When too much of a good thing is bad: chronic oxytocin, development, and social impairments
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Chronic exposure to exogenous oxytocin can lead to a dampening of the short-term improvement effect and to even counterproductive results.
“However, first indications exist that chronic exposure to exogenous oxytocin can lead to a dampening of this effect and to even counterproductive results (Bales et al., 2013; but see Young, 2013).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Young, 2013
Oxytocin does not directly cause prosocial behaviour.
“does not directly cause prosocial behaviour”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
For oxytocin administration to be therapeutic and influence behaviour, it must be paired with an appropriate social context.
“for oxytocin administration to be therapeutic and influence behaviour, it must be paired with an appropriate social context2–6”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
Oxytocin enhances social salience rather than social behaviour.
“oxytocin enhances social salience rather than social behaviour”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
Chronic, context-independent pharmacological intervention is likely to be less effective for addressing complex psychiatric issues such as social behavioural deficits than for other organ systems.
“this type of approach is likely to be less effective for addressing complex psychiatric issues such as social behavioural deficits2,6”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
Even in a therapeutic context, intranasal oxytocin is a suboptimal method for enhancing oxytocin signalling.
“Even in a therapeutic context, intranasal oxytocin is a suboptimal method for enhancing oxytocin signalling.”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
Oxytocin has a short half-life.
“Oxytocin has a short half-life”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
Oxytocin's ability to penetrate the blood-brain barrier is hotly contested.
“its ability to penetrate the blood–brain barrier is hotly contested”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
Oxytocin's ability to diffuse intracerebrally to reach relevant brain areas has been questioned.
“its ability to diffuse intracerebrally to reach relevant brain areas has been questioned2,4,6”
From Refining oxytocin therapy for autism: context is key (2022) · cites this paper as [2]
Cites
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Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
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Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · see citing works
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Developmental experiences and the oxytocin receptor system
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Porges, C. C., & Getz, L. (1996) · American Scientist · Cited by 122 · see citing works
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Yatawara, C. J., Einfeld, S. L., Hickie, I. B., Davenport, T. A., & Guastella, A. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.162 · Cited by 344 · see citing works
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Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety
Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.2 · Cited by 193 · see citing works
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Developmental Perspectives on Oxytocin and Vasopressin
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Self-citationOxytocin receptor dynamics in the brain across development and species
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Chronic central oxytocin infusion impairs sociability in mandarin voles
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Mate Selection, Sexual Orientation, and Pair Bonding
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- Authors
- Young, L. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Young, Larry J.
- ORCID
- Young, Larry J.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 74
- Issue
- 3
- Pages
- 160-161
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2012961992
- Cited by
- 22
- References
- 10
- Citations by year
- 2022: 1 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 5
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, Microtus ochrogaster, social bonding, mate preferences, social recognition, social cognition, social dysfunction, developmental effects, autism spectrum disorder, schizophrenia
- MeSH terms
- Animals, Female, Male, Oxytocin, Pair Bond, Sexual Behavior, Animal, Social Behavior Disorders
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