Cited by 224Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionLipid metabolism and biosynthesis

Storage of starch and lipids in microalgae: Biosynthesis and manipulation by nutrients

Ran, Wenyi, Wang, Haitao, Liu, Yinghui, Qi, Man, Xiang, Qi, Yao, Changhong, Zhang, Yongkui, Lan, Xianqiu·2019·Bioresource Technology

Abstract

Microalgae accumulate starch and lipid as storage metabolites under nutrient depletion, which can be used as sustainable feedstock for biorefinery. Omics analysis coupled with enzymatic and genetic verifications uncovered a partial picture of pathways and important enzymes or regulators related to starch and lipid biosynthesis as well as the carbon partitioning between them under nutrient depletion conditions. Depletion of macronutrients (N, P, and S) resulted in considerable enhancement of starch and/or lipid content in microalgae, but the accompanying declined photosynthesis hampered the achievements of high concentrations. This review summarized the current knowledge on the pathways and the committed steps as well as their carbon allocation involved in starch and lipid biosynthesis, and focused on the manipulation of different nutrients and the alleviation of oxidative stress for enhanced storage metabolites production. The biological and engineering approaches to cope with the conflict between biomass production and storage metabolites accumulation are proposed.

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Crossref · 10.1016/j.biortech.2019.121894

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  • Microalgae are good sources of carbohydrate (predominantly starch) for fermentation, such as Chlorella vulgaris (55%), Chlamydomonas reinhardtii (60%), and Scenedesmus obliquus (52%).

    “Microalgae are good sources of carbohydrate (predominatly starch) for fermentation such as Chlorella vulgaris (55%), Chlamydomonas reinhardtii (60%), Scenedesmus obliquus (52%) [77]”

    From Key Targets for Improving Algal Biofuel Production (2021) · cites this paper as [77]

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Authors
Ran, W., Wang, H., Liu, Y., Qi, M., Xiang, Q., Yao, C., Zhang, Y., & Lan, X.
Affiliations
  • Sichuan University (CN)
  • Dalian Polytechnic University (CN)
Corresponding author
Yao, Changhong
Venue
Bioresource Technology
Publisher
Elsevier BV
Published
2019-11
Volume
291
Pages
121894
ISSN
0960-8524 (ISSN-L)
OpenAlex
W2964071036
Cited by
224
References
146
Citations by year
2026: 31 · 2025: 50 · 2024: 34 · 2023: 31 · 2022: 36 · 2021: 21 · 2020: 20
FWCI
0.75
Type
journal article
Language
en
Open access
closed
Locations
  • Bioresource Technology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundamental Research Funds for the Central Universities (YJ201734)
  • National Natural Science Foundation of China (31500294, 31601389, 41406177)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
microalgae, starch biosynthesis, lipogenesis, nutrient depletion, carbon allocation, macronutrient limitation, photosynthesis, oxidative stress, biorefinery feedstock, metabolic engineering
MeSH terms
Nutrients, Lipids, Starch, Biomass, Lipid Metabolism, Microalgae

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