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Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component
Open accessAbstract
Recently, macrophages have been characterized as having an M1 or M2 phenotype based on receptor expression, cytokine and effector molecule production, and function. The effects of macrophage phenotype upon tissue remodeling following the implantation of a biomaterial are largely unknown. The objectives of this study were to determine the effects of a cellular component within an implanted extracellular matrix (ECM) scaffold upon macrophage phenotype, and to determine the relationship between macrophage phenotype and tissue remodeling. Partial-thickness defects in the abdominal wall musculature of Sprague-Dawley rats were repaired with autologous body wall tissue, acellular allogeneic rat body wall ECM, xenogeneic pig urinary bladder tissue, or acellular xenogeneic pig urinary bladder ECM. At 3, 7, 14, and 28 days the host tissue response was characterized using histologic, immunohistochemical, and RT-PCR methods. The acellular test articles were shown to elicit a predominantly M2 type response and resulted in constructive remodeling, while those containing a cellular component, even an autologous cellular component, elicited a predominantly M1 type response and resulted in deposition of dense connective tissue and/or scarring. We conclude that the presence of cellular material within an ECM scaffold modulates the phenotype of the macrophages participating in the host response following implantation, and that the phenotype of the macrophages participating in the host response appears to be related to tissue remodeling outcome.
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“What is more, it is widely accepted that during the degradation of implanted ECM bioscaffolds, ECM components are released into the environment and promote the transition to a remodeling phase [18,44,74,78].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [74]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Mechanistically, inadequate decellularization retains high amounts of damage-associated molecular patterns (DAMPs) or endotoxin, and excessive crosslinking biases macrophages toward pro-inflammatory phenotypes that drive fibrosis and poor remodeling [73,74].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [74]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Immunohistochemical and gene expression analysis using CCR7 and iNOS for M1 and CD163 and Arg for M2 macrophages revealed that cellular scaffolds had a majority of M1 phenotype and provided a dense, poorly organized collagenous FBC, while decellularized scaffolds favored the M2 phenotype, and displayed both neomatrix formation and early angiogenesis.”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [180]
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“Here we find that MΦ activation depends on biomaterial architecture in addition to previously implicated biomaterial chemistry and bioactivity (34–36).”
From Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010) · cites this paper as [34]
In the citing paper
“Recognition of the predominant MΦ phenotypic profile can provide a tool by which a tissue regenerative outcome can be predicted and possibly promoted [4].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [4]
In the citing paper
“Brown et al. [83], who demonstrated that the presence of even an autologous cellular component attracted M1 cells, which was not observed in cell free constructs.”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [83]
In the citing paper
“Briefly, scaffold materials composed of extracellular matrix (ECM) have been shown to promote a switch from a predominantly M1 cell population immediately following implantation to a population enriched in M2 cells by 7–14 days post implantation [154–156].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [156]
In the citing paper
“This constructive remodeling response has been directly linked to the ability of the material to modulate macrophage phenotype [154–157].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [156]
In the citing paper
“Previous in vivo studies demonstrated concurrent expression of M1 and M2 markers (37), and enhanced expression of M2 markers has been associated with improved outcomes for implanted biologic scaffolds (34).”
From Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010) · cites this paper as [34]
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Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · cited 1×
“Relative expression of the M1 and M2 genes was calculated using the 2 ðDCt Þ method [23,24].”
MethodAnalyzing real-time PCR data by the comparative CT method
Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190 · cited 1×
“Relative expression of the M1 and M2 genes was calculated using the 2 ðDCt Þ method [23,24].”
MethodThe chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · cited 3×
“Multiple studies have shown that CCR7 is highly expressed on M1 polarized cells and that CD163 is highly indicative of M2 type antiinflammatory polarization [14,35,36].”
BackgroundMANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · cited 1×
“M2 activated macrophages express IL-12, IL-23, and IL-10high; have high levels of scavenger, mannose, and galactose receptors; produce arginase in the place of arginine, subsequently producing ornithine and polyamines; are involved in polarized Th2 reactions; and possess the ability to facilitate tissue repair and reg…”
BackgroundMutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · cited 2×
“Polarized macrophages are referred to as either M1 or M2 cells, mimicking the Th1/Th2 nomenclature [9].”
BackgroundDecellularization of tissues and organs
Gilbert, T. W., Sellaro, T. L., & Badylak, S. F. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.014 · Cited by 2,222 · cited 2×
“The decellularization methods used to process ECM scaffolds may alter these molecules such that they can no longer negatively influence the host response or there may be a threshold amount required to alter the host response to an ECM scaffold [25].”
MethodSelf-citationMartinez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,125 · cited 1×
“Multiple studies have shown that CCR7 is highly expressed on M1 polarized cells and that CD163 is highly indicative of M2 type antiinflammatory polarization [14,35,36].”
BackgroundThe many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902 · cited 1×
“M2 activated macrophages express IL-12, IL-23, and IL-10high; have high levels of scavenger, mannose, and galactose receptors; produce arginase in the place of arginine, subsequently producing ornithine and polyamines; are involved in polarized Th2 reactions; and possess the ability to facilitate tissue repair and reg…”
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Sánchez-Palencia, D. M., Rathan, S., Ankeny, C. J., Fogg, R., Briceño, J. C., & Yoganathan, A. P. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2040 · Cited by 5
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BackgroundWang, Q., Rao, J., Zhang, M., Zhou, L., Chen, X., Ma, Y., Guo, H., Gu, J., Wang, Y., & Zhou, Q. (2025) · Cornea · doi:10.1097/ico.0000000000003787 · Cited by 4
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Yang, Y., He, X., Zhao, Z., & Yi, J. (2024) · Cureus · doi:10.7759/cureus.66621 · Cited by 4
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BackgroundZhong, M., He, H., Ni, P., Huang, C. L., Zhang, T., Chen, W., Liu, L., Wang, C., Jiang, X., Pu, L., et al. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae147 · Cited by 4
Mendoza‐Novelo, B., Castellano, L. E., Delgado, J., Quintero‐Ortega, I. A., Vargas‐Mancilla, J., & Vega‐González, A. (2015) · Materials Letters · doi:10.1016/j.matlet.2015.11.048 · Cited by 4
Tara, S., Dean, E. W., Rocco, K. A., Udelsman, B. V., Kurobe, H., Shinoka, T., & Breuer, C. K. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398523-1.00058-6 · Cited by 4
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Wang, Y., Wang, R., Zhao, Q. X., Tian, Y., Li, K., Liu, L., Zhao, N., Jiang, S., Zhu, Y., Li, N., et al. (2025) · MedMat. · doi:10.1097/mm9.0000000000000029 · Cited by 3
Bakhtazad, S., Mehdizadeh, S., Zarghami, N., Shabani, A. A., Dadashpour, M., & Pilehvar‐Soltanahmadi, Y. (2026) · BMC Biotechnology · doi:10.1186/s12896-026-01155-9 · Cited by 3
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Qiu, H., Zhang, L., Wang, D., & Miao, H. (2022) · Cellular Reprogramming · doi:10.1089/cell.2021.0071 · Cited by 3
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Liu, L., Liu, J., Weng, C., Sun, Z., Hou, Z., Zhang, S., Mo, X., Liu, Z., & Tang, R. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214587 · Cited by 2
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Bucciarelli, A., & Motta, A. (2026) · Precision medicine and engineering. · doi:10.1016/j.preme.2026.100063 · Cited by 2
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Hematti, P., & Hanson, S. E. (2012) · CRC Press eBooks · doi:10.1201/b12083-20 · Cited by 2
Dye, J. F. (2021) · Reference series in biomedical engineering · doi:10.1007/978-3-319-54586-8_20 · Cited by 2
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Self-citationMedberry, C. J. (2014) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 2
Wolf, M. T. (2014) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 2
Dye, J. F. (2020) · Springer eBooks · doi:10.1007/978-3-319-21056-8_20-1 · Cited by 2
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Werner, A. (2011) · Obere Extremität · doi:10.1007/s11678-011-0101-9 · Cited by 2
NOVEL DESIGN STRATEGIES TO REDUCE THE FOREIGN BODY RESPONSE TO CENTRAL NERVOUS SYSTEM IMPLANTS
Skousen, J. L. (2012) · doi:10.13140/2.1.3896.4485 · Cited by 2
Dixit, V. P., Agrawal, M., & Varma, M. (1981) · PubMed · Cited by 2
ON TISSUE ENGINEERING OF PIG, HUMAN, AND NON-HUMAN PRIMATE TISSUES
Nayakawde, N. B. (2020) · Gothenburg University Publications Electronic Archive (Gothenburg University) · doi:10.13140/rg.2.2.31294.72008 · Cited by 2
Moshkbouymatin, N. (2019) · doi:10.23889/suthesis.53568 · Cited by 2
Veettil, J. P., Lolitha, D. S., & Ramachandra, U. P. (2025) · Xenotransplantation · doi:10.1111/xen.70031 · Cited by 1
RetractedKızılkurtlu, A. A., & Yılmaz, Ö. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125350 · Cited by 3
Jin, H., Shin, B., Kim, D., Seo, Y., Lee, Y., & Lee, S.-M. (2026) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/22808000261460977 · Cited by 1
Dryg, I. D., Zhen, L., Darrow, R., Lawton, S., Crawford, L., Robinson, R., Perlmutter, S. I., Bryers, J. D., & Ratner, B. D. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71522 · Cited by 1
“Materials that shift the polarization of macrophages toward the pro-healing phenotype may increase the success of remodeling and healing [33–35].”
Tissue and Whole Organ Decellularization: An Evaluation of Cytocompatibility and Mechanics
Carruthers, C. A. (2014) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Sicari, B. M. (2013) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Galea, L. A., Lilja, H. E., Thomas, G. P. L., Abberton, K. M., Palmer, J. A., & Morrison, W. A. (2010) · Springer eBooks · doi:10.1007/978-3-642-02824-3_18 · Cited by 1
Acellular Lung Scaffolds in Lung Bioengineering
Wagner, D. E., Uhl, F. E., & Weiss, D. J. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21082-7_18 · Cited by 1
Engineering Vascular Niche for Bone Tissue Regeneration
Ng, J., Spiller, K. L., Bernhard, J., & Vunjak‐Novakovic, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802734-9.00032-9 · Cited by 1
Numerical Simulation by CFD of the Growth of Osteocytes within a Bioreactor
Paz, C., Suárez, E., Vence, J., & Sande, A. (2019) · Proceedings of the World Congress on Electrical Engineering and Computer Systems and Science · doi:10.11159/icbes19.104 · Cited by 1
“006 [15], [19] ρc 1020 kg/m(3) [15] Vcell 2.”
Haghdel, M., Imanieh, M. H., Hosseinpour, H., Ghasemi, Y., & Alizadeh, A. A. (2022) · PubMed Central · doi:10.30476/ijms.2021.89194.1991 · Cited by 1
The Intersection of Biomaterials, Tissue Engineering, and Immuno-oncology
Clevenger, A. J., VandenHeuvel, S. N., & Raghavan, S. A. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166013-00342 · Cited by 1
Biological applications of hydrogel coatings
Wang, X., Zhang, X., Zhang, T., Yin, D., & Deng, X. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823948-3.00031-2 · Cited by 1
Fabrication and Evaluation of Bioreactor to Decellularize and Recellularize Human Muscular Arteries
Ramirez-Fernandez, O., Zúñiga-Aguilar, E., Martínez-López, V., Abad-Contreras, D. E., & Barba, M. C. P. (2023) · IEEE EMBS R9 Conference · doi:10.1109/ieeeconf60929.2023.10525335 · Cited by 1
Macrophages in tissue engineering and regeneration
Clark, D. R., Nakamura, M. C., Miclau, T., & Marcucio, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-821754-2.00005-9 · Cited by 1
Grand, Z., Greer, K., Brutti, J. A., Ciesla, C. D., Rockwell, M., Shae, J., Rasmussen, J., & Frye, P. (2025) · Cureus · doi:10.7759/cureus.88733 · Cited by 1
“Preclinical studies have shown that implanted biological scaffolds can favorably shift macrophage phenotypes from pro-inflammatory M1 profiles toward pro-regenerative M2 phenotypes [23].”
Biological scaffolds for regenerative medicine
Agrawal, V., & Badylak, S. F. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511997839.012 · Cited by 1
Self-citationExtracellular Matrix Specification of Regenerative Cells in the Adult Lung
Burgess, J. K., & Tjin, G. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21082-7_11 · Cited by 1
Renal Regeneration: The Bioengineering Approach
Salvatori, M., Peloso, A., Patel, T. H., Hemal, S., Zambon, J. P., Katari, R., & Orlando, G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398523-1.00017-3 · Cited by 1
Hong, P. (2016) · DalSpace (Dalhousie University) · Cited by 1
Management of Complex Distal Lower Extremity Wounds Using a Porcine Urinary Bladder Matrix (UBM-ECM)
Kraemer, B. A. (2018) · Recent clinical techniques, results, and research in wounds · doi:10.1007/15695_2017_60 · Cited by 1
Regenerative medicine approaches in large animal models for the temporomandibular joint meniscus
Almarza, A. J., & Chung, W. (2019) · Stomatological Disease and Science · doi:10.20517/2573-0002.2019.02 · Cited by 1
“MACROPHAGE PHENOTYPE AS A PREDICTOR OF CONSTRUCTIVE REMODELING While there are many cell types involved in the inflammatory response, it has been shown that the phenotype of macrophages that participate in the remodeling of ECM scaffolds plays a critical role in determining whether the events follow a pro-inflammatory…”
BackgroundMacrophage Response to Biomaterials in Cardiovascular Applications
Roy, S., Schmuck, E. G., & Raval, A. N. (2021) · Springer eBooks · doi:10.1007/978-3-030-77052-5_6 · Cited by 1
Williams, D. F. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139026086.004 · Cited by 1
Biologic Scaffolds Composed of Extracellular Matrix as a Natural Material for Wound Healing
Kollar, E. W., Dearth, C. L., & Badylak, S. F. (2014) · Wiley eBooks · doi:10.1002/9781118843499.ch7 · Cited by 1
Self-citationTissue-engineered heart valves for minimally invasive surgery
Dijkman, P. P. (2012) · TU/e Research Portal · doi:10.6100/ir724567 · Cited by 1
Metadata
- Authors
- Brown, B. N., Valentin, J. E., Stewart-Akers, A. M., McCabe, G. P., & Badylak, S. F.
- Affiliations
- University of Pittsburgh (US)
- Purdue University West Lafayette (US)
- Corresponding author
- Badylak, Stephen F.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 30
- Issue
- 8
- Pages
- 1482-1491
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC2805023
- OpenAlex
- W1999579326
- Cited by
- 896
- References
- 38
- Citations by year
- 2026: 23 · 2025: 28 · 2024: 37 · 2023: 46 · 2022: 61 · 2021: 73 · 2020: 47 · 2019: 69 · 2018: 63 · 2017: 73 · 2016: 59 · 2015: 70 · 2014: 76 · 2013: 60 · 2012: 38
- FWCI
- 36.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (F31EB007914)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- macrophage phenotype, macrophage polarization, tissue remodeling, extracellular matrix scaffolds, acellular scaffolds, cellular scaffolds, host tissue response, scar formation, connective tissue deposition
- MeSH terms
- Animals, Cell Nucleus, Gene Expression Regulation, Immunohistochemistry, Indoles, Macrophages, Phenotype, Transplantation, Autologous, Transplantation, Heterologous, Transplantation, Homologous, Rats, Sprague-Dawley, Muscle, Skeletal, Prosthesis Implantation, Sus scrofa, Rats, Tissue Scaffolds
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