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Anhedonia and Emotional Experience in Schizophrenia: Neural and Behavioral Indicators
Open accessAbstract
Background Emotional impairments such as anhedonia are often considered key features of schizophrenia. However, self-report research suggests that emotional experience in response to affect-eliciting stimuli is intact in schizophrenia. Investigation of neural activity during emotional experience may help clarify whether symptoms of anhedonia more likely reflect alterations of in-the-moment hedonic experience or impairments in other aspects of goal-directed behavior.Methods Forty individuals with DSM-IV-TR schizophrenia or schizoaffective disorder and 32 healthy control subjects underwent functional magnetic resonance imaging while making valence and arousal ratings in response to emotional pictures, words, and faces. Blood oxygen level-dependent responses were compared between patients and control subjects and were correlated with questionnaire measures of anhedonia.Results Patients showed some evidence of blunted valence but not arousal ratings in response to emotional stimuli compared with control subjects. Higher anhedonia scores were associated with blunted valence ratings in both groups and fully mediated the group differences in valence ratings. Functional activity was largely intact in patients, except for regions in right ventral striatum and left putamen, which showed reduced responses to positive stimuli. Higher anhedonia was associated with reduced activation to positive versus negative stimuli in bilateral amygdala and right ventral striatum in patients and in bilateral caudate in control subjects.Conclusions Increased anhedonia is associated with a reduced experience of valence in both patients and control subjects, and group differences in experienced valence are likely driven by individual differences in anhedonia. Reduced activation of the striatum and amygdala may contribute to symptoms of anhedonia by failing to signal the salience of positive events.
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“Several authoritative reviews thus concluded that anhedonia (diminished ‘liking’) is a less prominent feature of schizophrenia than avolition (diminished ‘wanting’) [49,51-53].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [51]
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Metadata
- Authors
- Dowd, E. C., & Barch, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Dowd, Erin C.
- ORCID
- Barch, Deanna M.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 67
- Issue
- 10
- Pages
- 902-911
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3113677
- OpenAlex
- W2090852431
- Cited by
- 184
- References
- 61
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 12 · 2017: 10 · 2016: 12 · 2015: 26 · 2014: 16 · 2013: 20 · 2012: 19
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01MH06603101, MH071616)
- Conte Center for the Neuroscience of Mental Disorders
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anhedonia, schizophrenia, schizoaffective disorder, emotional experience, valence ratings, arousal ratings, amygdala, ventral striatum, putamen, caudate nucleus, positive valence, salience, individual differences
- MeSH terms
- Adult, Affect, Arousal, Brain, Brain Mapping, Emotions, Female, Humans, Male, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Pleasure
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