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Cited by 212Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesDevelopmental and Educational Neuropsychology

The DOI matches its Crossref record; 65 of the 68 references it cites were found in a registry or an index.

Functional neuroanatomy of working memory in adults with attention-deficit/hyperactivity disorder

Valera, Eve M., Faraone, Stephen V., Biederman, Joseph, Poldrack, Russell A., Seidman, Larry J.·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2004.11.034
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Abstract

Background Attention-deficit/hyperactivity disorder (ADHD) in adults is an increasingly recognized psychiatric disorder, linked with impairments in numerous life domains and with neurocognitive dysfunctions. However, the neural substrate of cognitive functioning in adults with this disorder has been relatively unexamined. The objective of this study was to examine neural functioning in ADHD adults during performance on a verbal working memory task.Methods A sample of unmedicated adults with ADHD (n = 20) and control subjects (n = 20) performed a 2-back task of working memory, and the blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) response was used as a measure of neural activity during working memory performance.Results Though working memory performance did not differ significantly between ADHD adults and control subjects, ADHD adults showed significantly decreased activity in cerebellar and occipital regions and a trend toward decreased activation in an a priori predicted region of the prefrontal cortex.Conclusions ADHD adults showed altered patterns of neural activity despite comparable performance on a verbal working memory task. These findings suggest that the cerebellum is involved in the pathophysiology of at least some cognitive deficits associated with ADHD and emphasize the need for additional research aimed at elucidating the role of the cerebellum in ADHD symptomatology.

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Research works printed but not linked: 4

  1. Barkley, 1997, Behavioral inhibition, sustained attention, and executive functions, Psychol Bull, 121, 65, 10.1037/0033-2909.121.1.65 · DOI · Paper page
  2. 1977, Assistance to states for education for handicapped children, Federal Register, 42, 62082
  3. Seidman, 2003, New frontiers of neuroimaging of ADHD
  4. Thermenos HW, Goldstein JM, Buka SL, Poldrack RA, Koch JK, Tsuang MT, et al (in press): The effect of working memory performance on fMRI in schizophrenia. Schizophr Res.

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Metadata

Authors
Valera, E. M., Faraone, S. V., Biederman, J., Poldrack, R. A., & Seidman, L. J.
Affiliations
  • Harvard University (US)
  • University of California, Los Angeles (US)
Corresponding author
Valera, Eve M.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-03
Volume
57
Issue
5
Pages
439-447
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2004.11.034
OpenAlex
W2012735958
Cited by
211
References
68
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 4 · 2015: 15 · 2014: 8 · 2013: 17 · 2012: 18
FWCI
9.02
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1f32mh065040-01a1)
  • National Institute of Mental Health (1 F32 MH065040-01A1, R01MH057934, MH-57934, MH62152-02, R01MH062152)
  • National Center for Research Resources (P41-RR-14075, P41RR014075)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords
adult ADHD, working memory, cerebellum, neural correlates, 2-back task, prefrontal cortex, occipital cortex, functional neuroanatomy, cognitive impairment
MeSH terms
Adolescent, Adult, Brain Mapping, Cerebellum, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Oxygen, Reaction Time, Prefrontal Cortex, Attention Deficit and Disruptive Behavior Disorders

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