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Cited by 2,173Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry

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Photodynamic therapy – mechanisms, photosensitizers and combinations

Kwiatkowski, Stanisław, Knap, Bartosz, Przystupski, Dawid, Saczko, Jolanta, Kędzierska, Ewa, Knap-Czop, Karolina, Kotlińska, Jolanta, Michel, Olga, Kotowski, Krzysztof, Kulbacka, Julita·2018·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2018.07.049
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Abstract

Photodynamic therapy (PDT) is a modern and non-invasive form of therapy, used in the treatment of non-oncological diseases as well as cancers of various types and locations. It is based on the local or systemic application of a photosensitive compound - the photosensitizer, which is accumulated in pathological tissues. The photosensitizer molecules absorb the light of the appropriate wavelength, initiating the activation processes leading to the selective destruction of the inappropriate cells. The photocytotoxic reactions occur only within the pathological tissues, in the area of photosensitizer distribution, enabling selective destruction. Over the last decade, a significant acceleration in the development of nanotechnology has been observed. The combination of photosensitizers with nanomaterials can improve the photodynamic therapy efficiency and eliminate its side effects as well. The use of nanoparticles enables achievement a targeted method which is focused on specific receptors, and, as a result, increases the selectivity of the photodynamic therapy. The object of this review is the anticancer application of PDT, its advantages and possible modifications to potentiate its effects.

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Metadata

Authors
Kwiatkowski, S., Knap, B., Przystupski, D., Saczko, J., Kędzierska, E., Knap-Czop, K., Kotlińska, J., Michel, O., Kotowski, K., & Kulbacka, J.
Affiliations
  • Wroclaw Medical University (PL)
  • Medical University of Lublin (PL)
Corresponding author
Kulbacka, Julita
ORCID
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2018-10
Volume
106
Pages
1098-1107
ISSN
0753-3322 (ISSN-L)
DOI
10.1016/j.biopha.2018.07.049
OpenAlex
W2884145325
Cited by
2,173
References
0
Citations by year
2026: 192 · 2025: 360 · 2024: 404 · 2023: 362 · 2022: 340 · 2021: 272 · 2020: 174 · 2019: 61 · 2018: 7
FWCI
22.96
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
  • Uniwersytet Medyczny w Lublinie
  • Servier
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
Keywords
photodynamic therapy, photosensitizers, photocytotoxicity, targeted drug delivery, nanoparticles, nanomaterials, combination therapy
MeSH terms
Animals, Drug Carriers, Humans, Neoplasms, Photochemotherapy, Drug Delivery Systems, Photosensitizing Agents, Nanomedicine, Electrochemotherapy, Nanoparticles

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