Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity
Abstract
Background Previous evidence has shown that genetic variations in the serotonergic system contribute to individual differences in personality traits germane to impulse control. The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. High-activity allele carriers have higher enzyme expression, lower amine concentration, and present higher scores on behavioral measures of impulsivity than low-activity allele carriers.Methods We studied the relationship of this polymorphism to brain activity elicited by a response inhibition task (Go/NoGo task), using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging in 24 healthy men.Results Direct comparison between groups revealed a greater BOLD response in the right ventrolateral prefrontal cortex (Brodmann's area [BA] 45/47) in high-activity allele carriers, whereas a greater response in the right superior parietal cortex (BA 7) and bilateral extrastriate cortex (BA 18) was found in low-activity allele carriers.Conclusions These data suggest that a specific genetic variation involving serotonergic catabolism can modulate BOLD response associated with human impulsivity.
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Polymorphisms of the MAO-A gene that increase MAO-A activity are associated with increased activity in the right IFG and ACC and decreased activity in the superior parietal cortex during action restraint.
“Polymorphisms of the MAO-A gene, which increase MAO-A activity, were associated with increased activity in the right IFG and ACC and decreased activity in the superior parietal cortex during action restraint (Passamonti et al., 2006).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Passamonti et al., 2006
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- Authors
- Passamonti, L., Fera, F., Magariello, A., Cerasa, A., Gioia, M. C., Muglia, M., Nicoletti, G., Gallo, O., Provinciali, L., & Quattrone, A.
- Affiliations
- Marche Polytechnic University (IT)
- Institute of Neurological Sciences (IT)
- Magna Graecia University (IT)
- Corresponding author
- Fera, Francesco
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 59
- Issue
- 4
- Pages
- 334-340
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2047503618
- Cited by
- 167
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2021: 2 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 5 · 2012: 13
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- monoamine oxidase A, MAOA gene, variable number tandem repeats, impulsivity, inhibitory control, response inhibition, go/no-go task, ventrolateral prefrontal cortex, serotonergic system, neural correlates, genetic polymorphism, BOLD signal
- MeSH terms
- Adolescent, Adult, Alleles, Brain, Brain Mapping, DNA, Genotype, Humans, Impulsive Behavior, Magnetic Resonance Imaging, Male, Monoamine Oxidase, Oxygen, Polymorphism, Genetic, Genetic Variation, Visual Cortex, Prefrontal Cortex, Minisatellite Repeats
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