CoChat
Sign Up
Cited by 43Attention Deficit Hyperactivity DisorderFunctional Brain Connectivity StudiesNeural and Behavioral Psychology Studies

Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder

Open access
Cortese, Samuele, Castellanos, F. Xavier, Eickhoff, Claudia R., D’Acunto, Giulia, Masi, Gabriele, Fox, Peter T., Laird, Angela R., Eickhoff, Simon B.·2016·Biological Psychiatry
DOI 10.1016/j.biopsych.2016.06.014PMC PMC5108674
Open this paper in CoChat — free account

Abstract

Background Task-based functional magnetic resonance imaging (fMRI) studies of adult attention-deficit/hyperactivity disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies. Methods We first conducted an activation likelihood estimation meta-analysis of 24 task-based fMRI studies in adults with ADHD. Each ADHD-related dysfunctional region resulting from the activation likelihood estimation meta-analysis was then analyzed using functional decoding based on ~7500 fMRI experiments in the BrainMap database. This approach allows mapping brain regions to functions not necessarily tested in individual studies, thus suggesting possible novel functions for those regions. Additionally, ADHD-related dysfunctional regions were clustered based on their functional coactivation profiles across all the experiments stored in BrainMap (meta-analytic connectivity modeling). Results ADHD-related hypoactivation was found in the left putamen, left inferior frontal gyrus (pars opercularis), left temporal pole, and right caudate. Functional decoding mapped the left putamen to cognitive aspects of music perception/reproduction and the left temporal lobe to language semantics; both these regions clustered together on the basis of their meta-analytic functional connectivity. Left inferior gyrus mapped to executive function tasks; right caudate mapped to both executive function tasks and music-related processes. Conclusions Our study provides meta-analytic support to the hypothesis that, in addition to well-known deficits in typical executive functions, impairment in processes related to music perception/reproduction and language semantics may be involved in the pathophysiology of adult ADHD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2016.06.014

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 53

  1. [1]Polanczyk G Rohde LA Epidemiology of attention-deficit/hyperactivity disorder across the lifespan Curr Opin Psychiatry 2007 20 4 386 392 17551354
  2. [2]Polanczyk G de Lima MS Horta BL Biederman J Rohde LA The worldwide prevalence of ADHD: a systematic review and metaregression analysis Am J Psychiatry 2007 164 6 942 948 17541055
  3. [5]Cortese S Castellanos FX Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians Curr Psychiatry Rep 2012 14 5 568 578 22851201 PMC3876939
  4. [8]Hart H Radua J Mataix-Cols D Rubia K Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD) Neurosci Biobehav Rev 2012 36 10 2248 2256 22922163
  5. [9]McCarthy H Skokauskas N Frodl T Identifying a consistent pattern of neural function in attention deficit hyperactivity disorder: a meta-analysis Psychol Med 2014 44 4 869 880 23663382
  6. [10]Dibbets P Evers L Hurks P Marchetta N Jolles J Differences in feedback- and inhibition-related neural activity in adult ADHD Brain Cogn 2009 70 1 73 83 19201515
  7. [11]Dillo W Goke A Prox-Vagedes V Szycik GR Roy M Donnerstag F Neuronal correlates of ADHD in adults with evidence for compensation strategies--a functional MRI study with a Go/No-Go paradigm Ger Med Sci 2010 8 Doc09 20421953 PMC2858877
  8. [12]Kooistra L van der Meere JJ Edwards JD Kaplan BJ Crawford S Goodyear BG Preliminary fMRI findings on the effects of event rate in adults with ADHD J Neural Transm 2010 117 5 655 662 20157743
  9. [13]Mulligan RC Knopik VS Sweet LH Fischer M Seidenberg M Rao SM Neural correlates of inhibitory control in adult attention deficit/hyperactivity disorder: evidence from the Milwaukee longitudinal sample Psychiatry Res 2011 194 2 119 129 21937201 PMC3196255
  10. [15]Poldrack RA Inferring mental states from neuroimaging data: from reverse inference to large-scale decoding Neuron 2011 72 5 692 697 22153367 PMC3240863
  11. [18]Reetz K Dogan I Rolfs A Binkofski F Schulz JB Laird AR Investigating function and connectivity of morphometric findings - Exemplified on cerebellar atrophy in spinocerebellar ataxia 17 (SCA17) Neuroimage 2012 62 3 1354 1366 22659444 PMC4801477
  12. [19]Laird AR Eickhoff SB Li K Robin DA Glahn DC Fox PT Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling J Neurosci 2009 29 46 14496 14505 19923283 PMC2820256
  13. [23]Cortese S Castellanos FX Eickhoff SB What are neuroimaging meta-analytic procedures? Epidemiol Psychiatr Sci 2013 22 2 121 123 23402627 PMC6998219
  14. [25]Lancaster JL Tordesillas-Gutierrez D Martinez M Salinas F Evans A Zilles K Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template Hum Brain Mapp 2007 28 11 1194 1205 17266101 PMC6871323
  15. [26]Eickhoff SB Bzdok D Laird AR Kurth F Fox PT Activation likelihood estimation meta-analysis revisited Neuroimage 2012 59 3 2349 2361 21963913 PMC3254820
  16. [27]Eickhoff SB Heim S Zilles K Amunts K A systems perspective on the effective connectivity of overt speech production Philos Trans A Math Phys Eng Sci 2009 367 1896 2399 2421 19414462 PMC3268212
  17. [28]Eickhoff SB Bzdok D Laird AR Kurth F Fox PT Activation likelihood estimation meta-analysis revisited Neuroimage 2012 59 3 2349 2361 21963913 PMC3254820
  18. [29]Turkeltaub PE Eickhoff SB Laird AR Fox M Wiener M Fox P Minimizing within-experiment and within-group effects in Activation Likelihood Estimation meta-analyses Hum Brain Mapp 2012 33 1 1 13 21305667 PMC4791073
  19. [31]Genon S Li H Fan L Muller VI Cieslik EC Hoffstaedter F The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity Cereb Cortex 2016 In press PMC5963821 26965906
  20. [32]Bzdok D Heeger A Langner R Laird AR Fox PT Palomero-Gallagher N Subspecialization in the human posterior medial cortex Neuroimage 2015 106 55 71 25462801 PMC4780672
  21. [34]Sammon J A non-linear mapping for data structure analysis IEEE Trans Comp C 1969 18 401 409
  22. [35]Carmona S Hoekzema E Ramos-Quiroga JA Richarte V Canals C Bosch R Response inhibition and reward anticipation in medication-naive adults with attention-deficit/hyperactivity disorder: a within-subject case-control neuroimaging study Hum Brain Mapp 2012 33 10 2350 2361 21826761 PMC6870239
  23. [36]Kappel V Lorenz RC Streifling M Renneberg B Lehmkuhl U Strohle A Effect of brain structure and function on reward anticipation in children and adults with attention deficit hyperactivity disorder combined subtype Soc Cogn Affect Neurosci 2015 10 7 945 951 25338631 PMC4483558
  24. [37]Ko CH Hsieh TJ Wang PW Lin WC Chen CS Yen JY The Altered Brain Activation of Phonological Working Memory, Dual Tasking, and Distraction Among Participants With Adult ADHD and the Effect of the MAOA Polymorphism J Atten Disord 2015 In,. press 25777072
  25. [38]Maier SJ Szalkowski A Kamphausen S Feige B Perlov E Kalisch R Altered cingulate and amygdala response towards threat and safe cues in attention deficit hyperactivity disorder Psychol Med 2014 44 1 85 98 23510549
  26. [40]Sebastian A Gerdes B Feige B Kloppel S Lange T Philipsen A Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD Psychiatry Res 2012 202 2 132 141 22475505
  27. [41]Vasic N Plichta MM Wolf RC Fallgatter AJ Sosic-Vasic Z Gron G Reduced neural error signaling in left inferior prefrontal cortex in young adults with ADHD J Atten Disord 2014 18 8 659 670 22660917
  28. [42]Wilbertz G van Elst LT Delgado MR Maier S Feige B Philipsen A Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder Neuroimage 2012 60 1 353 361 22197790
  29. [44]Liberati A Altman DG Tetzlaff J Mulrow C Gotzsche PC Ioannidis JP The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration BMJ 2009 339 b2700 19622552 PMC2714672
  30. [46]Bayerl M Dielentheis TF Vucurevic G Gesierich T Vogel F Fehr C Disturbed brain activation during a working memory task in drug-naive adult patients with ADHD Neuroreport 2010 21 6 442 446 20224456
  31. [47]Cubillo A Halari R Ecker C Giampietro V Taylor E Rubia K Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood Attention-Deficit Hyperactivity Disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switching J Psychiatr Res 2010 44 10 629 639 20060129
  32. [48]Cubillo A Halari R Giampietro V Taylor E Rubia K Fronto-striatal underactivation during interference inhibition and attention allocation in grown up children with attention deficit/hyperactivity disorder and persistent symptoms Psychiatry Res 2011 193 1 17 27 21601434
  33. [50]Dibbets P Evers EA Hurks PP Bakker K Jolles J Differential brain activation patterns in adult attention-deficit hyperactivity disorder (ADHD) associated with task switching Neuropsychology 2010 24 4 413 423 20604616
  34. [51]Hale TS Bookheimer S McGough JJ Phillips JM McCracken JT Atypical brain activation during simple & complex levels of processing in adult ADHD: an fMRI study J Atten Disord 2007 11 2 125 140 17494829
  35. [52]Karch S Thalmeier T Lutz J Cerovecki A Opgen-Rhein M Hock B Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients Eur Arch Psychiatry Clin Neurosci 2010 260 5 427 440 19907927
  36. [55]Valera EM Spencer RM Zeffiro TA Makris N Spencer TJ Faraone SV Neural substrates of impaired sensorimotor timing in adult attention-deficit/hyperactivity disorder Biol Psychiatry 2010 68 4 359 367 20619827 PMC2917236
  37. [57]Wolf RC Plichta MM Sambataro F Fallgatter AJ Jacob C Lesch KP Regional brain activation changes and abnormal functional connectivity of the ventrolateral prefrontal cortex during working memory processing in adults with attention-deficit/hyperactivity disorder Hum Brain Mapp 2009 30 7 2252 2266 19107748 PMC6870879
  38. [58]Nakao T Radua J Rubia K Mataix-Cols D Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication Am J Psychiatry 2011 168 11 1154 1163 21865529
  39. [59]Rubia K Halari R Christakou A Taylor E Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate Philos Trans R Soc Lond B Biol Sci 2009 364 1525 1919 1931 19487194 PMC2685816
  40. [61]Wiener M Turkeltaub P Coslett HB The image of time: a voxel-wise meta-analysis Neuroimage 2010 49 2 1728 1740 19800975
  41. [62]Jackson NA A survey of music therapy methods and their role in the treatment of early elementary school children with ADHD J Music Ther 2003 40 4 302 323 15015907
  42. [64]Calderone DJ Lakatos P Butler PD Castellanos FX Entrainment of neural oscillations as a modifiable substrate of attention Trends Cogn Sci 2014 18 6 300 309 24630166 PMC4037370
  43. [65]Sowell ER Thompson PM Welcome SE Henkenius AL Toga AW Peterson BS Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder Lancet 2003 362 9397 1699 1707 14643117
  44. [67]Shaw P Eckstrand K Sharp W Blumenthal J Lerch JP Greenstein D Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation Proc Natl Acad Sci U S A 2007 104 49 19649 19654 18024590 PMC2148343
  45. [68]Takacs A Kobor A Tarnok Z Csepe V Verbal fluency in children with ADHD: strategy using and temporal properties Child Neuropsychol 2014 20 4 415 429 23731209
  46. [71]Lapadat JC Pragmatic language skills of students with language and/or learning disabilities: a quantitative synthesis J Learn Disabil 1991 24 3 147 158 2026956
  47. [72]Segal D Mashal N Shalev L Semantic conflicts are resolved differently by adults with and without ADHD Res Dev Disabil 2015 47 416 429 26513742
  48. [73]Frith U Frith CD Development and neurophysiology of mentalizing Philos Trans R Soc Lond B Biol Sci 2003 358 1431 459 473 12689373 PMC1693139
  49. [75]Batty MJ Liddle EB Pitiot A Toro R Groom MJ Scerif G Cortical gray matter in attention-deficit/hyperactivity disorder: a structural magnetic resonance imaging study J Am Acad Child Adolesc Psychiatry 2010 49 3 229 238 20410712 PMC2829134
  50. [78]Retz W Stieglitz RD Corbisiero S Retz-Junginger P Rosler M Emotional dysregulation in adult ADHD: What is the empirical evidence? Expert Rev Neurother 2012 12 10 1241 1251 23082740
  51. [79]Solanto MV Schulz KP Fan J Tang CY Newcorn JH Event-related FMRI of inhibitory control in the predominantly inattentive and combined subtypes of ADHD J Neuroimaging 2009 19 3 205 212 19594667 PMC2711513
  52. [81]Chou TL Chia S Shang CY Gau SS Differential therapeutic effects of 12-week treatment of atomoxetine and methylphenidate on drug-naive children with attention deficit/hyperactivity disorder: A counting Stroop functional MRI study Eur Neuropsychopharmacol 2015 25 12 2300 2310 26409297
  53. [82]Konrad K Neufang S Hanisch C Fink GR Herpertz-Dahlmann B Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: evidence from an event-related functional magnetic resonance imaging study Biol Psychiatry 2006 59 7 643 651 16197925

Cited by

Sorted by citations

Authors
Cortese, S., Castellanos, F. X., Eickhoff, C. R., D’Acunto, G., Masi, G., Fox, P. T., Laird, A. R., & Eickhoff, S. B.
Affiliations
  • NYU Langone Health (US)
  • Nathan Kline Institute for Psychiatric Research (US)
  • Forschungszentrum Jülich (DE)
  • The University of Texas at San Antonio Health Science Center (US)
  • Florida International University (US)
Corresponding author
Cortese, Samuele
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2016-12
Volume
80
Issue
12
Pages
896-904
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2016.06.014
PMC
PMC5108674
OpenAlex
W2463441912
Cited by
43
References
28
Citations by year
2026: 4 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 6 · 2016: 1
FWCI
0.53
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Funders
  • H. Lundbeck A/S
  • National Institute of Mental Health (R01MH074457, R01MH083246)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
adult ADHD, meta-analytic connectivity modeling, activation likelihood estimation, putamen, caudate nucleus, inferior frontal gyrus, temporal pole, music perception, language semantics, executive function, brain dysfunction
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Neostriatum, Connectome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review