Real-world stress resilience is associated with the responsivity of the locus coeruleus
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Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience.
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Stressful events are inherently highly emotional and can increase vulnerability to psychopathology; the ability to regulate emotions may be a critically important factor in determining stress resilience and mental wellbeing.
“As stressful events are inherently highly emotional (Southwick et al., 2011) and can increase vulnerability to psychopathology (Grueschow et al., 2021), the ability to regulate emotions may be a critically important factor in determining stress resilience (Barzilay et al., 2020; Kaldewaij et al., 2021) and mental wellbeing (Satchit et al., 2011; Silton et al., 2020).”
From Mindfulness-Based Stress Reduction Increases Mental Wellbeing and Emotion Regulation During the First Wave of the COVID-19 Pandemic: A Synchronous Online Intervention Study (2021) · cites this paper as Grueschow et al., 2021
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- Authors
- Grueschow, M., Stenz, N., Thörn, H., Ehlert, U., Breckwoldt, J., Brodmann Maeder, M., Exadaktylos, A. K., Bingisser, R., Ruff, C. C., & Kleim, B.
- Affiliations
- University of Zurich (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Corresponding author
- Grueschow, Marcus
- Kleim, Birgit
- ORCID
- Venue
- Nature Communications
- Published
- 2021-04-15
- Volume
- 12
- Issue
- 1
- Pages
- 2275-2275
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8050280
- OpenAlex
- W3155821888
- Cited by
- 116
- References
- 147
- Citations by year
- 2026: 18 · 2025: 31 · 2024: 18 · 2023: 18 · 2022: 20 · 2021: 11
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Richard-Büchner-Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PZ00P1_126597, PZ00P1_150812)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- stress resilience, locus coeruleus, noradrenergic system, pupil dilation, amygdala, emotional conflict, anxiety, depression, medical residents, functional connectivity
- MeSH terms
- Occupational Stress, Adult, Amygdala, Anxiety, Depression, Emergency Service, Hospital, Female, Humans, Internship and Residency, Locus Coeruleus, Magnetic Resonance Imaging, Male, Predictive Value of Tests, Risk Factors, Students, Medical, Resilience, Psychological, Young Adult, Connectome
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