RETRACTED: Impaired Visual Cortical Plasticity in Schizophrenia
Open accessAbstract
Background Impaired cortical plasticity may be part of the core pathophysiology of schizophrenia (SZ). Long-term potentiation is a form of neuroplasticity that has been recently demonstrated in humans by showing that repetitive visual stimulation produces lasting enhancement of visual evoked potentials (VEP). Using this paradigm, we examined whether visual cortical plasticity is impaired in SZ.Methods Electroencephalographic data were recorded from 19 SZ and 22 healthy control (HC) subjects during a visual long-term potentiation paradigm. Visual evoked potentials were elicited by standard visual stimuli (∼.83 Hz, 2-minute blocks) at baseline and at 2, 4, and 20 minutes following exposure to visual high-frequency stimulation (HFS) (∼8.8 Hz, 2 minutes) designed to induce VEP potentiation. To ensure attentiveness during VEP assessments, subjects responded with a button press to infrequent (10%) target stimuli. Visual evoked potentials were subjected to principal components analysis. Two negative-voltage components prominent over occipital-parietal electrode sites were evident at 92 msec (C1) and at 146 msec (N1b). Changes in C1 and N1b component scores from baseline to the post-HFS assessments were compared between groups.Results High-frequency stimulation produced sustained potentiation of visual C1 and N1b in HCs but not in SZs. The HCs and SZs had comparable HFS-driven electroencephalographic visual steady state responses. However, greater visual steady state responses to the HFS predicted greater N1b potentiation in HCs but not in SZs. Schizophrenia patients with greater N1b potentiation decreased their reaction times to target stimuli.Conclusions Visual cortical plasticity is impaired in schizophrenia, consistent with hypothesized deficits in N-methyl-D-aspartate receptor function.
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In chronic schizophrenia patients, deficits in visual cortex and long-term potentiation-like plasticity are reported when probed by transcranial direct current stimulation.
“In chronic schizophrenia patients, deficits in visual cortex and long-term potentiation-like plasticity are reported when probed by transcranial direct current stimulation (55–58).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [58]
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- Authors
- Çavuş, I., Reinhart, R. M. G., Roach, B. J., Gueorguieva, R., Teyler, T. J., Clapp, W. C., Ford, J. M., Krystal, J. H., & Mathalon, D. H.
- Affiliations
- Yale University (US)
- San Francisco VA Medical Center (US)
- University of Idaho (US)
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 71
- Issue
- 6
- Pages
- 512-520
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3292767
- OpenAlex
- W2022047741
- Cited by
- 130
- References
- 68
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 21 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 2 · 2012: 4
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (1RO1 MH 06508-01A2)
- John Merck Fund
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- schizophrenia, visual cortical plasticity, long-term potentiation, visual evoked potentials, C1 component, neuroplasticity
- MeSH terms
- Adult, Electroencephalography, Evoked Potentials, Visual, Female, Humans, Male, Neuronal Plasticity, Photic Stimulation, Reaction Time, Schizophrenia, Time Factors, Visual Cortex
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