Cited by 116Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Real-world stress resilience is associated with the responsivity of the locus coeruleus

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Grueschow, Marcus, Stenz, Nico, Thörn, Hanna, Ehlert, Ulrike, Breckwoldt, Jan, Brodmann Maeder, Monika, Exadaktylos, Aristomenis K., Bingisser, Roland +2 more·2021·Nature Communications

Abstract

Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience.

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Research works printed but not linked: 6

  1. [101]Laeng B Orbo M Holmlund T Miozzo M Pupillary Stroop effects Cogn. Process 2011 12 13 21 10.1007/s10339-010-0370-z 20865297 PMC3026931 · DOI
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Authors
Grueschow, M., Stenz, N., Thörn, H., Ehlert, U., Breckwoldt, J., Brodmann Maeder, M., Exadaktylos, A. K., Bingisser, R., Ruff, C. C., & Kleim, B.
Affiliations
  • University of Zurich (CH)
  • University Hospital of Bern (CH)
  • University Hospital of Basel (CH)
Corresponding author
  • Grueschow, Marcus
  • Kleim, Birgit
Venue
Nature Communications
Published
2021-04-15
Volume
12
Issue
1
Pages
2275-2275
ISSN
2041-1723 (ISSN-L)
OpenAlex
W3155821888
Cited by
116
References
147
Citations by year
2026: 18 · 2025: 31 · 2024: 18 · 2023: 18 · 2022: 20 · 2021: 11
FWCI
10.72
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Richard-Büchner-Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PZ00P1_126597, PZ00P1_150812)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
stress resilience, locus coeruleus, noradrenergic system, pupil dilation, amygdala, emotional conflict, anxiety, depression, medical residents, functional connectivity
MeSH terms
Occupational Stress, Adult, Amygdala, Anxiety, Depression, Emergency Service, Hospital, Female, Humans, Internship and Residency, Locus Coeruleus, Magnetic Resonance Imaging, Male, Predictive Value of Tests, Risk Factors, Students, Medical, Resilience, Psychological, Young Adult, Connectome

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