Cited by 149Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMindfulness and Compassion InterventionsMental Health Research Topics

What, me worry and ruminate about dsm-5 and rdoc? The importance of targeting negative self-referential processing

Open access
Mennin, Douglas S., Fresco, David M.·2013·Clinical Psychology: Science and Practice

Abstract

Rumination, worry, and other forms of negative self-referential processing (NSRP) are familiar to everyone, as reflecting on the self is perhaps our most human characteristic. However, for a substantial subgroup of patients, NSRP arises in response to intense emotionality, worsening the clinical presentation, and diminishing the treatment response. The combination of emotionality and NSRP likely reflects an endophenotype of complicated and treatment refractory patients who fail to achieve a satisfactory treatment response in our trials and our clinics. An important next step is to personalize treatments by deliberately targeting NSRPs within established treatment protocols or in as yet novel treatments. Enriching treatments with mindfulness meditation is one possible avenue for personalized care of patients with this hypothesized endophenotype. © 2013 American Psychological Association.

Integrity signals

Registry

Crossref · 10.1111/cpsp.12038

Cites

89 of 89 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

19 of 37 cited sources checked · 2 supported · 1 flagged · accuracy not yet measured

  • Premisecitation

    RDoC does not directly cover NSRP because it emphasizes more molecular components.

    “alternative nosological systems that are showing promise, such as the Research Domain Criteria (RDoC; Insel et al., 2010) initiative at the National Institute of Mental Health (NIMH), also do not directly address NSRP phenomena given their focus on more molecular components (e.g., attention, working memory, learning processes), which are likely constituent mechanisms of NSRP but not specific to it”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites Insel et al., 2010 source

      The RDoC framework discussion (Am J Psychiatry 167:7, July 2010) identifies neural circuitry as its primary focus and includes working memory as an example, supporting the claim that RDoC examines constituent mechanisms. But the paper does not discuss NSRP or say whether RDoC directly addresses it. It also includes individual, family, and social-context levels, so the claim's characterization of its focus as molecular is too narrow. (LLM, conf=0.83)

      Experimental — accuracy not yet measured
  • Premisecitation

    Higher rumination before treatment predicts worse acute response in MDD, dysthymia, and panic disorder.

    “pretreatment levels of rumination predict an inferior acute treatment response in MDD and dysthymic disorder (e.g., Ciesla & Roberts, 2002; Jones et al., 2008; Schmaling, Dimidjian, Katon, & Sullivan, 2002) as well as panic disorder (Papageorgiou & Wells, 2003; Wells, 1990).”
    Quote in the paperSubstantial claim1 of 3 sources checked
    • cites Ciesla & Roberts, 2002 source
    • cites Jones et al., 2008 source

      The Results (Rumination Predicting Treatment Outcome) link higher pretreatment rumination to lower odds of remission with cognitive therapy, although the effect varies with initial depression severity. The Methods (Participants) specify that all participants had recurrent major depressive disorder; this study does not establish the prediction for dysthymia. In the citing sentence, separate citations accompany the panic-disorder claim, so that claim is not attributed to Jones et al. (LLM, conf=0.89)

      Experimental — accuracy not yet measured
    • cites Schmaling et al., 2002 source
  • Premisecitation

    More residual depression and rumination after acute MDD treatment with CBT or MBCT predict higher relapse risk.

    “higher levels of residual depression symptoms and rumination are associated with a greater likelihood of relapse following acute treatment for MDD with CBT (Watkins et al., 2011) and mindfulness based cognitive therapy (MBCT; Michalak, Hölz, & Teismann, 2011).”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites Watkins et al., 2011 source

      The Abstract links incomplete recovery after acute depression treatment to relapse risk, and the relapse-prevention section says residual symptoms tend to predict relapse. The Abstract also describes rumination as a predictor of later depression, but the paper does not establish that higher rumination predicts relapse specifically after acute CBT. MBCT is attributed to a different citation in the sentence. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
    • cites Michalak et al., 2011 source
  • Premisecitation

    Worry and rumination, as forms of NSRP, are negatively reinforced when aversive emotions decrease.

    “Theorists (e.g., Borkovec et al., 2004; Nolen-Hoeksema, Wisco, & Lyubomirsky, 2008; Watkins, 2008) have argued that NSRP including worry and rumination becomes negatively reinforced by the reduction in aversive emotions.”
    Quote in the paperSubstantial claim2 of 3 sources checked
    • cites Borkovec et al., 2004

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Nolen-Hoeksema et al., 2008 source
    • cites Watkins, 2008 source

      The sections on vulnerability to depression and anxiety report that rumination often exacerbates negative mood and that worry can increase anxiety, but they do not address whether reductions in aversive emotions negatively reinforce either form of thought. Searches for negative reinforcement and emotional avoidance found no passage establishing the attributed mechanism. The reported increases in distress do not rule out relief under other conditions. (LLM, conf=0.72)

      Experimental — accuracy not yet measured
  • Premisecitation

    Purposefully targeting worry and rumination improves how long treatment gains last.

    “deliberate efforts to target forms of negative self-referencing (worry and rumination) improve treatment durability (e.g., van Aalderen et al., 2011; Watkins et al., 2011; Wells et al., 2012).”
    Quote in the paperSubstantial claim1 of 3 sources checked
    • cites van Aalderen et al., 2011 source
    • cites Watkins et al., 2011 source

      The Secondary outcomes section reports less relapse between baseline and post-intervention with rumination-focused CBT than with treatment as usual, supporting the claim for targeting rumination during the study. It does not establish that treatment gains lasted longer after treatment, and this trial did not test targeting worry. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
    • cites Wells et al., 2012 source
  • May combine two claims. 13
  • Classified as probably not a substantial claim. 4
  • May combine two claims.

    Premisecitation

    Relative to healthy controls, GAD patients have stronger resting-state connectivity among the amygdala, vmPFC, and dlPFC, and this coupling increases with anxiety severity.

    “Etkin, Prater, Schatzberg, Menon, and Greicius (2009) found that generalized anxiety disorder (GAD) patients, as compared to healthy control participants, evidenced stronger resting state connectivity between the amygdala, the ventromedial PFC, and the dorsolateral PFC, and this connectivity was stronger as a function of anxiety severity.”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites Etkin et al., 2009 source

      The Comment section reports increased amygdala connectivity with both the ventromedial and dorsolateral PFC in GAD patients. But the Results section reports that amygdala–DLPFC connectivity was negatively correlated with all anxiety measures: it was strongest in the least anxious patients, contrary to the claimed increase with anxiety severity. Page numbers are not available in our copy. (LLM, conf=0.91)

      Checked by a reasoning model — may be wrong.

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    NSRP occurs in high-functioning individuals ('worried well') and across many disorders ('transdiagnostically').

    “Even in its dysfunctional forms, NSRP is seen in people with relatively high functioning (i.e., “the worried well”) as well as in many disorders (i.e., “transdiagnostically”).”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites Kertz et al., 2012 source
    • cites Watkins, 2009 source

      The Discussion (page unavailable) supports a transdiagnostic role for rumination: it reports associations with anxiety and depression, and links brooding to co-morbid OCD and GAD. The Introduction mentions studies using non-clinical samples, but the paper does not establish that dysfunctional rumination occurs in relatively high-functioning people or the “worried well.” Its findings concern rumination rather than NSRP as a whole. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    In mostly normative people, mindfulness meditation training lowers DMN-related neural recruitment, reduces mind wandering, and improves working memory.

    “Among largely normative individuals, training in mindfulness meditation has been shown to reduce recruitment of neural regions associated with the DMN (e.g., Brewer et al., 2011; Farb et al., 2007) and reduce mind wandering while improving working memory capacity (e.g., Mrazek, Franklin, Phillips, Baird, & Schooler, 2013).”
    Quote in the paperSubstantial claim2 of 3 sources checked
    • cites Brewer et al., 2011 source

      The Results (page not provided) report less activation in DMN regions during meditation in experienced meditators than in matched controls. But this was a comparison of groups, not a training experiment; the Discussion says prospective studies are needed to demonstrate the effect experimentally. The sentence cites Mrazek et al., rather than Brewer et al., for the separate mind-wandering and working-memory claim. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
    • cites Farb et al., 2007 source

      The Abstract reports greater reductions in medial prefrontal activity during experiential focus in the mindfulness-trained group than in novices. The Discussion explicitly cautions that the cross-sectional design does not show that training caused this difference. The sentence attributes the separate claims about mind wandering and working memory to Mrazek et al., not Farb et al. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
    • cites Mrazek et al., 2013 source
  • May combine two claims.

    Premisecitation

    Improvements from mindfulness-based meditation and therapies go with less NSRP and/or more decentering.

    “Increasingly, benefits from mindfulness-based meditation and therapies are associated with reductions in NSRPs and/or gains in decentering, defined as a meta-cognitive capacity to observe items that arise in the mind (e.g., thoughts, feelings, memories) with healthy psychological distance, greater self-awareness, and perspective taking (Fresco, Moore, et al., 2007; Fresco, Segal, Buis, & Kennedy,”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites Fresco, Moore, et al., 2007 source

      The introduction (p. 2) reports that mindfulness-based cognitive therapy (MBCT) increased decentering relative to usual treatment and describes evidence that MBCT reduced depression relapse. The general discussion (p. 10) treats decentering as a possible mechanism of treatment benefit, but the paper does not establish the broader association across mindfulness-based meditation and therapies claimed here. (LLM, conf=0.84)

      Experimental — accuracy not yet measured
    • cites Fresco, Segal, et al., 2007

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Premisecitation

    People with emotional disorders often show impaired reward and threat learning, producing narrow and rigid behavioral repertoires.

    “individuals with emotional disorders often exhibit deficiencies in reward (e.g., Bogdan & Pizzagalli, 2006) and threat learning (e.g., Lissek, 2012; Whitmer et al., 2012) that result in impoverished and inflexible repertoires of behavior in response to the situations that typically function to promote escape, avoidance, or inactivity as a means of attempting to manage emotional/motivational”
    Quote in the paperSubstantial claim3 of 3 sources checked
    • cites Bogdan & Pizzagalli, 2006 source

      The Results and Discussion report reduced reward responsiveness under acute stress in healthy female controls, especially those reporting more anhedonic symptoms. The citation is attached to reward learning, not threat learning, but the study does not establish that people with emotional disorders generally have reward-learning deficiencies or that these produce inflexible behavior. Page numbers are not available in our copy. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
    • cites Lissek, 2012 source

      The Introduction and Section III link anxiety disorders to abnormalities in fear conditioning and overgeneralization of learned threat. The paper does not establish that these abnormalities produce impoverished, inflexible behavioral repertoires, and its findings do not cover emotional disorders broadly. The citing sentence attributes reward learning to a different source. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
    • cites Whitmer et al., 2012 source

      The Discussion (page unavailable) reports impaired punishment learning in clinically depressed participants induced to ruminate, and suggests this could make them less likely to act. Whitmer et al. is cited for threat learning, but its findings are conditional on rumination in major depression; it does not establish a general threat-learning deficit across emotional disorders or demonstrate impoverished, inflexible behavioral repertoires. (LLM, conf=0.86)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Many people with co-occurring GAD and MDD do not achieve adequate treatment gains, which extends their deficits in functioning and satisfaction.

    “Despite significant treatment advances (e.g., Butler, Chapman, Forman, & Beck, 2006), a sizeable subgroup of individuals with co-occurring disorders such as GAD and major depressive disorder (MDD) fail to make sufficient treatment gains, thereby prolonging their deficits in life functioning and satisfaction.”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites Butler et al., 2006 source
  • May combine two claims.

    Premisecitation

    Elevated NSRP is linked to poorer cognitive and behavioral performance, worse treatment response, and more relapse.

    “High levels of NSRP are associated with considerable deficits in cognitive and behavioral responding (e.g., Lissek, 2012; Whitmer, Frank, & Gotlib, 2012) as well as an inferior treatment response and greater relapse (e.g., Jones, Siegle, & Thase, 2008).”
    Quote in the paperSubstantial claim3 of 3 sources checked
    • cites Lissek, 2012 source

      The sections on clinical testing and neural mechanisms discuss conditioned-fear overgeneralization in anxiety, not NSRP or a link between NSRP and cognitive or behavioral deficits. Searches for NSRP and the claimed deficits found no relevant passage in our copy. The treatment-response and relapse clause is cited to Jones et al., not Lissek. (LLM, conf=0.75)

      Experimental — accuracy not yet measured
    • cites Whitmer et al., 2012 source

      The Discussion (page unavailable) reports that induced rumination made clinically depressed participants poorer at learning punishment probabilities and avoiding highly punished stimuli, supporting a specific cognitive and behavioral deficit. It does not establish that high levels of NSRP broadly produce considerable deficits across cognitive and behavioral responding. The treatment-response and relapse claims are attached to Jones et al. (2008), not to this source. (LLM, conf=0.83)

      Experimental — accuracy not yet measured
    • cites Jones et al., 2008 source

      The Results (Rumination Predicting Treatment Outcome; page unavailable) link higher initial rumination to lower odds of initial remission during cognitive therapy, although that relationship varies with initial depression severity. The paper examines initial remission, not relapse, so it does not support the claim of greater relapse. The cognitive and behavioral deficits in the citing sentence are attached to other citations, not Jones et al. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Many psychiatric illnesses feature NSRP, which often causes excessive DMN activity and difficulty switching to the TPN, impairing cognitive load and emotion regulation.

    “considerable evidence now reveals that many forms of psychiatric illness are marked by NSRP often resulting in inordinate activation of the DMN and correspondingly, an inability to switch to the TPN, which in turn undermines cognitive load and emotion regulation capacities (e.g., Brewer et al., 2011; Whitfield-Gabrieli & Ford, 2012).”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites Brewer et al., 2011 source

      The Discussion links pathological states to altered DMN connectivity and its relationship with the task-positive network. It also describes DMN interference with goal-directed processing and attentional performance. It does not establish that self-referential processing in many psychiatric illnesses causes excessive DMN activation, an inability to switch networks, or impaired emotion regulation. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
    • cites Whitfield-Gabrieli & Ford, 2012 source
  • May combine two claims.

    Interpretationcitation

    NSRPs are an individual-difference factor spanning many emotional disorders, complicating presentation and treatment, and are key to address for lasting gains.

    “Taken together, the meta-analytic results from Olatunji et al. (2013) and the various treatment findings showing the corrosive effects of rumination, worry, and self-criticism indicate that NSRPs represent an individual difference factor that cuts across many forms of emotional disorders, complicates the clinical presentation and treatment of these disorders, and appears to be a crucial factor to”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S4 (based).

    Interpretationnone given

    In psychopathology, NSRPs are best explained by what they do in response to emotional/motivational situations.

    “these NSRPs, in the context of psychopathology, are best understood by their functional nature in response to emotional/motivational contexts”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    Self-criticism harms both acute treatment gains and the durability of treatment effects.

    “self-criticism has also shown deleterious effects on treatment efficacy both in the terms of acute treatment gains and in treatment durability (Blatt, 1995; Blatt, Quinlan, Pilkonis, & Shea, 1995; Blatt, Zuroff, Bondi, Sanislow, & Pilkonis, 1998; Blatt, Zuroff, Hawley, & Auerbach, 2010).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Blatt, 1995

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Blatt et al., 1995

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Blatt et al., 1998 source
  • May combine two claims.

    Interpretationreasoning

    NSRP's avoidance functions may be especially problematic and may explain why NSRP appears across many forms of psychopathology.

    “The avoidance functions of NSRP may be particularly problematic and responsible for their ubiquitous presence in many forms of psychopathology.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisecitation

    Comorbid mood and anxiety disorders are linked to more rumination, and concurrent worry partly explains the link between rumination and depression/anxiety symptoms.

    “diagnostic comorbidity composed of mood and anxiety disorders was associated with greater levels of rumination, and concurrent levels of worry partially accounted for the association between rumination to depression and anxiety symptoms.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Olatunji et al., 2013 source
  • May combine two claims.

    Interpretationreasoning

    DSM-5 and RDoC largely overlook this characteristic, and even effective treatments seldom focus on it.

    “Yet, this characteristic is largely overlooked in our systems of nosology (e.g., DSM-5, RDoC) and rarely becomes a major focus even in our efficacious treatments.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    Mindfulness-enriched treatments may fit well for NSRP that stems from avoidant emotional/motivational intensity.

    “treatments enriched with mindfulness meditation may be well suited to addressing the problems of NSRP that arise in response to avoidant-oriented emotional/motivational intensity.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Premisenone given

    Current nosological systems largely ignore NSRPs.

    “However, despite a clear need to better elucidate their role in the nature and treatment of psychopathology, current nosological systems all but ignore NSRPs.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Interpretationnone given

    Worry, rumination, and self-criticism are abnormal versions of normal self-referential processes that have reliable biobehavioral mechanisms.

    “we propose that (a) worry, rumination, and self-criticism reflect aberrations of normative self-referential processes with reliable biobehavioral mechanisms”
    Quote in the paperNot a substantial claim
17 of 17

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Individuals with GAD and/or MDD characteristically respond to aversive and often conflicting emotional and somatic experiences with repetitive or perseverative reactive cognitive processes such as worry and rumination.

    “Specifically, individuals with GAD and/or MDD characteristically respond to aversive and often conflicting emotional and somatic experiences with the use of repetitive or perseverative reactive cognitive processes such as worry and rumination (Mennin and Fresco, 2013).”

    From Distinct functional connectivities predict clinical response with emotion regulation therapy (2017) · cites this paper as Mennin and Fresco, 2013

    The “Disordered Self-Referential Processing” section describes worry and rumination as repetitive responses to distressing emotional or motivational states, and “Treating Refractory Self-Referential Processing” says GAD and MDD are especially marked by destructive negative self-referencing. The paper does not clearly establish the claim’s added specificity that these processes characteristically respond to aversive, conflicting somatic experiences. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • In summary, GAD and ruminative MDD patients exhibit intense emotional experiences coupled with excessive negative self-referentiality and low ability to effectively decenter from their emotions and somatic responses, likely reflecting disruption in the DN and SN.

    “In summary, GAD and ruminative MDD patients exhibit intense emotional experiences (e.g., somatic arousal) coupled with excessive negative self-referentiality and low ability to effectively decenter from their emotions and somatic responses (e.g., Mennin and Fresco, 2013), likely reflecting disruption in the DN and SN (e.g., insula).”

    From Distinct functional connectivities predict clinical response with emotion regulation therapy (2017) · cites this paper as Mennin and Fresco, 2013

    Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured
  • Perseverative negative thinking strategies are more likely to worsen and prolong rather than alleviate psychological distress.

    “However, these strategies are more likely to worsen and prolong rather than alleviate psychological distress (16,17).”

Cites

Flagged first, then by citations

3 of the 92 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Forbes, 2006, Alterations in reward-related decisions in boys with depressive and anxiety disorders, Biological Psychiatry, 59, 126S

Cited by

Sorted by citations

Authors
Mennin, D. S., & Fresco, D. M.
Affiliations
  • City University of New York (US)
  • Kent State University (US)
Venue
Clinical Psychology: Science and Practice
Published
2013-09
Volume
20
Issue
3
Pages
258-267
ISSN
  • 0969-5893 (ISSN-L)
  • 1468-2850
OpenAlex
W1897377682
Cited by
149
References
92
Citations by year
2026: 1 · 2025: 11 · 2024: 13 · 2023: 11 · 2022: 21 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 15 · 2017: 9 · 2016: 12 · 2015: 12 · 2014: 5 · 2013: 2
FWCI
14.00
Type
journal article
Language
en
Open access
Locations
  • Clinical Psychology Science and Practice (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R34MH070682)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
rumination, worry, emotionality, endophenotypes, treatment refractoriness, personalized treatment, mindfulness meditation, DSM-5, Research Domain Criteria, treatment response

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