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Neuronal Correlates of Cognitive Reappraisal in Borderline Patients with Affective Instability
Abstract
Background Borderline personality disorder has been characterized by enhanced emotional reactivity and deficient emotion regulation in behavioral and functional imaging studies. We aimed to validate patients' difficulties in the cognitive regulation of negative emotions and investigated if emotion regulation deficits are restricted to the decrease of negative emotions. A cognitive reappraisal paradigm was used and hence a regulation strategy that is typically applied in cognitive-behavioral therapy. Methods Fifteen unmedicated female borderline patients with affective instability and 15 healthy female control subjects underwent functional magnetic resonance imaging during a delayed reappraisal paradigm. Hemodynamic responses were measured in response to aversive pictures in an initial viewing phase and a subsequent reappraisal phase with three different conditions: decreasing, increasing, and maintaining the initial emotional reaction. Results Patients demonstrated enhanced activation of left amygdala and right insula during the initial viewing of aversive stimuli. During attempting to decrease the initial emotional reaction, patients showed attenuated activation of the left orbitofrontal cortex and increased activation of the bilateral insula. The attempt to increase negative emotions resulted in enhanced activity in amygdala and insula, whereas no group differences were found. Conclusions The results point to the role of two distinguishable processes of emotional difficulti…
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“Testing more complex emotional regulation targeting the OFC with cognitive reappraisal of emotional pictures, BPD patients have been found to activate lOFC to a lesser extent than controls while they activated amygdala and insula more (Schulze et al., 2011; Figure 8D).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Schulze et al., 2011
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Items 101–200 of 229
Schmitgen, M. M., Niedtfeld, I., Schmitt, R., Mancke, F., Winter, D., Schmahl, C. G., & Herpertz, S. C. (2019) · Brain and Behavior · doi:10.1002/brb3.1384 · Cited by 44
“…power of the mean activations in brain regions specifically connected with emotion regulation during the reappraisal task (Koenigsberg et al., 2009; Schulze et al., 2011) as well as GMV of the left amygdala) further highlight the relevance of emotion regulation skills in BPD psychopathology and…”
BackgroundSelf-citationDenny, B. T., Fan, J., Liu, X., Ochsner, K., Guerreri, S., Mayson, S., Rimsky, L., McMaster, A., New, A., Goodman, M., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.017 · Cited by 37
“…with other mood and anxiety disorders such as major depression (Johnstone et al., 2007), borderline personality disorder (Koenigsberg et al., 2009; Schulze et al., 2011), and social anxiety disorder (Goldin et al., 2009a; Goldin et al., 2009b; Klumpp et al., 2010; Marazziti et al., 2014) relative…”
Stange, J. P., Sylvia, L. G., Magalhães, P. V. D. S., Miklowitz, D. J., Otto, M. W., Frank, E., Yim, C., Berk, M., Dougherty, D. D., Nierenberg, A. A., et al. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.162073 · Cited by 39
Lischke, A., Domin, M., Freyberger, H. J., Grabe, H. J., Mentel, R., Bernheim, D., & Lotze, M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00196 · Cited by 35
“…(Tebartz van Elst et al., 2003; Hazlett et al., 2005; Koenigsberg et al., 2009a; Rüsch et al., 2010; Niedtfeld et al., 2013), dorsolateral and ventromedial prefrontal cortex (Tebartz van Elst et al., 2003; Rüsch et al., 2007b; Koenigsberg et al., 2009b; Schulze et al., 2011; Bruehl et al., 2013).”
BackgroundLapomarda, G., Grecucci, A., Messina, I., Pappaianni, E., & Dadomo, H. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147401 · Cited by 40
Cullen, K. R., LaRiviere, L. L., Vizueta, N., Thomas, K. M., Hunt, R. H., Miller, M. J., Lim, K. O., & Schulz, S. C. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9406-4 · Cited by 33
“…et al. 2012) prior studies have found greater amygdala activation to negative stimuli in patients with BPD compared to control subjects (Donegan et al. 2003; Hazlett et al. 2012; Herpertz et al. 2001; Koenigsberg et al. 2014, 2009; Minzenberg et al. 2007; Mitchell et al. 2014; Schulze et al. 2011).”
ResultKrauch, M., Ueltzhöffer, K. J., Brunner, R. M., Kaess, M., Hensel, S., Herpertz, S. C., & Bertsch, K. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00057 · Cited by 33
“In adult patients with BPD similarly elevated posterior insula activations in response to emotional stimuli have been interpreted as a neural correlate of deficient emotion regulation (Niedtfeld et al., 2010; Schulze et al., 2011).”
BackgroundSelf-citationFitzpatrick, S., Liebman, R. E., & Monson, C. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.101983 · Cited by 46
Schnell, K., & Herpertz, S. C. (2018) · Journal of Personality Disorders · doi:10.1521/pedi.2018.32.supp.12 · Cited by 29
Self-citationLischke, A., Domín, M., Freyberger, H. J., Grabe, H. J., Mentel, R., Bernheim, D., & Lotze, M. (2015) · Psychological Medicine · doi:10.1017/s0033291715001142 · Cited by 30
“…Schulze et al. 2011; Hazlett et al. 2012), such as the amygdala and hypoactivity in prefrontal brain regions (e.g. Koenigsberg et al. 2009a, b; Niedtfeld et al. 2010; Schulze et al. 2011), such as the anterior cingulate cortex (ACC), the orbitofrontal and dorsolateral prefrontal cortex (OFC, PFC).”
BackgroundInfluentialSilvers, J. A., Hubbard, A. D., Chaudhury, S., Biggs, E., Shu, J., Grunebaum, M. F., Fertuck, E., Weber, J., Kober, H., Carson-Wong, A., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.06.020 · Cited by 30
“Prior research indicates that healthy controls recruit prefrontal and occipitoparietal cortex to a greater extent than individuals with BPD (Koenigsberg et al., 2009; Lang et al., 2012; Schulze et al., 2011).”
BackgroundInfluentialLaddis, A., Dell, P. F., & Korzekwa, M. (2016) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2016.1194358 · Cited by 41
“In fact, BPD patients’ attempts to decrease their emotional response may increase the activation of their bilateral insulae (Schulze et al., 2011).”
BackgroundBuchheim, A., Erk, S., George, C. C., Kächele, H. U., Martius, P., Pokorný, D., Spitzer, M., & Walter, H. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00389 · Cited by 32
“Unresolved Frontiers in Human Neuroscience | www.frontiersin.org 9 August 2016 | Volume 10 | Article 389 controls, however, had increasing affective involvement.”
BackgroundInfluentialOscillatory responses to reward processing in borderline personality disorder
Andreou, C., Kleinert, J., Steinmann, S., Fuger, U., Leicht, G., & Mulert, C. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1054880 · Cited by 34
Reichenberger, J., Eibl, J. J., Pfaltz, M., Wilhelm, F., Voderholzer, U., Hillert, A., & Blechert, J. (2017) · Journal of Personality Disorders · doi:10.1521/pedi_2016_30_238 · Cited by 29
“Studies using IAPS, comprising predominantly nonsocial stimuli, are also inconsistent: On the one hand, emotional hyperreactivity was reported in individuals with BPD to negative and neutral slides in fMRI studies (Herpertz et al., 2001; Schulze et al., 2011), whereas on the other hand, no differences or emotional hyp…”
BackgroundReduced frontal cortex thickness and cortical volume associated with pathological narcissism
Mao, Y., Sang, N., Wang, Y., Hou, X., Huang, H., Wei, D., Zhang, J., & Qiu, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.025 · Cited by 35
van Zutphen, L., Siep, N., Jacob, G., Domes, G., Sprenger, A., Willenborg, B., Goebel, R., & Arntz, A. (2017) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.170008 · Cited by 29
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“Excessive neural responding in the amygdala and associated cortical regions to facial emotional expressions (Schulze et al., 2011; Schulze, Schmahl, & Niedtfeld, 2016) might be interpreted as the neural correlate of hypervigilance to social threat that distorts social perception towards potential…”
BackgroundSelf-citationDepping, M. S., Wolf, N. D., Vasić, N., Sambataro, F., Thomann, P. A., & Wolf, R. C. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.059 · Cited by 28
“These findings imply a pivotal role for ACC dysfunction in BPD, a disorder which is essentially characterized by affective instability, emotional deficits encompassing multiple domains of affective processing (Schnell et al., 2007; Niedtfeld et al., 2010; Schulze et al., 2011), and with a high degree of MDD comorbidit…”
BackgroundUnpacking reappraisal: a systematic review of fMRI studies of distancing and reinterpretation
Denny, B. T., Jungles, M. L., Goodson, P. N., Dicker, E. E., Chavez, J., Jones, J. S., & Lopez, R. B. (2023) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsad050 · Cited by 36
Feroz, F. S., Leicht, G., Steinmann, S., Andreou, C., & Mulert, C. (2016) · Brain Topography · doi:10.1007/s10548-016-0521-3 · Cited by 29
Ueltzhöffer, K. J., Herpertz, S. C., Krauch, M., Schmahl, C. G., & Bertsch, K. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.004 · Cited by 27
Self-citationValim, C. P. R. A. T., Marques, L. M., & Boggio, P. S. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00647 · Cited by 36
Neural Changes in Borderline Personality Disorder After Dialectical Behavior Therapy–A Review
Iskric, A., & Barkley-Levenson, E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.772081 · Cited by 25
Lamers, A., Toepper, M., Fernando, S., Schlosser, N., Bauer, E., Woermann, F., Driessen, M., & Beblo, T. (2019) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.180077 · Cited by 25
Dudas, R., Mole, T. B., Morris, L., Denman, C., Hill, E., Szalma, B., Evans, D., Dunn, B., Fletcher, P., & Voon, V. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.10.043 · Cited by 25
Urgesi, C., Mattiassi, A. D. A., Buiatti, T., & Marini, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.05.039 · Cited by 25
“Furthermore, people feel less intense negative emotions when they look at pictures that have been previously reappraised (Schulze et al., 2011; Vanderhasselt et al., 2012).”
BackgroundAnxiety, depression, and oscillatory dynamics in a social interaction model
Knyazev, G. G., Savostyanov, A. N., Bocharov, A. V., & Rimareva, J. M. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.075 · Cited by 26
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“…has been the focus of many studies of BPD because of its identified role in effortful emotion regulation (Ruocco, Medaglia, Ayaz, & Chute, 2010; Schulze et al., 2011) and response inhibition (Ruocco, McCloskey, Lee, & Coccaro, 2009; Ruocco, Laporte, Russell, Guttman, & Paris, 2012), has shown…”
BackgroundEmotional processes in borderline personality disorder: An update for clinical practice.
Dixon–Gordon, K. L., Peters, J. R., Fertuck, E. A., & Yen, S. (2016) · Journal of Psychotherapy Integration · doi:10.1037/int0000044 · Cited by 50
Mirror neuron activations in encoding of psychic pain in borderline personality disorder
Sosic-Vasic, Z., Eberhardt, J., Bosch, J. E., Dommes, L., Labek, K., Buchheim, A., & Viviani, R. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101737 · Cited by 28
Schulze, L., Grove, M., Tamm, S., Renneberg, B., & Roepke, S. (2019) · Scientific Reports · doi:10.1038/s41598-018-37315-x · Cited by 26
Self-citationEffects of prefrontal rTMS on autonomic reactions to affective pictures
Berger, C., Domes, G., Balschat, J., Thome, J., & Höppner, J. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1491-4 · Cited by 26
“For instance, impaired emotion regulation was reported in anxiety (Goldin et al. 2009; Hermann et al. 2009), borderline personality disorder (Schulze et al. 2011) and depression (Johnstone et al. 2007; Kanske et al. 2012).”
BackgroundSelf-citationSoloff, P. H., Abraham, K., Ramaseshan, K. S., Burgess, A., & Diwadkar, V. A. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.12.016 · Cited by 24
“Difficulties in emotion regulation during cognitive reappraisal were positively associated with insular activation and negatively associated with activity in the OFC (Schulze et al., 2011).”
McLachlan, J., Mehdikhani, M., Larham, B., & Centifanti, L. C. M. (2021) · Child Psychiatry & Human Development · doi:10.1007/s10578-021-01169-8 · Cited by 22
“People with a diagnosis of BPD have been found to engage in cognitive reappraisal less frequently, although this strategy may reduce their emotional lability [22, 23].”
Sarkheil, P., Ibrahim, C. N., Schneider, F., Mathiak, K., & Klasen, M. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00065-z · Cited by 22
Brain oscillations during emotion regulation and the two-dimensional model of adult attachment
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“These findings underscore a complex interaction between brain regions in response to emotional stimuli (Eippert et al., 2007; Goldin et al., 2009; Ochsner & Gross, 2005; Schulze et al., 2011).”
Flasbeck, V., Enzi, B., & Brüne, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00357 · Cited by 20
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“Neuroimaging studies in BPD have consistently described increased amygdala activation during exposure to emotionally arousing pictures compared to healthy controls, suggesting enhanced emotional reactivity (Donegan et al., 2003; Schulze et al., 2011, 2016).”
BackgroundSelf-citationScherpiet, S., Herwig, U., Opialla, S., Scheerer, H., Habermeyer, V., Jäncke, L., & Brühl, A. B. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.05.008 · Cited by 24
“though numerous studies have shown shortfalls in emotion regulation on the neural level (e.g., Koenigsberg et al., 2009a; Schulze et al., 2011), we did not find statistically significant group differences in regards of down-regulation of amygdala activity during mindful introspection between patients and healthy parti…”
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“Notably, previous studies used reappraisal (in the form of reinterpretation) and distraction, two well-known strategies 918 | SULPIZIO et aL. able to regulate emotions (Banks et al., 2007; Kanske et al., 2011; Ochsner et al., 2004; Schulze et al., 2011).”
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“La visualisation de scènes à valence affective négative a aussi été associée à une hyperactivation de l’amygdale chez les adultes avec TPL (Hazlett et al., 2012 ; Herpertz et al., 2001 ; Koenigsberg, et al., 2009 ; Krause-Utz et al., 2012 ; Niedtfeld et al., 2010 ; Schulze et al., 2011).”
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Vega, D., Torrúbia, R., Marco‐Pallarés, J., Soto, À., & Rodríguez‐Fornells, A. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.033 · Cited by 20
Defrin, R., Sagy, N. C., Biran, I., Goor‐Aryeh, I., Shai, R., & Ginzburg, K. (2019) · European Journal of Pain · doi:10.1002/ejp.1504 · Cited by 16
“…involved in both pain- and emotion modulation including the amygdala, prefrontal cortex and cingulate cortex (Cullen et al., 2016; Hazlett et al., 2012; Kraus et al., 2009; Niedtfeld et al., 2012, 2010; Ruocco, Amirthavasagam, Choi-Kain, & McMain, 2013; Schmahl et al., 2006; Schulze et al., 2011).”
BackgroundChange in Emotional and Theory of Mind Processing in Borderline Personality Disorder: A Pilot Study
Kramer, U., Kolly, S., Maillard, P., Pascual-Leone, A., Samson, A., Schmitt, R., Bernini, A., Allenbach, G., Charbon, P., de Roten, Y., et al. (2018) · Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000905 · Cited by 17
Borderline-Persönlichkeitsstörung
Schmahl, C., Niedtfeld, I., & Herpertz, S. (2018) · Der Nervenarzt · doi:10.1007/s00115-018-0587-0 · Cited by 17
Self-citationMothers Who Were Neglected in Childhood Show Differences in Neural Response to Their Infant’s Cry
Wright, D. B., Laurent, H. K., & Ablow, J. C. (2016) · Child Maltreatment · doi:10.1177/1077559516683503 · Cited by 19
“The precentral gyrus has also been implicated in the processing of rewarding and aversive stimuli (e.g., Bohon & Stice, 2011; Schulze et al., 2011), supporting the idea that individual differences in activation may help to explain differences in mothers’ approach behavior with their infants.”
BackgroundTackling the Electro-Topography of the Selves Through the Sphere Model of Consciousness
Paoletti, P., Leshem, R., PELLEGRINO, M. A., & Ben‐Soussan, T. D. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.836290 · Cited by 23
Xia, C. H., Barnett, I., Tapera, T. M., Adebimpe, A., Baker, J. T., Bassett, D. S., Brotman, M. A., Calkins, M. E., Cui, Z., Leibenluft, E., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01351-z · Cited by 15
“prefrontal cortex of the control network) may relate to person-specific mobility patterns [58].”
BackgroundFitzpatrick, S., Varma, S., & Kuo, J. R. (2020) · Psychological Medicine · doi:10.1017/s0033291720004225 · Cited by 23
“, 2018), studies suggest that they can suppress emotions and reappraise emotional content following training in these strategies to a similar or better extant than healthy groups across neural, self-report, and parasympathetic indices (e.g. Baczkowski et al., 2017; Chapman, Rosenthal, & Leung, 2009; Krause-Utz, Walthe…”
BackgroundDaros, A. R., Rodrigo, A., Norouzian, N., Darboh, B., McRae, K., & Ruocco, A. (2020) · Journal of Personality Disorders · doi:10.1521/pedi_2018_32_390 · Cited by 16
Krüger, T. H. C., Schulze, J., Bechinie, A., Neumann, I., Jung, S., Sperling, C., Engel, J., Müller, A., Kneer, J., Kahl, K. G., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17509-0 · Cited by 18
Vanicek, T., Unterholzner, J., Lanzenberger, R., Naderi-Heiden, A., Kasper, S., & Praschak-rieder, N. (2022) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2031287 · Cited by 15
“In patients with BPD, higher levels of glutamate in cortical brain regions have been associated with increased impulsivity (Hoerst et al. 2010; Schulze et al. 2011).”
BackgroundParet, C., Kluetsch, R., Ruf, M., Demirakca, T., Kalisch, R., Schmahl, C., & Ende, G. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.08.054 · Cited by 15
“Most of the studies included in this meta-analysis do not modulate emotional information during the reappraisal episode and used picture presentation durations of 10 seconds or more (Eippert et al., 2007; Schulze et al., 2011).”
Self-citationHouston, E., Sandfort, T., Watson, K. T., & Caton, C. (2012) · Journal of Health Psychology · doi:10.1177/1359105312464674 · Cited by 15
“These findings contrast with other studies investigating the link between childhood abuse and sexual risk outcomes during adulthood in that PTSD symptoms alone did not have a significant relationship (Limberg et al., 2011; Schulze et al., 2011).”
ResultA service evaluation of short-term mentalisation based treatment for personality disorder
McGowan, N. M., Syam, N., McKenna, D., Pearce, S., & Saunders, K. E. A. (2021) · BJPsych Open · doi:10.1192/bjo.2021.974 · Cited by 14
Stopyra, M. A., Simon, J. J., Rheude, C., & Nikendei, C. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0014 · Cited by 17
Challenging control over emotions in borderline personality disorder - a tDCS study
Wolkenstein, L., Rombold, F., Bingmann, T., Sommer, A., Kanske, P., & Plewnia, C. (2021) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2021.107850 · Cited by 14
Fitzpatrick, S., Khoury, J., & Kuo, J. R. (2018) · Counselling Psychology Quarterly · doi:10.1080/09515070.2016.1211509 · Cited by 14
“For example, self-report and electrophysiology studies suggest that individuals with BPD can decrease emotional responding using cognitive reappraisal to the same extent as healthy controls (HCs) and individuals with a history of trauma (e.g. Lang et al., 2012; Ruocco et al., 2010; Schulze et al., 2011).”
BackgroundInfluentialkhodadadifar, T., Soltaninejad, Z., Ebneabbasi, A., Eickhoff, C. R., Sorg, C., van Eimeren, T., Vogeley, K. T., Zarei, M., Eickhoff, S. B., & Tahmasian, M. (2021) · Human Brain Mapping · doi:10.1002/hbm.25722 · Cited by 21
Suboptimal Decision Making in Borderline Personality Disorder: Effect of Potential Losses
Sánchez‐Navarro, J. P., Weller, J. A., López-Navarro, J. M., Martínez‐Selva, J. M., & Bechara, A. (2014) · The Spanish Journal of Psychology · doi:10.1017/sjp.2014.39 · Cited by 11
“…has revealed that the disorder is associated with a dysfunctional frontolimbic network including the medial and lateral prefrontal cortex, the insula, anterior cingulate, and amygdala (Ruocco, Medaglia, Ayaz, & Chute, 2010; Silbersweig et al., 2007; Schmahl & Bremmer, 2006; Schulze et al., 2011).”
BackgroundHaro, M. V. N., Guillén, V., Badenes‐Ribera, L., Borao, L., & García‐Palacios, A. (2020) · Cognitive Therapy and Research · doi:10.1007/s10608-020-10170-9 · Cited by 15
“A recent laboratory study has suggested that individuals with BPD may have more difficulties with learning cognitive reappraisal (Schulze et al. 2011).”
BackgroundFitzpatrick, S., & Kuo, J. R. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.05.004 · Cited by 17
Susceptibility to Distraction by Social Cues in Borderline Personality Disorder
Krause-Utz, A., Elzinga, B. M., Oei, N. Y. L., Spinhoven, P., Bohus, M., & Schmahl, C. G. (2013) · Psychopathology · doi:10.1159/000351740 · Cited by 11
Self-citationSchulze, L., Bürkner, P., Bohländer, J., & Zetsche, U. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022694 · Cited by 14
Self-citationHurtado, M. M., Triviño, M., Panadero, M. A., Arnedo, M., & Tudela, P. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2018.07.016 · Cited by 12
Falquez, R., Dinu-Biringer, R., Stopsack, M., Arens, E. A., Wick, W., & Barnow, S. (2015) · Neurorehabilitation · doi:10.3233/nre-151242 · Cited by 13
Decoding acceptance and reappraisal strategies from resting state macro networks
Ghomroudi, P. A., Šiugždaitė, R., Messina, I., & Grecucci, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-68490-9 · Cited by 13
Yang, W., Jia, H., Feng, Q., Wei, D., Qiu, J., & Hulbert, J. C. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.057 · Cited by 12
“The ROIs was defined based on the noted role of the insula (Carlson and Mujica-Parodi, 2010; Goldin et al., 2008; Grecucci et al., 2013; Hermann et al., 2014; Schulze et al., 2011; Zhang et al., 2020) and amygdala”
Jarnecke, A. M., Miller, M. L., & South, S. C. (2015) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000157 · Cited by 10
“In fact, previous studies show that trauma-exposed individuals with BPD have more difficulty engaging in cognitive reappraisal exercises to reduce negative emotions (Lang et al., 2012; Schulze et al., 2011).”
BackgroundFrontal theta oscillations during emotion regulation in people with borderline personality disorder
Haaf, M., Polomac, N., Starčević, A., Lack, M., Kellner, S., Dohrmann, A.-L., Fuger, U., Steinmann, S., Rauh, J., Nolte, G., et al. (2024) · BJPsych Open · doi:10.1192/bjo.2024.17 · Cited by 11
Kulakova, E., Graumann, L., Cho, A. B., Deuter, C. E., Wolf, O. T., Roepke, S., Otte, C., & Wingenfeld, K. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01678-8 · Cited by 9
“This is in line with findings of deficient top-down regulation of affective processes in BPD, potentially related to frontal dysfunction [48] and deficient fronto-limbic connectivity [1, 49].”
ResultFitzpatrick, S., & Kuo, J. R. (2021) · Cognition & Emotion · doi:10.1080/02699931.2021.2018291 · Cited by 14
“, 2010), although research with neural indices is more mixed (e.g. Koenigsberg et al., 2009; Ruocco et al., 2010; Schulze et al., 2011).”
BackgroundEmotionsregulation: Überblick und kritische Reflexion des aktuellen Forschungsstandes
Heber, E., Lehr, D., Riper, H. M., & Berking, M. (2014) · Zeitschrift für Klinische Psychologie und Psychotherapie · doi:10.1026/1616-3443/a000265 · Cited by 10
Emotionale Dysregulation bei der Borderline-Persönlichkeitsstörung
Niedtfeld, I., & Schmahl, C. G. (2012) · Zeitschrift für Psychiatrie Psychologie und Psychotherapie · doi:10.1024/1661-4747/a000115 · Cited by 7
Self-citationGawrysiak, M. J., Swan, S. A., Nicholas, C. R. N., Rogers, B. P., Dougherty, J. H., & Hopko, D. R. (2013) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.2013.67.3.237 · Cited by 8
Denny, B. T., Lopez, R. B., Wu-Chung, E., Dicker, E. E., Goodson, P. N., Fan, J., Schulz, K., Ochsner, K., Trumbull, J., Lopez, M. M., et al. (2024) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.03.007 · Cited by 7
Functional MRI findings in personality disorders: A review
Zarnowski, O., Ziton, S., Holmberg, R., Musto, S., Riegle, S., Antwerp, E. V., & Santos‐Nunez, G. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12924 · Cited by 9
Marco, J., Fernández-Felipe, I., Fonseca, S., García-Palacios, A., Baños, R., & Guillén, V. (2021) · Clinical Psychology and Psychotherapy · doi:10.1002/cpp.2605 · Cited by 7
Kramer, U., Grandjean, L., Beuchat, H., Kolly, S., Conus, P., de Roten, Y., Draganski, B., & Despland, J. (2020) · Trials · doi:10.1186/s13063-020-4229-z · Cited by 9
“Using a previously validated procedure of cognitive reappraisal [40], Schmitt and colleagues (2016) partially confirmed these results in a sample of patients with BPD (N = 32 patients) undergoing DBT and identified enhanced neural connectivity between ventro-lateral pre-frontal cortex areas and the amygdala [32], cons…”
ResultTo BD or not to BD: functional neuroimaging and the boundaries of bipolarity
Kuiper, S., McLean, L., & Malhi, G. S. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.126 · Cited by 6
Sicorello, M., Herzog, J., Wager, T. D., Ende, G., Müller‐Engelmann, M., Herpertz, S. C., Bohus, M., Schmahl, C. G., Paret, C., & Niedtfeld, I. (2021) · Neuroimage Reports · doi:10.1016/j.ynirp.2021.100019 · Cited by 8
“Post-session valence ratings of negative pictures did not differ considerably between participants, as has been previously reported (Koenigsberg et al., 2009; Schulze et al., 2011), but are not necessarily a valid surrogate of momentary affect, immediately following negative trials.”
ResultSelf-citationGreening, S., Lee, T.-H., Burleigh, L., Grégoire, L., Robinson, T. D., Jiang, X.-R., Mather, M., & Kaplan, J. T. (2021) · bioRxiv · doi:10.1101/2021.02.04.429795 · Cited by 5
Uscinska, M., & Bellino, S. (2018) · Future Neurology · doi:10.2217/fnl-2018-0006 · Cited by 4
fMRI neurofeedback for disorders of emotion regulation
Young, K. D., Fine, N. B., & Hendler, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822421-2.00014-4 · Cited by 6
Schulze, L., & Roepke, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-54542-9_17 · Cited by 2
Self-citationBedeutung der Neurobiologie für die modulare Psychotherapie
Schmahl, C., & Bohus, M. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3872-y · Cited by 4
Self-citationDepressive Disorders in Borderline Personality Disorder: Phenomenology and Biological Markers
Goodman, M. S., Chowdhury, S., New, A. S., & Siever, L. J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1314-5_2 · Cited by 7
“, “unresolved” life events), emotional faces [ 137 ], scenes of threat and suffering [ 138 ], positive and negative emotional pictures [ 139 ], and scripts [ 140 ].”
BackgroundMessina, I., Spataro, P., Gagliardini, G., Rossi, T., & Grecucci, A. (2026) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-025-00323-1 · Cited by 3
“Supporting this view, research on adult attachment consistently demonstrates a strong connection between BPD and insecure attachment styles, alongside a negative association with secure attachment [1, 54, 81].”
Kot, E., Pluta, A., Wojciechowski, J., Wayda-Zalewska, M., Wojtczak, M., Wolak, T., & Kucharska, K. (2025) · European eating disorders review · doi:10.1002/erv.70031 · Cited by 3
Peng, W.-R., Liu, S., & Yi, J.-Y. (2025) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.03.009 · Cited by 3
Kulesza, M., Rekawek, K., Holas, P., Żołnierczyk-Zreda, D., Sokół-Szawłowska, M., Poleszczyk, A., Marchewka, A., & Wypych, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-81840-x · Cited by 3
“However, the current literature on the topic is based on similar or smaller samples and obtained significant group differences (for example, 15–24 participants; 36,64,65 ).”
Pizarro‐Campagna, E., Terrett, G., Jovev, M., Rendell, P. G., Henry, J. D., & Chanen, A. M. (2023) · Journal of Personality Disorders · doi:10.1521/pedi.2023.37.2.156 · Cited by 5
Crying in borderline personality disorder patients
Peter, M., Arntz, A. R., Klimstra, T. A., & Vingerhoets, A. J. J. M. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.01.024 · Cited by 3
Borderline Personality Disorder
Rizvi, S. L., & Thomas, M. C. (2017) · Wiley eBooks · doi:10.1002/9781118877142.ch24 · Cited by 9
Borderline Personality Disorder and the Heart
Boldrini, A. (2020) · Springer eBooks · doi:10.1007/978-3-319-90305-7_25-1 · Cited by 1
Ghomroudi, P. A., Siugzdaite, R., Messina, I., & Grecucci, A. (2024) · doi:10.48550/arxiv.2401.16533 · Cited by 2
“For example, anxiety, depression, and personality disorders have all been linked to emotion dysregulation (Mennin and Fresco, 2009; Schulze et al., 2011).”
Background
Metadata
- Authors
- Schulze, L., Domes, G., Krüger, A., Berger, C., Fleischer, M., Prehn, K., Schmahl, C., Grossmann, A., Hauenstein, K., & Herpertz, S. C.
- Affiliations
- University of Rostock (DE)
- University of Freiburg (DE)
- Freie Universität Berlin (DE)
- Heidelberg University (DE)
- Corresponding author
- Herpertz, Sabine C.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 69
- Issue
- 6
- Pages
- 564-573
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1992311480
- Cited by
- 266
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 12 · 2023: 6 · 2022: 10 · 2021: 28 · 2020: 13 · 2019: 18 · 2018: 25 · 2017: 14 · 2016: 33 · 2015: 20 · 2014: 24 · 2013: 25 · 2012: 23
- FWCI
- 25.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- German Research Foundation (DFG He 2660/7-1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, cognitive reappraisal, emotion regulation, neuroticism, amygdala, insula, orbitofrontal cortex, emotional reactivity, negative emotions, aversive stimuli, prefrontal cortex dysfunction
- MeSH terms
- Adult, Arousal, Borderline Personality Disorder, Brain, Brain Mapping, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Neuropsychological Tests, Photic Stimulation, Psychometrics, Mood Disorders, Young Adult
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