Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships

Pohl, Tobias T.; Young, Larry J.; Bosch, Oliver J.

doi:10.1016/j.ijpsycho.2017.12.011

Cited by 83Neuroendocrine regulation and behaviorAttachment and Relationship DynamicsStress Responses and Cortisol

Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships

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Pohl, Tobias T., Young, Larry J., Bosch, Oliver J.·2019·International Journal of Psychophysiology

DOI 10.1016/j.ijpsycho.2017.12.011PMC PMC6037618

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Abstract

In humans and rodent animal models, the brain oxytocin system is paramount for facilitating social bonds, from the formation and consequences of early-life parent-infant bonds to adult pair bond relationships. In social species, oxytocin also mediates the positive effects of healthy social bonds on the partners' well-being. However, new evidence suggests that the negative consequences of early neglect or partner loss may be mediated by disruptions in the oxytocin system as well. With a focus on oxytocin and its receptor, we review studies from humans and animal models, i.e. mainly from the biparental, socially monogamous prairie vole (Microtus ochrogaster), on the beneficial effects of positive social relationships both between offspring and parents and in adult partners. The abundance of social bonds and benevolent social relationships, in general, are associated with protective effects against psycho- and physiopathology not only in the developing infant, but also during adulthood. Furthermore, we discuss the negative effects on well-being, emotionality and behavior, when these bonds are diminished in quality or are disrupted, for example through parental neglect of the young or the loss of the partner in adulthood. Strikingly, in prairie voles, oxytocinergic signaling plays an important developmental role in the ability to form bonds later in life in the face of early-life neglect, while disruption of oxytocin signaling following partner loss results in the emergence of depressive-like behavior and physiology. This review demonstrates the translational value of animal models for investigating the oxytocinergic mechanisms that underlie the detrimental effects of developmental parental neglect and pair bond disruption, encouraging future translationally relevant studies on this topic that is so central to our daily lives.

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Being away from a partner leads to rumination about that partner and a desire to be reunited, and longer-term separations are followed by psychological and physiological changes similar to those seen in prairie voles.
“Being away from a partner leads to rumination about that partner and a desire to be reunited, and longer-term separations are followed by psychological and physiological changes similar to those seen in prairie voles [170,171].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [170]
Section 3.2 (page unavailable) describes longing after a partner’s death and psychological and physical effects of separation, particularly in prolonged complicated grief; it only tentatively links those effects to animal models. Sections 4.5–4.6 (pages unavailable) describe comparable effects in separated prairie voles. The paper does not establish rumination during ordinary time away from a partner, and its account of prolonged effects is more qualified than the claim. (LLM, conf=0.85)
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Parent–child interaction and children's depression: the relationships between Parent–Child interaction and children's depressive symptoms in Taiwan
Liu, Y. (2003) · Journal of Adolescence · doi:10.1016/s0140-1971(03)00029-0 · Cited by 74 · see citing works
Maternal imprints and the origins of variation
Champagne, F. A. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.02.016 · Cited by 74 · see citing works
The neurobiology of pair bond formation, bond disruption, and social buffering
Lieberwirth, C., & Wang, Z. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.05.006 · Cited by 72 · see citing works
Central vasopressin V1a receptor activation is independently necessary for both partner preference formation and expression in socially monogamous male prairie voles
Donaldson, Z. R., Spiegel, L., & Young, L. J. (2010) · Behavioral Neuroscience · doi:10.1037/a0018094 · Cited by 71 · see citing works
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Love: Neuroscience reveals all
Young, L. J. (2009) · Nature · doi:10.1038/457148a · Cited by 71 · see citing works
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Paternal deprivation affects social behaviors and neurochemical systems in the offspring of socially monogamous prairie voles
Tabbaa, M., Lei, K., Liu, Y., & Wang, Z. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.011 · Cited by 68 · see citing works
Oxytocin, social cognition and psychiatry
Young, L. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.186 · Cited by 64 · see citing works
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Relationship quality and oxytocin
Holt‐Lunstad, J., Birmingham, W. C., & Light, K. C. (2014) · Journal of Social and Personal Relationships · doi:10.1177/0265407514536294 · Cited by 59 · see citing works
Artificial rearing causes changes in maternal behavior and c-fos expression in juvenile female rats.
González, A., & Fleming, A. S. (2002) · Behavioral Neuroscience · doi:10.1037//0735-7044.116.6.999 · Cited by 57 · see citing works
24-Hour Autonomic Dysfunction and Depressive Behaviors in an Animal Model of Social Isolation: Implications for the Study of Depression and Cardiovascular Disease
Grippo, A. J., Carter, C. S., McNeal, N., Chandler, D. L., LaRocca, M. A., Bates, S. L., & Porges, S. W. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820019e4 · Cited by 54 · see citing works
Social Integration, Social Support and Mortality in the US National Health Interview Survey
Barger, S. D. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318292ad99 · Cited by 54 · see citing works
The Role of the Child in Physical Abuse: A Reappraisal
Ammerman, R. T. (1991) · Violence and Victims · doi:10.1891/0886-6708.6.2.87 · Cited by 54 · see citing works
Social support and mental health in late adolescence are correlated for genetic, as well as environmental, reasons
Wang, A., Davis, O. S. P., Wootton, R. E., Mottershaw, A. L., & Haworth, C. M. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-13449-2 · Cited by 54 · see citing works
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model
Tabbaa, M., Paedae, B., Liu, Y., & Wang, Z. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150055 · Cited by 53 · see citing works
The daily life of complicated grief patients—What gets missed, what gets added?
Monk, T. H., Houck, P. R., & Katherine Shear, M. (2006) · Death Studies · doi:10.1080/07481180500348860 · Cited by 47 · see citing works
Artificial rearing causes changes in maternal behavior and c-fos expression in juvenile female rats.
González, A., & Fleming, A. S. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.6.999 · Cited by 46 · see citing works
Maternal care associates with play dominance rank among adult female rats
Parent, C. I., Corpo, A. D., Cameron, N. M., & Meaney, M. J. (2012) · Developmental Psychobiology · doi:10.1002/dev.21070 · Cited by 43 · see citing works
Parental separation/divorce in childhood and partnership outcomes at age 30
Fergusson, D. M., McLeod, G. F. H., & Horwood, L. J. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12107 · Cited by 42 · see citing works
The protective effects of social bonding on behavioral and pituitary-adrenal axis reactivity to chronic mild stress in prairie voles
McNeal, N., Appleton, K. M., Johnson, A. K., Scotti, M. L., Wardwell, J., Murphy, R., Bishop, C., Knecht, A., & Grippo, A. J. (2017) · Stress · doi:10.1080/10253890.2017.1295444 · Cited by 39 · see citing works
The Chemistry Between Us: Love, Sex, and the Science of Attraction
Young, L. J., & Alexander, B. G. (2012) · Cited by 36 · see citing works
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Early deprivation reduced anxiety and enhanced memory in adult male rats
Zhang, X., Wang, B., Jin, J., An, S., Zeng, Q., Duan, Y., Yang, L., Ma, J., & Cao, X. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.08.005 · Cited by 31 · see citing works
The Unique Influences of Parental Divorce and Parental Conflict on Emerging Adults in Romantic Relationships
Braithwaite, S. R., Doxey, R. A., Dowdle, K. K., & Fincham, F. (2016) · Journal of Adult Development · doi:10.1007/s10804-016-9237-6 · Cited by 31 · see citing works

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The neural mechanisms and circuitry of the pair bond
Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353 · see citing works
Self-citation
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
Self-citation
Emotional neglect in childhood shapes social dysfunctioning in adults by influencing the oxytocin and the attachment system: Results from a population-based study
Müller, L. E., Bertsch, K., Bülau, K., Herpertz, S. C., & Buchheim, A. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.05.011 · Cited by 92 · see citing works
Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors
Horie, K., Inoue, K., Suzuki, S., Adachi, S., Yada, S., Hirayama, T., Hidema, S., Young, L. J., & Nishimori, K. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.10.011 · Cited by 77 · see citing works
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Effects of Oxytocin on Fear Memory and Neuroinflammation in a Rodent Model of Posttraumatic Stress Disorder
Wang, S.-C., Lin, C.-C., Chen, C.-C., Tzeng, N., & Liu, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123848 · Cited by 73 · see citing works
Sex, love and oxytocin: Two metaphors and a molecule
Carter, C. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104948 · Cited by 70 · see citing works
The Roadmap for Resilience: The California Surgeon General's Report on Adverse Childhood Experiences, Toxic Stress, and Health
Bhushan, D., Kotz, K. J., McCall, J., Wirtz, S., Gilgoff, R., Dube, S. R., Powers, C., Olson-Morgan, J., Galeste, M., Patterson, K., et al. (2020) · doi:10.48019/peam8812 · Cited by 71 · see citing works
The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives
Blumenthal, S. A., & Young, L. J. (2023) · Biology · doi:10.3390/biology12060844 · Cited by 59 · see citing works
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Maternal stress and the MPOA: Activation of CRF receptor 1 impairs maternal behavior and triggers local oxytocin release in lactating rats
Klampfl, S. M., Schramm, M. M., Gaßner, B. M., Hübner, K., Seasholtz, A. F., Brunton, P. J., Bayerl, D. S., & Bosch, O. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.019 · Cited by 57 · see citing works
Self-citation
Oxytocin and love: myths, metaphors and mysteries.
Carter, C. S. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100107 · Cited by 57 · see citing works
Mom doesn’t care: When increased brain CRF system activity leads to maternal neglect in rodents
Klampfl, S. M., & Bosch, O. J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.01.001 · Cited by 51 · see citing works
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Microglia react to partner loss in a sex- and brain site-specific manner in prairie voles
Pohl, T. T., Jung, O., Benedetto, B. D., Young, L. J., & Bosch, O. J. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.026 · Cited by 48 · see citing works
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Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 49 · see citing works
Investigation of Oxtr-expressing Neurons Projecting to Nucleus Accumbens using Oxtr-ires-Cre Knock-in prairie Voles (Microtus ochrogaster)
Horie, K., Inoue, K., Nishimori, K., & Young, L. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.08.023 · Cited by 46 · see citing works
“Disruption of social bonds can have devastating effects on mental and physical health (Bosch and Young, 2018; Pohl et al., 2019).”
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Oxytocin receptors are widely distributed in the prairie vole (Microtus ochrogaster) brain: Relation to social behavior, genetic polymorphisms, and the dopamine system
Inoue, K., Ford, C. L., Horie, K., & Young, L. J. (2022) · Journal of Comparative Neurology · doi:10.1002/cne.25382 · Cited by 45 · see citing works
Self-citation
Grieving as a Form of Learning: Insights from Neuroscience Applied to Grief and Loss
O'Connor, M., & Seeley, S. H. (2021) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2021.08.019 · Cited by 38 · see citing works
Animal models of social stress: the dark side of social interactions
Masís-Calvo, M., Schmidtner, A. K., Oliveira, V. E. D. M., Grossmann, C. P., A, T. R. D. J., & Neumann, I. D. (2018) · Stress · doi:10.1080/10253890.2018.1462327 · Cited by 41 · see citing works
The behavioral neuroendocrinology of maternal behavior: Past accomplishments and future directions
Bridges, R. S. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104662 · Cited by 37 · see citing works
The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation
Zilkha, N., Sofer, Y., Kashash, Y., & Kimchi, T. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.03.005 · Cited by 39 · see citing works
Measurement of interpersonal physiological synchrony in dyads: A review of timing parameters used in the literature
Marzoratti, A., & Evans, T. M. (2022) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-022-01011-1 · Cited by 38 · see citing works
Neuroendocrine mechanisms of grief and bereavement: A systematic review and implications for future interventions
Hopf, D., Eckstein, M., Aguilar‐Raab, C., Warth, M., & Ditzen, B. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12887 · Cited by 39 · see citing works
Effects of oxytocin on prosocial behavior and the associated profiles of oxytocinergic and corticotropin-releasing hormone receptors in a rodent model of posttraumatic stress disorder
Wang, S.-C., Lin, C.-C., Tzeng, N., Tung, C., & Liu, Y. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0514-0 · Cited by 34 · see citing works
Social creatures: Model animal systems for studying the neuroendocrine mechanisms of social behaviour
Robinson, K. J., Bosch, O. J., Levkowitz, G., Busch, K. E., Jarman, A. P., & Ludwig, M. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12807 · Cited by 33 · see citing works
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Epigenetic Mechanisms in the Neurodevelopmental Theory of Depression
Talarowska, M. E. (2020) · Depression Research and Treatment · doi:10.1155/2020/6357873 · Cited by 34 · see citing works
How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles
Harbert, K. J., Pellegrini, M., Gordon, K. M., & Donaldson, Z. R. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104847 · Cited by 32 · see citing works
Oxytocin and oxygen: the evolution of a solution to the ‘stress of life’
Carter, C. S., & Kingsbury, M. A. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0054 · Cited by 32 · see citing works
Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles
Sadino, J. M., Bradeen, X., Kelly, C. J., Brusman, L. E., Walker, D. M., & Donaldson, Z. R. (2023) · eLife · doi:10.7554/elife.80517 · Cited by 28 · see citing works
Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Putnam, P. T., Young, L. J., & Gothard, K. M. (2018) · American Journal of Primatology · doi:10.1002/ajp.22756 · Cited by 28 · see citing works
“Striatal OT receptors also mediate the onset of depressive-like “grieving” behavior in prairie voles following loss of a partner (Bosch et al., 2016), a phenomenon that has been proposedtomaintain socialbonds (Bosch& Young,2017; Pohl,Young, & Bosch, 2018).”
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Positive mental health mediates the relationship between physical activity and suicide-related outcomes: a three-year follow-up study
Brailovskaia, J., Teismann, T., & Margraf, J. (2020) · Current Psychology · doi:10.1007/s12144-020-01152-x · Cited by 29 · see citing works
Serum oxytocin concentrations in current and recent suicide survivors are lower than in healthy controls
Jahangard, L., Shayganfard, M., Ghiasi, F., Salehi, I., Haghighi, M., Ahmadpanah, M., Bahmani, D. S., & Brand, S. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.05.014 · Cited by 27 · see citing works
Stress and Fear
Karnatovskaia, L. V., Johnson, M. M., Varga, K., Highfield, J. A., Wolfrom, B., Philbrick, K. L., Ely, E. W., Jackson, J. C., Gajic, O., Ahmad, S. R., et al. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.08.028 · Cited by 26 · see citing works
Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system
Bosch, O. J., Pohl, T. T., Neumann, I. D., & Young, L. J. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.034 · Cited by 26 · see citing works
Self-citation
The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn
Demarchi, L., Pawluski, J. L., & Bosch, O. J. (2021) · Peptides · doi:10.1016/j.peptides.2021.170593 · Cited by 24 · see citing works
Self-citation
Dysfunctions of brain oxytocin signaling: Implications for poor mothering
Sanson, A., & Bosch, O. J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109049 · Cited by 20 · see citing works
Self-citation
Immediate, uninterrupted skin-to-skin contact and breastfeeding after birth: A cross-sectional electronic survey
Allen, J., Parratt, J., Rolfe, M. I., Hastie, C. R., Saxton, A., & Fahy, K. M. (2019) · Midwifery · doi:10.1016/j.midw.2019.102535 · Cited by 22 · see citing works
Rewritable fidelity: How repeated pairings and age influence subsequent pair-bond formation in male prairie voles
Kenkel, W. M., Perkeybile, A. M., Yee, J. R., & Carter, C. S. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.015 · Cited by 21 · see citing works
Alteration in oxytocin levels induced by early social environment affects maternal behavior and estrogen receptor alpha in mandarin voles (Microtus mandarinus)
Feng, T., An, S., Kinden, R., Zhang, X., Jia, R., & Tai, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.038 · Cited by 18 · see citing works
Interactions between the κ opioid system, corticotropin-releasing hormone and oxytocin in partner loss
Bales, K. L., & Rogers, F. D. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0061 · Cited by 17 · see citing works
Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles
Watanasriyakul, W. T., Scotti, M. L., Carter, C. S., McNeal, N., Colburn, W., Wardwell, J., & Grippo, A. J. (2022) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.102967 · Cited by 14 · see citing works
Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration
Seeley, S. H., Andrews‐Hanna, J. R., Allen, J. J. B., & O'Connor, M. (2022) · Human Brain Mapping · doi:10.1002/hbm.26071 · Cited by 14 · see citing works
Current rodent models for the study of empathic processes
Cox, S. S., & Reichel, C. M. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000590 · Cited by 15 · see citing works
Effects of Chronic and Acute Intranasal Oxytocin Treatments on Temporary Social Separation in Adult Titi Monkeys (Plecturocebus cupreus)
Razo, R. A., Vázquez, M. D. L. V., Turcanu, P., Legrand, M., Lau, A. R., Weinstein, T. A. R., Goetze, L. R., & Bales, K. L. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.877631 · Cited by 13 · see citing works
On the origins of diversity in social behavior
YOUNG, L. J., & ZHANG, Q. (2021) · Japanese Journal of Animal Psychology · doi:10.2502/janip.71.1.4 · Cited by 13 · see citing works
Self-citation
Risk-Taking Behavior among Suicide Attempters
Abdoli, N., Salari, N., Farnia, V., Khodamoradi, M., Jahangiri, S., Mohammadi, M., Brühl, A. B., Bahmani, D. S., & Brand, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144177 · Cited by 14 · see citing works
Brief versus long maternal separation in lactating rats: Consequences on maternal behavior, emotionality, and brain oxytocin receptor binding
Demarchi, L., Sanson, A., & Bosch, O. J. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13252 · Cited by 11 · see citing works
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Harnessing the healing power of love
Ford, C. L., & Young, L. J. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.07.010 · Cited by 11 · see citing works
Self-citation
Paternal Deprivation and Female Biparental Family Rearing Induce Dendritic and Synaptic Changes in Octodon degus: I. Medial Prefrontal Cortex
de Schultz, T. F., Bock, J., & Braun, K. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00038 · Cited by 11 · see citing works
Differential paraventricular nucleus activation and behavioral responses to social isolation in prairie voles following environmental enrichment with and without physical exercise
Normann, M. C., Cox, M., Akinbo, O. I., Watanasriyakul, W. T., Kovalev, D. Y., Ciosek, S., Miller, T., & Grippo, A. J. (2021) · Social Neuroscience · doi:10.1080/17470919.2021.1926320 · Cited by 11 · see citing works
Neurobiology and treatment advances for prolonged grief disorder
Donaldson, Z. R., & Shear, M. K. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01663-8 · Cited by 9 · see citing works
Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner
Sadino, J., & Donaldson, Z. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15134 · Cited by 7 · see citing works
Separation from a bonded partner alters neural response to inflammatory pain in monogamous rodents
Okuda, T., Osako, Y., Hidaka, C., Nishihara, M., Young, L. J., Mitsui, S., & Yuri, K. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113650 · Cited by 7 · see citing works
Self-citation
Sex-dependent effects of pair bond interruption on anxiety- and depression-like behaviors in adult mandarin voles
Feng, Y., Yang, Y., Wang, Y., Lv, X., Zhang, X., Wang, Y., Zhu, Y., Wang, Q., He, Z., Tai, F., et al. (2021) · Behavioural Processes · doi:10.1016/j.beproc.2021.104497 · Cited by 8 · see citing works
Oxytocin, social relationships, and health: An introduction to the special issue
Holt‐Lunstad, J., Ditzen, B., & Light, K. C. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.12.008 · Cited by 8 · see citing works
A monoclonal antibody raised against a synthetic oxytocin peptide stains mouse hypothalamic neurones
Kogami, Y., Tsuji, T., Tsuji, C., Yokoyama, S., Furuhara, K., Lopatina, O. L., Shabalova, A. A., Salmina, A. B., Watanabe, Y., Hattori, T., et al. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12815 · Cited by 7 · see citing works
Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (Microtus ochrogaster)
Marinello, W. P., Gillera, S. E. A., Han, Y., Richardson, J. R., St Armour, G., Horman, B. M., & Patisaul, H. B. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112041 · Cited by 6 · see citing works
Microbiome and Metabolome Variation as Indicator of Social Stress in Female Prairie Voles
Nuccio, D. A., Normann, M. C., Zhou, H., Grippo, A. J., & Singh, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021677 · Cited by 7 · see citing works
Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers’ brain and stress-coping behavior in the first week postpartum
Demarchi, L., Sanson, A., & Bosch, O. J. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104065 · Cited by 5 · see citing works
Self-citation
Prolonged Grief Disorder: Treatment Approaches and the Spiritual Dimensions of Healing
Ungar-Sargon, J. (2025) · Addiction Research · doi:10.33425/2639-8451.1052 · Cited by 2 · see citing works
Oxytocin: A developmental journey
Bales, K. L. (2023) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2023.100203 · Cited by 4 · see citing works
Salivary oxytocin response of dairy cows to nursing and permanent separation from their calves, and the influence of the cow-calf bond
Neave, H. W., Rault, J., Jensen, E. H., & Jensen, M. B. (2024) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2024.106429 · Cited by 5 · see citing works
Paternal Deprivation and Female Biparental Family Rearing Induce Dendritic and Synaptic Changes in Octodon degus: II. Nucleus Accumbens
de Schultz, T. F., Braun, K. A., & Bock, J. (2023) · Developmental Neuroscience · doi:10.1159/000530050 · Cited by 3 · see citing works
Correction to: Positive mental health mediates the relationship between physical activity and suicide-related outcomes: a three-year follow-up study
Brailovskaia, J., Teismann, T., & Margraf, J. (2021) · Current Psychology · doi:10.1007/s12144-021-02330-1 · Cited by 3 · see citing works
A neurobiological perspective on prolonged grief disorder
Bryant, R. A., Breukelaar, I. A., & Korgaonkar, M. S. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.01.001 · Cited by 3 · see citing works
Possible Mechanisms of the Influence of Oxytocin and Vasopressin on Perception and Memory of Odors and on Social Behavior
Silkis, I. G. (2024) · Neurochemical Journal · doi:10.1134/s1819712424010215 · Cited by 2 · see citing works
Perinatal Epigenetic Programming of Functional Brain Circuits
Bock, J. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_8 · Cited by 2 · see citing works
Functional significance of some common oxytocin receptor SNPs involved in complex human traits
Ma, S. L., Bowen, M. T., & Dadds, M. R. (2025) · BMC Molecular and Cell Biology · doi:10.1186/s12860-024-00529-1 · Cited by 2 · see citing works
An overview of the use of oxytocin measures in leisure studies
Boccia, M. L., Melton, K. K., & Larson, M. (2019) · Journal of Leisure Research · doi:10.1080/00222216.2019.1687265 · Cited by 2 · see citing works
Grief-Related Psychopathology from Complicated Grief to DSM-5-TR Prolonged Grief Disorder: A Systematic Review of Biochemical Findings
Pedrinelli, V., Rimoldi, B., Conti, L., Bordacchini, A., Parrini, L., Betti, L., Giannaccini, G., Dell’Oste, V., & Carmassi, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411835 · Cited by 4 · see citing works
Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus
Naderi, A., Liles, K., Burns, T., Chavez, B., Huynh-Dam, K.-T., & Kiaris, H. (2023) · BMC Genomics · doi:10.1186/s12864-023-09873-6 · Cited by 1 · see citing works
Was wirkt, um Wohlbefinden zu erreichen?
Markowitsch, H. J., & Schreier, M. M. (2019) · Springer eBooks · doi:10.1007/978-3-662-58265-7_3
Translational research from animal models
Grippo, A. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00003-9
Elements of Purchasing in Nature
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Authors: Pohl, T. T., Young, L. J., & Bosch, O. J.
Affiliations: University of Regensburg (DE)
Emory University (US)
Corresponding author: Young, Larry J.
Bosch, Oliver J.
ORCID: Pohl, Tobias T.
Young, Larry J.
Bosch, Oliver J.
Venue: International Journal of Psychophysiology
Publisher: Elsevier BV
Published: 2019-02
Volume: 136
Pages: 54-63
ISSN: 0167-8760 (ISSN-L)
DOI: 10.1016/j.ijpsycho.2017.12.011
PMC: PMC6037618
OpenAlex: W2782910182
Cited by: 83
References: 202
Citations by year: 2026: 8 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 12 · 2021: 12 · 2020: 13 · 2019: 11 · 2018: 8 · 2017: 1
FWCI: 1.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Psychophysiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Deutsche Forschungsgemeinschaft (DFG GRK 2174/1)
NIH (R01MH096983, 1P50MH100023, P51-OD011132-55)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: oxytocin, oxytocin receptor, social bonds, parent-infant bonding, loss of a partner, Microtus ochrogaster, social monogamy, depression-like behavior, well-being, emotionality
MeSH terms: Animals, Arvicolinae, Female, Humans, Interpersonal Relations, Male, Object Attachment, Oxytocin, Pair Bond, Parent-Child Relations

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Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships

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