balance signals from adipocytes
Trayhurn, P., & Bing, C. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1859 · Cited by 145
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 140
Adipose tissue macrophage in obesity-associated metabolic diseases
Yao, J., Wu, D., & Qiu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977485 · Cited by 151
Jové, M., Planavila, A., Laguna, J. C., & Vázquez-Carrera, M. (2005) · Endocrinology · doi:10.1210/en.2004-1560 · Cited by 133
Role of interleukins in obesity: implications for metabolic disease
Febbraio, M. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.02.004 · Cited by 134
gp130 receptor ligands as potential therapeutic targets for obesity
Febbraio, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30453 · Cited by 124
Takagaki, Y., Lee, S. M., Dongqing, Z., Kitada, M., Kanasaki, K., & Koya, D. (2020) · Autophagy · doi:10.1080/15548627.2020.1713641 · Cited by 123
Rodríguez‐Calvo, R., Serrano, L., Coll, T., Moullan, N., Sánchez, R. M., Merlos, M., Palomer, X., Laguna, J. C., Michalik, L., Wahli, W., et al. (2008) · Diabetes · doi:10.2337/db08-0176 · Cited by 121
Hammarstedt, A., Sopasakis, V. R., Gogg, S., Jansson, P., & Smith, U. (2004) · Diabetologia · doi:10.1007/s00125-004-1612-3 · Cited by 119
Guo, L., & Tabrizchi, R. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.009 · Cited by 117
The effect of PPARγ ligands on the adipose tissue in insulin resistance
Hammarstedt, A., Andersson, C. X., Sopasakis, V. R., & Smith, U. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.008 · Cited by 119
Insulin resistance in patients with rheumatoid arthritis: effect of anti‐TNFα therapy
Rosenvinge, A., Krogh‐Madsen, R., Baslund, B., & Pedersen, B. K. (2007) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740601179605 · Cited by 112
Andreozzi, F., Laratta, E., Procopio, M. C., Hribal, M. L., Sciacqua, A., Perticone, M., Miele, C., Perticone, F., & Sesti, G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01340-06 · Cited by 116
Caron, M., Auclair, M., Lagathu, C., Lombès, A., Walker, U. A., Kornprobst, M., & Capeau, J. (2004) · AIDS · doi:10.1097/00002030-200411050-00004 · Cited by 107
Self-citationContribution of adipocyte-derived factors to beta-cell dysfunction in diabetes
Zhao, Y.-F., Feng, D. D., & Chen, C. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.11.008 · Cited by 110
Almuraikhy, S., Kafienah, W., Bashah, M., Diboun, I., Jaganjac, M., Al‐Khelaifi, F., Abdesselem, H., Mazloum, N. A., Alsayrafi, M., Mohamed‐Ali, V., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4031-3 · Cited by 107
Li, Y., Rong, Y., Bao, L., Nie, B., Ren, G., Chen, Z., Amin, R., Arnold, R. D., Jeganathan, R. B., & Huggins, K. W. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0574-7 · Cited by 98
Cytokines and inflammation in adipogenesis: an updated review
Jiang, N., Yao, L., Shu, T., & Wang, J. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0625-0 · Cited by 104
Lagathu, C., Bastard, J., Auclair, M., Maachi, M., Kornprobst, M., Capeau, J., & Caron, M. (2004) · Antiviral Therapy · doi:10.1177/135965350400900607 · Cited by 97
Self-citation
Metadata
- Authors
- Lagathu, C., Bastard, J.-P., Auclair, M., Maachi, M., Capeau, J., & Caron, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Caron, Martine
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 311
- Issue
- 2
- Pages
- 372-379
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2061613314
- Cited by
- 385
- References
- 45
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 15 · 2023: 11 · 2022: 15 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 12 · 2014: 17 · 2013: 25 · 2012: 29
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- interleukin-6, insulin resistance, adipocytes, rosiglitazone, insulin signaling, insulin receptor beta, IRS-1, Akt, ERK1/2, GLUT4, lipogenesis, adipogenesis, SOCS3, type 2 diabetes, 3T3-L1 cells
- MeSH terms
- Suppressor of Cytokine Signaling 3 Protein, Rosiglitazone, Animals, Dose-Response Relationship, Drug, Glucose, Insulin Resistance, Proteins, Repressor Proteins, Transcription Factors, Signal Transduction, Interleukin-6, Up-Regulation, 3T3 Cells, Adipocytes, 3T3-L1 Cells, Thiazolidinediones, Suppressor of Cytokine Signaling Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
