Cited by 14Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Biotechnological advances and applications of human pluripotent stem cell-derived heart models

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Muniyandi, Priyadharshni, O’Hern, Colin, Popa, Mirel Adrian, Aguirre, Aitor·2023·Frontiers in Bioengineering and Biotechnology

Abstract

In recent years, significant biotechnological advancements have been made in engineering human cardiac tissues and organ-like models. This field of research is crucial for both basic and translational research due to cardiovascular disease being the leading cause of death in the developed world. Additionally, drug-associated cardiotoxicity poses a major challenge for drug development in the pharmaceutical and biotechnological industries. Progress in three-dimensional cell culture and microfluidic devices has enabled the generation of human cardiac models that faithfully recapitulate key aspects of human physiology. In this review, we will discuss 3D pluripotent stem cell (PSC)-models of the human heart, such as engineered heart tissues and organoids, and their applications in disease modeling and drug screening.

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Crossref · 10.3389/fbioe.2023.1214431

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  • There is a great need for more predictive human-based cardiac in vitro models to enhance CVD therapeutic strategies and avoid drug-induced cardiotoxicity.

    “Thus, there is a great need for more predictive human-based cardiac in vitro models to enhance CVD therapeutic strategies and avoid drug-induced cardiotoxicity (Marshall et al., 2018; Muniyandi et al., 2023).”

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  1. Viloria-Petit A. Richard A. Zours S. Jarad M. Coomber B. L. (2013). Advances in biochemistry in Health and disease biochemical basis and therapeutic implications of angiogenesis. Berlin, Germany: Springer.

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Authors
Muniyandi, P., O’Hern, C., Popa, M. A., & Aguirre, A.
Affiliations
Michigan State University (US)
Corresponding author
Aguirre, Aitor
Venue
Frontiers in Bioengineering and Biotechnology
Published
2023-07-25
Volume
11
Pages
1214431-1214431
ISSN
2296-4185 (ISSN-L)
OpenAlex
W4385256660
Cited by
14
References
183
Citations by year
2026: 4 · 2025: 6 · 2024: 4
FWCI
0.37
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • American Heart Association (19IPLOI34660342)
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (K01HL135464, R01HL151505)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
human pluripotent stem cells, cardiac tissue engineering, cardiac organoids, 3D cell culture, microfluidics, disease modeling, drug screening, cardiotoxicity, cardiovascular disease, cardiac models

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