Longitudinal Evidence for Unfavorable Effects of Antidepressants on Heart Rate Variability

Licht, Carmilla M.M.; de Geus, Eco J.C.; van Dyck, Richard; Penninx, Brenda W.J.H.

doi:10.1016/j.biopsych.2010.06.032

Cited by 225Heart Rate Variability and Autonomic ControlCardiac Health and Mental HealthVagus Nerve Stimulation Research

Longitudinal Evidence for Unfavorable Effects of Antidepressants on Heart Rate Variability

Licht, Carmilla M.M., de Geus, Eco J.C., van Dyck, Richard, Penninx, Brenda W.J.H.·2010·Biological Psychiatry

DOI 10.1016/j.biopsych.2010.06.032

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Abstract

Background It was previously shown that antidepressants are associated with diminished vagal control over the heart. Longitudinal studies are needed to test the causality of this association further.Methods Longitudinal data were obtained in the Netherlands Study of Depression and Anxiety. At baseline and at 2-year follow-up, heart rate and cardiac vagal control as indexed by respiratory sinus arrhythmia were measured in 2114 subjects (mean age = 42.0 years; 66.2% female), who either used antidepressants at one or two time points (n = 603) or did not use antidepressants at any time point (n = 1511). Linear mixed-model analyses were conducted to compare changes in respiratory sinus arrhythmia and heart rate over time across antidepressant-naive subjects, subjects who started using an antidepressant during follow-up, subjects who stopped using an antidepressant, and persistent antidepressant users. Analyses were adjusted for demographics, health, and lifestyle factors.Results Compared with continuous nonusers, subjects who started the use of a tricyclic antidepressant or a serotonergic and noradrenergic antidepressant showed a significantly greater increase in heart rate and a decrease of respiratory sinus arrhythmia at 2 years. Subjects who started the use of selective serotonin reuptake inhibitors also showed a decrease in respiratory sinus arrhythmia, but their heart rate did not increase. Discontinuing antidepressants systematically caused opposite effects; levels returned in the direction of those observed among nonusers.Conclusions These 2-year longitudinal results indicate that all antidepressants cause a decrease in cardiac vagal control. After discontinuing antidepressants, autonomic function recovers, suggesting that the unfavorable effects are (partly) reversible.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
An inventory for measuring clinical anxiety: Psychometric properties.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.893 · Cited by 14,407 · see citing works
Measuring individual differences in implicit cognition: The implicit association test.
Greenwald, A. G., McGhee, D. E., & Schwartz, J. L. K. (1998) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.74.6.1464 · Cited by 11,720 · see citing works
Measuring individual differences in implicit cognition: the implicit association test
Greenwald, A. G., McGhee, D. E., & Schwartz, J. L. K. (1998) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.74.6.1464 · Cited by 9,210 · see citing works
Reliability and validity studies of the WHO-Composite International Diagnostic Interview (CIDI): A critical review
Wittchen, H.-U. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90036-1 · Cited by 2,348 · see citing works
The Inventory of Depressive Symptomatology (IDS): Psychometric properties
Rush, A. J., Gullion, C. M., Basco, M. R., Jarrett, R. B., & Trivedi, M. H. (1996) · Psychological Medicine · doi:10.1017/s0033291700035558 · Cited by 2,177 · see citing works
The polyvagal theory: phylogenetic substrates of a social nervous system.
Porges, S. W. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00162-3 · Cited by 1,582 · see citing works
The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment
Musselman, D. L., Evans, D. L., & Nemeroff, C. B. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.580 · Cited by 1,532 · see citing works
Assessment of Physical Activity: An International Perspective
Booth, M. L. (2000) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2000.11082794 · Cited by 1,098 · see citing works
Depression and cardiac mortality: results from a community-based longitudinal study.
Penninx, B., Beekman, A., Honig, A., Deeg, D., Schoevers, R., van Eijk, J., & van Tilburg, W. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.221 · Cited by 983 · see citing works
Self-citation
The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
Penninx, B. W. J. H., Beekman, A. T. F., Smit, J. H., Zitman, F. G., Nolen, W. A., Spinhoven, P., Cuijpers, P. J., de Jong, P. J., van Marwijk, H., Assendelft, W. J., et al. (2008) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.256 · Cited by 918 · see citing works
Self-citation
Depression, Psychotropic Medication, and Risk of Myocardial Infarction: Prospective Data From the Baltimore ECA Follow-up
Pratt, L. A., Ford, D. E., Crum, R. M., Armenian, H. K., Gallo, J. J., & Eaton, W. W. (1996) · Circulation · doi:10.1161/01.cir.94.12.3123 · Cited by 643 · see citing works
Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease
Frasure-Smith, N., & Lespérance, F. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.4 · Cited by 571 · see citing works
Effects of Antidepressant Medication on Morbidity and Mortality in Depressed Patients After Myocardial Infarction
Taylor, C. B. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.792 · Cited by 512 · see citing works
Prediction of Tonic Parasympathetic Cardiac Control Using Respiratory Sinus Arrhythmia: The Need for Respiratory Control
Grossman, P., Karemaker, J. M., & Wieling, W. (1991) · Psychophysiology · doi:10.1111/j.1469-8986.1991.tb00412.x · Cited by 462 · see citing works
Sympathetic Nervous System Activity in Major Depression
Veith, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950050071008 · Cited by 457 · see citing works
Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents
Cohen, H. W., Gibson, G., & Alderman, M. H. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00301-0 · Cited by 390 · see citing works
Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA)
Licht, C. M. M., de Geus, E. J. C., Zitman, F. G., Hoogendijk, W. J. G., van Dyck, R., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1358 · Cited by 379 · see citing works
Self-citation
Depression and Risk of Sudden Cardiac Death and Coronary Heart Disease in Women
Whang, W., Kubzansky, L. D., Kawachi, I. I., Rexrode, K. M., Kroenke, C. H., Glynn, R. J., Garan, H., & Albert, C. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.060 · Cited by 342 · see citing works
Cardiac Autonomic Function and Incident Coronary Heart Disease: A Population-based Case-Cohort Study: The ARIC Study
Liao, D., Cai, J., Rosamond, W. D., Barnes, R. W., Hutchinson, R. G., Whitsel, E. A., Rautaharju, P. M., & HEISS, G. M. (1997) · American Journal of Epidemiology · doi:10.1093/aje/145.8.696 · Cited by 337 · see citing works
Phobic Anxiety and Risk of Coronary Heart Disease and Sudden Cardiac Death Among Women
Albert, C. M., Chae, C. U., Rexrode, K. M., Manson, J. E., & Kawachi, I. I. (2005) · Circulation · doi:10.1161/01.cir.0000153813.64165.5d · Cited by 330 · see citing works
Ambulatory measurement of respiratory sinus arrhythmia and respiration rate
de Geus, E. J. C., Willemsen, G. A. H. M., Klaver, C. H. A. M., & van Doornen, L. J. P. (1995) · Biological Psychology · doi:10.1016/0301-0511(95)05137-6 · Cited by 314 · see citing works
Elevated Heart Rate: A Major Risk Factor for Cardiovascular Disease
Palatini, P., & Julius, S. (2004) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200031959 · Cited by 302 · see citing works
Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?
Barton, D. A., Dawood, T., Lambert, E. A., Esler, M. D., Haikerwal, D., Brenchley, C., Socratous, F., Kaye, D. M., Schlaich, M. P., Hickie, I., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e32829baae7 · Cited by 291 · see citing works
Serotonin Is Associated with Coronary Artery Disease and Cardiac Events
Vikenes, K., Farstad, M., & Nordrehaug, J. E. (1999) · Circulation · doi:10.1161/01.cir.100.5.483 · Cited by 290 · see citing works
Depressed Mood Is Related to High-Frequency Heart Rate Variability During Stressors
Hughes, J. W., & Stoney, C. M. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200011000-00009 · Cited by 276 · see citing works
Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study
Smoller, J. W. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.436 · Cited by 256 · see citing works
Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities
Licht, C. M. M., Vreeburg, S. A., van Reedt Dortland, A. K. B., Giltay, E. J., Hoogendijk, W. J. G., DeRijk, R. H., Vogelzangs, N., Zitman, F. G., de Geus, E. J. C., & Penninx, B. W. J. H. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2801 · Cited by 240 · see citing works
Self-citation
Ambulatory monitoring of the impedance cardiogram
Willemsen, G. A. H. M., de Geus, E. J. C., Klaver, C. H. A. M., VanDoornen, L. J. P., & Carrofl, D. (1996) · Psychophysiology · doi:10.1111/j.1469-8986.1996.tb02122.x · Cited by 222 · see citing works
5-Hydroxytryptamine and cardiovascular regulation
Ramage, A. G., & Villalón, C. M. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.06.009 · Cited by 219 · see citing works
Association between anxiety disorders and heart rate variability in The Netherlands Study of Depression and Anxiety (NESDA)
Licht, C. M. M., de Geus, E. J. C., van Dyck, R., & Penninx, B. W. J. H. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a292a6 · Cited by 215 · see citing works
Self-citation
Noradrenaline Release And Sympathetic Nervous System Activity
Esler, M., Hasking, G. J., Willett, I. R., Leonard, P., & Jennings, G. (1985) · Journal of Hypertension · doi:10.1097/00004872-198504000-00003 · Cited by 165 · see citing works
Central cardiovascular regulation and 5-hydroxytryptamine receptors
Ramage, A. G. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00612-8 · Cited by 158 · see citing works
General population based study of the impact of tricyclic and selective serotonin reuptake inhibitor antidepressants on the risk of acute myocardial infarction
Tata, L. J., West, J., Smith, C., Farrington, P., Card, T. R., Smeeth, L. L., & Hubbard, R. (2005) · Heart · doi:10.1136/hrt.2004.037457 · Cited by 143 · see citing works
Effects of antidepressant treatment on heart rate variability in major depression: A quantitative review
van Zyl, L. T., Hasegawa, T., & Nagata, K. (2008) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-2-12 · Cited by 118 · see citing works
Depression and Heart Rate Variability in Patients With Stable Coronary Heart Disease
Gehi, A. K., Mangano, D. T., Pipkin, S. S., Browner, W. S., & Whooley, M. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.661 · Cited by 117 · see citing works
Effect of frequency of stimulation on the inhibition by noradrenaline of the acetylcholine output from parasympathetic nerve terminals
Knoll, J. E., & Vizi, E. S. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07107.x · Cited by 86 · see citing works
Cardiovascular Variability in Major Depressive Disorder and Effects of Imipramine or Mirtazapine (Org 3770)
Tulen, J. H. M., Bruijn, J. A., de Man, K. J., Pepplinkhuizen, L., van den Meiracker, A. H., & Veld, A. J. M. (1996) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199604000-00006 · Cited by 81 · see citing works
Presynaptic interaction between vagal and sympathetic innervation in the heart: modulation of acetylcholine and noradrenaline release
Manabe, N., Földes, F. F., Törőcsik, A., Nagashima, H., GOLDINER, P. L., & Vizi, E. S. (1991) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(91)90117-l · Cited by 77 · see citing works
Baroreceptor reflex inhibition induced by the stimulation of serotonin3 receptors in the nucleus tractus solitarius of the rat
Merahi, N., Orer, H. S., Laporte, A., GOZLAN, H., Hamon, M., & Laguzzi, R. F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90011-p · Cited by 75 · see citing works
Adverse Cardiovascular Events in Antidepressant Trials Involving High-Risk Patients: A Systematic Review of Randomized Trials
Swenson, J. R., Doucette, S. P., & Fergusson, D. A. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605101408 · Cited by 72 · see citing works
Prognosis in Heart Failure and the Value of β-Blockers Are Altered by the Use of Antidepressants and Depend on the Type of Antidepressants Used
Fosbøl, E. L., Gislason, G., Poulsen, H. E., Hansen, M. L., Folke, F., Schramm, T. K., Olesen, J. B., Bretler, D., Abildstr�m, S. Z., S�rensen, R., et al. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.851246 · Cited by 69 · see citing works
Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75
Hoard, J. L., Hoover, D. B., Mabe, A. M., Blakely, R., Feng, N., & Paolocci, N. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.063 · Cited by 64 · see citing works
Serotonin2 Receptors in the Nucleus Tractus Solitarius: Characterization and Role in the Baroreceptor Reflex Arc
Laguzzi, R. F. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025096718559 · Cited by 60 · see citing works
Depression and Cardiovascular Disease
Glassman, A. H. (2008) · Pharmacopsychiatry · doi:10.1055/s-2008-1058108 · Cited by 59 · see citing works
Stimulation of 5-HT3 receptors in the NTS inhibits the cardiac Bezold-Jarisch reflex response
Sévoz‐Couche, C., Nosjean, A., Callera, J. C., Machado, B., Hamon, M., & Laguzzi, R. F. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.1.h80 · Cited by 53 · see citing works
Assessment of physical activity.
Sjöström, M., Ekelund, U., Yngve, A., Gibney, M. J., Margetts, B. M., Kearney, J. M., & Arab, L. (2004) · Cited by 51 · see citing works
Cardiovascular disease risk factors, depression symptoms and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes
Rubin, R. R., Gaussoin, S. A., Peyrot, M. F., DiLillo, V. G., Miller, K., Wadden, T. A., West, D. S., Wing, R. R., & Knowler, W. C. (2010) · Diabetologia · doi:10.1007/s00125-010-1765-1 · Cited by 48 · see citing works
Is the Use of Psychotropic Drugs Associated with Increased Risk of Ischemic Heart Disease?
Lapane, K. L., Zierkr, S., Lasater, T. M., Barbour, M. M., Carleton, R. A., & Hume, A. L. (1995) · Epidemiology · doi:10.1097/00001648-199507000-00008 · Cited by 45 · see citing works
Influence of 5-HT1A Receptor Agonists on Sympathetic and Parasympathetic Nerve Activity
Ramage, A. G. (1990) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199001001-00010 · Cited by 42 · see citing works
The microelectrophoretic administration of noradrenaline, 5-hydroxytryptamine, acetylcholine and glycine to sacral parasympathetic preganglionic neurones
Ryall, R. W., & de Groat, W. C. (1972) · Brain Research · doi:10.1016/0006-8993(72)90683-x · Cited by 39 · see citing works
Influence of 5-HT1A Receptor Agonists on Sympathetic and Parasympathetic Nerve Activity
Ramage, A. G. (1990) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199000157-00010 · Cited by 38 · see citing works
Antidepressive Treatment With Amitriptyline and Paroxetine: Comparable Effects On Heart Rate Variability
Lederbogen, F., Gernoth, C., Weber, B., Colla, M., Kniest, A., Heuser, I., & Deuschle, M. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200104000-00018 · Cited by 37 · see citing works
Bioaminergic neuromodulation of respiratory rhythm in vitro
Viemari, J., & Tryba, A. K. (2009) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2009.03.011 · Cited by 33 · see citing works
Effects of Imipramine, Fluvoxamine and Depressive Mood on Autonomic Cardiac Functioning in Major Depressive Disorder
Volkers, A. C. W., Tulen, J. H. M., van den Broek, W. W., Bruyn, J. A., Passchier, J., & Pepplinkhuizen, L. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-815470 · Cited by 27 · see citing works
The Modulatory Effects of Noradrenaline on Vagal Control of Heart Rate in the Dogfish,Squalus acanthias
Agnisola, C., Randall, D. J., & Taylor, E. W. (2003) · Physiological and Biochemical Zoology · doi:10.1086/374283 · Cited by 22 · see citing works
Norepinephrine transporter (NET) is expressed in cardiac sympathetic ganglia of adult rat
He, L. I., Sun, K., Xiao Ping, H. U., ZHANG, G. Y., & Fei, J. (2001) · Cell Research · doi:10.1038/sj.cr.7290102 · Cited by 21 · see citing works
Depression and cardiovascular risk: does blood pressure play a role?
Scuteri, A. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e32830dfff7 · Cited by 20 · see citing works
PRESYNAPTIC INHIBITION BY SEROTONIN OF CARDIAC SYMPATHETIC TRANSMISSION IN DOGS
Kimura, T., & Satoh, S. (1983) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1983.tb00222.x · Cited by 20 · see citing works
Effects of noradrenaline on human vagal baroreflexes
Airaksinen, J. K. E., Huikuri, H. V., Hubti, L., Kuusela, T., Tahvanainen, K. U. O., Tulppo, M. P., Mäkikallio, T. H., & Eckberg, D. L. (2001) · Annals of Medicine · doi:10.3109/07853890109002077 · Cited by 16 · see citing works
Central 5-HT1A receptors and vagal tone to the airways
Ramage, A. G. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01481-4 · Cited by 13 · see citing works
Is It Time to Treat Depression in Patients With Cardiovascular Disease?
Whang, W., & Davidson, K. W. (2009) · Circulation · doi:10.1161/circulationaha.109.881987 · Cited by 11 · see citing works

Flagged first, then by citations

2 of the 64 references couldn’t be matched to a known paper.

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Penninx, B. W., Milaneschi, Y., Lamers, F., & Vogelzangs, N. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-129 · Cited by 839 · see citing works
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Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications
Penninx, B. W. J. H., & Lange, S. M. M. (2018) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2018.20.1/bpenninx · Cited by 566 · see citing works
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Kemp, A. H., & Quintana, D. S. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.06.018 · Cited by 538 · see citing works
Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies
Meng, L., Chen, D., Yang, Y., Zheng, Y., & Hui, R. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835080b7 · Cited by 526 · see citing works
Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease: A Scientific Statement From the American Heart Association
Goldstein, B. I., Carnethon, M. R., Matthews, K. A., McIntyre, R. S., Miller, G. E., Raghuveer, G., Stoney, C. M., Wasiak, H., & McCrindle, B. W. (2015) · Circulation · doi:10.1161/cir.0000000000000229 · Cited by 519 · see citing works
Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis
Alvares, G. A., Quintana, D. S., Hickie, I. B., & Guastella, A. J. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140217 · Cited by 503 · see citing works
A meta-analysis of heart rate variability in major depression
Koch, C., Wilhelm, M., Salzmann, S., Rief, W., & Euteneuer, F. (2019) · Psychological Medicine · doi:10.1017/s0033291719001351 · Cited by 489 · see citing works
Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation
Vaccarino, V., Badimon, L., Bremner, J. D., Cenko, E., Cubedo, J., Dorobantu, M., Duncker, D. J., Koller, A., Manfrini, O., Milicic, D., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehy913 · Cited by 404 · see citing works
Autonomic dysfunction and heart rate variability in depression
Sgoifo, A., Carnevali, L., Alfonso, M. D. L. A. P., & Amore, M. (2015) · Stress · doi:10.3109/10253890.2015.1045868 · Cited by 342 · see citing works
Association of depressive disorders, depression characteristics and antidepressant medication with inflammation
Vogelzangs, N., Duivis, H. E., Beekman, A. T. F., Kluft, C., Neuteboom, J., Hoogendijk, W., Smit, J. H., de Jonge, P., & Penninx, B. W. J. H. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.8 · Cited by 323 · see citing works
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Heart rate and high frequency heart rate variability during stress as biomarker for clinical depression. A systematic review
Schiweck, C., Piette, D., Berckmans, D., Claes, S. J., & Vrieze, E. (2018) · Psychological Medicine · doi:10.1017/s0033291718001988 · Cited by 293 · see citing works
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Self-citation
Heart rate variability is a trait marker of major depressive disorder: evidence from the sertraline vs. electric current therapy to treat depression clinical study
Brunoni, A. R., Kemp, A. H., Dantas, E. M., Goulart, A. C., Nunes, M. A., Boggio, P. S., Mill, J. G., Lotufo, P. A., Fregni, F., & Benseñor, I. M. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000497 · Cited by 149 · see citing works
Does Evidence Support the American Heart Association's Recommendation to Screen Patients for Depression in Cardiovascular Care? An Updated Systematic Review
Thombs, B. D., Roseman, M., Coyne, J. C., de Jonge, P., Delisle, V. C., Arthurs, E., Levis, B., & Ziegelstein, R. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052654 · Cited by 132 · see citing works
Heart rate variability and depressive symptoms: a cross-lagged analysis over a 10-year period in the Whitehall II study
Jandackova, V. K., Britton, A. R., Malík, M., & Steptoe, A. (2016) · Psychological Medicine · doi:10.1017/s003329171600060x · Cited by 127 · see citing works
The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression
Dortland, A. K. B. V. R., Vreeburg, S. A., Giltay, E. J., Licht, C. M. M., Vogelzangs, N., van Veen, T., de Geus, E. J. C., Penninx, B. W. J. H., & Zitman, F. G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.017 · Cited by 125 · see citing works
Self-citation
Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders
Nousen, E. K., Franco, J. G., & Sullivan, E. L. (2013) · Neuroendocrinology · doi:10.1159/000355632 · Cited by 123 · see citing works
Heart rate variability in bipolar disorder: A systematic review and meta-analysis
Faurholt‐Jepsen, M., Kessing, L. V., & Munkholm, K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.007 · Cited by 121 · see citing works
From psychological moments to mortality: a multidisciplinary synthesis on heart rate variability spanning the continuum of time
Kemp, A. H., Koenig, J., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.006 · Cited by 114 · see citing works
Detection of major depressive disorder from linear and nonlinear heart rate variability features during mental task protocol
Byun, S., Kim, A. Y., Jang, E. H., Kim, S., Choi, K. W., Yu, H. Y., & Jeon, H. J. (2019) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2019.103381 · Cited by 115 · see citing works
An integrated approach to understand biological stress system dysregulation across depressive and anxiety disorders
Vinkers, C. H., Kuzminskaite, E., Lamers, F., Giltay, E. J., & Penninx, B. W. J. H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.01.051 · Cited by 113 · see citing works
Self-citation
Antidepressants or running therapy: comparing effects on mental and physical health in patients with depression and anxiety disorders
Verhoeven, J. E., Han, L. K. M., Lever-van Milligen, B. A., Hu, M. X., Révész, D., Hoogendoorn, A. W., Batelaan, N. M., van Schaik, D. J. F., van Balkom, A. J. L. M., van Oppen, P., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.064 · Cited by 112 · see citing works
Self-citation
Antidepressants strongly influence the relationship between depression and heart rate variability: findings from The Irish Longitudinal Study on Ageing (TILDA)
O’Regan, C., Kenny, R. A., Cronin, H., Finucane, C., & Kearney, P. M. (2014) · Psychological Medicine · doi:10.1017/s0033291714001767 · Cited by 107 · see citing works
Depression, anxiety, and arterial stiffness
Seldenrijk, A., van Hout, H. P. J., van Marwijk, H. W. J., de Groot, E., Gort, J., Rustemeijer, C., Diamant, M., & Penninx, B. W. J. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.034 · Cited by 101 · see citing works
Self-citation
There are no randomized controlled trials that support the United States Preventive Services Task Force guideline on screening for depression in primary care: a systematic review
Thombs, B. D., Ziegelstein, R. C., Roseman, M., Kloda, L. A., & Ioannidis, J. P. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-13 · Cited by 100 · see citing works
Cohort profile of the longitudinal Netherlands Study of Depression and Anxiety (NESDA) on etiology, course and consequences of depressive and anxiety disorders
Penninx, B. W. J. H., Eikelenboom, M., Giltay, E. J., van Hemert, A. M., Riese, H., Schoevers, R. A., & Beekman, A. T. F. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.03.026 · Cited by 100 · see citing works
Self-citation
Mind and heart: Heart rate variability in major depressive disorder and coronary heart disease - a review and recommendations
Stapelberg, N. J. C., Hamilton‐Craig, I. R., Neumann, D. L., Shum, D., & McConnell, H. W. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412444624 · Cited by 99 · see citing works
Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality
Kemp, A. H., Quintana, D. S., Quinn, C. R., Hopkinson, P., & Harris, A. W. F. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01387 · Cited by 94 · see citing works
Respiratory sinus arrhythmia reactivity in current and remitted major depressive disorder
Bylsma, L. M., Salomon, K., Taylor-Clift, A., Morris, B. H., & Rottenberg, J. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000019 · Cited by 89 · see citing works
Differential Autonomic Nervous System Reactivity in Depression and Anxiety During Stress Depending on Type of Stressor
Hu, M. X., Lamers, F., de Geus, E. J. C., & Penninx, B. W. J. H. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000313 · Cited by 93 · see citing works
Self-citation
Prevalence of depressive symptoms and predictors of treatment among U.S. adults from 2005 to 2010
Wittayanukorn, S., Qian, J., & Hansen, R. A. (2014) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.12.009 · Cited by 86 · see citing works
MDMA decreases the effects of simulated social rejection
Frye, C. G., Wardle, M. C., Norman, G. J., & de Wit, H. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.030 · Cited by 85 · see citing works
Associations between DSM-IV mental disorders and subsequent heart disease onset: Beyond depression
Scott, K. M., de Jonge, P., Alonso, J., Viana, M. C., Liu, Z., O’Neill, S. M., Aguilar‐Gaxiola, S., Bruffaerts, R., Caldas‐de‐Almeida, J. M., Stein, D. J., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.012 · Cited by 86 · see citing works
Autonomic Dysfunction in Mild Cognitive Impairment: Evidence from Power Spectral Analysis of Heart Rate Variability in a Cross-Sectional Case-Control Study
Nicolini, P., Ciulla, M. M., Malfatto, G., Abbate, C., Mari, D., Rossi, P. D., Pettenuzzo, E., Magrini, F., Consonni, D., & Lombardi, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096656 · Cited by 85 · see citing works
Low heart rate variability in patients with clinical burnout
Lennartsson, A.-K., Jónsdóttir, I. H., & Sjörs, A. (2016) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2016.08.005 · Cited by 84 · see citing works
Entropy analysis of heart rate variability and its application to recognize major depressive disorder: A pilot study
Byun, S., Kim, A. Y., Jang, E. H., Kim, S., Choi, K. W., Yu, H. Y., & Jeon, H. J. (2019) · Technology and Health Care · doi:10.3233/thc-199037 · Cited by 81 · see citing works
Prognostic Value of Heart Rate Variability in Patients With Cancer
Guo, Y., Koshy, S., Hui, D. S.-C., Palmer, J. L., Shin, K. Y., Bozkurt, M., & Yusuf, S. W. (2015) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000210 · Cited by 82 · see citing works
Heart and Brain Interaction of Psychiatric Illness: A Review Focused on Heart Rate Variability, Cognitive Function, and Quantitative Electroencephalography
Jung, W., Jang, K.-I., & Lee, S.-H. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.4.459 · Cited by 81 · see citing works
Vagally mediated heart rate variability in headache patients—a systematic review and meta-analysis
Koenig, J., Williams, D. P., Kemp, A. H., & Thayer, J. F. (2015) · Cephalalgia · doi:10.1177/0333102415583989 · Cited by 81 · see citing works
Effects of Antidepressants, but not Psychopathology, on Cardiac Sympathetic Control: A Longitudinal Study
Licht, C. M. M., Penninx, B. W. J. H., & de Geus, E. J. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.107 · Cited by 76 · see citing works
Self-citation
Differences of sympathetic and parasympathetic modulation in major depression
Schumann, A., Andrack, C., & Bär, K. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.009 · Cited by 79 · see citing works
Heart rate variability as a biomarker of anxious depression response to antidepressant medication
Kircanski, K., Williams, L. M., & Gotlib, I. H. (2018) · Depression and Anxiety · doi:10.1002/da.22843 · Cited by 77 · see citing works
Sleep heart rate variability assists the automatic prediction of long-term cardiovascular outcomes
Zhang, L., Wu, H., Zhang, X., Wei, X., Hou, F., & Ma, Y. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.11.1259 · Cited by 77 · see citing works
A multi-method laboratory investigation of emotional reactivity and emotion regulation abilities in borderline personality disorder.
Kuo, J. R., Fitzpatrick, S., Metcalfe, R. K., & McMain, S. F. (2016) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2015.05.002 · Cited by 73 · see citing works
Association of Depressive Symptoms and Heart Rate Variability in Vietnam War–Era Twins
Huang, M.-X., Shah, A. J., Su, S., Goldberg, J., Lampert, R., Levantsevych, O., Shallenberger, L., Pimple, P., Bremner, J., & Vaccarino, V. (2018) · JAMA psychiatry · doi:10.1001/jamapsychiatry.2018.0747 · Cited by 72 · see citing works
Heart rate variability in major depressive disorder and after antidepressant treatment with agomelatine and paroxetine: Findings from the Taiwan Study of Depression and Anxiety (TAISDA)
Yeh, T., Kao, L.-C., Tzeng, N., Kuo, T. B. J., Huang, S., Chang, C.-C., & Chang, H. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.07.007 · Cited by 72 · see citing works
The variable heart: High frequency and very low frequency correlates of depressive symptoms in children and adolescents
Blood, J. D., Wu, J., Chaplin, T. M., Hommer, R. E., Vazquez, L., Rutherford, H. J. V., Mayes, L. C., & Crowley, M. J. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.057 · Cited by 68 · see citing works
Antidepressant use and risk of adverse outcomes: population-based cohort study
Bansal, N., Hudda, M. T., Payne, R., Smıth, D. J., Kessler, D. S., & Wiles, N. (2022) · BJPsych Open · doi:10.1192/bjo.2022.563 · Cited by 64 · see citing works
The association of depression and anxiety with cardiac autonomic activity: The role of confounding effects of antidepressants
Hu, M. X., Milaneschi, Y., Lamers, F., Nolte, I. M., Snieder, H., Dolan, C. V., Penninx, B. W. J. H., & de Geus, E. J. C. (2019) · Depression and Anxiety · doi:10.1002/da.22966 · Cited by 61 · see citing works
Self-citation
Antidepressant use and risk for mortality in 121,252 heart failure patients with or without a diagnosis of clinical depression
Brouwers, C., Christensen, S. B., Damen, N. L., Denollet, J., Torp-Pedersen, C., Gislason, G. H., & Pedersen, S. S. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.11.032 · Cited by 60 · see citing works
Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia
Ribeiro, R. P. D. C., Roschel, H., Artioli, G. G., Dassouki, T., Perandini, L. A., Calich, A. L., Pinto, A. L. D. S., Lima, F. R., Bonfá, E., & Gualano, B. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3519 · Cited by 59 · see citing works
An Integrative Assessment of the Psychophysiologic Alterations in Young Women With Recurrent Major Depressive Disorder
Chang, J. S., Yoo, C. S., Yi, S. H., Her, J. Y., Choi, H. M., Ha, T. H., Park, T., & Ha, K. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31824d0da0 · Cited by 54 · see citing works
CNS- and ANS-arousal predict response to antidepressant medication: Findings from the randomized iSPOT-D study
Olbrich, S., Tränkner, A., Surova, G., Gevirtz, R., Gordon, E., Hegerl, U., & Arns, M. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.12.001 · Cited by 53 · see citing works
Resting heart rate variability, emotion regulation, psychological wellbeing and autism symptomatology in adults with and without autism
Cai, R. Y., Richdale, A. L., Dissanayake, C., & Uljarević, M. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.12.010 · Cited by 55 · see citing works
Integrating Breathing Techniques Into Psychotherapy to Improve HRV: Which Approach Is Best?
Steffen, P. R., Bartlett, D., Channell, R., Jackman, K. N., Cressman, M., Bills, J., & Pescatello, M. S. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.624254 · Cited by 56 · see citing works
Reduced heart rate variability is associated with vulnerability to depression
Dell’Acqua, C., Bò, E. D., Benvenuti, S. M., & Palomba, D. (2020) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2020.100006 · Cited by 52 · see citing works
Associations between sleep-related heart rate variability and both sleep and symptoms of depression and anxiety: A systematic review
Correia, A. T. L., Lipinska, G., Rauch, L., Forshaw, P. E., Roden, L. C., & Rae, D. E. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.10.018 · Cited by 54 · see citing works
Heart Rate Variability, Homeostasis, and Brain Function
Riganello, F., Garbarino, S., & Sannita, W. G. (2012) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000080 · Cited by 52 · see citing works
Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain
Barakat, A., Vogelzangs, N., Licht, C. M. M., Geenen, R., Macfarlane, G. J., de Geus, E. J. C., Smit, J. H., Penninx, B. W. J. H., & Dekker, J. (2012) · Arthritis Care & Research · doi:10.1002/acr.21669 · Cited by 51 · see citing works
Self-citation
Attention biases in female survivors of chronic interpersonal violence: relationship to trauma-related symptoms and physiology
DePierro, J. M., D'Andrea, W. M., & Pole, N. (2013) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v4i0.19135 · Cited by 50 · see citing works
Physical Exercise for Late-Life Depression: Effects on Heart Rate Variability
Toni, G., Murri, M. B., Piepoli, M. F., Zanetidou, S., Cabassi, A., Squatrito, S., Bagnoli, L., Piras, A., Mussi, C., Senaldi, R., et al. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.08.005 · Cited by 49 · see citing works
Heart rate variability and treatment outcome in major depression: A pilot study
Jain, F. A., Cook, I. A., Leuchter, A. F., Hunter, A. M., Davydov, D. M., Ottaviani, C., Tartter, M. A., Crump, C., & Shapiro, D. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.04.006 · Cited by 48 · see citing works
Effects of Serotonin Reuptake Inhibitors on Heart Rate Variability: Methodological Issues, Medical Comorbidity, and Clinical Relevance
Kemp, A. H., Quintana, D. S., & Malhi, G. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.035 · Cited by 46 · see citing works
Heart rate variability in children with autism spectrum disorder and associations with medication and symptom severity
Thapa, R., Pokorski, I., Ambarchi, Z., Thomas, E., Demayo, M., Boulton, K., Matthews, S., Patel, S., Sedeli, I., Hickie, I. B., et al. (2021) · Autism Research · doi:10.1002/aur.2437 · Cited by 44 · see citing works
Gender differences in the impact of daily sadness on 24‐h heart rate variability
Verkuil, B., BROSSCHOT, J. F., Marques, A. H., Kampschroer, K., STERNBERG, E. M., & Thayer, J. F. (2015) · Psychophysiology · doi:10.1111/psyp.12541 · Cited by 43 · see citing works
Psychological Co-morbidities of Physical Illness
Pagoto, S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0029-6 · Cited by 42 · see citing works
Respiratory sinus arrhythmia reactivity to a sad film predicts depression symptom improvement and symptomatic trajectory
Panaite, V., Hindash, A. C., Bylsma, L. M., Small, B. J., Salomon, K., & Rottenberg, J. A. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.12.002 · Cited by 41 · see citing works
Autonomic Nervous System Function in Anorexia Nervosa: A Systematic Review
Jenkins, Z., Eikelis, N., Phillipou, A., Castle, D. J., Wilding, H., & Lambert, É. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.682208 · Cited by 42 · see citing works
Impaired resting vagal tone in patients with functional movement disorders
Maurer, C. W., Liu, V. D., LaFaver, K., Ameli, R., Wu, T., Toledo, R., Epstein, S. A., & Hallett, M. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.06.009 · Cited by 38 · see citing works
A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment
Gaburro, S., Stiedl, O., Giusti, P., Sartori, S. B., Landgraf, R., & Singewald, N. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000058 · Cited by 38 · see citing works
Antidepressants and heart-rate variability in older adults: a population-based study
Noordam, R., van den Berg, M. E., Niemeijer, M. N., Aarts, N., Albert Hofman, D., Tiemeier, H. W., Kors, J. A., Stricker, B. H. C., Eijgelsheim, M., Visser, L. E., et al. (2015) · Psychological Medicine · doi:10.1017/s0033291715002779 · Cited by 37 · see citing works
Impact of antidepressant use on the autonomic nervous system: A meta-analysis and systematic review
Fiani, D., Campbell, H. M., Solmi, M., Fiedorowicz, J. G., & Calarge, C. A. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.03.013 · Cited by 36 · see citing works
Respiratory sinus arrhythmia reactivity in anxiety and posttraumatic stress disorder: A review of literature
Campbell, A. A., & Wisco, B. E. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102034 · Cited by 36 · see citing works
Differential Associations of Specific Selective Serotonin Reuptake Inhibitors With Resting-State Heart Rate and Heart Rate Variability: Implications for Health and Well-Being
Kemp, A. H., Fráguas, R., Brunoni, A. R., Bittencourt, M. S., Nunes, M. A., Dantas, E. M., Andreão, R. V., Mill, J. G., Ribeiro, A. L. P., Koenig, J., et al. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000336 · Cited by 36 · see citing works
Heart rate variability and cordance in rapid eye movement sleep as biomarkers of depression and treatment response
Pawlowski, M. A., Gazea, M., Wollweber, B., Dresler, M., Holsboer, F., Keck, M. E., Steiger, A., Adamczyk, M., & Mikoteit, T. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.026 · Cited by 35 · see citing works
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats
Carnevali, L., Vacondio, F., Rossi, S., Callegari, S., Macchi, E., Spadoni, G., Bedini, A., Rivara, S., Mor, M., & Sgoifo, A. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.07.015 · Cited by 34 · see citing works
Is Depression the Wrong Treatment Target for Improving Outcome in Coronary Artery Disease?
Rafanelli, C., Sirri, L., Grandi, S., & Fava, G. A. (2013) · Psychotherapy and Psychosomatics · doi:10.1159/000351586 · Cited by 34 · see citing works
Does respiratory sinus arrhythmia (RSA) predict anxiety reduction during cognitive behavioral therapy (CBT) for social anxiety disorder (SAD)?
Mathewson, K. J., Schmidt, L. A., Miskovic, V., Santesso, D. L., Duku, E., McCabe, R. E., Antony, M. M., & Moscovitch, D. A. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.03.016 · Cited by 34 · see citing works
Physical activity, heart rate variability–based stress and recovery, and subjective stress during a 9‐month study period
Föhr, T., Tolvanen, A. J., Myllymäki, T., Järvelä‐Reijonen, E., Peuhkuri, K., Rantala, S., Kolehmainen, M., Korpela, R., Lappalainen, R. I., Ermes, M., et al. (2016) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12683 · Cited by 34 · see citing works
Explicit Facial Emotion Processing in Patients With Dissociative Seizures
Pick, S., Mellers, J. D. C., & Goldstein, L. H. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000327 · Cited by 33 · see citing works
To Include or Not to Include? A Response to the Meta-Analysis of Heart Rate Variability and Depression
Licht, C. M. M., Penninx, B. W. J. H., & de Geus, E. J. C. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.034 · Cited by 33 · see citing works
Self-citation
Heart Rate Variability for the Prediction of Treatment Response in Major Depressive Disorder
Choi, K. W., & Jeon, H. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00607 · Cited by 32 · see citing works
Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia
Fang, S., & Zhang, W. Y. (2024) · Biomedicines · doi:10.3390/biomedicines12081719 · Cited by 37 · see citing works
Rodent models of depression-cardiovascular comorbidity: Bridging the known to the new
Carnevali, L., Montano, N., Statello, R., & Sgoifo, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.006 · Cited by 32 · see citing works
Associations of depression severity with heart rate and heart rate variability in young adults across normative and clinical populations
Lesnewich, L. M., Conway, F. N., Buckman, J. F., Brush, C. J., Ehmann, P. J., Eddie, D., Olson, R. L., Alderman, B. L., & Bates, M. E. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.06.005 · Cited by 30 · see citing works
Chronic fluoxetine reduces autonomic control of cardiac rhythms in rats with congestive heart failure
Henze, M., Tiniakov, R. L., Samarel, A. M., HOLMES, E. W., & Scrogin, K. E. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00763.2012 · Cited by 30 · see citing works
Psychotropic Drug Use in São Paulo, Brazil – An Epidemiological Survey
Quintana, M. I., Andreoli, S. B., Peluffo, M. P., Ribeiro, W. S., Feijo, M. M., Bressan, R. A., Coutinho, E. S. F., & Mari, J. D. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135059 · Cited by 30 · see citing works
The Association Between Depressive Disorder and Cardiac Autonomic Control in Adults 60 Years and Older
Licht, C. M. M., Naarding, P., Penninx, B. W. J. H., van der Mast, R. C., de Geus, E. J. C., & Comijs, H. C. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000165 · Cited by 26 · see citing works
Self-citation
Psychological pain and reduced resting‐state heart rate variability in adults with a history of depression
Meerwijk, E. L., Chesla, C. A., & Weiss, S. J. (2014) · Psychophysiology · doi:10.1111/psyp.12175 · Cited by 25 · see citing works
Associations of immunometabolic risk factors with symptoms of depression and anxiety: The role of cardiac vagal activity
Hu, M. X., Penninx, B. W. J. H., de Geus, E. J. C., Lamers, F., Kuan, D. C.-H., Wright, A. G. C., Marsland, A. L., Muldoon, M. F., Manuck, S. B., & Gianaros, P. J. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.013 · Cited by 22 · see citing works
Self-citation
Use your words: The role of emotion labeling in regulating emotion in borderline personality disorder
Fitzpatrick, S., Ip, J., Krantz, L. H., Zeifman, R. J., & Kuo, J. R. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103447 · Cited by 24 · see citing works
Features of autonomic cardiovascular control during cognition in major depressive disorder
Bair, A., Marksteiner, J., Falch, R., Ettinger, U., del Paso, G. A. R., & Duschek, S. (2020) · Psychophysiology · doi:10.1111/psyp.13628 · Cited by 25 · see citing works
Predictive value of heart rate in treatment of major depression with ketamine in two controlled trials
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Self-citation

Authors: Licht, C. M. M., de Geus, E. J. C., van Dyck, R., & Penninx, B. W. J. H.
Affiliations: Amsterdam Public Health (NL)
University Medical Center Groningen (NL)
Corresponding author: Licht, Carmilla M.M.
ORCID: Penninx, Brenda W.J.H.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2010-11
Volume: 68
Issue: 9
Pages: 861-868
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2010.06.032
OpenAlex: W2104647616
Cited by: 225
References: 64
Citations by year: 2026: 2 · 2025: 8 · 2024: 10 · 2023: 16 · 2022: 7 · 2021: 21 · 2020: 10 · 2019: 18 · 2018: 13 · 2017: 14 · 2016: 20 · 2015: 25 · 2014: 15 · 2013: 21 · 2012: 13
FWCI: 9.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
VU Research Portal (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: Netherlands Organisation for Health Research and Development (10-000-1002)
VU University Medical Center
GGZ inGeest
Arkin
Leiden University Medical Center
GGZ Rivierduinen
University Medical Center Groningen
Lentus
GGZ Friesland
GGZ Drenthe
Scientific Institute for Quality of Healthcare
Netherlands Institute for Health Services Research
Netherlands Institute of Mental Health and Addiction
Netherlands Organisation for Scientific Research (NWO) (917.66.320)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: antidepressants, heart rate variability, respiratory sinus arrhythmia, cardiac vagal control, tricyclic antidepressants, selective serotonin reuptake inhibitors, antidepressant discontinuation, autonomic function, heart rate, depression, anxiety
MeSH terms: Adolescent, Adult, Aged, Antidepressive Agents, Anxiety Disorders, Arrhythmia, Sinus, Depressive Disorder, Female, Heart Rate, Humans, Longitudinal Studies, Male, Middle Aged, Netherlands, Vagus Nerve

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Longitudinal Evidence for Unfavorable Effects of Antidepressants on Heart Rate Variability

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