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Cited by 266Personality Disorders and PsychopathologyNeural and Behavioral Psychology StudiesPsychopathy, Forensic Psychiatry, Sexual Offending

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Neuronal Correlates of Cognitive Reappraisal in Borderline Patients with Affective Instability

Schulze, Lars, Domes, Gregor, Krüger, Alexander, Berger, Christoph, Fleischer, Monika, Prehn, Kristin, Schmahl, Christian, Grossmann, Annette, Hauenstein, Karlheinz, Herpertz, Sabine C.·2011·Biological Psychiatry
DOI 10.1016/j.biopsych.2010.10.025
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Abstract

Background Borderline personality disorder has been characterized by enhanced emotional reactivity and deficient emotion regulation in behavioral and functional imaging studies. We aimed to validate patients' difficulties in the cognitive regulation of negative emotions and investigated if emotion regulation deficits are restricted to the decrease of negative emotions. A cognitive reappraisal paradigm was used and hence a regulation strategy that is typically applied in cognitive-behavioral therapy. Methods Fifteen unmedicated female borderline patients with affective instability and 15 healthy female control subjects underwent functional magnetic resonance imaging during a delayed reappraisal paradigm. Hemodynamic responses were measured in response to aversive pictures in an initial viewing phase and a subsequent reappraisal phase with three different conditions: decreasing, increasing, and maintaining the initial emotional reaction. Results Patients demonstrated enhanced activation of left amygdala and right insula during the initial viewing of aversive stimuli. During attempting to decrease the initial emotional reaction, patients showed attenuated activation of the left orbitofrontal cortex and increased activation of the bilateral insula. The attempt to increase negative emotions resulted in enhanced activity in amygdala and insula, whereas no group differences were found. Conclusions The results point to the role of two distinguishable processes of emotional difficulti…

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Metadata

Authors
Schulze, L., Domes, G., Krüger, A., Berger, C., Fleischer, M., Prehn, K., Schmahl, C., Grossmann, A., Hauenstein, K., & Herpertz, S. C.
Affiliations
  • University of Rostock (DE)
  • University of Freiburg (DE)
  • Freie Universität Berlin (DE)
  • Heidelberg University (DE)
Corresponding author
Herpertz, Sabine C.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2011-03
Volume
69
Issue
6
Pages
564-573
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2010.10.025
OpenAlex
W1992311480
Cited by
266
References
0
Citations by year
2026: 4 · 2025: 4 · 2024: 12 · 2023: 6 · 2022: 10 · 2021: 28 · 2020: 13 · 2019: 18 · 2018: 25 · 2017: 14 · 2016: 33 · 2015: 20 · 2014: 24 · 2013: 25 · 2012: 23
FWCI
25.90
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders
German Research Foundation (DFG He 2660/7-1)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords
borderline personality disorder, cognitive reappraisal, emotion regulation, neuroticism, amygdala, insula, orbitofrontal cortex, emotional reactivity, negative emotions, aversive stimuli, prefrontal cortex dysfunction
MeSH terms
Adult, Arousal, Borderline Personality Disorder, Brain, Brain Mapping, Cognition Disorders, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Neuropsychological Tests, Photic Stimulation, Psychometrics, Mood Disorders, Young Adult

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