Neurophysiological Responses to Traumatic Reminders in the Acute Aftermath of Serious Motor Vehicle Collisions Using [15O]-H2O Positron Emission Tomography
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Background Neuroimaging studies report that individuals with posttraumatic stress disorder show abnormal responses in the amygdala and medial prefrontal cortex (mPFC)/anterior cingulate cortex (ACC) during exposure to traumatic reminders. However, neural responses arising in the early aftermath of a traumatic event have not been studied.Methods Twenty-two motor vehicle collision survivors and 12 nontraumatized control subjects participated. Regional cerebral blood flow (rCBF) was measured using [(15)O]-H(2)O positron emission tomography (PET) at rest and as subjects listened to scripts of traumatic and neutral events. Self-report measures rated emotional responses to the scripts; standardized assessments (Impact of Events--Revised) evaluated acute stress symptoms at scanning and at 3-month follow-up. Most subjects improved symptomatically.Results At rest, trauma subjects showed hyperperfusion in right mPFC/ACC and hypoperfusion in right amygdala compared with control subjects. In trauma subjects, listening to trauma scripts versus neutral scripts resulted in decreased flow in the right amygdala and left amygdala/perirhinal cortex, and symptom scores correlated negatively with right hippocampal flow changes. Symptom improvement at 3 months correlated negatively with rCBF changes in right perirhinal cortex and hippocampus during the trauma versus neutral script contrast. Subjective disturbance during the trauma versus neutral contrast correlated positively with rCBF changes in right amygdala and left mPFC. Functional connectivity analyses of rCBF changes during trauma versus neutral scripts demonstrated left amygdala coupling with right ACC and bilateral anterior insula, as well as coupling between the amygdala and contralateral hippocampus.Conclusions In recently traumatized subjects functional interactions between the amygdala, perirhinal cortex and ACC/mPFC that occur during exposure to traumatic reminders may underlie adaptive/recuperative processes.
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In individuals with PTSD, amygdala connectivity during task-based studies has yielded inconsistent findings.
“In individuals with PTSD, amygdala connectivity during task-based studies has yielded inconsistent findings.”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [16]
Recent fMRI studies have reported greater insula activation in anticipation of negative images and negative emotional faces in individuals with PTSD as well as enhanced coupling between the insula and amygdala during negative emotion induction in healthy volunteers and during symptom provocation in recently traumatized individuals.
“Recent fMRI studies have reported greater insula activation in anticipation of negative images19 and negative emotional faces18 in individuals with PTSD as well as enhanced coupling between the insula and amygdala during negative emotion induction in healthy volunteers26 and during symptom provocation in recently traumatized individuals.16”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [16]
A [15O]-H2O PET study of recently traumatized individuals found positive functional connectivity between the amygdala and ACC in response to trauma scripts.
“a [15O]-H2O positron emission tomography (PET) study of recently traumatized individuals found positive functional connectivity between the amygdala and ACC in response to trauma scripts.16”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [16]
Most studies have found diminished strength of connectivity in individuals with PTSD compared with controls, regardless of the direction of connectivity identified.
“regardless of the direction of the connectivity identified (positive connectivity v. anticorrelation), most studies have found diminished strength of connectivity in individuals with PTSD compared with controls.2,16,18,19”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [16]
Enhanced connectivity between the insula and amygdala was previously reported in studies of recently traumatized individuals during symptom provocation.
“Similar findings of enhanced connectivity between the insula and amygdala were previously reported in studies of recently traumatized individuals during symptom provocation.16”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [16]
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- Authors
- Osuch, E. A., Willis, M. W., Bluhm, R., Ursano, R. J., & Drevets, W. C.
- Affiliations
- Western University (CA)
- Uniformed Services University of the Health Sciences (US)
- Corresponding author
- Osuch, Elizabeth A.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 64
- Issue
- 4
- Pages
- 327-335
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2597354
- OpenAlex
- W2030851987
- Cited by
- 67
- References
- 82
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 4 · 2022: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 4
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (U01 MH63397-01A1, U01MH063397)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- traffic accidents, post-traumatic stress disorder, amygdala, medial prefrontal cortex, anterior cingulate cortex, perirhinal cortex, hippocampus, regional cerebral blood flow, acute stress symptoms, functional connectivity, trauma recovery, emotional reactivity
- MeSH terms
- Accidents, Traffic, Adult, Amygdala, Brain Mapping, Cerebrovascular Circulation, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Oxygen Radioisotopes, Psychometrics, Regional Blood Flow, Stress Disorders, Post-Traumatic, Positron-Emission Tomography
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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