Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics

A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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The NLRP3 inflammasome: molecular activation and regulation to therapeutics

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Mitochondrial Fission, Fusion, and Stress

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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Mechanism and Regulation of NLRP3 Inflammasome Activation

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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The pathways of mitophagy for quality control and clearance of mitochondria

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Selective degradation of mitochondria by mitophagy

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Mitochondrial Dynamics and Its Involvement in Disease

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Functions and dysfunctions of mitochondrial dynamics

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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

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Inflammasome activation and regulation: toward a better understanding of complex mechanisms

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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Mitochondrial dynamics and mitochondrial quality control

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Critical role for calcium mobilization in activation of the NLRP3 inflammasome

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

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Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

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Lysosome biology in autophagy

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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

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The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

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Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

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Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

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Autophagy and apoptosis: where do they meet?

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Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

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Mitochondria as playmakers of apoptosis, autophagy and senescence

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PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

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The role of mitochondria in NLRP3 inflammasome activation

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NLRP3 inflammasome in neurological diseases, from functions to therapies

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Mitochondrial dynamics in neurodegeneration

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Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy

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The inflammasomes: mechanisms of activation and function

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Inflammasome activation and assembly at a glance

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A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

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Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

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Mitophagy and Neuroprotection

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The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

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Mitochondria: diversity in the regulation of the NLRP3 inflammasome

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Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

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The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics

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Autophagy and disease: unanswered questions

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RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

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Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

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Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

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The NLRP3 Inflammasome in Alzheimer’s Disease

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Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition

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Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

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Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

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Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation

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Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy

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FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

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Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.

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Inflammasomes link vascular disease with neuroinflammation and brain disorders

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Defective mitochondrial fission augments NLRP3 inflammasome activation

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Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

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Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts

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Cyanidin‐3‐O‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice

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Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress

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URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

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Parkin-Dependent Mitophagy Is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

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Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

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Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics

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Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

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TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation

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Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation

Shan, S., Shen, Z., Zhang, C., Kou, R., Xie, K., & Song, F. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113643 · Cited by 92 · see citing works

RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage

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Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus

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Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy

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Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson’s disease via promoting mitophagy

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Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation

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Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion

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Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation

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Morphine induces dysfunction of PINK1/Parkin-mediated mitophagy in spinal cord neurons implying involvement in antinociceptive tolerance

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Miltefosine increases macrophage cholesterol release and inhibits NLRP3-inflammasome assembly and IL-1β release

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Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection

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Inflammasomes in cancer: Effect of epigenetic and autophagic modulations

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Bacopa monnieri inhibits apoptosis and senescence through mitophagy in human astrocytes

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Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances

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SARS-CoV-2, COVID-19 and the aging immune system

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Exploring the Role of Neuroplasticity in Development, Aging, and Neurodegeneration

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Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

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The Role of NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets

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Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model

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Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments

Rehman, M. U., Sehar, N., Dar, N. J., Khan, A., Arafah, A., Rashid, S., Rashid, S. M., & Ganaie, M. A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104961 · Cited by 130 · see citing works

Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy

Luo, T., Jia, X., Feng, W.-D., Wang, J., Xie, F., Kong, L., Wang, X., Lian, R., Liu, X., Chu, Y.-J., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01094-7 · Cited by 122 · see citing works

Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy

Chen, Y., Shi, S., & Dai, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113903 · Cited by 123 · see citing works

Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model

Pu, X., Liu, J., Wang, Y., Guan, X., Wu, Q., Zhang, Q., Liu, R., & Chang, X. (2025) · Journal of Ginseng Research · doi:10.1016/j.jgr.2025.04.006 · Cited by 103 · see citing works

Macrophage Polarization Mediated by Mitochondrial Dysfunction Induces Adipose Tissue Inflammation in Obesity

Xu, L., Yan, X., Zhao, Y., Song, J., Liu, B., Yu, S., Fu, J., Liu, Y., & Su, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169252 · Cited by 102 · see citing works

IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8 + T-cell tumour infiltration

Feng, W., Zhang, Y., Xu, Z., Yu, S.-Y., Huo, J., Tuersun, A., Zheng, M., Zhao, J., Zong, Y., & Lu, A. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04187-3 · Cited by 88 · see citing works

Mitochondrial Dysfunction in Vascular Wall Cells and Its Role in Atherosclerosis

Salnikova, D. I., Orekhova, V. A., Grechko, A. V., Starodubova, A. V., Bezsonov, E. E., Попкова, Т. В., & Orekhov, A. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168990 · Cited by 84 · see citing works

Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions

Pu, X., Zhang, Q., Liu, J., Wang, Y., Guan, X., Wu, Q., Liu, Z., Liu, Z., & Chang, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155880 · Cited by 84 · see citing works

Natural polysaccharides protect against diet-induced obesity by improving lipid metabolism and regulating the immune system

Tang, C., Wang, Y., Chen, D., Zhang, M., Xu, J., Chen, X., Liu, J., Kan, J., & Jin, C. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113192 · Cited by 88 · see citing works

Role of mitochondria in physiological activities, diseases, and therapy

Wang, L., Zhou, X., & Lu, T. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00284-5 · Cited by 79 · see citing works

Immunosenescence and inflamm-ageing in COVID-19

Zinatizadeh, M. R., Zarandi, P. K., Ghiasi, M., Kooshki, H., Mohammadi, M., Amani, J., & Rezaei, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101818 · Cited by 62 · see citing works

Mitophagy in atherosclerosis: from mechanism to therapy

Zhang, Y., Weng, J., Huan, L., Sheng, S., & Xu, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1165507 · Cited by 65 · see citing works

NLRP3 Inflammasome’s Activation in Acute and Chronic Brain Diseases—An Update on Pathogenetic Mechanisms and Therapeutic Perspectives with Respect to Other Inflammasomes

Chiarini, A., Gui, L., Viviani, C., Armato, U., & Prà, I. D. (2023) · Biomedicines · doi:10.3390/biomedicines11040999 · Cited by 61 · see citing works

Chronic kidney disease and NLRP3 inflammasome: Pathogenesis, development and targeted therapeutic strategies

Huang, G., Zhang, Y., Zhang, Y., & Ma, Y. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101417 · Cited by 59 · see citing works

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae

Wei, X., Qian, W., Narasimhan, H., Chan, T., Liu, X., Arish, M., Young, S., Li, C., Cheon, I. S., Yu, Q., et al. (2025) · Science · doi:10.1126/science.adq2509 · Cited by 58 · see citing works

Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)

Zhang, X., Zeng, W., Zhang, Y., Yu, Q., Zeng, M., Gan, J., Zhang, W., Jiang, X., & Li, H. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5130 · Cited by 56 · see citing works

Myocardial ischemia-reperfusion injury: The balance mechanism between mitophagy and NLRP3 inflammasome

Chen, L., Mao, L., Xue, J.-Y., Jian, Y.-H., Deng, Z.-W., Mazhar, M., Zou, Y., Liu, P., Chen, M., Luo, G., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122998 · Cited by 56 · see citing works

Mitochondrial Dysfunction in Cardiac Arrhythmias

Deng, J., Jiang, Y., Chen, Z., Rhee, J., Deng, Y., & Wang, Z. V. (2023) · Cells · doi:10.3390/cells12050679 · Cited by 47 · see citing works

Effects of mitochondrial dysfunction on cellular function: Role in atherosclerosis

Xu, M., Wang, W., Cheng, J., Qu, H., Xu, M., & Wang, L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116587 · Cited by 48 · see citing works

Mitochondrial Dynamics: Working with the Cytoskeleton and Intracellular Organelles to Mediate Mechanotransduction

Huang, D., Chen, S., Xiong, D., Wang, H., Zhu, L., Wei, Y., Li, Y., & Zou, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.0201 · Cited by 40 · see citing works

Mechanism of Baicalein in Brain Injury After Intracerebral Hemorrhage by Inhibiting the ROS/NLRP3 Inflammasome Pathway

Chen, X., Zhou, Y., Wang, S., & Wang, W. (2021) · Inflammation · doi:10.1007/s10753-021-01569-x · Cited by 36 · see citing works

MitoTEMPO protects against podocyte injury by inhibiting NLRP3 inflammasome via PINK1/Parkin pathway-mediated mitophagy

Liu, B., Wang, D., Cao, Y., Wu, J., Zhou, Y., Wu, W., Wu, J., Zhou, J., & Qiu, J. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175136 · Cited by 34 · see citing works

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

Chirumbolo, S., Tirelli, U., Franzini, M., Pandolfi, S., Ricevuti, G., Vaiano, F., & Valdenassi, L. (2023) · Human & Experimental Toxicology · doi:10.1177/09603271231218926 · Cited by 34 · see citing works

Targeting Inflammatory Imbalance in Chronic Kidney Disease: Focus on Anti-Inflammatory and Resolution Mediators

Rispoli, R. M., Popolo, A., Fabrizio, V. D., Bianca, R. D. D. V., Autore, G., Dalli, J., & Marzocco, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073072 · Cited by 34 · see citing works

The Impact of Pathogens on Sepsis Prevalence and Outcome

Dyck, B., Unterberg, M., Adamzik, M., & Koos, B. (2024) · Pathogens · doi:10.3390/pathogens13010089 · Cited by 35 · see citing works

Role of gut microbiota in doxorubicin-induced cardiotoxicity: from pathogenesis to related interventions

Huang, C., Li, X., Li, H., Chen, R., Li, Z., Li, D., Xu, X., Zhang, G., Qin, L., Li, B., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05232-5 · Cited by 35 · see citing works

Ononin alleviates DSS‐induced colitis through inhibiting NLRP3 inflammasome via triggering mitophagy

Yu, T., Lu, X., Liang, Y., Yang, L., Yin, Y., & Chen, H. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.776 · Cited by 33 · see citing works

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

Wikramanayake, T. C., Chéret, J., Sevilla, A., Birch‐Machin, M. A., & Paus, R. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2049756 · Cited by 31 · see citing works

Aflatoxin B1 Induced Oxidative Stress and Gut Microbiota Disorder to Increase the Infection of Cyprinid Herpesvirus 2 in Gibel Carp (Carassius auratus gibelio)

Xue, M., Fu, M., Zhang, M., Xu, C., Meng, Y., Jiang, N., Li, Y., Liu, W., Fan, Y., & Zhou, Y. K. (2023) · Antioxidants · doi:10.3390/antiox12020306 · Cited by 31 · see citing works

Liraglutide ameliorates delirium-like behaviors of aged mice undergoing cardiac surgery by mitigating microglia activation via promoting mitophagy

Jia, M., Lv, X., Zhu, T., Shen, J.-C., Liu, W., & Yang, J. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06492-7 · Cited by 31 · see citing works

C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect

Fu, R., Tsai, C.-W., Chiu, S., Liu, S., Chiang, Y.-T., Kuo, Y.-H., Shyu, W., & Lin, S. (2022) · Cells · doi:10.3390/cells11193128 · Cited by 30 · see citing works

Focus on the role of NLRP3 inflammasome in the pathology of endometriosis: a review on molecular mechanisms and possible medical applications

Irandoost, E., Najibi, S., Talebbeigi, S., & Nassiri, S. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02365-6 · Cited by 30 · see citing works

Dihydromyricetin suppresses endothelial NLRP3 inflammasome activation and attenuates atherogenesis by promoting mitophagy

Hu, Q., Li, C., Zhang, T., Yi, L., Shan, Y., Ma, X., Cai, T., Li, R., Shen, H., & Li, Y. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02263-1 · Cited by 28 · see citing works

Potential intervention target of atherosclerosis: Ferroptosis (Review)

Li, J., Xu, L., Zuo, Y., Chang, X., & Chi, H. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12859 · Cited by 28 · see citing works

The interplay between mitochondrial dysfunction and NLRP3 inflammasome in multiple sclerosis: Therapeutic implications and animal model studies

Shadab, A., Abbasi‐Kolli, M., Saharkhiz, M., Ahadi, S. H., Shokouhi, B., & Nahand, J. S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116673 · Cited by 27 · see citing works

The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor

Chen, S., Ma, J., Yin, P., & Liang, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1188482 · Cited by 26 · see citing works

Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy

Wu, W., Jia, H., Chen, S., Ma, X., Zhou, S. F., Qiu, L., Wu, X., Li, P., Chu, H., & Zhang, G. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00843-6 · Cited by 25 · see citing works

Mitochondrial dysfunction in diabetic neuropathy: Impaired mitophagy triggers NLRP3 inflammasome

Sriwastawa, K. K., & Kumar, A. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101972 · Cited by 25 · see citing works

Targeting inflammasomes as an immunotherapeutic strategy for cancer

Huang, L., Chen, X., Liu, R., Nan, D., Bao, W., Yang, L., Dai, X., Tang, J., Zhang, H., & Lu, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06665-2 · Cited by 23 · see citing works

Advances in Mitochondrial Dysfunction and Its Role in Cardiovascular Diseases

Qiu, Y. J., Chang, S., Zeng, Y., & Wang, X. (2025) · Cells · doi:10.3390/cells14201621 · Cited by 24 · see citing works

Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome

Wang, N., Zhang, X., Shen, P., Huang, C., Deng, H.-F., Zhou, L., Yue, L., Shen, B.-Y., Zhou, W., & Gao, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.883865 · Cited by 24 · see citing works

Bibliometric and visual analysis of doxorubicin-induced cardiotoxicity

Lin, X., Wu, G., Wang, S., & Huang, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1255158 · Cited by 47 · see citing works

Microglial NLRP3 Inflammasomes in Alzheimer’s Disease Pathogenesis: From Interaction with Autophagy/Mitophagy to Therapeutics

Ayyubova, G., & Madhu, L. N. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04758-z · Cited by 23 · see citing works

Elamipretide reduces pyroptosis and improves functional recovery after spinal cord injury

Jiang, W., He, F., Ding, G., & Wu, J. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14221 · Cited by 22 · see citing works

Methylated urolithin A, mitigates cognitive impairment by inhibiting NLRP3 inflammasome and ameliorating mitochondrial dysfunction in aging mice

Chen, P., Wang, Y., Xie, J., Lei, J., & Zhou, B. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109950 · Cited by 20 · see citing works

PANoptosis in Sepsis: A Central Role and Emerging Therapeutic Target

Wu, Q., Qi, S., Kang, Z., Bai, X., Li, Z., Cheng, J., & Dong, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s513367 · Cited by 19 · see citing works

Roles and Mechanisms of NLRP3 in Influenza Viral Infection

Niu, J., & Meng, G. (2023) · Viruses · doi:10.3390/v15061339 · Cited by 19 · see citing works

Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma

Mishra, S. R., Behera, B. P., Singh, V. K., Mahapatra, K. K., Mundkinajeddu, D., Bhat, D., Minz, A. M., Sethi, G., Efferth, T., Das, S., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155157 · Cited by 18 · see citing works

A comprehensive insight into the immunomodulatory role of MSCs‐derived exosomes (MSC‐Exos) through modulating pattern‐recognition receptors (PRRs)

Alshahrani, M. Y., Jasim, S. A., Altalbawy, F. M. A., Bansal, P., Kaur, H., Al‐Hamdani, M. M., Deorari, M., Abosaoda, M. K., Hamzah, H. F., & Mohammed, B. A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4029 · Cited by 18 · see citing works

Bay 11-7082 mitigates oxidative stress and mitochondrial dysfunction via NLRP3 inhibition in experimental diabetic neuropathy

Sharan, L., Pal, A., Babu, S., Kumar, A., & Banerjee, S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123203 · Cited by 18 · see citing works

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

Loh, D., & Reiter, R. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158122 · Cited by 17 · see citing works

NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder

Vallese, A., Cordone, V., Ferrara, F., Guiotto, A., Gemmo, L., Cervellati, F., Hayek, J., Pecorelli, A., & Valacchi, G. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.297 · Cited by 16 · see citing works

BAM15 inhibits endothelial pyroptosis via the NLRP3/ASC/caspase-1 pathway to alleviate atherosclerosis

Zhong, S., Shen, H., Dai, X., Liao, L., & Huang, C. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119226 · Cited by 16 · see citing works

Acetyl zingerone inhibits chondrocyte pyroptosis and alleviates osteoarthritis progression by promoting mitophagy through the PINK1/parkin signaling pathway

Zhang, Z., Huang, T., Chen, X., Chen, J., Yuan, H., Yi, N., Miao, C., Sun, R., & Ni, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115055 · Cited by 16 · see citing works

Mitochondria-mediated pyroptosis: anti-glioblastoma mechanism of the frankincense-derived compound β-boswellic acid

Tang, N., Wang, H., He, M., Geng, N., Zhao, X., Zhu, X., Yang, R., Gao, J., & Hang, C. (2026) · 3 Biotech · doi:10.1007/s13205-025-04691-x · Cited by 16 · see citing works

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Liao, X., Wang, Y., Zhang, Z., Qu, X., & Zhou, G. (2026) · Mediators of Inflammation · doi:10.1155/mi/3168669 · Cited by 22 · see citing works

PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models

Wang, X., Xue, Y.-Q., Yao, Y., Li, Y., Ji, X., Chi, T., Liu, P., & Zou, L. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105298 · Cited by 16 · see citing works

Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod-induced psoriatic inflammation in mice

Liang, S., Yang, Z., Hua, L., Chen, Y., Zhou, Y., Ou, Y., Chen, X., Hu, Y., Yang, X., Wu, X., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175156 · Cited by 16 · see citing works

Immunosenescence and Inflammaging in COVID-19

Asghari, F., Asghary, A., Zolbanin, N. M., Faraji, F., & Jafari, R. (2023) · Viral Immunology · doi:10.1089/vim.2023.0045 · Cited by 16 · see citing works

Emerging insights into the role of NLRP3 inflammasome and endoplasmic reticulum stress in renal diseases

Zhang, Y.-T. Y., Guo, S., Fu, X., Zhang, Q., & Wang, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112342 · Cited by 16 · see citing works

Targeting Wnt/beta-catenin signaling to attenuate short-chain chlorinated paraffins-triggered hepatocyte mitochondrial fission and subsequent pyroptosis

Xiao, J., Huang, D., Wang, F., Gan, L., Zhang, W., Zhang, F., Tang, J., Shen, Z., Jiang, M., Egbobe, J. O., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115102 · Cited by 15 · see citing works

Understanding the Role of NLRP3 Inflammasome in Acute Pancreatitis

Papantoniou, K., Aggeletopoulou, I., Michailides, C., Pastras, P., & Triantos, C. K. (2024) · Biology · doi:10.3390/biology13110945 · Cited by 15 · see citing works

Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center

Wang, J., Wu, M., Xiao, L., Du, G., Chen, M., Magupalli, V. G., Dahlberg, P. D., Wu, H., & Jensen, G. J. (2026) · Science Advances · doi:10.1126/sciadv.aee2473 · Cited by 15 · see citing works

Interplay Between Dietary Bioactive Compounds and Gut Microbiota in Modulating Obesity-Associated Inflammation and Metabolic Dysfunction

Seifishahpar, M., Kalupahana, N. S., Kim, J. H., & Moustaïd‐Moussa, N. (2025) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111224-024937 · Cited by 14 · see citing works

Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications

Ni, F.-X., Wang, H., Hu, J., Chen, P., Huang, H.-J., Chen, H., Huang, D., & Jiang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1686175 · Cited by 14 · see citing works

Imeglimin attenuates NLRP3 inflammasome activation by restoring mitochondrial functions in macrophages

Lee, J. Y., KANG, Y. Y., Jeon, J. Y., Kim, H. J., Kim, D. J., Lee, K. W., & Han, S. J. (2024) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2024.03.004 · Cited by 14 · see citing works

Mitophagy in Alzheimer's disease and its potential as a therapeutic target

Wei, J., Xiao, T., Lyu, J., Zhao, Y., Zhang, Y., Du, X., He, Y., Zhao, M., Yang, X., Yao, Y., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107162 · Cited by 13 · see citing works

Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

Dissanayake, L. V., Zietara, A. P., Levchenko, V., Spires, D. R., Angulo, M. B., El‐Meanawy, A., Geurts, A. M., Dwinell, M. R., Palygin, O., & Staruschenko, A. (2022) · iScience · doi:10.1016/j.isci.2022.104887 · Cited by 13 · see citing works

An ROS-Responsive Antioxidative Macromolecular Prodrug of Caffeate for Uveitis Treatment

Li, Y., Sheng, S.-T., Yu, B., Jia, F., Wang, K., Han, H.-J., Jin, Q., Wang, Y., & Ji, J. (2022) · Chinese Journal of Polymer Science · doi:10.1007/s10118-022-2798-x · Cited by 12 · see citing works

Enhanced inflammasome-mediated inflammation and impaired autophagy in peripheral blood mononuclear cells is associated with non-alcoholic fatty liver disease severity

Saha, S., Ray, S., Mandal, A., Das, U. B., Bhattacharya, T., Shireen, Z., Sarkar, S., Sharma, R. D., Ghosh, S., & Dey, S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121911 · Cited by 12 · see citing works

Astrocyte-derived Exosomal GJA1-20 k Targets Pink1-mediated Mitophagy to Attenuate Traumatic Brain Injury

Li, Y., Chen, W., & Feng, J. (2025) · Translational Stroke Research · doi:10.1007/s12975-025-01374-w · Cited by 11 · see citing works

Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression

Mishra, S. R., Mishra, P., Senapati, P. K., Mahapatra, K. K., & Bhutia, S. K. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189453 · Cited by 11 · see citing works

Spatiotemporal crosstalk among mitochondrial dynamics, NLRP3 inflammasome activation, and histone lactylation drives α-synuclein pathology in prodromal Parkinson’s disease

Lv, P., Chen, X., Liu, S., Zhang, Y., Bai, Y., Wang, S., & Wang, Y. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1636185 · Cited by 11 · see citing works

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

Gan, Y.-Q., Cai, Y.-W., Liang, X., Wang, L., Shi, F., Sun, N., Li, Y., Xu, R., Hu, B., Zha, Q., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1631152 · Cited by 11 · see citing works

Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro

Shrivastava, G., Leon, P. C. V., Botello, K., & Calvo, E. (2023) · iScience · doi:10.1016/j.isci.2023.108620 · Cited by 11 · see citing works

Inflammasome activation and accelerated immune aging in autoimmune disorders

Mittal, R., Saavedra, D., Mittal, M., Lemos, J. R. N., & Hirani, K. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1688060 · Cited by 12 · see citing works

Research progress on the correlation between renin-angiotensin-aldosterone system (RAAS) and cardiovascular and cerebrovascular diseases

Zhao, G., Wang, T., Luan, Y., Xu, Y., Qin, N., Chen, W., & Wang, Q. (2025) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/14703203251351194 · Cited by 11 · see citing works

Investigating the Potential Shared Molecular Mechanisms between COVID-19 and Alzheimer’s Disease via Transcriptomic Analysis

Fan, Y., Liu, X., Guan, F., Hang, X., He, X., & Jin, J. (2024) · Viruses · doi:10.3390/v16010100 · Cited by 10 · see citing works

Mitochondria in pyroptosis: Mechanisms and implications

Eldakhakhny, B. M., Abdulaal, W. H., Khan, J., Ajoolabady, A., Praticò, D., Bahijri, S., Tuomilehto, J. O., Borai, A., Kim, B., & Ren, J. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.12.002 · Cited by 9 · see citing works

Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice

Zhong, C., Yang, J., Deng, K., Lang, X., Zhang, J., Li, M., Qiu, L., Zhong, G., & Yu, J. (2023) · Molecules · doi:10.3390/molecules28227527 · Cited by 9 · see citing works

Glycation Produces Topologically Different α-Synuclein Oligomeric Strains and Modulates Microglia Response via the NLRP3-Inflammasome Pathway

Kumari, M., Bisht, K. S., Ahuja, K., Motiani, R. K., & Maiti, T. K. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00057 · Cited by 12 · see citing works

Kaempferol attenuated LPS-induced microglial neurotoxicity by promoting mitophagy to inhibit mtDNA-mediated NLRP3 inflammasome activation

Xiao, L., Liang, L., Zhou, S., Fan, P., & Yuan, C. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157486 · Cited by 8 · see citing works

Cell death and its interaction with mitochondrial dysfunction in pathogenesis of acute pancreatitis: a comprehensive review

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Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure

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